Tag: M.W=250-300

Lahner, Harald; Mathew, Annie; Klocker, Anna Lisa; Unger, Nicole; Theysohn, Jens; Rekowski, Jan; Joeckel, Karl-Heinz; Theurer, Sarah; Schmid, Kurt Werner; Herrmann, Ken; Fuehrer, Dagmar published the artcile< Streptozocin/5-fluorouracil chemotherapy of pancreatic neuroendocrine tumours in the era of targeted therapy>, Related Products of 112-63-0, the main research area is pancreatic neuroendocrine tumor streptozocin fluorouracil chemotherapy; 5-fluorouracil; Objective response; Pancreatic neuroendocrine tumor; Streptozocin; Survival.

The role of streptozocin-based chemotherapy (STZ CTx) in advanced, well-differentiated pancreatic neuroendocrine tumors (PanNET) and the best sequence of treatments in advanced PanNET are unclear. We examined the outcomes after STZ CTx in patients who had been selected according to the current therapeutic guidelines. Data from 50 PanNET patients consecutively treated with STZ CTx between 2010 and 2018 were analyzed. The endpoints of the study were the objective-response rate (ORR), progression-free survival (PFS), and overall survival (OS). STZ CTx was the first-line treatment in 54% of patients. The PanNET grades were as follows: 6% G1, 88% G2, and 6% well-differentiated G3. The ORR was 38%. Stable disease was the best response in 38% of patients and 24% showed progressive disease. Treatment was discontinued because of toxicity in one patient. Median PFS and OS were 12 (95% confidence interval (CI), 8.5-15.5) and 38 mo (95% CI, 20.4-55.6), resp. In the Kaplan-Meier anal., the median OS was 89 mo (95% CI, 34.9-143.1) for STZ CTx as first-line therapy compared with 22 mo (95% CI, 19.3-24.7; p = 0.001, log-rank test) for subsequent lines. Bone metastases neg. impacted survival (HR, 2.71, p = 0.009, univariate anal., HR, 2.64, p = 0.015, multivariate anal., and Cox regression). In patients selected according to current guidelines, PFS, and OS after STZ CTx were lower than previously reported, whereas ORR was unchanged. First-line treatment was pos. associated with OS and the presence of bone metastases was neg. associated with OS. Pre-treatment with targeted or peptide-receptor radionuclide therapy did not alter ORR, PFS, or OS.

Endocrine published new progress about Anemia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kondo, Hiroki; Uno, Shingo; Moriuchi, Fumio; Sunamoto, Junzo; Ogushi, Susumu; Tsuru, Daisuke published the artcile< Synthesis and enzymatic carboxylation of a biotin-containing peptide representing the coenzyme binding site of E. coli acetyl-CoA carboxylase>, Electric Literature of 112-63-0, the main research area is acetyl CoA carboxylase biotin binding site; peptide biotin acetyl CoA carboxylase.

A biotin-containing pentapeptide, Boc-Glu-Ala-Met-Bct-Met (I) (where Boc = tert-butoxycarbonyl and Bct = N’-biotinyl-L-lysine), that corresponds to the coenzyme-binding site of Escherichia coli acetyl-CoA carboxylase (II) was prepared I, as well as free biotin, served as substrate for the carboxylation reaction catalyzed by the biotin carboxylase subunit dimer of E. coli II. The Km and Vmax values for I were 18 mM and 2.8 μM min-1, resp. The corresponding values for biotin were 214 mM and 28 μM min-1. Thus, the overall reactivity (Vmax/Km) of I exceeded that of biotin by 20%.

Bulletin of the Chemical Society of Japan published new progress about Escherichia coli. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Zhaoqiang; Kang, Chengjun; Peh, Shing Bo; Shi, Dongchen; Yang, Fengxia; Liu, Qixing; Zhao, Dan published the artcile< Efficient Adsorption of Acetylene over CO2 in Bioinspired Covalent Organic Frameworks>, Formula: C19H34O2, the main research area is adsorption acetylene CO2 bioinspired covalent organic framework.

Rational design of covalent organic frameworks (COFs) to broaden their diversity is highly desirable but challenging due to the limited, expensive, and complex building blocks, especially compared with other easily available porous materials. In this work, we fabricated two novel bioinspired COFs, namely, NUS-71 and NUS-72, using reticular chem. with ellagic acid and triboronic acid-based building blocks. Both COFs with AB stacking mode exhibit high acetylene (C2H2) adsorption capacity and excellent separation performance for C2H2/CO2 mixtures, which is significant but rarely explored using COFs. The impressive affinities for C2H2 appear to be related to the sandwich structure formed by C2H2 and the host framework via multiple host-guest interactions. This work not only represents a new avenue for the construction of low-cost COFs but also expands the variety of the COF family using natural biochems. as building blocks for broad application.

Journal of the American Chemical Society published new progress about Adsorbents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Dan; Dai, Yitong; Chen, Xuejiao; Zhang, Xuena; Yue, Danwei; Wang, Jingying; Guo, Yongsheng published the artcile< Stability and catalytic activity of hyperbranched polyglycerol stabilized gold nanofluids>, Quality Control of 112-63-0, the main research area is polyglycerol stabilized gold nanofluid stability catalytic activity.

A gold nanofluid with good suspension stability was prepared using hyperbranched polyglycerol (HPG) as a stabilizer because of the functional hydroxyl groups at the end of every branch in its structure. The effects of reaction-medium pH and temperature on the preparation of the HPG-gold nanofluids were discussed. The influences of pH on the stability of HPG-gold nanofluids after preparation were investigated. The HPG-gold nanofluid was employed as catalyst for the reduction of 4-nitrophenol. The results showed that HPG-Au nanofluid stabilized at high pH range (pH = 10). The nanofluid exhibited high activity in the catalytic hydrogenation of 4-nitrophenol. The HPG-gold nanofluid was promising for applications of quasi-homogeneous catalysis.

Journal of Molecular Liquids published new progress about Catalysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Kyungae; Campbell, Jennifer; Swoboda, Jonathan G.; Cuny, Gregory D.; Walker, Suzanne published the artcile< Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is antibacterial Staphylococcus wall teichoate biosynthesis inhibitor preparation structure activity.

A small mol. (1835F03) that inhibits Staphylococcus aureus wall teichoic acid biosynthesis, a proposed antibiotic target, has been discovered. Rapid, parallel, solution-phase synthesis was employed to generate a focused library of analogs, providing detailed information about structure-activity relationships and leading to the identification of targocil, a potent antibiotic.

Bioorganic & Medicinal Chemistry Letters published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ruan, Yonglan; Ling, Jinying; Ye, Fan; Cheng, Nuo; Wu, Fei; Tang, Zongxiang; Cheng, Xiaolan; Liu, Hongquan published the artcile< Paeoniflorin alleviates CFA-induced inflammatory pain by inhibiting TRPV1 and succinate/SUCNR1-HIF-1α/NLPR3 pathway>, Product Details of C19H34O2, the main research area is paeoniflorin SUCNR TRPV HIF NLRP CFA inflammatory pain signaling; Inflammatory pain; NLPR3; Paeoniflorin; SUCNR1; Succinate; TRPV1.

Treatment of chronic inflammatory pain remains a major goal in the clinic. It is thus of prime importance to characterize inherent pathophysiol. pathways to design new therapeutic strategies and analgesics for pain management. Paeoniflorin (PF), a monoterpenoid glycoside from Paeonia lactiflora Pallas plants, possesses promising anti-nociceptive property. However, therapeutic effect and underlying mechanism of action of PF on inflammatory pain have not yet been fully elucidated. In this study, we aim to investigate the analgesic effect further and clarify its mechanism of action of PF on complete freund’s adjuvant (CFA)-evoked inflammatory pain. Twenty-four male mice were divided into 3 groups: sham, CFA, and CFA + PF groups (n = 8/group). Mice were treated with normal saline or PF (30 mg/kg) for 11 days. Footpad swelling (n = 8/group), mech. (n = 8/group) and thermal hypersensitivity (n = 8/group) were measured to evaluate the analgesic effect of PF on CFA-injected mice. At the end of the animal experiment, blood and L4-L6 dorsal root ganglion neurons were collected to assess the therapeutic effect of PF on CFA-induced inflammatory pain. Next, hematoxylin and eosin, quant. realtime PCR, ELISA, capsaicin and di-Me succinate induced pain test (n = 8/group), motor coordination test (n = 8/group), tail flicking test (n = 8/group), pyruvate and succinate dehydrogenase assay (n = 6/group), immunohistochem. staining, were performed to clarify the action mechanism of PF on CFA-evoked inflammatory pain. Besides, the effect of PF on TRPV1 was evaluated by whole-cell patch clamp recording on primary neurons (n = 7). Finally, mol. docking further performed to evaluate the binding ability of PF to TRPV1. PF significantly relieved inflammatory pain (P < 0.001) and paw edema (P < 0.001) on a complete Freund adjuvant (CFA)-induced peripheral inflammatory pain model. Furthermore, PF inhibited neutrophil infiltration (P < 0.01), IL-1β increase (P< 0.01), and pain-related peptide substance P release (P < 0.001). Intriguingly, CFA-induced succinate aggregation was notably reversed by PF via modulating pyruvate and SDH activity (P < 0.01). In addition, PF dampened the high expression of subsequent succinate receptor SUCNR1 (P < 0.01), HIF-1α(P < 0.05), as well as the activation of NLRP3 inflammasome (P < 0.05) and TRPV1 (P < 0.05). More importantly, both capsaicin and di-Me succinate supplementation obviously counteracted the pain-relieving effect of PF and TRPV1 (P < 0.01 or P < 0.001). Our findings suggest that PF can significantly relieve CFA-induced paw swelling, as well as mech. and thermal hyperalgesia. PF alleviated inflammatory pain partly through inhibiting the activation of TRPV1 and succinate/SUCNR1-HIF-1α/NLRP3 pathway. Furthermore, we found that PF exerted its analgesic effect without affecting motor coordination and pain-related cold ion-channels. In summary, this study may provide valuable evidence for the potential application of PF as therapeutic strategy for inflammatory pain treatment. International Immunopharmacology published new progress about Analgesia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peng, Yiyuan; Liu, Hanliang; Tang, Min; Cai, Lisheng; Pike, Victor published the artcile< Highly efficient N-monomethylation of primary aryl amines>, Related Products of 112-63-0, the main research area is monomethylation primary aryl amine.

A highly efficient method for specific synthesis of N-monomethylarylamines is presented. Anilines were treated with acetic anhydride and triethylamine in dry CH2Cl2 to give the corresponding acetamides. The subsequent N-monomethylation of acetyl aryl amines with Me iodide and NaH in THF introduced Me group. Acid hydrolysis of the N-Me acetanilides in ethylene glycol generated the corresponding N-methyl-N-aryl amines in high yields. This method was also used to synthesize (E)-2-bromo-5-(4-methylaminostyryl)pyridine that may be useful as an amyloid imaging agent for Alzheimer’s disease.

Chinese Journal of Chemistry published new progress about Acetylation (protection of amines before methylation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Suri, Deepa; Banerji, Kalyan K.; Kothari, Seema published the artcile< Correlation analysis of reactivity in the oxidation of substituted benzyl alcohols by pyridinium hydrobromide perbromide>, Product Details of C19H34O2, the main research area is correlation analysis reactivity oxidation benzyl alc; pyridinium hydrobromide perbromide oxidation benzyl alc; LFER oxidation benzyl alc.

Correlation anal. of the effect of substituents in the oxidation of benzyl alc. by pyridinium hydrobromide perbromide indicates the presence of an electron-deficient carbon center in the transition state and a steric acceleration of the reaction.

Journal of Chemical Research, Synopses published new progress about Formation constant. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Manzocchi, E.; Martin, B.; Bord, C.; Verdier-Metz, I.; Bouchon, M.; De Marchi, M.; Constant, I.; Giller, K.; Kreuzer, M.; Berard, J.; Musci, M.; Coppa, M. published the artcile< Feeding cows with hay, silage, or fresh herbage on pasture or indoors affects sensory properties and chemical composition of milk and cheese>, Related Products of 112-63-0, the main research area is milk cheese feeding cow silage herbage indoor sensory property; cheese sensory profile; dairy cow; herbage utilization method; milk sensory profile.

In European countries, silage-free feeding is an ancient tradition and has a particularly pos. reputation among consumers. In the present study, we compared grass-based forages from the same plot conserved as hay or silage or fed fresh either on pasture or indoors, and we evaluated the differences in sensory properties of milk and uncooked pressed cheese. All herbage from the first cut of a grassland dominated by perennial ryegrass was harvested on the same day and preserved either as hay or silage. The first regrowth of the same plot was used for strip grazing or green feeding indoors. Balanced by breed, 24 Montbeliarde and 24 Holstein cows were allocated to the 4 treatments. Apart from the forages, the late-lactation cows received 3 kg/d of dry matter from concentrate After 2 wk of dietary adaptation, the bulk milk of 3 subgroups, each with 4 cows, was collected. Part of the milk was pasteurized, and part was left raw and partly transformed to small-sized Cantal-type cheese ripened for 9 wk. Milk and cheese underwent descriptive sensory anal. by a trained sensory panel, as well as analyses of physicochem. traits. Volatile organic compounds of the cheeses were also analyzed. Raw and pasteurized milk from hay-fed cows had less intense odors of cooked milk, cream, and barnyard than milk from grazing cows, whereby the effect of pasteurization did not differ between herbage utilization methods. Cheeses obtained from cows fed fresh herbage (grazing and indoors) were clearly yellower than cheeses from silage- and hay-fed cows, which coincided with the color intensity perceived by the panelists. Moreover, cheeses from cows fed fresh herbage had more intense barnyard and dry fruit flavors, were perceived as creamier and having less lactic odor, and exhibited more fat exudation than those from cows fed conserved herbage. Only a few differences were observed in milk and cheeses from hay-fed compared with silage-fed cows, and those differences were far less pronounced than those of milk and cheeses from cows fed fresh herbage. In conclusion, the present study did not substantiate assumptions of clear sensory differences of milk and uncooked pressed cheese from hay-fed compared with silage-fed cows. For the first time, this study reports that the global flavor intensity of cheeses from indoor green-fed cows is similar to that of cheeses derived from cows fed conserved forages, whereas cheeses from grazing cows have the greatest global flavor intensity.

Journal of Dairy Science published new progress about Acids Role: FFD (Food or Feed Use), PRP (Properties), BIOL (Biological Study), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shibata, Norio; Suzuki, Emiko; Asahi, Toru; Shiro, Motoo published the artcile< Enantioselective Fluorination Mediated by Cinchona Alkaloid Derivatives/Selectfluor Combinations: Reaction Scope and Structural Information for N-Fluoro cinchona Alkaloids>, Reference of 112-63-0, the main research area is crystal structure fluoroammonium cinchona alkaloid fluorination reagent; oxindole enantioselective fluorination cinchona alkaloid Selectfluor; fluorocyanoacetate enantioselective preparation; dihydroquinine chlorobenzoate Selectfluor enantioselective fluorination; enantioselective fluorination cinchona alkaloid mediated.

Cinchona-alkaloid/Selectfluor combinations efficiently fluorinated a variety of carbonyl compounds in a highly enantioselective manner to furnish chiral α-fluorocarbonyl compounds The dihydroquinine 4-chlorobenzoate/Selectfluor combination was effective for enantioselective fluorination of indanone silyl ethers I (R = benzyl, Me, Et) and tetralone silyl ethers II (R = benzyl, Me, Et) to give fluoroindanones III and fluorotetralones IV in up to 91% ee. The first enantioselective syntheses of chiral derivatizing reagents 4-MeC6H4CF(CN)CO2Et, R1CF(CN)CO2Me (R1 = 2-naphthyl), and PhCF(CN)CO2Et were accomplished with high ee and in high chem. yields using the dihydroquinidine acetate/Selectfluor combination. 3-Fluorooxindoles were prepared with ee up to 83% using 1,4-bis(9-O-dihydroquininyl)anthraquinone/Selectfluor or 2,5-bis(9-O-dihydroquinidinyl)-2,5-diphenylpyrimidine/Selectfluor combinations. Since the combinations are conveniently prepared in situ from readily available reagents, the present system represents a practical method for enantioselective fluorination. X-ray crystallog. and 1H NMR analyses of the cinchona alkaloids/Selectfluor combination have established that the species that mediate this novel reaction are N-fluoroammonium cinchona alkaloid tetrafluoroborates, which adopt open conformations.

Journal of the American Chemical Society published new progress about Cinchona alkaloids Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics