Tag: M.W=250-300

Marsault, Eric; Hoveyda, Hamid R.; Peterson, Mark L.; Saint-Louis, Carl; Landry, Annick; Vezina, Martin; Ouellet, Luc; Wang, Zhigang; Ramaseshan, Mahesh; Beaubien, Sylvie; Benakli, Kamel; Beauchemin, Sophie; Deziel, Robert; Peeters, Theo; Fraser, Graeme L. published the artcile< Discovery of a New Class of Macrocyclic Antagonists to the Human Motilin Receptor>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is macrocyclic peptidomimetic preparation antagonist SAR human motilin receptor.

A novel class of macrocyclic peptidomimetics was identified and optimized as potent antagonists to the human motilin receptor (hMOT-R). Well-defined structure-activity relationships allowed for rapid optimization of potency that eventually led to high affinity antagonists to hMOT-R. Potency and antagonist functional activity were confirmed both in functional and cell-based assays, as well as on isolated rabbit intestinal smooth muscle strips. Rapid access to this novel class of macrocyclic target structures was made possible through two efficient and complementary solid-phase parallel synthetic approaches, both of which are reported herein.

Journal of Medicinal Chemistry published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Potikha, L. M.; Kovtunenko, V. O. published the artcile< Rearrangement of benzyl derivatives of condensed 3-aminoisoquinolinones>, Application of C19H34O2, the main research area is benzophenathridine preparation; isoquinoIinenone isoquinazolinone phenylacetonitrile rearrangement.

A new method for contructing the benzo[b]phenathridine system is proposed. Melting of benzimidazo[1,2-b]isoquinoline-11(5H)-one or 5,13-dihydro-11H-isoquino[3,2-b]quinazolin-11-one with [2-(bromomethyl)phenyl]acetonitrile leads to the formation of C-benzylation products, which is accompanied by intramol. acylation over the β-Carbon of the enamine fragment of the mols. Heating the fusion product in the presence of an acid provokes splitting of the isoquinoline ring and rearrangement to the 12,12a-dihydrobenzo[b]phenanthridine-5(6H)-one derivatives The features of the spatial structure of reaction products and their chem. behavior are considered.

Ukrainskii Khimicheskii Zhurnal (Russian Edition) published new progress about Phenanthridines Role: SPN (Synthetic Preparation), PREP (Preparation) (benzo). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Du, Xiaohui; Kim, Yong-Jae; Lai, SuJen; Chen, Xi; Lizarzaburu, Mike; Turcotte, Simon; Fu, Zice; Liu, Qingxiang; Zhang, Ying; Motani, Alykhan; Oda, Kozo; Okuyama, Ryo; Nara, Futoshi; Murakoshi, Michiko; Fu, Angela; Reagan, Jeff D.; Fan, Peter; Xiong, Yumei; Shen, Wang; Li, Leping; Houze, Jonathan; Medina, Julio C. published the artcile< Phenylalanine derivatives as GPR142 agonists for the treatment of Type II diabetes>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is phenylalanine derivative preparation GPR142 agonists NIDDM diabetes.

GPR142 is a novel GPCR that is predominantly expressed in pancreatic β-cells. GPR142 agonists potentiate glucose-dependent insulin secretion, and therefore can reduce the risk of hypoglycemia. Optimization of our lead pyridinone-phenylalanine series led to a proof-of-concept compound 22, which showed in vivo efficacy in mice with dose-dependent increase in insulin secretion and a decrease in glucose levels.

Bioorganic & Medicinal Chemistry Letters published new progress about Antidiabetic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Babichev, F. S.; Patratii, V. K.; Kovtunenko, V. A.; Prodanchuk, N. G.; Sinchenko, V. G.; Kisel, V. M. published the artcile< Synthesis and antimicrobial activity of 2-aryl-1,4-dihydroisoquinoline-3-imines>, Formula: C19H34O2, the main research area is bactericide aryldihydroisoquinoline imine derivative; fungicide aryldihydroisoquinoline imine derivative; antimicrobial aryldihydroisoquinoline imine derivative.

Reaction of o-(bromomethyl)phenylacetonitrile with aromatic amines gave rise to a number of hydrobromides of 2-aryl-1,4-dihydroisoquinoline-3-imines that were tested for their antimicrobial activity. The structure-activity relationship of the synthesized compounds is discussed.

Khimiko-Farmatsevticheskii Zhurnal published new progress about Fungicides. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lewinski, Piotr; Kaluzynski, Krzysztof; Pretula, Julia; Mielniczak, Grazyna; Penczek, Stanislaw published the artcile< Catalysis in polymerization of cyclic esters. Catalyst and initiator in one molecule. Polymerization of lactide>, Related Products of 112-63-0, the main research area is lactide ring opening polymerization catalyst.

Poly(L-lactide) (PLA) was synthesized with initiator and catalyst in one mol. (CINICAT): 5-ethyl-2-hydroxy-5-hydroxymethyl-1,3,2-dioxaphosphorinane-2-oxide (GM). Polymerizations were conducted at the relatively high temperature (170-190°C) because of the low basicity of LA. Nevertheless, the studied processes were found to be living/controlled, no side reactions were determined and only PLA with fragments of GM as the end-groups were detected. PLA with Mn up to ∼40·103 g/mol. Kinetic studies indicated second order dependence of the rate of polymerization on the initial concentration of the CINICAT. This result is suggesting activation of the monomer and propagation with two independent macromols.

Journal of Catalysis published new progress about Cationic ring-opening polymerization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Skupinska, Krystyna A.; McEachern, Ernest J.; Skerlj, Renato T.; Bridger, Gary J. published the artcile< Concise Preparation of Amino-5,6,7,8-tetrahydroquinolines and Amino-5,6,7,8-tetrahydroisoquinolines via Catalytic Hydrogenation of Acetamidoquinolines and Acetamidoisoquinolines>, Reference of 112-63-0, the main research area is aminotetrahydroquinoline aminotetrahydroisoquinoline preparation; hydrogenation acetamidoquinoline acetamidoisoquinoline; hydrolysis acetamidotetrahydroquinoline; regioselective reduction quinoline derivative.

A method to prepare amino-substituted 5,6,7,8-tetrahydroquinolines and 5,6,7,8-tetrahydroisoquinolines via catalytic hydrogenation of the corresponding acetamido-substituted quinolines and isoquinolines followed by acetamide hydrolysis is described. The yields of the products are good when the acetamido substituent is present on the pyridine ring and moderate with the acetamido substituent on the benzene ring. This method has also been applied to the regioselective reduction of quinoline substrates bearing other substituents (R = OMe, CO2Me, Ph).

Journal of Organic Chemistry published new progress about Hydrogenation, regioselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yao, Di; Ma, Lixue; Wu, Mengna; Wang, Xiaoyu; Xu, Lei; Yu, Qiaoru; Wang, Changyuan published the artcile< Effect of microbial communities on the quality characteristics of northeast soybean paste: Correlation between microorganisms and metabolites>, Computed Properties of 112-63-0, the main research area is soybean paste microorganism metabolite microbial community.

To systematically explore the impact of microbial community composition on the quality characteristics of northeast soybean paste, the microbial community structure was determined by high-throughput sequencing technol. and the flavor substance, free amino acid (FAA) and biogenic amine (BA) contents were determined by HS-SPME-GC-MS and HPLC. Furthermore, the correlation between microorganisms and metabolites was investigated. The results indicated that the core bacteria mainly included Tetragenococcus, Bacillus and Lactobacillus; Candida_f__norank, Wickerhamomyces and Aspergillus were the dominant fungi. A total of 139 flavor compounds were detected in all samples, and decamethylcyclopentasiloxane, isoamyl phenylacetate and octamethylcyclotetrasiloxane accounted for the highest proportion. A total of 24 FAAs were detected in the soybean paste. Pantoea, Kroppenstedtia and Kocuria were significantly pos. correlated with most FAAs (p < 0.05). Addnl. 5 BAs were detected in the soybean paste, and the contents of BAs in Y4 were highest, which was affected by different microbes. This study provided relevant information for the microbial community composition and metabolites of northeast soybean paste, which was of great significance for understanding the characteristics and safety of soybean paste. LWT--Food Science and Technology published new progress about Acaulium. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Luo, Yunxia; Chen, Hansen; Tsoi, Bun; Wang, Qi; Shen, Jiangang published the artcile< Danggui-Shaoyao-San (DSS) ameliorates cerebral ischemia-reperfusion injury via activating SIRT1 signaling and inhibiting NADPH oxidases>, Electric Literature of 112-63-0, the main research area is DSS cerebral ischemia reperfusion injury SIRT signaling NADPH oxidase; Danggui-Shaoyao-San; SIRT1; oxidative stress; peroxynitrite; stroke.

Danggui-Shayao-San (DSS) is a famous Traditional Chinese Medicine formula that used for treating pain disorders and maintaining neurol. health. Recent studies indicate that DSS has neuroprotective effects against ischemic brain damage but its underlining mechanisms remain unclear. Herein, we investigated the neuroprotective mechanisms of DSS for treating ischemic stroke. Adult male Sprague-Dawley (S.D.) rats were subjected to 2 h of middle cerebral artery occlusion (MCAO) plus 22 h of reperfusion. Both ethanol extract and aqueous extract of DSS (12 g/kg) were orally administrated into the rats at 30 min prior to MCAO ischemic onset. We found that 1 ethanol extract of DSS, instead of aqueous extract, reduced infarct sizes and improved neurol. deficit scores in the post-ischemic stroke rats; 2 Ethanol extract of DSS down-regulated the expression of the cleaved-caspase 3 and Bax, up-regulated bcl-2 and attenuated apoptotic cell death in the ischemic brains; 3 Ethanol extract of DSS decreased the production of superoxide and peroxynitrite; 4 Ethanol extract of DSS significantly down-regulated the expression of p67phox but has no effect on p47phox and iNOS statistically. 5 Ethanol extract of DSS significantly up-regulated the expression of SIRT1 in the cortex and striatum of the postischemic brains; 6 Co-treatment of EX527, a SIRT1 inhibitor, abolished the DSS’s neuroprotective effects. Taken together, DSS could attenuate oxidative/nitrosative stress and inhibit neuronal apoptosis against cerebral ischemic-reperfusion injury via SIRT1-dependent manner.

Frontiers in Pharmacology published new progress about Animal gene, Bcl-2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhu, Wenjuan; Yu, Huizhu; Zhu, Xiaoquan; Li, Haoran published the artcile< A luminescence europium Metal-organic coordination polymer for Room-Temperature X-ray detection>, Quality Control of 112-63-0, the main research area is preparation europium pyrenetetrasulfonate coordination polymer xray detection luminescence scintillator.

A novel Eu ions-based metal-organic coordination polymer (MOCP) named Eu(1,3,6,8-PTS)(H2O)7·4H2OHbipy (1) (PTS = pyrenetetrasulfonic acid) was prepared, and its structure, stability, photoluminescence and scintillation properties were systematically investigated. Compound 1 gives a peculiar snake-shaped chain structure with the aid of π-π stacking effect of 4,4′-bipyridine auxiliary template. An efficient and stable light emission was detected under x-ray irradiation, which presents an excellent linear response to X-ray dose. Also, this compound demonstrates high radiation stability, illustrating its potential as a scintillator for x-ray detection. This work not only provides guidance for the design and fabrication of sulfonic ligand derived MOCPs with Eu (III) ions coordination, but also demonstrates the potential of MOCPs scintillators for x-ray detection technol.

Inorganic Chemistry Communications published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Di; Chang, Shiquan; Li, Xin; Shi, Huimei; Jing, Bei; Chen, Zhenni; Lin, Yi; Zheng, Yachun; Qian, Guoqiang; Pan, Yuwei; Zhao, Guoping published the artcile< Therapeutic effect of paeoniflorin on chronic constriction injury of the sciatic nerve via the inhibition of Schwann cell apoptosis>, SDS of cas: 112-63-0, the main research area is mecobalamin neuroprotectant sciatic nerve chronic constriction injury; Schwann cells; TLR4/NF-kB; chronic constriction injury; chronic neuralgia; paeoniflorin; sciatica.

Therapeutic drugs of chronic neuralgia have a high risk of addiction, making it crucial to identify novel drugs for chronic neuralgia. This study aimed to explore the therapeutic effect of paeoniflorin on chronic sciatica via inhibiting Schwann cell apoptosis. 28 SD rats were randomly divided into four groups, including the sham operation group, chronic constriction injury (CCI) group, mecobalamin group, and paeoniflorin group. The therapeutic effect and mechanism of paeoniflorin were evaluated via rat and cell experiments Mech., hot, or cold hyperalgesia was induced in the rats after CCI operation, while paeoniflorin relieved chronic neuralgia. Besides, paeoniflorin decreased the levels of IL1, IL6, TNF-α, CRP, and LPS and increased the level of IL10 in serum. As for the sciatic nerve, the number of inflammatory cells was decreased, and Schwann cells were present after paeoniflorin treatment, and paeoniflorin promoted the recovery of nerve structure. In cell experiments, LPS induced Schwann cell apoptosis via the TLR4/NF-kB pathway. And paeoniflorin attenuated LPS-induced Schwann cell apoptosis by decreasing the levels of TLR4, p-NF-kB, caspase3, cleaved-caspase3, and cleaved-caspase7. Overall, these results suggest that paeoniflorin alleviates chronic sciatica by decreasing inflammatory factor levels and promotes the repair of damaged nerves by reducing Schwann cell apoptosis.

Phytotherapy Research published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics