Tag: M.W=250-300

Gracia, Jordi published the artcileBiphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships, Name: Methyl 4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate, the publication is Journal of Medicinal Chemistry (2016), 59(23), 10479-10497, database is CAplus and MEDLINE.

Cyclic nucleotide cAMP is an ubiquitous second messenger involved in a plethora of cellular responses to biol. agents involving activation of adenylyl cyclase. Its intracellular levels are tightly controlled by a family of cyclic nucleotide degrading enzymes, the PDEs. In recent years, cyclic nucleotide phosphodiesterase type 4 (PDE4) has aroused scientific attention as a suitable target for anti-inflammatory therapy in respiratory diseases, particularly in the management of asthma and COPD. Here the authors describe efforts to discover novel, highly potent inhaled inhibitors of PDE4. Through structure based design, with the intervention of a wide variety of functional groups and physichochem. profiles to occupy the solvent-filled pocket of the PDE4 enzyme, the authors modified the structure of the authors’ oral PDE4 inhibitors to reach compounds up to picomolar enzymic potencies. In vitro potencies were demonstrated in a rat lung neutrophilia model by suspension microspray administration.

Journal of Medicinal Chemistry published new progress about 757982-31-3. 757982-31-3 belongs to esters-buliding-blocks, auxiliary class Boronic acid and ester,Boronic acid and ester, name is Methyl 4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate, and the molecular formula is C14H18BFO4, Name: Methyl 4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kreutz, Jennifer Anna published the artcileA 1-year study of the activities of seven hydrolases in a communal wastewater treatment plant: trends and correlations, Related Products of esters-buliding-blocks, the publication is Applied Microbiology and Biotechnology (2016), 100(15), 6903-6915, database is CAplus and MEDLINE.

The activities of seven hydrolytic enzymes (L-alanine aminopeptidase, esterase, α-and β-glucosidase, phosphomonoesterase, phosphodiesterase, sulfatase) were monitored during 1 yr in parallel and serial treatment units of the biol. stage of a communal wastewater treatment plant. The spatial homogeneity of enzyme activities was high (coefficients of variation <10% for the entire treatment stage). A significant difference between aerated and stirred tanks was not observed Temperature seemed not to exert a direct influence. Long periods with comparably constant activities were interrupted by a few strong, short-time rises. The mean enzyme activities followed the sequence sulfatase < α-glucosidase < phosphodiesterase ≈ β-glucosidase≈esterase < phosphomonoesterase < L-alanine aminopeptidase. The enzyme activities correlated among themselves at different levels. Very strong (r > 0.8) and highly significant (p < 0.01) correlations between the activities of both glucosidases, both phosphoesterases, and between phosphomonoesterase and both glucosidases were ascertained, pointing to the importance of substrate specificity and similarity of metabolic functions. Moderate and strong activity correlations with various wastewater constituents and with process parameters, e.g., concentrations, loads and eliminated amounts of phosphorous, TOC concentrations and loads of the plant effluent, dry matter content of activated sludge, and sludge volume, were found.

Applied Microbiology and Biotechnology published new progress about 6217-68-1. 6217-68-1 belongs to esters-buliding-blocks, auxiliary class Salt,Nitro Compound,Sulfonate,Benzene, name is Potassium 4-nitrophenyl sulfate, and the molecular formula is C6H4KNO6S, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Breloy, Louise published the artcileMethacrylated Quinizarin Derivatives for Visible-Light Mediated Photopolymerization: Promising Applications in 3D-Printing Biosourced Materials under LED@405 nm, Computed Properties of 15625-89-5, the publication is ACS Applied Polymer Materials (2022), 4(1), 210-228, database is CAplus.

The high initiating properties of mono- (Q-1Ac) and dimethacrylated (Q-2Ac) quinizarin derivatives under visible-light irradiation are reported here. Associated with various co-initiators, such as iodonium salt (electron acceptor), an amine derivative (electron donor) or thiol crosslinker (H-donor), the quinizarin derived photosensitizers lead to high conversions by radical photopolymerization in laminate or under air. Mechanisms of photoinitiation were deeply investigated by fluorescence, laser flash photolysis (LFP) and ESR experiments The use of soybean oil acrylate (SOA) as biobased monomer leads to highly crosslinked materials under visible-light, with comparable mech. properties than UV-induced ones previously described in literature. Copolymerization of the photosensitizer (PS) with the polymer matrix not only prevents leakage, but also ensures antiadhesion properties of SOA materials against Staphylococcus aureus (S. aureus) under visible-light activation. Finally, complex 3D biobased structures are successfully obtained by 3D-printing under visible-light irradiation (LED@405 nm), opening opportunities to design photoinduced biosourced materials.

ACS Applied Polymer Materials published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Computed Properties of 15625-89-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Guivisdalsky, Pedro N. published the artcileAn efficient stereocontrolled route to both enantiomers of platelet activating factor and analogs with long-chain esters at C-2: saturated and unsaturated ether glycerolipids by opening of glycidyl arenesulfonates, Name: (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, the publication is Journal of Organic Chemistry (1989), 54(19), 4643-8, database is CAplus.

Both enantiomers of various ether/ester glycerophosphocholines (R)-I and (S)-II (R¹ = e.g., hexadecyl, R² = pentadecyl, Me), including platelet activating factor I (R¹ = hexadecyl, R² = Me), were synthesized from arenesulfonate derivatives of glycidol (R)- and (S)-III (R³ = C₆H₄Me-4, C₆H₄NO₂-3) readily available in high enantiomeric purity. Regio- and stereospecific opening of (R)- or (S)-III with 1.0-1.4 equiv of long-chain saturated or unsaturated alc. using BF₃.Et₂O as catalyst in CH₂Cl₂ or CHCl₃ afforded (R)- and (S)-R³SO₃CH₂CH(OH)CH₂OR⁴ (IV; R³ = C₆H₄Me-4, C₆H₄NO₂-3; R⁴ = oleyl, petroselinyl, hexadecyl) in 73-83% yields and with the same very high optical purity of the parent glycidyl arenesulfonate (94-99% enantiomeric excess). For saturated alkyl/acyl I and II O-benzylation of IV was achieved with retention of the arenesulfonte group by using benzyl trifluoromethanesulfonate in the presence of excess 2,6-di-tert-butyl-4-methylpyridine; the C-2 hydroxyl of unsaturated O-alkyl IV is protected as the methoxymethyl ether under mild conditions in which the arenesulfonate group is retained. Displacement of the arenesulfonate group and introduction of the phosphocholine group to produce PAF analogs complete this route to chiral ether-ester phospholipids.

Journal of Organic Chemistry published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Name: (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Guivisdalsky, Pedro N. published the artcileGlycidyl derivatives as chiral C₃ synthons. Ring opening catalyzed by boron trifluoride etherate, Quality Control of 115314-17-5, the publication is Journal of the American Chemical Society (1989), 111(8), 3077-9, database is CAplus.

The BF₃.OEt₂ mediated regio- and stereoselective opening reactions of (R)- and (S)-glycidyl arenesulfonates I (R = 4-MeC₆H₅SO₂, 3-O₂NC₆H₄SO₂) and tert-butyldiphenylsilyl ether I (R = Me₃CPh₂Si) with R¹XH [R¹ = PhCH₂, Me(CH)₁₅, oleyl, petroselinyl, X = O; R¹ = Ph, X = S] in CH₂Cl₂ or CHCl₃ is reported. BF₃.Et₂ was a more effective catalyst than other Lewis acids used previously for opening of glycidol, giving rise to (+)- and (-)-ROCH₂CH(OH)CH₂XR¹ (R, R¹, X = same as above) in good yield and high enantiomeric excess. Glycidyl arenesulfonates underwent attack exclusively at C(3), whereas the silyl ethers gave products resulting from C(3):C(2) attack in a ratio of 9:1. The BF₃.Et₂O catalyzed opening of glycidyl derivatives is a more convenient method for preparing suitably protected vic-diols than the previously described Ti-mediated opening the the parent glycidol.

Journal of the American Chemical Society published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Quality Control of 115314-17-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Triquet, Juliette published the artcileChemical surface densification of hardwood through lateral monomer impregnation and in situ EB polymerization, Part II: effect of irradiation dose on hardness, wood chemistry and polymer conversion, Recommanded Product: Trimethylolpropane triacrylate, the publication is Journal of Materials Science (2022), 57(12), 6656-6668, database is CAplus.

Surface chem. densification was recently introduced as a low cost and fast process to improve surface hardness of wood. The asym. d. profile at the surface due to polymer filled cells was achieved through unilateral impregnation of monomers and their fast in situ polymerization under electron beam radiations. This study investigates the effect of electron beam dose on the newly developed material in order to optimize and increase the performances. Effect of doses from 25 to 125 kGy on wood and polymer in situ were investigated by FTIR spectroscopy, confocal Raman microscopy and GC-MS quantification of extracted residual monomers. Brinell hardness of irradiated controls decreased with increased dose while it remained unchanged for densified samples. The effect of 25 kGy on the irradiated wood controls was insignificant, but evidence of cellulose depolymerization and decrease of hydrogen bonds strength was found at higher dose through FTIR anal. Raman investigation of the acrylate conversion in situ showed that most of the polymerization was achieved with 25 kGy. Residual monomers were still present in the wood samples up to 100 kGy. Thus, 25 kGy was sufficient to polymerize monomers in situ and increase Brinell hardness of densified wood while avoiding degradation of wood. However, 100 kGy was necessary to ensure highest conversion and no residual monomers. This study is opening perspectives on radiation effects on wood for optimal materials development.

Journal of Materials Science published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C20H12N2O2, Recommanded Product: Trimethylolpropane triacrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lunzer, Markus published the artcileBeyond the Threshold: A Study of Chalcogenophene-Based Two-Photon Initiators, Name: Trimethylolpropane triacrylate, the publication is Chemistry of Materials (2022), 34(7), 3042-3052, database is CAplus and MEDLINE.

A series of nine soluble, sym. chalcogenophenes bearing hexyl-substituted triphenylamines, indolocarbazoles, or phenylcarbazoles was designed and synthesized as potential two-photon absorption (2PA) initiators. A detailed photophys. anal. of these mols. revealed good 2PA properties of the series and, in particular, a strong influence of selenium on the 2PA cross sections, rendering these materials especially promising new 2PA photoinitiators. Structuring and threshold tests proved the efficiency and broad spectral versatility of two selenium-containing lead compounds as well as their applicability in an acrylate resin formulation. A comparison with com. photoinitiators Irg369 and BAPO as well as sensitizer ITX showed that the newly designed selenium-based materials TPA-S and TPA-BBS outperform these traditional initiators by far both in terms of reactivity and dose. Moreover, by increasing the ultralow concentration of TPA-BBS, a further reduction of the polymerization threshold can be achieved, revealing the great potential of this series for application in two-photon polymerization (2PP) systems where only low laser power is available.

Chemistry of Materials published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Name: Trimethylolpropane triacrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ursinyova, Nina published the artcileCopper-Catalyzed Borylation of Cyclic Sulfamidates: Access to Enantiomerically Pure (β-and γ-Amino-alkyl)boronic Esters, Recommanded Product: tert-Butyl N-[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]carbamate, the publication is European Journal of Organic Chemistry (2016), 2016(4), 673-677, database is CAplus.

Cyclic sulfamidates undergo borylation under Cu-catalyzed conditions using B₂pin₂ to give enantiomerically (and diastereomerically) defined (aminoalkyl)boronic esters. External iodide is essential, but the intermediacy of simple alkyl iodides was excluded; N-sulfated intermediates are key in the borylation sequence. Based on stereochem. studies and trapping experiments, the involvement of C-centered radicals under these Cu-catalyzed conditions appears likely.

European Journal of Organic Chemistry published new progress about 1850305-80-4. 1850305-80-4 belongs to esters-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is tert-Butyl N-[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]carbamate, and the molecular formula is C5H6BNO3, Recommanded Product: tert-Butyl N-[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]carbamate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Shaw, Charles J. published the artcileA direct HPLC method for the resolution of glycidyl tosylate and glycidyl 3-nitrobenzenesulfonate enantiomers, Quality Control of 115314-17-5, the publication is Journal of Pharmaceutical and Biomedical Analysis (1991), 9(10-12), 793-6, database is CAplus and MEDLINE.

The enantiomeric composition of glycidyl tosylate and glycidyl 3-nitrobenzenesulfonate is obtained using an enantiomeric HPLC column. The chiral oxiranes were resolved on a cellulose carbamate column using a mobile phase of hexane/2-propanol. The method is simple, sensitive, and does not require derivatization.

Journal of Pharmaceutical and Biomedical Analysis published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C7H8INO, Quality Control of 115314-17-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Murray, Stephen published the artcileDirect derivatization of sulfate esters for analysis by gas chromatography mass spectrometry, Synthetic Route of 6217-68-1, the publication is Biomedical Mass Spectrometry (1979), 6(2), 82-9, database is CAplus.

Gas chromatog.-mass spectrometry was used to study the reaction between 13 aromatic, steroidal and aliphatic sulfate esters and 3 perfluoroacylating reagents, viz. (CF₃CO)₂O, (C₂F₅CO)₂O and (CF₃CF₂CF₂CO)₂O. Aromatic sulfates reacted readily with 1:1 anhydride:AcOEt to give the perfluoro ester of the parent phenol quant. Nonaromatic sulfates gave a variety of products. A mechanism is proposed for the 1-step derivatization of aromatic sulfates, and the potential of the procedure for the anal. of sulfate conjugates by mass spectrometry is discussed.

Biomedical Mass Spectrometry published new progress about 6217-68-1. 6217-68-1 belongs to esters-buliding-blocks, auxiliary class Salt,Nitro Compound,Sulfonate,Benzene, name is Potassium 4-nitrophenyl sulfate, and the molecular formula is C6H4KNO6S, Synthetic Route of 6217-68-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics