Tag: M.W=250-300

Sheng, Yan-Hua; Wang, Rui; Wang, Yi-Kai; Li, Meng-Meng; Liu, Fang-Xin; Huang, Xin; Chen, Chang-Bao published the artcile< Evaluation of multicomponent changes of Schisandra chinensis fruits with different drying process by UPLC-QQQ-MS-based targeted metabolomics analysis>, Category: esters-buliding-blocks, the main research area is Schisandra fruit drying process metabolomics UPLC QQQ MS.

Schisandra chinensis fruit is a famous tonic traditional Chinese medicine and healthy food. The chem. components of dried fruits may vary with the initial processing methods of fresh fruits. Therefore, in this study, the influence of drying was evaluated based on targeted metabolomics anal. The ultrahigh performance liquid chromatog.-triple quadrupole mass spectrometry (UPLC-QQQ-MS) was applied in determination of multicomponent including lignans, organic acids, and oligosaccharides. The fresh fruits of Schisandra chinensis were processed by natural drying in the sun, hot air drying and vacuum drying at different temperatures, and vacuum freeze drying, resp. The contents of lignans, organic acids, and oligosaccharides in different fruit samples were quantified and statistically analyzed by partial least squares discriminant anal. (PLS-DA). The variation of totally 10 lignans, 5 organic acids, and 9 oligosaccharides with different drying process were compared. The results showed that the drying time of natural drying method was much longer than the other methods using instrument. For hot air and vacuum drying samples, most of lignans, organic acids, and oligosaccharides gradually decreased with the increase of temperature And the appearance of fruit drying at higher temperature was dark red. At the same processing temperature, vacuum drying takes longer time than hot air drying. In addition, organic acid and oligosaccharide contents of vacuum freeze drying treated samples were higher than the other processed samples significantly. According to the targeted metabolomics anal., the lignans, organic acids, and oligosaccharides markers were screened out for holistic quality evaluation of Schisandra chinensis fruits. In comprehensive consideration of multicomponent, drying time, fruit appearance and storage, and production feasibility, hot air drying at 50° C is more suitable for the process of Schisandra chinensis. The result is expected to provide a scientific basis for the selection of proper method for drying process of fresh Schisandra chinensis fruit.

Journal of Chemistry published new progress about Air drying process (hot). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yousfi, F. Z.; Boutahiri, N.; Ouerdja, I.; Rguig, N.; Nader, S.; Aharmim, M.; Bourkadi, J. E. published the artcile< Multi-Drug Resistant Tuberculosis and HIV Infection about 06 Cases>, Computed Properties of 112-63-0, the main research area is diagnosis risk factor HIV infection multidrug resistant tuberculosis.

Multi-drug-resistant tuberculosis remains a significant threat in people living with HIV and promotes increased mortality rates. It is often a combination of pulmonary tuberculosis forms and extra-pulmonary forms. We report 6 cases of patients with HIV and multi-drug-resistant tuberculosis collected over a two-year period from 01/01/2018 to 31/12/2019 hospitalized for multi-drug-resistant tuberculosis at Moulay Youssef Hospital. We describe the radiol., evolutionary and therapeutic clin. characteristics of resistant TB in this patient category. The average age of our patients was 36. These are 2 women and 4 men. Of which 4 were known to carry retroviral infection, followed and treated with antiretroviral therapy, there was only one diabetic patient on insulin therapy. The signs of calls were respiratory in 3 patients, digestive in one patient, neurol. in one case, and an alteration of the general state in the last case. Exclusive pulmonary involvement was noted in 4 patients, associated with neuromeningeal localization in one patient and cervical lymph node localization in the last case The radiol. aspect was dominated by bilateral micronodular opacities often associated with sequellary opacities. Based on the results of the xpert Tb Rif and Hain Test 1 st line and 2 nd line 3 cases of our patients were Prexdr (resistant to injectable 1/3 cases, resistant to furoquinolone 2/3 cases), MDR in one patient, two patients were classified as RR due to the unavailability of genotypic tests. The evolution during hospitalization was marked by the occurrence of pneumocystosis in 2 patients who had progressed well under Bactrim high curative dose and systemic corticosteroids, pneumothorax in one case; we deplore the death of a patient by tuberculosis meningitis. Five patients were put individualized regimen of 20-24 mo and only one case on a standardized regimen for 9-11 mo, antiretroviral treatment was initiated after 1 mo of the start of anti-bacillary treatment in 2 cases (CD4 rate > 500). Major adverse effects were observed in 3 patients. These were bilateral deafness, significant hepatic cytolysis, and severe cytopenia which required the permanent discontinuation of amikacin, Pza, Linezolid resp. Minor side effects, a type of digestive intolerance, were noted in 2 patients who progressed well under symptomatic treatment. Minor side effects, a type of digestive intolerance, were noted in 2 patients who progressed well under symptomatic treatment.HIV infection increases the risk of the emergence of resistant strains of the TB bacillus in HIV-pos. subjects. The combination of multi-drug-resistant tuberculosis and HIV infection is a major risk factor for morbidity-mortality.

Elixir International Journal published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zeng, Jiuseng; Ji, Yafei; Luan, Fei; Hu, Jingwen; Rui, Yixing; Liu, Yao; Rao, Zhili; Liu, Rong; Zeng, Nan published the artcile< Xiaoyaosan ethyl acetate fraction alleviates depression-like behaviors in CUMS mice by promoting hippocampal neurogenesis via modulating the IGF-1Rβ/PI3K/Akt signaling pathway>, HPLC of Formula: 112-63-0, the main research area is xiaoyaosan antidepressant IGF1R beta PI3K Akt depression; Apoptosis; CUMS; IGF-1/IGF-1Rβ; Neurogenesis; PI3K/Akt pathway; Xiaoyaosan ethyl acetate fraction.

Xiaoyaosan (XYS), a representative and classic traditional Chinese medicine (TCM) prescription with function of dispersing stagnated liver and strengthening spleen, has been used for thousands of years to treat depression. XYS anti-depression effect has been demonstrated both clin. and expremental; however, the material basis for this effect has yet to be elucidated. To evaluate the impact and underlying action mechanism of XYS antidepressant active component (Xiaoyaosan Et acetate fraction, XYSEF) against chronic unpredictable mild stress (CUMS)-induced depression-like behavior in mice. First, we established a behavioral despair depression mouse model to preliminarily determine the effective antidepressant dose of XYSEF. Then, we created a CUMS mouse model and used various classic behavioral tests, including SPT, ST, NFST, and TST, to assess XYSEFs antidepressant properties. IGF-1 levels in mouse serum and hippocampus were quantified using ELISA. The average optical d. of Nissl bodies in the mouse hippocampal CA3 region was determined utilizing toluidine blue staining. Brdu and DCX expression in the hippocampal dentate gyrus (DG) was assayed using the immunofluorescence method. IGF-1Rβ, PI3K, p-PI3K, Akt, p-Akt, Caspase-3, and cleaved Caspase-3 protein levels in the hippocampus were determined with Western blot. The behavioral despair mouse model findings showed that 9.1 and 40 g/kg of XYSEF both significantly shortened the immobility time of mice, suggesting that the ED range was 9.1-40 g/kg. Compared to the CUMS mouse model, XYSEF at 20 and 40 g/kg markedly increased the sucrose preference percentage in the SPT and grooming time in the ST, shortened the immobility time in the TST and the feeding latency in the NSFT, and reversed the downregulated IGF-1 content in mouse serum and hippocampus. In addition, XYSEF amplified the average optical d. of Nissl bodies in the hippocampal CA3 region, promoted Brdu and DCX expression in DG, and diminished IGF-1Rβ, p-PI3K/PI3K, p-Akt/Akt, and cleaved Caspase-3/Caspase-3 protein levels in the hippocampi of CUMS mice. XYSEF acted as an antidepressant in mice exhibiting CUMS-induced depression-like behaviors, possibly by promoting hippocampal neurogenesis, reducing neuronal apoptosis, and inhibiting the over-activation of the IGF-1Rβ/PI3K/Akt pathway.

Journal of Ethnopharmacology published new progress about Antidepressants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yuen, Carlen A.; Barbaro, Marissa; Haggiagi, Aya published the artcile< Newly Diagnosed Glioblastoma in Elderly Patients>, Category: esters-buliding-blocks, the main research area is review glioblastoma o6 methylguanine dna methyltransferase; Bevacizumab; Elderly; Glioblastoma; Hypofractionated radiation therapy; Temozolomide; Tumor-treating fields.

A review. A Review. Abstract: Purpose of Review: Elderly patients with newly diagnosed glioblastoma (eGBM) carry a worse prognosis compared with their younger counterparts. eGBM garners special attention due to the unique challenges, including increased treatment-associated toxicity, less relative benefit from aggressive therapy, medical comorbidities, and immunosuppression. The pivotal GBM trials excluded patients > 70 years old and the optimal treatment approach remains unsettled for eGBM. In this review, we analyze the historical evidence-based data for treating eGBM and discuss the future direction for managing this vulnerable population. Recent Findings: Treatment for eGBM continues to evolve. Therapy choice is guided by performance status and presence of O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation. For eGBM with good performance status, combinatorial hypofractionated radiation therapy (hRT) and temozolomide should be recommended. For those with poor performance status, further stratification based on MGMT promoter methylation test result is recommended. Single-agent temozolomide is a viable treatment option for MGMT methylated tumors (mMGMT); in particular, those classified with receptor tyrosine kinase II methylation. hRT alone can be considered in MGMT unmethylated (uMGMT) eGBM patients. As precision oncol. continues to advance, effective targeted and immunotherapy may emerge as new treatment options for eGBM. Summary: Management of elderly patients with newly diagnosed GBM carries a unique set of challenges. Progress has been made in defining the optimal therapeutic approach for these patients, but many questions remain to be answered.

Current Oncology Reports published new progress about Comorbidity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Musser, J. H.; Hudec, T. T.; Bailey, K. published the artcile< A simple one-step synthesis of alkyl benzazol-2-carboxylates>, COA of Formula: C19H34O2, the main research area is benzoxazolecarboxylate ester; cyclocondensation aminophenol trialkoxyacetate; oxalate ortho ester cyclocondensation aminophenol.

Benzoxazoles, benzothiazole derivative, and benzimidazoles I (Z = CH, N; Z1 = O, S, NH, NPh; R = Me, Et; R1 = H and R2 = H, Cl, OMe, or R1R2 = benzo) were prepared from the resp. II and (RO)3CCO2R. Thus, 2-H2NC6H4OH was treated with (MeO)3CCO2Me to give I (R = Me, Z = CH, Z1 = O, R1 = R2 = H).

Synthetic Communications published new progress about Cyclocondensation reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Watanabe, Hitoshi; Ishida, Kyoji; Yamamoto, Masanori; Horiguchi, Masakuni; Isobe, Yoshiaki published the artcile< Synthesis and pharmacological evaluation of 11-(1,6-dimethyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepines with clozapine-like receptor occupancy at dopamine D1/D2 receptor>, Quality Control of 112-63-0, the main research area is dibenzo diazepine preparation dopamine schizophrenia agranulocytosis antipsychotic; Agranulocytosis; Antipsychotics; Clozapine; Dopamine; Reactive metabolites; Treatment resistant schizophrenia.

Clozapine-like compound without agranulocytosis risk is need to cure the treatment resistant schizophrenia (TRS). We discovered I as Clozapine-like dopamine D2/D1 receptor selectivity and improved reactive metabolites formation profile by the modification of piperazine moiety in Clozapine. The optimization of I gave compound II to be best compound (approx. 10-fold stronger affinity for D2/D1 receptor and similar D2/D1 selectivity ratio with Clozapine). Clozapine-like D2/D1 receptor occupancy profile was proved by in vivo evaluation. In addition, the reactive metabolites derived agranulocytosis risk of compound II was considered to be lower than Clozapine. The pharmacol. detail of compound II is being investigated to develop it for TRS treatment.

Bioorganic & Medicinal Chemistry Letters published new progress about Agranulocytosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Odashima, Tsugikatsu; Kikuchi, Takemitsu; Ohtani, Wataru; Ishii, Hajime published the artcile< Synthesis and chromogenic properties of water-soluble substituted 2-pyridyl-3'-sulfophenylmethanone 2-pyridylhydrazones and spectrophotometric and analog derivative spectrophotometric determination of trace amounts of cobalt with 2-pyridyl-3'-sulfophenylmethanone 2-(5-nitro)pyridylhydrazone>, Related Products of 112-63-0, the main research area is cobalt determination spectrophotometry; steel analysis cobalt spectrophotometry; pyridylsulfophenylmethanone nitropyridylhydrazone reagent cobalt determination; ionization pyridylsulfophenylmethanone pyridylhydrazone substituent effect.

Three water-soluble hydrazones, in which the 5-position of the pyridine ring in the hydrazine moiety of 2-pyridyl-3′-sulfophenylmethanone 2-pyridylhydrazone was substituted by a Me, chloro or nitro group, were synthesized and their chromogenic properties and reactivities with metal ions investigated. The acid dissociation constants (Ka) of the synthesized hydrazones were determined spectrophotometrically. These values obeyed Hammett’s law; the inductive effect of the substituents reflect the pKa values. Of the synthesized hydrazones, 2-pyridyl-3′-sulfophenylmethanone 2-(5-nitro)pyridylhydrazone (PSNPH) is the most sensitive for Co(II) determination It reacts with Co(II) complex to form a 1:2 (metal:ligand) complex. This complex is rapidly oxidized above pH 2 to give a stable Co(III) complex with an absorption maximum at 496 nm. Beer’s law is obeyed over the range 0.05-1.0 μg mL-1 of Co and the apparent molar absorptivity of the complex is 5.69 × 104 L mol-1cm-1 at 496 nm. A sensitive and practical spectrophotometric method for the determination of trace amounts of Co with PSNPH is proposed and was successfully applied to the determination of Co in steel samples. The method may be made more sensitive by employing an analog derivative spectrophotometric technique.

Analyst (Cambridge, United Kingdom) published new progress about Ionization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Halat, David M.; Fang, Chao; Hickson, Darby; Mistry, Aashutosh; Reimer, Jeffrey A.; Balsara, Nitash P.; Wang, Rui published the artcile< Electric-field-induced spatially dynamic heterogeneity of solvent motion and cation transference in electrolytes>, Reference of 112-63-0, the main research area is electrolytic solution elec field liquid electrolyte solvent motion.

While elec. fields primarily result in migration of charged species in electrolytic solutions, the solutions are dynamically heterogeneous. Solvent mols. within the solvation shells of the cation will be dragged by the field while free solvent mols. will not. We combine electrophoretic NMR measurements of ion and solvent velocities under applied elec. fields with mol. dynamics simulations to interrogate different solvation motifs in a model liquid electrolyte. Measured values of the cation transference number (t0+) agree quant. with simulation-based predictions over a range of electrolyte concentrations Solvent-cation interactions strongly influence the concentration-dependent behavior of t+0. We identify a critical concentration at whichmost of the solventmols. liewithin solvation shells of the cations. The dynamic heterogeneity of solvent mols. is minimized at this concentration where t+0 is approx. equal to zero.

Physical Review Letters published new progress about Concentration (process). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thangavel, Vigneshwaran; Mastouri, Afef; Guery, Claude; Morcrette, Mathieu; Franco, Alejandro A. published the artcile< Understanding the Reaction Steps Involving Polysulfides in 1 M LiTFSI in TEGDME : DOL Using Cyclic Voltammetry Experiments and Modelling>, SDS of cas: 112-63-0, the main research area is lithium bistrifluoromethanesulfonylimide tetraethylene glycol dimethy ether dioxolane cyclic voltammetry.

The reaction mechanisms of polysulfides in the electrolytes of lithium sulfur (Li-S) batteries are known to be complex. These reaction mechanisms may also change with the electrolyte used. Understanding the reaction steps of the polysulfides in a Li-S battery electrolyte is important to assess the underlying phenomena behind the Li-S cell performance limitations. Here, we investigate the reaction steps of polysulfides in electrolyte solutions containing S8, Li2S8 and Li2S6 in 1 M LiTFSI in TEGDME : DOL (volume/volume 1 : 1) (one of the most interesting electrolytes for use in Li-S batteries), using exptl. cyclic voltammetry and a math. model. The math. model assists in understanding the reaction steps behind the characteristics changes of cyclic voltammograms (CVs) with the scan rate and polysulfides speciation. Our systematic study shows that the reaction steps conventionally used in Li-S battery models are not sufficient to simulate all the CV characteristics of the investigated electrolyte solutions

Batteries & Supercaps published new progress about Cyclic voltammetry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lou, Jiang; He, Yuan; Li, Yunlong; Yu, Zhengkun published the artcile< Transition-Metal-Promoted Direct C-H Cyanoalkylation and Cyanoalkoxylation of Internal Alkenes via Radical C-C Bond Cleavage of Cycloketone Oxime Esters>, SDS of cas: 112-63-0, the main research area is cyanoalkylated alkene preparation cyanoalkoxylation bond cleavage cycloketone oxime ester; cyanoalkoxylation internal alkene bond cleavage cycloketone oxime ester.

Transition-metal-catalyzed alkyl-Heck-type cross-coupling of olefinic C-H bonds has been a challenge in the C-H activation area. Herein, we report FeCl3-promoted efficient direct C-H cyanoalkylation of internal alkenes, i.e., ketene dithioacetals, with cycloketone oxime esters via radical C-C bond cleavage under the redox-neutral conditions. With CuCl2 as the catalyst under a dioxygen atm. direct C-H cyanoalkoxylation of the same internal alkenes was achieved. The cyanoalkylated tetrasubstituted alkene products could be diversely transformed to cyanoalkyl-functionalized N- and S-heterocyclic compounds The mechanistic studies have revealed that these C-H cyanoalkylation and cyanoalkoxylation reactions proceed through a radical pathway.

Advanced Synthesis & Catalysis published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (internal). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics