Tag: M.W=250-300

Guan, Yun; Pan, Mingyuan; Yang, Jun; Lu, Qiuxia; Han, Liangfu; Liu, Ying; Li, Jing; Zhu, Huaguang; Gong, Xiu; Mei, Guanghai; Liu, Xiaoxia; Pan, Li; Dai, Jiazhong; Wang, Yang; Wang, Enmin; Wang, Xin published the artcile< A phase II open label, single arm study of hypofractionated stereotactic radiotherapy with chemoradiotherapy using intensity-modulated radiotherapy for newly diagnosed glioblastoma after surgery: the HSCK-010 trial protocol>, HPLC of Formula: 112-63-0, the main research area is Adjuvant chemoradiotherapy; Hypofractionated stereotactic radiotherapy; Newly diagnosed glioblastoma.

Abstract: Background: The most frequently diagnosed primary brain tumor is glioblastoma (GBM). Nearly all patients experience tumor recurrence and up to 90% of which is local recurrence. Thus, increasing the therapeutic ratio of radiotherapy using hypofractionated stereotactic radiotherapy (HSRT) can reduce treatment time and may increase tumor control and improve survival. To evaluate the efficacy and toxicity of the combination of HSRT and intensity-modulated radiotherapy (IMRT) with temozolomide after surgery in GBM patients and provide evidence for further randomized controlled trials. Methods/design: HSCK-010 is an open-label, single-arm phase II trial (NCT04547621) which includes newly diagnosed GBM patients who underwent gross total resection. Patients will receive the combination of 30 Gy/5fx HSRT, and 20 Gy/10fx IMRT adjuvant therapy with concurrent temozolomide and adjuvant chemotherapy. The primary endpoint is overall survival (OS). Secondary outcomes include progression-free survival (PFS) rate, objective-response rate (ORR), quality of life (Qol) before and after the treatment, cognitive function before and after the treatment, and rate of treatment-related adverse events (AE). The combination of HSRT and IMRT with temozolomide can benefit the patients after surgery with good survival, acceptable toxicity, and reduced treatment time. Trial registration: NCT04547621. Registered on 14 Sept. 2020.

BMC Cancer published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Qin; Law, Andy; Crowder, Michael W.; Geysen, H. Mario published the artcile< Homo-cysteinyl peptide inhibitors of the L1 metallo-β-lactamase, and SAR as determined by combinatorial library synthesis>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is homocysteinyl peptide inhibitor metallo beta lactamase QSAR combinatorial library.

Homo-cysteinyl peptides were found to be more active than cysteinyl peptides toward L1 metallo-β-lactamase as reversible competitive inhibitors. A combinatorial library of more than 90 homo-cysteinyl peptides was synthesized and screened for their inhibitory activity toward the L1 enzyme. A systematic structure-activity relationship anal. has revealed the preferred interaction groups for L1 conserved binding sites of β-lactam substrates. The most active compound 95b, had a Ki of 2.1 nM.

Bioorganic & Medicinal Chemistry Letters published new progress about Combinatorial library. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Robins, Morris J.; Miranda, Karl; Rajwanshi, Vivek K.; Peterson, Matt A.; Andrei, Graciela; Snoeck, Robert; De Clercq, Erik; Balzarini, Jan published the artcile< Synthesis and Biological Evaluation of 6-(Alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one Base and Nucleoside Derivatives>, Synthetic Route of 112-63-0, the main research area is cytotoxicity cyclization desilylation cross coupling ammonolysis nucleoside bicyclic furopyrimidinone; alkynyl furopyrimidinone bicyclic nucleoside kinase antiviral synthesis human cytomegalovirus.

Derivatives of the 2′-deoxynucleoside of furo[2,3-d]pyrimidin-2(3H)-one with long-chain alkyl (or 4-alkylphenyl) substituents at C6 exhibit remarkable anti-VZV (varicella-zoster virus) potency and selectivity, and analogous 2′,3′-dideoxynucleoside derivatives show anti-HCMV (human cytomegalovirus) activity. We now report a synthetic approach that enables the preparation of long-chain 6-(alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-ones, e.g. I, in which the rod-like acetylene spacer replaces the 4-substituted-Ph ring at C6 via desilylation, Cu-catalyzed 5-endo-Dig cyclization, cross-coupling, and ammonolysis reactions. Analogs with Me, β-D-ribofuranosyl, β-D-arabinofuranosyl, and 2-deoxy-β-D-erythro-pentofuranosyl substituents at N3 have been prepared Long-chain derivatives at C6 in the 2′-deoxynucleoside series showed virus-encoded nucleoside kinase-sensitive anti-VZV activity. Surprisingly, 3-methyl-6-(octyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one (prepared as a neg. anti-VZV test control) exhibited anti-HCMV activity, which supports the possibility of development of non-nucleoside anti-HCMV agents originating from uncomplicated derivatives of such bicyclic ring systems.

Journal of Medicinal Chemistry published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Koppenhoefer, Bernhard; Allmendinger, Hans published the artcile< Derivatization reactions for enantiomer resolution of hydroxy acids by gas chromatography: a comparison of methods>, Application of C19H34O2, the main research area is derivatization hydroxy acid gas chromatog; enantiomer resolution gas chromatog derivatization; esterification enantiomer resolution gas chromatog.

Mandelic acid was converted to several derivatives that are resolved into enantiomers by gas chromatog. on the chiral stationary phase Chirasil-Val. Only the easily performed esterification by an alc. such as 3-pentanol, catalyzed by dry HCl, is satisfactory in terms of racemization, side-reactions, and chromatog. properties.

Fresenius’ Zeitschrift fuer Analytische Chemie published new progress about Alcohols Role: USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Meng, Lingqiao; Shi, Xingzhao; Zhang, Ruilong; Yan, Long; Liang, Zhaopeng; Nie, Yijing; Zhou, Zhiping; Hao, Tongfan published the artcile< Preparation and properties study of waterborne polyurethane synthesized by mixing polyester diols and isocyanates>, Formula: C19H34O2, the main research area is polyester diol isocyanate polymerization; waterborne polyurethane preparation.

In view of environmental protection requirements, it is an inevitable trend for waterborne coatings to replace traditional coatings. Waterborne polyurethane (WPU), a kind of typical resin used in coatings, has become a research hot topic of waterborne coatings because of its advantages, such as non-polluting, safe and reliable, excellent properties, good compatibility, and easy modification. In this article, solvent-free WPU is prepared by mixing 4,4′-dicyclohexylmethane diisocyanate/isophorone diisocyanate (HMDI/IPDI) and polycarbonate diol/ Polycaprolactone diol (PCDL/PCL). Through the comparison of the properties of the polymer, the best amount of raw materials was determined Specifically, R = 1.35 (R is NCO/OH ratio), the content of dimethylolpropionic acid (DMPA) is 5.5%, the content of trimethylol propane (TMP) is 2.5%, the mole ratio of HMDI/IPDI is 2:1, the mole ratio of PCDL/PCL is 2:1, and the preeminent WPU shows the excellent thermal stability, the contact angle of 118.04°, the hardness is H. The chem. structures and rough surface morphologies of the WPU films were characterized by FT-IR, TG, AFM, and SEM, resp. Therefore, considering the film properties, and the low cost, simple, and green process, this research will offer the possibility of application of this free-solvent WPU in industrial production and large-scale application.

Journal of Applied Polymer Science published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Hao; Xie, Fei; Zhao, Zhang; Afsar, Noor Ul; Sheng, Fangmeng; Ge, Liang; Li, Xingya; Zhang, Xiwang; Xu, Tongwen published the artcile< Novel Poly(ester amide) Membranes with Tunable Crosslinked Structures for Nanofiltration>, Formula: C19H34O2, the main research area is polyester amide membrane tunable crosslinked nanofiltration; crosslinking density; desalination; dye/salt separation; interfacial polymerization; nanofiltration; poly(ester amide).

Tuning the crosslinking d. of interfacial-polymerized nanofiltration (NF) membranes varying from loose to dense structures can make them meet the demand of various applications. The properties (e.g., pore size and porosity) of NF membranes can be tuned by choosing monomers with different structures and reactivities. Herein, tris(hydroxymethyl)aminomethane (THAM), a low-cost and green monomer, is first employed for the preparation of poly(ester amide) (PEA) thin-film composite membranes via interfacial polymerization The moderate reactivity of THAM enables rational regulation of the crosslinking d. of PEA membranes from loose to dense structures by varying the THAM concentration, which can hardly be achieved for traditional polyamide or polyester membranes. The developed PEA membranes with a wide tunability range of crosslinking densities broaden their potential utility in NF. PEA membranes with dense structures show exceptional desalination performance with a water permeance of 11.1 L m-2 h-1 bar-1 and a Na2SO4 rejection of 97.1%. However, loose PEA membranes exhibit good dye/salt separation performance with a dye removal rate over 95.0% and negligible NaCl rejection (<7.5%), as well as high water permeance (>45 L m-2 h-1 bar-1). This work implies that PEA membranes with tunable crosslinked structures provide new possibilities for the development of task-specific separation membranes.

ACS Applied Materials & Interfaces published new progress about Antifouling agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhu, Yong-liang; Li, Shuang-long; Zhu, Chun-yang; Wang, Wan; Zuo, Wen-fei; Qiu, Xiang-jun published the artcile< Metabolomics analysis of the antidepressant prescription Danzhi Xiaoyao Powder in a rat model of Chronic Unpredictable Mild Stress (CUMS)>, Computed Properties of 112-63-0, the main research area is Danzhi Xiaoyao powder antidepressant mild stress; CUMS; Danzhi Xiaoyao powder; Depression; Metabolomics; UPLC/Q-TOF-MS.

Danzhi Xiaoyao Powder (DZXY) is a classical prescription, that has been extensively used in traditional Chinese medicine (TMC) to treat depression for many years. However, the mechanism of DZXY is still unclear. The aim was to investigate the mechanism of the antidepressant effect of DZXY on a rat model of chronic unpredictable mild stress (CUMS). Forty male SD (Sprague-Dawley) rats with similar open field test (OFT) results were randomLy divided into a control group (n = 10) and an exptl. group (n = 30). A depression model was established in the exptl. group using the CUMS method. After the CUMS model was established successfully, the rats were randomLy divided into a depression model group and a DZXY group. The DZXY group was fed DZXY, while the depression model group and control group were given an equal amount of 0.5% sodium CM-cellulose suspension. Intragastric administration was performed once daily for 14 consecutive days. Animal weight, the sugar preference test, the open field test and the forced swimming test were used to evaluate the modeling effect and the antidepressant effect of DZXY. After the experiment, the plasma of rats was collected and the changes in plasma metabolites were analyzed by UPLC/Q-TOF-MS. The UPLC/Q-TOF-MS spectra data were evaluated by pattern recognition anal. to determine the changes in endogenous metabolites in the rat plasma samples. The results of the behavioral investigation showed that the rat model of depression was successfully replicated and that DZXY had an antidepressant effect. Using the UPLC-MS/MS metabolomics platform, partial least squares (PLS) and orthogonal partial least squares (OPLS), metabolic profile models (R2 and Q2 ≥ 0.5) of rat plasma were successfully constructed. The model could distinguish among the control group, the depression model group and the DZXY group. Finally, 38 differential metabolites were identified in the plasma. According to KEGG (http://www.kegg.jp) pathway anal., amino acid metabolism, lipid metabolism, purine metabolism, the prolactin signaling pathway and bile secretion were enriched and represented the main metabolic pathways influenced in the plasma. This study successfully established a CUMS depression model. A total of 38 differential metabolites associated with depression were identified in the plasma of rats, 24 of which were modulated by DZXY. These results suggest that DZXY can improve excitability and play an antidepressant role by regulating phenylalanine metabolism, arachidonic acid metabolism, porphyrin metabolism, D-arginine and D-ornithine metabolism, steroid hormone biosynthesis, unsaturated fatty acid biosynthesis and steroid biosynthesis.

Journal of Ethnopharmacology published new progress about Antidepressants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vannoni, Lorenzo; Pizzimenti, Silvia; Caroti, Giulia; La Nasa, Jacopo; Duce, Celia; Bonaduce, Ilaria published the artcile< Disclosing the chemistry of oil curing by mass spectrometry using methyl linoleate as a model binder>, Quality Control of 112-63-0, the main research area is mass spectrometry methyl linoleate model binder oil curing.

The structure of the polymeric fraction in an oil painting is believed to be strongly connected to the stability of the paint layers over time, but its mol. characterization is extremely difficult given the complex composition of a vegetable oil-based polymer. In this study we report the implementation of a methodol. approach for the systematic mass spectrometric investigation of the mol. features of the products of oxidative degradation and crosslinking of oil paint layers upon curing. The approach is based on the use of Me linoleate as a simplified model of an oil paint binder. Gas-chromatog. coupled with mass spectrometry, solid phase microextraction gas chromatog. mass spectrometry, flow injection electrospray mass spectrometry and evolved gas anal. mass spectrometry, are used to analyze the evolution of compounds produced over seven months of natural ageing, from the volatile products to the macromol. and cross-linked fractions. The aim is to improve our fundamental mol. understanding of the curing process of oil paints, and to investigate the balance between oxidative degradation and crosslinking when specific binder-pigment combinations are in place. Model paint layers were prepared using lead white and ultramarine blue as pigments. These two pigments are known to produce paint layers with different stability over time. The use of Me linoleate as model oil binder greatly simplifies the mass spectral features of the lipid paint fraction, enabling the detection of products of oxidation and crosslinking with a new high level of mol. detail. Data clearly show that crucial differences between paints containing the two pigments establish with time, which are mostly related to the cross-linked fraction.

Microchemical Journal published new progress about Chemistry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Correia, Jose Tiago M.; Acconcia, Lais V.; Coelho, Fernando published the artcile< Studies on Pumiliotoxin A Alkaloids: An Approach to Preparing the Indolizidinic Core by Intramolecular Diastereoselective N-Heterocyclic Carbene Catalyzed Benzoin Reaction>, Quality Control of 112-63-0, the main research area is pumiliotoxin A indolizidinic core preparation intramol diastereoselective benzoin; diastereoselective heterocyclic carbene catalyst benzoin reaction.

In this article, we describe the development of a convergent organocatalytic strategy to prepare the indolizidinic core I of the pumiliotoxin A alkaloid family. The key step of the proposed strategy is based on a diastereoselective N-heterocyclic carbene catalyzed benzoin reaction, in which the Breslow intermediate generated from an enal moiety in dicarbonyl compound II (umpolung a1 to d1 – acyl anion equivalent) attacks a ketone moiety intramolecularly to provide the indolizidinone core in good yield with good selectivity.

European Journal of Organic Chemistry published new progress about Benzoin condensation reaction (stereoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Simsek, Rahime; Linden, Anthony; Safak, Cihat published the artcile< (±)-9-(2-Bromophenyl)-7,7-dimethyl-1,3,4,5,6,7,8,9-octahydrofuro[3,4-b]quinoline-1,8-dione>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is mol structure bromophenyl methyl furoquinolinedione.

The title compound, C19H18BrNO3, has potential Ca modulatory properties. Crystallog. data are given. The 1,4-dihydropyridine ring has a very shallow boat conformation and is one of the most planar examples of this moiety. The 2-bromophenyl substituent is in the axial synperiplanar orientation. The quinoline ring has a half-chair conformation, with the unusual arrangement of the out-of-plane atom being on the opposite side of the ring plane to the bromophenyl substituent. The mols. are linked into chains by intermol. H bonds.

Acta Crystallographica, Section C: Crystal Structure Communications published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics