Tag: M.W=250-300

Kakoee, Alireza; Gharehghani, Ayat; Mostafei, Mohsen published the artcile< Development of a reduced chemical kinetic mechanism for biodiesel/natural gas mixture>, Electric Literature of 112-63-0, the main research area is methyl palmitate heptane chem kinetics one dimensional model.

Biodiesel as an alternative fuel for diesel in compression ignition engines cab be used directly to this type of engine without any significant changes in geometry. Some neg. points of biodiesel in compression ignition (CI) engines such as high viscosity, injector carbonize and high NOx emissions cause to use this fuel with other fuels such as alc. fuels and natural gas based on desired properties of second fuel. Numerical study of fuels such as biodiesel needs to have a chem. kinetic mechanism that can predict combustion characteristics and output emissions. In this study, a reduced detailed mechanism of biodiesel introduced by Zhang et al. is chosen to merged with natural gas GRI-Mech 3.0 mechanism to obtain a chem. kinetic mechanism of biodiesel/natural gas. Direct relation graph with error propagation (DRGP) method and consequently sensitivity anal. was employed to 525 reactions and 126 species that modified with highly sensitive reactions. At first, reduced mechanism of biodiesel/natural gas compared with merged mechanism of these fuels’ mixture with 0-Dimension simulation of ignition delay and 1-Dimension simulation of flame speed. Obtained results show error less than 1% for all intake temperatures and equivalence ratios. In the following, the reduced mechanism with zero percent of natural gas compared with original biodiesel mechanism. Yet again, results show errors almost near zero in lower equivalence ratio and acceptable error, in maximum condition about 10%, in moderate and high equivalence ratios (ERs) during predicting ignition delay with 0-Dimension simulation. Also, flame speed in this evaluation shows less than 2% error in 1-Dimension simulation.

Fuel published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kelly, Martha J.; Pietranico-Cole, Sherrie; Larigan, J. Douglas; Haynes, Nancy-Ellen; Reynolds, Charles H.; Scott, Nathan; Vermeulen, John; Dvorozniak, Mark; Conde-Knape, Karin; Huang, Kuo-Sen; So, Sung-Sau; Thakkar, Kshitij; Qian, Yimin; Banner, Bruce; Mennona, Frank; Danzi, Sara; Klein, Irwin; Taub, Rebecca; Tilley, Jefferson published the artcile< Discovery of 2-[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β Agonist in Clinical Trials for the Treatment of Dyslipidemia>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is tetrahydrotriazinecarbonitrile derivative MGL3196 thyroid hormone receptor agonist dyslipidemia treatment.

The beneficial effects of thyroid hormone (TH) on lipid levels are primarily due to its action at the thyroid hormone receptor β (THR-β) in the liver, while adverse effects, including cardiac effects, are mediated by thyroid hormone receptor α (THR-α). A pyridazinone series has been identified that is significantly more THR-β selective than earlier analogs. Optimization of this series by the addition of a cyanoazauracil substituent improved both the potency and selectivity and led to MGL-3196 (53), which is 28-fold selective for THR-β over THR-α in a functional assay. Compound 53 showed outstanding safety in a rat heart model and was efficacious in a preclin. model at doses that showed no impact on the central thyroid axis. In reported studies in healthy volunteers, 53 exhibited an excellent safety profile and decreased LDL cholesterol (LDL-C) and triglycerides (TG) at once daily oral doses of 50 mg or higher given for 2 wk.

Journal of Medicinal Chemistry published new progress about Anticholesteremic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jablonowski, Jill A.; Grice, Cheryl A.; Chai, Wenying; Dvorak, Curt A.; Venable, Jennifer D.; Kwok, Annette K.; Ly, Kiev S.; Wei, Jianmei; Baker, Sherry M.; Desai, Pragyna J.; Jiang, Wen; Wilson, Sandy J.; Thurmond, Robin L.; Karlsson, Lars; Edwards, James P.; Lovenberg, Timothy W.; Carruthers, Nicholas I. published the artcile< The First Potent and Selective Non-Imidazole Human Histamine H4 Receptor Antagonists>, Quality Control of 112-63-0, the main research area is indole derivative preparation histamine H4 receptor antagonist structure activity.

Following the discovery of the human histamine H4 receptor, a high throughput screen of our corporate compound collection identified a potential lead compound Investigation of the structure-activity relationship (SAR) resulted in the discovery of novel compounds, which are the first potent and selective histamine H4 receptor antagonists to be described.

Journal of Medicinal Chemistry published new progress about Antihistamines. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Paulo, Pedro M. R.; Laia, Cesar A. T.; Costa, Silvia M. B. published the artcile< Clusters in Polymer-Surfactant AOT Microemulsions Probed by Excited State Quenching Kinetics>, Formula: C19H34O2, the main research area is dynamics PEG bisethylhexyl sulfosuccinate surfactant cluster microemulsion quenching kinetics; fluorescence quenching laser flash photolysis dynamics polymer surfactant microemulsion.

Excited-state quenching kinetics were applied to sodium 1,4-bis(2-ethylhexyl)sulfosuccinate (AOT) reversed micelles with poly(oxy)ethylene (POE) of mol. weight 35 000 Da where clusters were previously detected [Laia, C. A. T., et al, 2000]. The data obtained in AOT reversed micelles, with a fixed value of the molar ratio of water to surfactant (w0 = [H2O]/[AOT]) w0 = 20, were compared in the absence and presence of the polymer. Two reaction time scales were studied with different probes: 1,3,6,8-pyrenetetrasulfonic acid (PTSA) in the nanosecond range and Cr(bpy)33+ in the microsecond range, using, resp., time-resolved fluorescence with picosecond resolution and laser flash photolysis techniques. The exptl. decays were analyzed assuming two components, one due to polymer-free micelles described by a Poisson distribution model kinetics and another associated with the polymer-induced micelle clusters, analyzed according to a model based on the concept of random walks in regular compact lattices. A step frequency, kw = 107 s-1, was extracted from the nanosecond results for the quencher’s random walk within the cluster. By contrast, the triplet absorption quenching studies did not distinguish between free micelles and clusters and afforded an aggregation number for the former in the range 260 ± 40, in good agreement with literature data. Decay simulations confirm the validity of the data treatment used in the nanosecond range, but the short time behavior predicted in the microsecond range was not observed within the equipment time resolution

Journal of Physical Chemistry B published new progress about Anionic surfactants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cheng, Yunlei; Cao, Youming published the artcile< Synthesis of imine carboxylic acid chelating resin>, COA of Formula: C19H34O2, the main research area is bromostyrene divinylbenzene copolymer diethyl iminodiacetate reaction chelating resin synthesis.

An imine carboxylic acid chelating resin was synthesized via suspension polymerization with 1, 2-divinyl benzene (o-DVB) and iminodiacetic acid di-Et ester as feedstock, polyethylene glycol as emulsifier, NaCl water solution as dispersed phase, and toluene as oil phase solvent. The functional group and morphol. of the product were characterized, and the impact of bromide time, initiator, mole ratio of feedstock on yield of brominated polystyrene were observed as well. The yield of brominated polystyrene increases and then decreases with the increasing of bromide time, and the optimal bromide time is 45 min; it also surges then drops slightly with the initiator increasing and reaches the peak of 72% when the initiator is 0.18 g; the yield of the product follows the increasing of the mole ratio of o-DVB and brominated DVB, while the destiny of functional group is decreased. There the more the initiator are, the smaller the particle of brominated polystyrene becomes, and the greater granulation rate achieves.

Hecheng Shuzhi Ji Suliao published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xia, Fei; Chen, Xiang-Yu; Ye, Song published the artcile< [3 + 4] Annulation of Bromoenals and 1,2-Benzenedithiol: Base-Promoted [2 + 4] Reaction and N-Heterocyclic Carbene-Catalyzed Ring-Expansion>, Quality Control of 112-63-0, the main research area is benzo dithiepinone preparation bromoenal benzenedithiol heterocyclic carbene catalyzed annulation; benzodithiine preparation bromoenal benzenedithiol ring expansion.

The [3 + 4] and [2 + 4] annulations of bromoenals and 1,2-benzenedithiol were developed in the presence or absence of N-heterocyclic carbene, resp. Control experiment and kinetic investigation revealed the [3 + 4] annulation involves the base-promoted [2 + 4] annulation and the following carbene-catalyzed ring-expansion.

Journal of Organic Chemistry published new progress about [4+2] Cycloaddition reaction (catalysts). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Peng-Yang; Huang, Chen-Yang; Li, Jia-Wun; Shen, Sheng-Yen; Cheng, Chih-Chia; Chiu, Chih-Wei; Jeng, Ru-Jong; Lin, Jiang-Jen published the artcile< Immobilization of Air-Stable Copper Nanoparticles on Graphene Oxide Flexible Hybrid Films for Smart Clothes>, Application of C19H34O2, the main research area is graphene oxide copper film nanoparticle immobilization anti oxidation property; copper nanoparticles; electrical conductivity; electrocardiogram; graphene oxide; nanohybrids; polymeric dispersant; smart clothes.

Through the use of organic/inorganic hybrid dispersants-which are composed of polymeric dispersant and two-dimension nanomaterial graphene oxide (GO)-copper nanoparticles (CuNPs) were found to exhibit nano stability, air-stable characteristics, as well as long-term conductive stability. The polymeric dispersant consists of branched poly(oxyethylene)-segmented esters of trimellitic anhydride adduct (polyethylene glycol-trimethylolpropane-trimellitic anhydride, designated as PTT). PTT acts as a stabilizer for CuNPs, which are synthesized via in situ polymerization and redox reaction of the precursor Cu(CH3COO)2 within an aqueous system, and use graphene oxide to avoid the reduction reaction of CuNPs. The results show that after 30 days of storage the CuNPs/PTT/GO composite film maintains a highly conductive network (9.06 x 10-1 Ω/sq). These results indicate that organic/inorganic PTT/GO hybrid dispersants can effectively maintain the conductivity stability of CuNPs and address the problem of CuNP oxidation Finally, the new CuNPs/PTT/GO composite film was applied to the ECG (ECG) smart clothes. This way, a stable and antioxidant-sensing electrode can be produced, which is expected to serve as a long-term ECG monitoring device.

Polymers (Basel, Switzerland) published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ciesluk, Mateusz; Piktel, Ewelina; Wnorowska, Urszula; Sklodowski, Karol; Kochanowicz, Jan; Kulakowska, Alina; Bucki, Robert; Pogoda, Katarzyna published the artcile< Substrate viscosity impairs temozolomide-mediated inhibition of glioblastoma cells′ growth>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Drug effectiveness; Glioblastoma; Polyacrylamide hydrogels; Rheology; Temozolomide; Viscoelasticity.

The mech. state of the extracellular environment of the brain cells considerably affects their phenotype during the development of central nervous system (CNS) pathologies, and when the cells respond to drugs. The reports on the evaluation of the viscoelastic properties of different brain tumors have shown that both tissue stiffness and viscosity can be altered during cancer development. Although a compelling number of reports established the role of substrate stiffness on the proliferation, motility, and drug sensitivity of brain cancer cells, there is a lack of parallel data in terms of alterations in substrate viscosity. Based on viscoelasticity measurements of rat brain samples using strain rheometry, polyacrylamide (PAA) hydrogels mimicking elastic and viscous parameters of the tissues were prepared Optical microscopy and flow cytometry were employed to assess the differences in glioblastoma cells morphol., proliferation, and cytotoxicity of anticancer drug temozolomide (TMZ) due to increased substrate viscosity. Our results indicate that changes in substrate viscosity affect the proliferation of untreated glioma cells to a lesser extent, but have a significant impact on the apoptosis-associated depolarization of mitochondria and level of DNA fragmentation. This suggests that viscosity sensing and stiffness sensing machinery can activate different signaling pathways in glioma cells. Collected data indicate that viscosity should be considered an important parameter in in vitro polymer-based cell culture systems used for drug screening.

Biochimica et Biophysica Acta, Molecular Basis of Disease published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Xiao; Cai, Liang; Chen, Tao; Qiao, Jingyi; Zhang, Xiaosong published the artcile< Vapor-liquid equilibrium measurements and assessments of Low-GWP absorption working pairs (R32+DMETEG, R152a+DMETEG, and R161+DMETEG) for absorption refrigeration systems>, Reference of 112-63-0, the main research area is R32 R152a R161 DMETEG vapor liquid equilibrium absorption refrigeration.

This research aims to develop novel binary working pairs using low-GWP refrigerants (R32, R152a, or R161) and one chem. absorbent (DMETEG) for absorption refrigeration systems. The solubility data were determined from 293.15 to 343.15 K using a static method and were correlated with the five-parameter non-random two-liquid (NRTL) activity coefficient model with an average relative absolute error of <2.4%. All three binary mixtures exhibited neg. deviations from Raoult's law. DMETEG was further assessed with other organic solvents that were previously measured to verify its highest affinity with HFCs. Based on the obtained VLE data, the thermodn. performances in both the single-stage absorption refrigeration system (ARS) and the absorption-compression hybrid refrigeration system (ACHRS) were assessed. R161 yielded the highest cooling COP of 0.519-0.555 when the generation temperature was above 135°C, followed by the R152a at 0.231-0.518 when below 135°C. Different from the trends of COP variations, R152a had the highest ECOP of 0.091-0.158 when the generation temperature was below 135°C while R161 showed the highest ECOP of 0.116-0.137 over 135°C. ACHRS can effectively enhance the cooling performances of ARS via compression and its compression ratios got optimized. Overall, the R161 + DMETEG showed the best potential as the working pair. Energy (Oxford, United Kingdom) published new progress about Absorptive refrigeration. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Planas, Oriol; Wang, Feng; Leutzsch, Markus; Cornella, Josep published the artcile< Fluorination of arylboronic esters enabled by bismuth redox catalysis>, Product Details of C19H34O2, the main research area is bismuth triarylbismuth oxidative addition reductive elimination fluorination catalyst; organoboron compound arylboronic acid fluorination substitution triarylbismuth complex catalyst; crystal structure triarylbismuth sulfinimide complex difluoride.

Triarylbismuth complexes undergo oxidative addition to yield difluorobismuth(V) derivatives, which, upon the reductive elimination provide a valuable route for catalytic fluorination of organoboron compounds Bismuth catalysis has traditionally relied on the Lewis acidic properties of the element in a fixed oxidation state. In this paper, we report a series of bismuth complexes that can undergo oxidative addition, reductive elimination, and transmetalation in a manner akin to transition metals. Rational ligand optimization featuring a sulfoximine moiety produced an active catalyst for the fluorination of aryl boronic esters through a bismuth (III)/bismuth (V) redox cycle. Crystallog. characterization of the different bismuth species involved, together with a mechanistic investigation of the carbon-fluorine bond-forming event, identified the crucial features that were combined to implement the full catalytic cycle.

Science (Washington, DC, United States) published new progress about Aryl fluorides Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics