Tag: M.W=250-300

Wan, Qijuan; Wu, Liqun; Yang, Qiuhua; Lin, Mao; Guo, Songlin published the artcile< First identification and pathogenicity study of Vibrio harveyi isolated from diseased American eel (Anguilla rostrata) cultivated in freshwater>, Electric Literature of 112-63-0, the main research area is Anguilla rostrata disease freshwater Vibrio harveyi isolation pathogenicity.

Diseases caused by Vibrio harveyi in marine organisms have been generally reported in aquaculture, but there has been no reported V. harveyi infection in fish cultivated in freshwater. Herein, we isolated 3 strains of V. harveyi from diseased American eels (Anguilla rostrata) cultivated in freshwater and subsequently confirmed the virulence of V. harveyi and the extracellular product (ECP). The three isolates were identified as V. harveyi based on phenotypic features and homol. of 16S rDNA and 3 house-keeping genes (HKGs). Exptl. infection revealed that V. harveyi and ECP were highly pathogenic to American eels, and the median LDs (LD50) were 1.67 x 103 cfu/g and 7.29μg/g body weight, resp. Moreover, our antibiotic susceptibility test showed that V. harveyi was susceptible to 16 of 20 antibiotics using the VITEK system of Merieux. Furthermore, liver and kidney samples were collected for paraffin sectioning, stained with haematoxylin-eosin (H & E) and Periodic Acid-Schiff (PAS). H & E staining results revealed hepatocyte atrophy and necrosis, hepatic intercellular hemorrhage and intrahepatic venous thrombosis, while the kidney was characterized by renal tubular epithelial cell swelling and renal interstitial haematopoietic cell loss. Interestingly, glycogen deposition was more obvious in the kidney compared with the liver after PAS staining. Cultivated eel infected by V. harveyii was reported for the first time, and the results of this study provide a valuable reference for further prevention and control of fish diseases caused by V. harveyi.

Aquaculture Research published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Williams, Georgia E.; Kociok-Kohn, Gabriele; James, Tony D.; Lewis, Simon E. published the artcile< C4-aldehyde of guaiazulene: synthesis and derivatisation>, Application of C19H34O2, the main research area is guaiazulene aldehyde preparation derivatization halochromism.

Guaiazulene is an alkyl-substituted azulene available from natural sources and is a much lower cost starting material for the synthesis of azulene derivatives than azulene itself. Here we report an approach for the selective functionalization of guaiazulene which takes advantage of the acidity of the protons on the guaiazulene C4 Me group. The aldehyde produced by this approach (I) constitutes a building block for the construction of azulenes substituted on the seven-membered ring. Derivatives of this aldehyde synthesized by alkenylation, reduction and condensation are reported, and the halochromic properties of a subset of these derivatives have been studied.

Organic & Biomolecular Chemistry published new progress about Azulenes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Donghyun; Park, Ji Young; Lee, Dong Hyun; Lim, Jae-Eun; Moon, Hyo-Bang; Kim, Sungkyoon; Lee, Kiyoung published the artcile< Simultaneous assessment of organophosphate flame retardants, plasticizers, trace metals, and house dust mite allergens in settled house dust>, Quality Control of 112-63-0, the main research area is organophosphate flame retardant phenol plasticizer mite allergens house dust; OPFR; alternative; house dust mite allergens; plasticizer; settled house dust.

Settled house dust (SHD) is a reservoir for various contaminants, including endocrine-disrupting chems. (EDCs), trace metals, and house dust mite allergens. This study aimed to characterize various chem. and biol. contaminants in SHD and identify determinants governing the indoor contaminants. In total, 106 SHD samples were collected from 106 houses in Seoul and Gyeonggi Province, Korea, in 2021. Bedding dust samples were collected from 30 of these 106 houses. All participants completed a questionnaire comprised of housing and lifestyle-related factors. The samples were analyzed for 18 organophosphate flame retardants (OPFRs), 16 phthalates, five alternative plasticizers (APs), seven trace metals, and two house dust mite allergens (Dermatophagoides farinae type 1 [Der f1] and Dermatophagoides pteronyssinus type 1 [Der p1]). A multiple regression anal. was conducted to identify the determinants governing the concentrations and profiles of various contaminants. OPFRs, phthalates, APs, and trace metals were detected in all SHD samples, indicating ubiquitous contamination in indoor environments. Among the three EDC groups, APs were detected at the highest concentrations (geometric mean [GM] (geometric standard deviation, [GSD]): 1452 (1.6)μg/g in total), followed by phthalates (GM (GSD): 676 (1.4) μg/g in total) and OPFRs (GM (GSD): 10 (1.4) μg/g in total). Der f1 was detected in all bedding dust samples with significantly higher levels than Der p1 (GM (GSD): 0.1 (1.8) μg/g vs. 1.4 x 10-3 (2.3) μg/g). The concentrations of OPFRs, plasticizers, and trace metals in SHD were significantly associated with the type and number of electronic appliances and combustion activities. Der f1 was significantly associated with the number of occupants and water penetration. Ventilation, vacuum cleaning, and wet cleaning or dry mopping significantly reduced the levels of most contaminants in SHD. As residents are persistently exposed to a wide array of pollutants, comprehensive and adequate measures are required to prevent potential exposures.

Indoor Air published new progress about Allergen Der f Role: ANT (Analyte), ANST (Analytical Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bokharaei-Salim, Farah; Esghaei, Maryam; Khanaliha, Khadijeh; Kalantari, Saeed; Marjani, Arezoo; Fakhim, Atousa; Keyvani, Hossein published the artcile< HIV-1 reverse transcriptase and protease mutations for drug-resistance detection among treatment-experienced and naive HIV-infected individuals>, Formula: C19H34O2, the main research area is HIV infection drug resistance reverse transcriptase protease mutation.

The current study aimed at assessing the prevalence of HIV-1 DRMs among naive and treatment-experienced HIV-1-infected patients in Iran. Methods: From Apr. 2013 to Sept. 2018, the HIV-1 protease and reverse transcriptase genes were amplified and sequenced in plasma specimens of 60 newly diagnosed antiretroviral-naive individuals and 46 participants receiving antiretroviral therapies (ARTs) for at least six months with an HIV viral load of more than 1000 IU/mL to determine the HIV-1 DRMs and subtypes. Results: The SDRMs, D67N and D67E, belonged to the NRTIs class in two patients and K103N and V106A belonged to the NNRTIs class in three patients. Among the 46 ART-experienced participants, 33 (71.7%) carried HIV-1 variants with SDRMs (9.1% against PIs, 78.8% against NRTIs, and 100% against NNRTIs). M46I and I47V were the most common mutations for PIs, M184V was the most common mutation for the NRTIs, and K103N/S was the most common mutation for NNRTIs. Phylogenetic anal. of the polymerase region showed that all of the 46 HIV-1-infected patients who failed on ART carried CRF35_AD. The moderate prevalence of SDRMs (8.3%) in treatment-naive and ART-failed (77.1%) Iranian patients with HIV-1-infection emphasizes the need for systematic viral load monitoring, expanding drug resistance testing, carefully surveilling individuals on ART regimens, and facilitating access to new antiretrovirals by health authorities.

PLoS One published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Patra, Atanu; James, Anjima; Das, Tamal Kanti; Biju, Akkattu T. published the artcile< Oxidative NHC Catalysis for the Generation of Imidoyl Azoliums: Synthesis of Benzoxazoles>, Application of C19H34O2, the main research area is benzoxazole preparation; iminophenol oxidative cyclization heterocyclic carbene catalyst.

N-Heterocyclic carbene (NHC)-catalyzed intramol. cyclization of aldimines generated from 2-amino phenols and aromatic aldehydes leading to the synthesis of 2-arylbenzoxazoles under mild conditions is presented. The reaction proceeds via the generation of the aza-Breslow intermediates from imines and NHC, which under oxidative conditions form the key imidoyl azoliums and a subsequent intramol. cyclization furnishes the product. The reaction tolerates a broad range of functional groups, and the products are formed in generally good yields.

Journal of Organic Chemistry published new progress about Benzoxazoles Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Xin; Li, Tao; Yang, Mengdi; Du, Qianming; Wang, Rui; Fu, Bin; Tan, Yingying; Cao, Mengran; Chen, Yaxin; Wang, Qing; Hu, Rong published the artcile< Acquired temozolomide resistance in MGMTlow gliomas is associated with regulation of homologous recombination repair by ROCK2>, Quality Control of 112-63-0, the main research area is temozolomide resistance ROCK MGMT glioma homologous recombination repair.

It was reported that MGMTlow gliomas may still be resistant to TMZ, while the mechanisms remain poorly understood. In this study, we demonstrated that rho-associated kinase 2 (ROCK2), a cytoskeleton regulator, was highly expressed in MGMTlow recurrent gliomas, and its expression strongly correlated with poor overall survival (OS) time in a subset of MGMTlow recurrent gliomas patients with TMZ therapy. And we also found that overactive ROCK2 enhanced homologous recombination repair (HR) in TMZ-resistant (TMZ-R) glioma cell lines with low MGMT expression. Silencing ROCK2 impaired HR repair, and induced double-strand break (DSB) and eradicated TMZ-R glioma cells in culture. Notably, in MGMTlow TMZ-R models, as a key factor of HR, ataxia telangiectasia-mutated (ATM) expression was upregulated directly by hyper-activation of ROCK2 to improve HR efficiency. ROCK2 enhanced the binding of transcription factor zinc finger E-box binding homeobox 1 (ZEB1) to ATM promoter for increasing ATM expression. Moreover, ROCK2 transformed ZEB1 into a gene activator via Yes-associated protein 1 (YAP1). These results provide evidence for the use of ROCK inhibitors in the clin. therapy for MGMTlow TMZ-resistant glioma. Our study also offered novel insights for improving therapeutic management of MGMTlow gliomas.

Cell Death & Disease published new progress about Ataxia telangiectasia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xiao, Chunwu; Bai, Yun; Pu, Yuji; Luo, Haiqiang; Xiao, Sui; He, Bin published the artcile< Effect of polymer architecture and hard/soft segment ratio on the surface morphology and mechanical properties of polyurethane films for potential orthodontic treatment>, COA of Formula: C19H34O2, the main research area is orthodontic polyurethane film surface morphol property cytocompatibility.

In this study, polyurethane (PU) films are prepared by using 1,4-butanediol and trimethylolpropane as chain extender and crosslinking agent, resp. A series of prepolymers are synthesized by varying the feeding molar ratios of methylene diisocyanate to polytetramethylene ether glycol, which are hard and soft segments, resp. The influence of polymer architecture, chem. composition, and artificial saliva treatment on the surface morphol. and mech. strength of PU films are studied. The crosslinking polymer architecture and higher content of hard segment correlates with enhanced tensile strength and less decrease of tensile strength in the condition of artificial saliva, but reduced elongation at break. The in vitro cytotoxicity study demonstrates that PU films have excellent cytocompatibility.

Journal of Applied Polymer Science published new progress about Artificial saliva. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wei, Shu-jun; Zhang, Qing; Xiang, Yong-jing; Peng, Lan-yu; Peng, Wei; Ren, Qiang; Gao, Yong-xiang published the artcile< Guizhi-Shaoyao-Zhimu decoction attenuates bone erosion in rats that have collagen-induced arthritis via modulating NF-κB signalling to suppress osteoclastogenesis>, Reference of 112-63-0, the main research area is GuiZhi ShaoYao ZhiMu decoction antiarthritic agent collagen induced arthritis; RANKL; Rheumatoid arthritis; osteoclast; osteoprotegerin.

Guizhi-Shaoyao-Zhimu decoction (GSZD) is commonly used to treat rheumatoid arthritis (RA), but its mechanism is unclear. To investigate the effect of GSZD on bone erosion in type II collagen (CII)-induced arthritis (CIA) in rats and to identify the underlying mechanism. The CIA model was prepared in male Wistar rats by two s.c. injections of CII, 1 mg/mL. Fifty CIA rats were randomized equally into the control group given saline daily, the pos. group given saline daily and methotrexate 0.75 mg/kg once a week, and three GSZD-treated groups gavaged daily with 800, 1600 and 3200 mg/kg of GSZD for 21 days. GSZD effects were assessed by paw volume, arthritic severity index and histopathol. Cytokine levels were determined by ELISA. The effects of GSZD on RAW264.7 cells were evaluated by receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis and bone resorption assay. Expression of IκB-α and p65 was measured by Western blotting. Major components of GSZD were identified by HPLC. Arthritis index score, paw volume and bone destruction score showed that GSZD improved inflammatory symptoms and reduced joint tissue erosion (p < 0.01). GSZD decreased RANKL, and the number of osteoclasts (OCs) in joint tissues (p < 0.01) and increased osteoprotegerin levels (p < 0.01). GSZD inhibited RANKL-induced RAW264.7 differentiation and reduced bone resorption by OCs. GSZD upregulated IκB (p < 0.01) and p65 (p < 0.01) in the cytoplasm and downregulated p65 (p < 0.01) in the cell nucleus. Guizhi-Shaoyao-Zhimu decoction has an anti-RA effect, suggesting its possible use as a supplement and alternative drug therapy for RA. Pharmaceutical Biology (Abingdon, United Kingdom) published new progress about Ankle. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yue, Rong; Lu, Qing; Zhou, Yikai published the artcile< A novel nitrite biosensor based on single-layer graphene nanoplatelet-protein composite film>, Category: esters-buliding-blocks, the main research area is nitrite biosensor single layer graphene nanoplatelet protein composite film.

A novel nitrite biosensor was developed through a sensing platform consisted of single-layer graphene nanoplatelet (SLGnP)-protein composite film. SLGnP with the virtues of excellent biocompatibility, conductivity and high sensitivity to the local perturbations can provide a biocompatible microenvironment for protein immobilization and a suitable electron transfer distance between electroactive centers of heme protein and electrode surface. A pair of well-defined and quasi-reversible cyclic voltammetric peaks that reflected the direct electrochem. for ferric/ferrous couple of myoglobin (Mb) was achieved at the composite film modified electrode. Field emission SEM (FESEM) and UV visible spectra (UV-vis) were utilized to characterize the composite film. The results demonstrated that the morphol. of the composite film was unique and the protein in the composite film retained its secondary structure similar to the native state. The composite film also displayed excellent electrocatalytic ability for the reduction of nitric oxide, which was applied to determine nitrite indirectly. It exhibited good electrochem. response to nitrite with a linear range from 0.05 to 2.5 mM and a detection limit of 0.01 mM.

Biosensors & Bioelectronics published new progress about Chemically modified electrodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kato, Taka-aki; Saeki, Ken-ichi; Kawazoe, Yutaka; Hakura, Atsushi published the artcile< Effects of oligofluorine substitution on the mutagenicity of quinoline: a study with twelve fluoroquinoline derivatives>, SDS of cas: 112-63-0, the main research area is fluoroquinoline mutagenicity oligofluorine substitution.

A total of 12 variously fluorinated derivatives of quinoline (Q) were tested for their mutagenicity in Salmonella typhimurium TA100 in the presence of S9 mix to investigate the structure-mutagenicity relation in oligofluorinated quinolines. Nine of them, 3,7-di-, 5,6-di-, 6,7-di-, 6,8-di-, 7,8-di-, 3,5,7-tri-, 5,6,8-tri-, 6,7,8-tri-, and 5,6,7,8-tetrafluoroquinolines (FQs), were newly synthesized for this purpose. Those fluorinated at position 3 were all non-mutagenic. Mutagenicity was enhanced by fluorine-substitution at position 5 or 7, but not in 3-FQs (i.e., 3,5-di-, 3,7-di-, and 3,5,7-triFQs). Some of the 6-fluorinated derivatives showed less maximum induced-revertants with more mutagenic potencies in terms of induced-revertants per dose than quinoline. No marked change occurred by fluorine-substitution at position 8. These results show that the effect of di- and trifluoro-substitution on mutagenicity is generally additive, while that of tetrafluorination approaches the deactivating effect of perfluorination. The authors study suggests that 3-fluorine-substitution in the pyridine moiety may be a useful means of antimutagenic structural modification in pyridine-fused aromatic chems. for medicinal and agricultural use.

Mutation Research, Genetic Toxicology and Environmental Mutagenesis published new progress about Mutagens. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics