Tag: M.W=250-300

Hsu, Shih-Hsin published the artcileHigh-Speed One-Photon 3D Nanolithography Using Controlled Initiator Depletion and Inhibitor Transport, Product Details of C15H20O6, the publication is Advanced Optical Materials (2022), 10(4), 2102262, database is CAplus.

Additive manufacturing of sophisticated 3D nanoscale objects commonly uses femtosecond lasers to photopolymerize a light-sensitive resin using multi-photon absorption. This nonlinear process provides high accuracy and flexibility in advanced 3D fabrication; however, it typically has limited throughput and high cost. This work makes use of a one-photon-based dosage-nonlinearity to fabricate 3D nanostructures, demonstrating a cost-effective method for 3D nanolithog. using a low-cost 405 nm continuous-wave diode laser. This dosage-nonlinearity is achieved by using controlled depletion of photo-initiation species in an environment containing inhibiting species. By controlling multiple competing processes, the undesired dose accumulation outside the writing voxel is stopped, and thereby this method creates a confined writing voxel in space. A multiphysics model is developed to numerically study the one-photon nonlinear photopolymerization process, which is compared with exptl. results.

Advanced Optical Materials published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Product Details of C15H20O6.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Barton, Lisa M. published the artcileElectrochemical borylation of carboxylic acids, COA of Formula: C14H28BNO4, the publication is Proceedings of the National Academy of Sciences of the United States of America (2021), 118(34), e2109408118, database is CAplus and MEDLINE.

A simple electrochem. mediated method for the conversion of alkyl carboxylic acids to their borylated congeners is presented. This protocol features an undivided cell setup with inexpensive carbon-based electrodes and exhibits a broad substrate scope and scalability in both flow and batch reactors. The use of this method in challenging contexts is exemplified with a modular formal synthesis of jawsamycin, a natural product harboring five cyclopropane rings.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 1850305-80-4. 1850305-80-4 belongs to esters-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is tert-Butyl N-[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]carbamate, and the molecular formula is C14H28BNO4, COA of Formula: C14H28BNO4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sinsheimer, J. E. published the artcileThe genotoxicity of enantiomeric aliphatic epoxides, Recommanded Product: (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, the publication is Mutation Research, Genetic Toxicology Testing (1993), 298(3), 197-206, database is CAplus and MEDLINE.

The (R)- and (S)-optical isomers of 9 epoxides, benzyloxymethyloxirane, epichlorohydrin, glycidol, glycidyl 3-nitrobenzenesulfonate, glycidyl 4-nitrobenzoate, glycidyl tosylate, styrene oxide, glycidyl 1-naphthyl ether, and glycidyl 4-nitrophenyl ether, were compared for their in vivo and in vitro genotoxicity. Differences in mutagenicity between isomers were established with Salmonella TA100 for all the compounds While 13 of the isomers were genotoxic compared to a neg. control by chromosomal aberration measurements, only in the case of glycidyl 4-nitrobenzoate could a significant difference be found between isomers by this test. However, with sister chromatid exchange evaluations, differences were detected between the (R)- and (S)-isomers for all the pairs of compounds with the exception of those for benzyloxymethyloxirane and glycidyl 4-nitrophenyl ether. At least in part, differences in the patterns of genotoxicity among compounds can be related to their differences in reaction pathways.

Mutation Research, Genetic Toxicology Testing published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C20H28B2O4S2, Recommanded Product: (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Jinwei published the artcilePhotocured polyacrylate coatings modified by polybutadiene derivatives with multiunsaturated reactive bonds, Application of Trimethylolpropane triacrylate, the publication is Journal of Coatings Technology and Research, database is CAplus.

Maleic anhydride-g-poly(1,2-butadiene) (MLPB) is used as a rubber flexibilizer to modify UV-curable polyacrylate coatings (PA) in an attempt to improve their wear resistance and water tolerance. Fourier transform IR spectra results show that the unsaturated reactive bonds of MLPB fully participate in the UV-curing reaction and successfully copolymerized with acrylates to obtain robust coatings. The smooth and broad differential scanning calorimeter curves show that the cured systems had good compatibility and their glass transition temperatures (Tg) increase from about 63°C to 74°C with the increase of MLPB addition up to 6 wt%. With the addition of MLPB in PA matrix, their cross-sectional scanning electron microscope (SEM) pictures show brittle features with coarser and dimpled microcracks transforming to toughened fracture morphol. with particles offsetting microcrack propagation when MLPB content is added up to 4-6 wt%. The wear scar profiles show that the cross-sectional areas decrease significantly with the MLPB addition, implying the improvement in the wear-resisting ability of PA composite toughened by MLPB; the hardness, impact resistance, and adhesion could be also improved when MLPB was controlled less than 6 wt%. Compared with the pure polyacrylate coatings, the modified coatings exhibited an improvement in water resistance before and after 48-h UV aging.

Journal of Coatings Technology and Research published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C9H21NO3, Application of Trimethylolpropane triacrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Liu, Jie published the artcileSingle-, Dual-, Triple, and Quadruple-Wavelength Surface-Emitting Lasing in Blue-Phase Liquid Crystal, Product Details of C15H20O6, the publication is Advanced Materials (Weinheim, Germany) (2022), 34(9), 2108330, database is CAplus and MEDLINE.

Soft organic lasers with multiwavelength output and high spectral purity are of crucial importance for versatile photonic devices, owing to their monochromaticity, coherence, and high intensity. However, there remain challenges for the achievement of surface-emitting multiwavelength lasing in soft photonic crystals, and the relative mechanisms need to be investigated. Herein, single-, dual-, triple-, and quadruple-wavelength lasers are successfully achieved in dye-doped blue-phase liquid crystal (BPLC) film. The number and wavelength of the lasing peaks can be manipulated by tuning the center of the bandgap, the order parameter of the laser dye, the quality of the resonance cavity, and even the pump energy. For single-wavelength lasing, a lasing peak with an ultranarrow linewidth of 0.04 nm (Q-factor of 13 454) is achieved. Multiwavelength lasing is attained based on the following aspects: i the narrow bandgaps of the BPLCs with full width at half maximum of 14-20 nm; ii a laser dye with high gain over a wide wavelength band, having a low-order parameter in the liquid crystal matrix; iii appropriate relative positions between the reflection and fluorescence peaks; and iv the highly ordered crystal lattice of BPLC film. The proposed single-to-quadruple-wavelength surface-emitting lasers can be employed as coherent light sources for next-generation optical devices.

Advanced Materials (Weinheim, Germany) published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Product Details of C15H20O6.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tang, Jie published the artcilePreparation of photosensitive SiO₂SiC ceramic slurry with high solid content for stereolithography, Related Products of esters-buliding-blocks, the publication is Ceramics International, database is CAplus.

Stereolithog. is a popular three-dimensional (3D) printing technol., which is widely used for manufacturing ceramic components owing to its high efficiency and precision. However, it is a big challenge to prepare SiC ceramic slurry with high solid content for stereolithog. due to the strong light absorption and high refractive index of dark SiC powders φ. Here, we propose a novel strategy to develop photosensitive SiO₂/SiC ceramic slurry with high solid content of 50-65 vol% by adding spherical silica with low light absorbance and applying a stacking flow model to improve the solid content of the slurry. The as-prepared slurry exhibits excellent stereolithog. properties with a dynamic viscosity lower than 20 Pa s and curing thickness more than 120 μm. Therefore, it can be successfully applied for stereolithog.-based additive manufacturing of SiC green ν bodies with large size (100 mm), sub-millimeter accuracy (0.2 mm), and complex structure. The stacking flow model also shows immense potential for the stereolithog. of other dark-color ceramics with high solid content.

Ceramics International published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C14H12N2S, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ananth, Ramagopal published the artcileOptical purification of chiral glycidyl arenesulfonates, Application In Synthesis of 115314-17-5, the publication is Tetrahedron: Asymmetry (1995), 6(2), 317-20, database is CAplus.

The m.p. point phase diagrams of glycidyl tosylate (1), glycidyl 3-nitrobenzenesulfonate (2), and trans-3-methylglycidyl tosylate (3) have been investigated. Compounds 1 and 2 exhibit a more significant solid solution behavior in the terminal zones of the phase diagram than 3, and are therefore more difficult to enrich enantiomerically by recrystallizations The crystallization of 2 in ethanol is further complicated by polymorphism which can be followed by differential scanning calorimetry. The effects of these properties on the optical purification of 1–3 are discussed.

Tetrahedron: Asymmetry published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Application In Synthesis of 115314-17-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bethel, Paul A. published the artcileOptimized scale up of 3-pyrimidinylpyrazolo[1,5-a]pyridine via Suzuki coupling; a general method of accessing a range of 3-(hetero)arylpyrazolo[1,5-a]pyridines, Application of 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine, the publication is Tetrahedron (2012), 68(27-28), 5434-5444, database is CAplus.

We have developed an improved synthesis of 3-(hetero)aryl pyrazolo[1,5-a]pyridines [such as 3-(2,5-dichloropyrimidin-4-yl)pyrazolo[1,5-a]pyridine (I)] via an optimized synthesis and Suzuki coupling of 3-pyrazolo[1,5-a]pyridine boronic ester (II). These conditions are applicable to both high throughput chem. and large scale synthesis of these medicinally important compounds The scope of this chem. has been further extended to include the synthesis and coupling of a novel boronic ester, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine.

Tetrahedron published new progress about 1383675-83-9. 1383675-83-9 belongs to esters-buliding-blocks, auxiliary class Boronic acid and ester,Boronic acid and ester, name is 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine, and the molecular formula is C12H19BN2O3, Application of 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Godoy, William M. published the artcileKinetic modeling of glycerol acetylation catalyzed by styrene-divinylbenzene and styrene-trimethylolpropane triacrylate sulfonated resins, Recommanded Product: Trimethylolpropane triacrylate, the publication is Reaction Kinetics, Mechanisms and Catalysis (2022), 135(1), 233-245, database is CAplus.

The present work reports a kinetic comparison between two resins made with different cross-linkers, Amberlyst 36 and PS-TMPTA. The latter was synthesized in this study. Both resins were used as catalysts in glycerol acetylation in a batch reactor at 80 and 90°C, with 5 and 10 g L^-1 of catalyst concentration under a molar ratio 4:1 of acetic acid/glycerol. The synthesized resin (PS-TMPTA) presented low ion exchange capacity (1.5 mmol g^-1) compared to the com. resin (Amberlyst 36, 5.45 mmol g^-1), but both presented similar efficiency in catalysis, probably due to the difference in crosslinking densities. The exptl. results explain the resins behavior and properties in detail (ion exchange capacities, swelling index and catalytic efficiency) and the kinetic models were compared utilizing the difference between the corrected Akaike Information Criterion (ΔAICc), Standard Deviation (s) and P-value (student t distribution). According to the results, the irreversible first order model had the best fit of the two models for the exptl. conditions studied for this work.

Reaction Kinetics, Mechanisms and Catalysis published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Recommanded Product: Trimethylolpropane triacrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Barlaam, Bernard published the artcileDiscovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies, Name: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine, the publication is Journal of Medicinal Chemistry (2020), 63(24), 15564-15590, database is CAplus and MEDLINE.

A CDK9 inhibitor having short target engagement would enable a reduction of Mcl-1 activity, resulting in apoptosis in cancer cells dependent on Mcl-1 for survival. We report the optimization of a series of amidopyridines (from compound 2), focusing on properties suitable for achieving short target engagement after i.v. administration. By increasing potency and human metabolic clearance, we identified compound 24, a potent and selective CDK9 inhibitor with suitable predicted human pharmacokinetic properties to deliver transient inhibition of CDK9. Furthermore, the solubility of 24 was considered adequate to allow i.v. formulation at the anticipated ED. Short-term treatment with compound 24 led to a rapid dose- and time-dependent decrease of pSer2-RNAP2 and Mcl-1, resulting in cell apoptosis in multiple hematol. cancer cell lines. Intermittent dosing of compound 24 demonstrated efficacy in xenograft models derived from multiple hematol. tumors. Compound 24 is currently in clin. trials for the treatment of hematol. malignancies.

Journal of Medicinal Chemistry published new progress about 1383675-83-9. 1383675-83-9 belongs to esters-buliding-blocks, auxiliary class Boronic acid and ester,Boronic acid and ester, name is 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine, and the molecular formula is C12H19BN2O3, Name: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics