Tag: M.W=250-300

Ito, Kenji; Chuang, Jeffrey; Alvarez-Lorenzo, Carmen; Watanabe, Tsuyoshi; Ando, Nozomi; Grosberg, Alexander Yu. published the artcile< Multiple-contact adsorption of target molecules by heteropolymer gels>, Electric Literature of 112-63-0, the main research area is thermal sensitive isopropylacrylamide copolymer gel adsorption.

We examined adsorption of target mols. through a multiple-contact interaction in a thermo-sensitive heteropolymer gel which can undergo a volume transition at 34 °C in water. Multi-valent anionic target mols. were adsorbed electrostatically by monovalent cationic adsorbing sites in the gel. The overall affinity (SK) between the gel and the target mol. was calculated from the initial slope of the Langmuir adsorption isotherm: [Tads] = KS[Tsol]/(1 + K[Tsol]), where S, K, [Tsol] and [Tads] represent the number of adsorption sites per unit volume of the gel, the effective binding constant, the equilibrium target concentration in the external solution, and the target concentration adsorbed in the gel, resp. The affinity for the collapsed gel at 60° was studied in terms of the concentrations of three factors: the adsorber, the coexistent salt, and the cross-linker. We found that the relationship between the affinity and these factors can be summarized by an equation first suggested by T. Tanaka.

Macromolecular Symposia published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Khan, Anowar H.; Cook, Jeffery K.; Wortmann, Wayne J. III; Kersker, Nathan D.; Rao, Asha; Pojman, John A.; Melvin, Adam T. published the artcile< Synthesis and characterization of thiol-acrylate hydrogels using a base-catalyzed Michael addition for 3D cell culture applications>, Reference of 112-63-0, the main research area is thiol acrylate hydrogel Michael addition 3D cell culture.

There is significant interest in developing new approaches for culturing mammalian cells in a three-dimensional (3D) environment due to the fact that it better recapitulates the in vivo environment. The goal of this work was to develop thiol-acrylate, biodegradable hydrogels that possess highly tunable properties to support in vitro 3D culture. Six different hydrogel formulations were synthesized using two readily available monomers, a trithiol (ETTMP 1300 [ethoxylated trimethylolpropane tri(3-mercaptopropionate) 1300]) and a diacrylate (PEGDA 700 [polyethylene glycol diacrylate 700]), polymerized by a base-catalyzed Michael addition reaction. The resultant hydrogels were homogeneous, hydrophilic, and biodegradable. Different mech. properties such as gelation time, storage modulus (or the elasticity G’), swelling ratio, and rate of degradation were tuned by varying the weight percentage of polymer, the molar ratio of thiol-to-acrylate groups, and the pH of the solution Cytocompatibility was assessed using two model breast cancer cell lines by both 2D and 3D cell culturing approaches. The hydrogel formulations with a thiol-to-acrylate molar ratio of 1.05 were found to be optimal for both 2D and 3D cultures with MDA-MB-231 cellular aggregates found to be viable after 17 days of 3D continuous culture. Finally, MCF7 cells were observed to form 3D spheroids up to 600μm in diameter as proof of principle for the thiol-acrylate hydrogel to function as a scaffold for in vitro 3D cell culture. A comparison of the different mech. properties of the six hydrogel formulations coupled with in vitro cell culture results and findings from previously published hydrogels conclude that the thiol-acrylate hydrogels have significant potential as a scaffold for 3D cell culture.

Journal of Biomedical Materials Research, Part B: Applied Biomaterials published new progress about Animal tissue culture. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nishikawa, Toshio; Urabe, Daisuke; Yoshida, Kazumasa; Iwabuchi, Tomoko; Asai, Masanori; Isobe, Minoru published the artcile< Stereocontrolled Synthesis of 8,11-Dideoxytetrodotoxin, Unnatural Analogue of Puffer Fish Toxin>, SDS of cas: 112-63-0, the main research area is asym synthesis deoxytetrodotoxin analog Puffer fish toxin synthon.

8,11-Dideoxytetrodotoxin, an unnatural tetrodotoxin analog, was synthesized in a highly stereoselective manner from a common intermediate in our synthetic studies on tetrodotoxin. The synthesis features neighboring group participation of trichloroacetamide for stereoselective hydroxylation, protection of ortho ester, and guanidine installation with Boc-protected isothiourea.

Organic Letters published new progress about Hydroxylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jang, Keun Sam; Shin, Dong Seok; Srisook, Ekaruth; Song, Ho-Chun; Chi, Dae Yoon published the artcile< Versatile functionalization of electron rich-fused heterocyclic arenes via electrophilic aromatic addition reaction and their applications>, SDS of cas: 112-63-0, the main research area is methoxyquinaldine regioselective bromomethoxylation; bromo alkoxyquinaldine preparation; dibromo dimethoxydihydroquinaldine amine regioselective nucleophilic substitution reaction; amino bromo methoxyyquinaldine preparation.

Divergent functionalized 8-methoxyquinaldines were synthesized via regioselective debromination, 1,3-bromine shift process, aromatization with treatment of a strong base, nucleophilic substitution reaction at the C7 position using amines and cyanide as a nucleophile in the absence of a metal source and a catalyst from an unusual electrophilic aromatic addition (AdEAr) reaction products. In addition, quinaldine-7,8-dione was prepared by presence of CAN (ceric ammonium nitrate) in AcOH and H2O for 10 min at room temperature from N-(alkylamino)-8-methoxyquinalidines. During the AdEAr reaction, new stereoselective dearomatized addition products were generated via discriminative reaction routes depending on the methoxy and bromine occupancy position. The AdEAr reaction not only allowed for the functionalization of electron rich-fused heterocyclic arenes, but also provided a new synthetic route to an alternative mechanism for electrophilic aromatic substitution reactions.

Tetrahedron published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kikalishvili, T. J.; Kereselidze, J. A. published the artcile< Trimeric mechanism of proton transfer in imidazole>, Formula: C19H34O2, the main research area is imidazole derivative proton transfer trimeric mechanism AM1 MO.

The energy, electronic, and structural characteristics of the tautomeric transformation of imidazole were calculated by the quantum-chem. semiempirical AM1 method. It was concluded on the basis of the calculated data that proton transfer in the tautomeric transformation 1H-imidazole ⇄ 3H-imidazole can take place by a trimeric mechanism.

Chemistry of Heterocyclic Compounds (New York, NY, United States)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) published new progress about Potential energy surface (proton transfer). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bollini, Mariela; Domaoal, Robert A.; Thakur, Vinay V.; Gallardo-Macias, Ricardo; Spasov, Krasimir A.; Anderson, Karen S.; Jorgensen, William L. published the artcile< Computationally-Guided Optimization of a Docking Hit to Yield Catechol Diethers as Potent Anti-HIV Agents>, Quality Control of 112-63-0, the main research area is catechol ether anti HIV reverse transcriptase inhibitor computational optimization.

A 5-μM docking hit has been optimized to an extraordinarily potent (55 pM) non-nucleoside inhibitor of HIV reverse transcriptase. Use of free energy perturbation (FEP) calculations to predict relative free energies of binding aided the optimizations by identifying optimal substitution patterns for Ph rings and a linker. The most potent resultant catechol diethers feature terminal uracil and cyanovinylphenyl groups. A halogen bond with Pro95 likely contributes to the extreme potency of compound 42 (I). In addition, several examples are provided illustrating failures of attempted grafting of a substructure from a very active compound onto a seemingly related scaffold to improve its activity.

Journal of Medicinal Chemistry published new progress about AIDS (disease). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nogales-Delgado, Sergio; Encinar Martin, Jose Maria; Sanchez Ocana, Mercedes published the artcile< Use of mild reaction conditions to improve quality parameters and sustainability during biolubricant production>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is safflower oil biolubricant production oxidative stability biodegradability sustainability viscosity.

The use of alternative sources to produce less pollutant biofuels and biomaterials, replacing petroleum-derived products, is becoming an important issue for international organizations, governments, and society. Thus, biodiesel and biolubricant production has been increasingly researched, offering promising results. These products present some advantages such as sustainability or biodegradability, among others. However, some of their quality parameters can be altered during storage, mainly due to their low oxidative stability. Consequently, auto-oxidation processes can take place, increasing viscosity or acid number, which can compromise their marketability. To avoid these inconveniences, some alternatives have been presented, such as the use of antioxidants, vegetable oil selection or the promotion of mild chem. conditions during production The aim of this work was to assess the use of vacuum during biolubricant production from high-oleic safflower oil through double transesterification with methanol and 2-ethyl-2-(hydroxymethyl)-1,3-propanediol to obtain mild chem. conditions. Under these circumstances (working pressure at 210 mmHg) and compared to previous studies, temperature and catalyst addition could be reduced from 140 to 100°C and from 0.5 to 0.3%, resp., increasing the reaction yield from 92.9 to 94.69% and improving the quality of the biolubricant, with 30% increase in viscosity index.

Biomass and Bioenergy published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mutlu, Tutku; Demir-Cakan, Rezan published the artcile< Carbonate or ether based electrolyte for Li-Se batteries: An in-situ study of intermediate polyselenide formation>, Application In Synthesis of 112-63-0, the main research area is carbonate ether electrolyte lithium selenium battery intermediate polyselenide formation.

Li-Se batteries have recently been considered as one of the most promising battery systems to satisfy the future energy storage needs. However, to further improve the electrochem. cell performances, understanding of the Li-Se cell working mechanism, especially focusing on the formation of dissolved Li polyselenides, is essential. An in-situ study of intermediate polyselenide formation based on the 4-electrode cycling voltammetry (CV) and 3-electrode electrochem. impedance spectroscopy (EIS) were used to detect the existence of polyselenides in carbonate and ether-based electrolytes. CV measurements reveal dissolved polyselenide intermediate formations in ether-based solvent while no signatures are observed in carbonate-based electrolytes. Similar findings are also observed by EIS measurements as well as studying the self-discharge behavior. Therefore, these two electrochem. characterizations can be easily implemented as prompt and cost-effective techniques to study the impact of the electrolyte solvents. Contrary to the Li-S counterparts, the outcome of the work suggests that carbonate-based electrolytes can be simply employed in the field of Li-Se batteries.

Electrochimica Acta published new progress about Battery electrolytes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Modrocka, Viktoria; Veverkova, Eva; Baran, Rastislav; Sebesta, Radovan published the artcile< Enantioselective Synthesis of 2,3-Dihydrofurocoumarins by Squaramide-Catalyzed Michael Addition/Cyclization of 4-Hydroxycoumarins with β-Nitrostyrenes>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is hydroxycoumarin nitrostyrene squaramide organocatalyst enantioselective diastereoselective Michael addition heterocyclization; hydroxyimino phenyl furochromenone preparation.

The enantioselective synthesis of chiral 2,3-dihydrofurocoumarins by squaramide-catalyzed Michael addition of 4-hydroxycoumarins to β-nitrostyrenes, followed by a cyclization reaction was described. A coumarin moiety was present in many chiral bioactive compounds, but the organocatalysis has still not reached its full potential in the synthesis of chiral coumarins. Squaramide catalysts comprising two chiral units, (S)-phenylethylamine and cyclohexane-1,2-diamine was used. These catalysts showed high reactivity and enantioselectivity in this transformation. Following this procedure, a series of 2,3-dihydrofurocoumarin derivatives in 47-93% yields and enantiomeric purities in the range of 78-94% ee were prepared Polystyrene-immobilized squaramide catalyst performed well for the initial two reaction cycles but then slowly degraded. The absolute configuration of 2,3-dihydrofurocoumarin products was determined by the comparison of the exptl. and d. functional theory-calculated electronic CD spectra.

ChemistrySelect published new progress about Circular dichroism. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Kai; Schaefer, Agnes; Zhang, Zhuo; Elsaesser, Katharina; Culmsee, Carsten; Zhong, Li; Pagenstecher, Axel; Nimsky, Christopher; Bartsch, Joerg W. published the artcile< Inhibition of Carbonic Anhydrase 2 Overcomes Temozolomide Resistance in Glioblastoma Cells>, HPLC of Formula: 112-63-0, the main research area is temozolomide anticancer agent carbonic anhydrase2 glioblastoma; GBM recurrence; GBM stem-like cells; acetazolamide; autophagy; brinzolamide; carbonic anhydrase 2; chemoresistance; glioblastoma; temozolomide.

About 95% of Glioblastoma (GBM) patients experience tumor relapse as a consequence of resistance to the first-line standard chemotherapy using temozolomide (TMZ). Recent studies reported consistently elevated expression levels of carbonic anhydrase CA2 in recurrent glioblastoma and temozolomide-resistant glioblastoma stem-like cells (GSCs). Here we show that CA2 is preferentially expressed in GSCs and upregulated by TMZ treatment. When expressed in GBM cell lines, CA2 exerts significant metabolic changes reflected by enhanced oxygen consumption and increased extracellular acidification causing higher rates of cell invasion. Notably, GBM cells expressing CA2 respond to combined treatment with TMZ and brinzolamide (BRZ), a non-toxic and potent CA2 inhibitor. Interestingly, brinzolamide was more effective than the pan-CA inhibitor Acetazolamide (ACZ) to sensitize naive GSCs and TMZ-resistant GSCs to TMZ induced cell death. Mechanistically, we demonstrated that the combined treatment of GBM stem cells with TMZ and BRZ caused autophagy of GBM cell lines and GSCs, reflected by enhanced LC3 cleavage (LC3-II) and p62 reduction Our findings illustrate the potential of CA2 as a chemo-sensitizing drug target in recurrent GBM and propose a combined treatment of TMZ with CA2 inhibitor to tackle GBM chemoresistance and recurrence.

International Journal of Molecular Sciences published new progress about Acidification. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics