Tag: M.W=250-300

Singh, Simranjit X.; Yang, Rui; Roso, Kristen; Hansen, Landon J.; Du, Changzheng; Chen, Lee H.; Greer, Paula K.; Pirozzi, Christopher J.; He, Yiping published the artcile< Purine Synthesis Inhibitor L-Alanosine Impairs Mitochondrial Function and Stemness of Brain Tumor Initiating Cells>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is brain tumor mitochondrial function purine synthesis inhibitor alanosine; MTAP; adenine; alanosine; drug resistance; glioma stem cells; mitochondria; purine.

Glioblastoma (GBM) is a lethal brain cancer exhibiting high levels of drug resistance, a feature partially imparted by tumor cell stemness. Recent work shows that homozygous MTAP deletion, a genetic alteration occurring in about half of all GBMs, promotes stemness in GBM cells. Exploiting MTAP loss-conferred deficiency in purine salvage, we demonstrate that purine blockade via treatment with L-Alanosine (ALA), an inhibitor of de novo purine synthesis, attenuates stemness of MTAP-deficient GBM cells. This ALA-induced reduction in stemness is mediated in part by compromised mitochondrial function, highlighted by ALA-induced elimination of mitochondrial spare respiratory capacity. Notably, these effects of ALA are apparent even when the treatment was transient and with a low dose. Finally, in agreement with diminished stemness and compromised mitochondrial function, we show that ALA sensitizes GBM cells to temozolomide (TMZ) in vitro and in an orthotopic GBM model. Collectively, these results identify purine supply as an essential component in maintaining mitochondrial function in GBM cells and highlight a critical role of mitochondrial function in sustaining GBM stemness. We propose that purine synthesis inhibition can be beneficial in combination with the standard of care for MTAP-deficient GBMs, and that it may be feasible to achieve this benefit without inflicting major toxicity.

Biomedicines published new progress about Brain neoplasm. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Niculescu, S. P.; Atkinson, A.; Hammond, G.; Lewis, M. published the artcile< Using fragment chemistry data mining and probabilistic neural networks in screening chemicals for acute toxicity to the fathead minnow>, Quality Control of 112-63-0, the main research area is model probabilistic neural network toxicity fathead minnow; structure activity relationship organic chem toxicity Pimephales.

The paper is illustrating how the general data mining methodol. may be adapted to provide solutions to the problem of high throughput virtual screening of organic chems. for possible acute toxicity to the fathead minnow fish. The present approach involves mining fragment information from chem. structures and is using probabilistic neural networks to model the relationship between structure and toxicity. Probabilistic neural networks implement a special class of multivariate non-linear Bayesian statistical models. The math. principles supporting their use for value prediction purposes are clarified and their peculiarities discussed. As part of the research phase of the data mining process, a dataset consisting of 800 structures and associated fathead minnow (Pimephales promelas) 96-h LC50 acute toxicity endpoint information is used for both the purpose of identifying an advantageous combination of fragment descriptors and for training the neural networks. As a result, two powerful models are generated. Model 1 implements the basic PNN with Gaussian kernel (statistical corrections included) while Model 2 implements the PNN with Gaussian kernel and separated variables. External validation is performed using a sep. dataset consisting of 86 structures and associated toxicity information. Both learning and generalization capabilities of the two models are investigated and their limitations discussed.

SAR and QSAR in Environmental Research published new progress about Alcohols, C12-13, ethoxylated Role: ADV (Adverse Effect, Including Toxicity), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xue, Liming; Xu, Jiale; Feng, Chao; Zhou, Zhijun; Jin, Yu’e; Lu, Dasheng; Wang, Guoquan published the artcile< Flurochloridone induces responses of free radical reactions and energy metabolism disorders to BRL-3A cell>, Application In Synthesis of 112-63-0, the main research area is free radical reaction energy metabolism disorder BRL 3A flurochloridone; AKT/GSK-3β; Energy metabolism dysfunction; Flurochloridone; Glucose isotopic tracing flux technology; Hepatotoxicity.

Flurochloridone (FLC), a wildly used herbicide, could induce hepatotoxicity after long-term exposure to male rat, in addition to its reactive oxygen species (ROS)-dependent reproductive toxicity. The hepatotoxicity effect and mechanism was investigeted using 1, 10 and 100μmol L-1 FLC treated BRL-3A liver cell in this study. The function of mitochondrial respiration, glycolysis rate and real time ATP production rate are determined by seahorse XF analyzer, and the bio-transformers of FLC, intermediates of TCA cycle and glycolysis, and related amino acids are determined and identified by [U-13C] Glucose metabolic flux technol. based on UPLC-HRMS. The mRNA expression of cytochrome P450s and the key regulatory enzymes of glucose metabolism and γ- glutamyl cycle pathway. The protein expressions of protein kinase B (AKT) and glycogen synthase kinase-3 beta (GSK-3β) were determined The results show dechlorination and glutathione (GSH) conjugate products of FLC are predominant bio-transformmers after 24 h treatment in BRL-3A cell. FLC could enhance glycolysis function and inhibit mitochondrial aerobic respiratory, which is accompanied by the decreased total ATP level and ATP produced rate. Increased glucose-6-phosphate, fructose-6-phosphate, pyruvate and lactate levels, and elevated level of GSH and its precursor 5-glutamate-cysteine (γ-Glu-Cys) are observed in FLC treated cells, which indicates that energy metabolism dysfunction and GSH accumulation could be potentially mediated by activating γ- Glutamyl cycle pathway. Conclusively, FLC induced hepatotoxicity could be potentially related to some free radical reactions, including inhibiting mitochondrial function, glucose metabolism via glycolysis, regulating γ- glutamyl cycle pathway to promote reactive oxygen species (ROS) level, and then induced cell apoptosis by inhibiting AKT/GSK-3β signal.

Ecotoxicology and Environmental Safety published new progress about Animal cell line (BRL-3A). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Peng; Korcova, Jana; Barath, Peter; Cizova, Alzbeta; Valarikova, Jana; Qadri, Firdausi; Kelly, Meagan; O’Connor, Robert D.; Ryan, Edward T.; Bystricky, Slavomir; Kovac, Pavol published the artcile< Isolation, purification, characterization and direct conjugation of the lipid A-free lipopolysaccharide of Vibrio cholerae O139>, Application In Synthesis of 112-63-0, the main research area is lipopolysaccharide O antigen O139 Vibrio isolation purification; O antigen O139 BSA conjugation cholera antiserum immunoreactivity; NMR spectroscopy; Vibrio cholerae; glycoconjugate vaccines; polysaccharides; squaric acid.

The lipopolysaccharide (LPS) of Vibrio cholerae O139, strain CIRS245, was isolated conventionally, and the lipid A was removed by mild acid hydrolysis (0.1 M NaOAc buffer containing 1% SDS, pH 4.2, 95°C, 8 h). The crude product was a complex mixture consisting mainly of constituent fragments of the O-specific polysaccharide-core (OSPc). The OSPc was only a minor component in the mixture Two-stage purification of the crude OSPc by HPLC gave pure OSPc fragment of the LPS, as shown by NMR spectroscopy, anal. HPLC and ESI-MS. This material is the purest OSPc fragment of the LPS from Vibrio cholerae O139 reported to date. The purified OSPc was readily converted to the corresponding Me squarate derivative and the latter was conjugated to BSA. The conjugate, when examined by ELISA, showed immunoreactivity with sera from patients in Bangladesh recovering from cholera caused by V. cholerae O139, but not O1.

Chemistry – A European Journal published new progress about Antibacterial vaccines (against V. cholerae O139, possibility for). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rojas, A. H.; Lafuente, L.; Echeverria, G. A.; Piro, O. E.; Vetere, V.; Ponzinibbio, A. published the artcile< Synthesis and structure of novel iodinated N-glycosyl-sulfonamides through Aza-Ferrier reaction of 2-substituted glycals>, Formula: C12H16O7, the main research area is iodinated glycosyl sulfonamide preparation aza Ferrier rearrangement glycal.

We obtained a series of novel N-(2-iodo-2,3-dideoxy-2-en-glycopyranosides)-sulfonamides via the Aza-Ferrier rearrangement of protected-2-iodoglycals in good yields and high stereoselectivity. Their structure and conformation features were determined by NMR. Moreover, we report here the first in detail structure anal. by X-ray diffraction techniques of a 2-iodo-pseudoglycal.

Tetrahedron Letters published new progress about Bond angle, torsional. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Formula: C12H16O7.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ouyang, Siming; Xie, Yuqing; Fu, Wangxing; Ding, Yongbo; Shen, Liang published the artcile< Preparation of autoxidative water-reducible alkyd resins from waste polyethylene terephthalate>, Related Products of 112-63-0, the main research area is autoxidative aqueous reducible alkyd resin waste polyethylene terephthalate; hardness; physical properties; waste polyethylene terephthalate; water resistance; water-borne alkyd resin.

In this paper, the waste polyethylene terephthalate (PET) was glycolyzed by trimethylolpropane with zinc acetate as catalyst. The effects of different content glycolysis product of waste PET on the appearance, viscosity, particle size and mol. weight of autoxidative water-reducible alkyd resins and the corresponding film adhesion, flexibility, impact resistance, gloss, hardness and chem. resistance were studied. Meanwhile, exptl. results were compared with com. water-reducible alkyd and water-reducible alkyd without the glycolysis product of waste PET. The results show that the maximum concentration of PET in autoxidative waterreducible alkyd resins can reach 8.5 weight%, and the mol. weight, particle size and viscosity of water-reducible alkyd resin do not change much with the increase of PET concentration The introduction of PET resulted in the viscosity of waterreducible alkyd resins being greater than that of water-reducible alkyd resin without PET; this is mainly because PET contains harder terephthalic acid monomer units. However, the particle size of water-reducible alkyd resins with waste PET is significantly lower than that of the water-reducible alkyd resin without PET; this is due to PET-free water-reducible alkyd resin containing more pentaerythritol with greater steric hindrance. In addition, the hardness of the water-reducible alkyd resin paint film (PET content is 8.5%) reaches 1H, which is higher than the hardness (HB) of the water-reducible alkyd resin paint film without PET and the com. alkyd resin paint film, while the phys. properties and chem. resistance of the former are comparable to those of the latter two kinds of paint films. Therefore, the use of waste PET in water-borne coatings systems not only reduces the cost of coatings, but also opens up a new market for recycled PET, which may contribute a promising method for management of waste PET.

Royal Society Open Science published new progress about Adhesion, physical. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Ding-Li; Hu, Yi-Kao; Wang, Ji-Hua; Zhao, Yan; Huang, Yu-Ping; Zeng, Gui-Jun; Zhao, Yong published the artcile< A New Monoterpenoid Glycoside from Syzygium fluviatile>, Synthetic Route of 112-63-0, the main research area is Syzygium Fluviaterpenoside monoterpenoid glycoside.

A new monoterpenoid glycoside, together with seven known aliphatic acid derivatives, was isolated from the twigs and leaves of Syzygium fluviatile. Their structures were elucidated by means of NMR and HR-ESI-MS data and comparison with the reported values. This is the first example of a monoterpenoid glycoside from Syzygium plants.

Chemistry of Natural Compounds published new progress about Leaf. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wen, Zhe; Ma, Zewei; Mai, Fuhang; Yan, Fei; Yu, Linhao; Jin, Meng; Sang, Yushuai; Bai, Yunfei; Cui, Kai; Wu, Kai; Chen, Mengmeng; Chen, Hong; Li, Yongdan published the artcile< Catalytic ethanolysis of microcrystalline cellulose over a sulfonated hydrothermal carbon catalyst>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is catalytic ethanolysis microcrystalline cellulose sulfonated hydrothermal carbon catalyst.

The catalytic ethanolysis of microcrystalline cellulose in supercritical ethanol is examined over a sulfonated hydrothermal carbon catalyst (SHTC). SHTC is amorphous carbon containing -OH, -COOH and -SO3H groups with total acidity of 7.15 mmol/g and -SO3H acidity of 1.72 mmol/g. SHTC shows high catalytic activity towards the ethanolysis of cellulose in supercritical ethanol. Complete conversion of microcrystalline cellulose with high yields of Et levulinate and Et glucoside is obtained. The reaction temperature, time and catalyst amount have significant effects on the catalytic performances of SHTC. Appropriate reaction time and less catalyst amount are favorable for the production of Et glucoside, while prolonged reaction time and appropriate catalyst amount favor the production of Et levulinate. The highest yield of Et glucoside as 420.9 mg/g cellulose is obtained over 0.1 g SHTC at 245°C for 1 h. The highest yield of Et levulinate as 817.6 mg/g cellulose is achieved over 0.3 g SHTC at 245°C for 1 h. SHTC shows good stability in the recycle experiments with slight loss of catalytic activity.

Catalysis Today published new progress about Ethanolysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Jingyan; Ji, Xiaoming; Hao, Shuai; Zhao, Mingqin; Lai, Miao; Ren, Tianbao; Xi, Gaolei; Wang, Erbin; Wang, Juanjuan; Wu, Zhiyong published the artcile< Regioselective C-H sulfenylation of N-sulfonyl protected 7-azaindoles promoted by TBAI: a rapid synthesis of 3-thio-7-azaindoles>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is thioazaindole regioselective preparation; chloride sulfonyl protected azaindole TBAI CH sulfenylation.

This paper described the synthesis of 3-thio-7-azaindoles I [R1 = H, 2-Me, 5-Cl, 5-Br, 2-I; R2 = Ph, 4-FC6H4, 4-MeC6H4, etc.] via regioselective C-3 sulfenylation of N-sulfonyl protected 7-azaindoles with sulfonyl chlorides. In this transformation, dual roles of TBAI served as both promoter and desulfonylation reagent was demonstrated. The reaction proceeded smoothly under simple conditions to afford 3-thio-7-azaindoles I in moderate to good yields with broad substrate scopes. This protocol refrained from the use of transition-metal catalysts, strong oxidants or bases and showed its practical synthetic value in organic synthesis.

RSC Advances published new progress about Arenesulfonyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Knight, Steven D.; Adams, Nicholas D.; Burgess, Joelle L.; Chaudhari, Amita M.; Darcy, Michael G.; Donatelli, Carla A.; Luengo, Juan I.; Newlander, Ken A.; Parrish, Cynthia A.; Ridgers, Lance H.; Sarpong, Martha A.; Schmidt, Stanley J.; Van Aller, Glenn S.; Carson, Jeffrey D.; Diamond, Melody A.; Elkins, Patricia A.; Gardiner, Christine M.; Garver, Eric; Gilbert, Seth A.; Gontarek, Richard R.; Jackson, Jeffrey R.; Kershner, Kevin L.; Luo, Lusong; Raha, Kaushik; Sherk, Christian S.; Sung, Chiu-Mei; Sutton, David; Tummino, Peter J.; Wegrzyn, Ronald J.; Auger, Kurt R.; Dhanak, Dashyant published the artcile< Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin>, Formula: C19H34O2, the main research area is cancer PI3K inhibitor antitumor agent quinoline derivative SAR preparation; GSK2126458; PI3K/AKT pathway; mammalian target of rapamycin; phosphoinositide 3-kinase α.

Phosphoinositide 3-kinase α (PI3Kα) is a critical regulator of cell growth and transformation, and its signaling pathway is the most commonly mutated pathway in human cancers. The mammalian target of rapamycin (mTOR), a class IV PI3K protein kinase, is also a central regulator of cell growth, and mTOR inhibitors are believed to augment the antiproliferative efficacy of PI3K/AKT pathway inhibition. 2,4-Difluoro-N-{2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide (GSK2126458, 1 (I)) has been identified as a highly potent, orally bioavailable inhibitor of PI3Kα and mTOR with in vivo activity in both pharmacodynamic and tumor growth efficacy models. Compound 1 is currently being evaluated in human clin. trials for the treatment of cancer.

ACS Medicinal Chemistry Letters published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics