Tag: M.W=250-300

Chotana, Ghayoor A. published the artcileIridium-catalyzed borylation of thiophenes: versatile, synthetic elaboration founded on selective C-H functionalization, Recommanded Product: Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carboxylate, the publication is Tetrahedron (2008), 64(26), 6103-6114, database is CAplus and MEDLINE.

Iridium-catalyzed borylation has been applied to various substituted thiophenes to synthesize poly-functionalized thiophenes in good to excellent yields. Apart from common functionalities compatible with iridium-catalyzed borylations, addnl. functional group tolerance to acyl (COMe) and trimethylsilyl (TMS) groups was also observed High regioselectivities were observed in borylation of 3- and 2,5-di-substituted thiophenes. Electrophilic aromatic C-H/C-Si bromination on thiophene boronate esters is shown to take place without breaking the C-B bond, and one-pot C-H borylation/Suzuki-Miyaura cross-coupling has been accomplished on 2- and 3-borylated thiophenes.

Tetrahedron published new progress about 1040281-86-4. 1040281-86-4 belongs to esters-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Ester,Boronate Esters,Boronic Acids,Boronic acid and ester,Boronate Esters,, name is Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carboxylate, and the molecular formula is C12H17BO4S, Recommanded Product: Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carboxylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Seki, Toshimi published the artcileStudies on agents with vasodilator and β-blocking activities. V. Synthesis and pharmacological activity of the optical isomers of TZC-5665, SDS of cas: 115314-17-5, the publication is Chemical & Pharmaceutical Bulletin (1998), 46(1), 84-96, database is CAplus and MEDLINE.

Synthesis of the four optical isomers of TZC-5665, a candidate for the treatment of congestive heart failure, was achieved by the reaction of chiral diaminopyridazinones with chiral glycidyl ethers. The hypotensive and β-blocking activities of TZC-5665 and its optical isomers were examined when given i.v. into anesthetized rats. Furthermore these compounds were evaluated for inhibitory activity on cAMP phosphodiesterase III.

Chemical & Pharmaceutical Bulletin published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C8H10S, SDS of cas: 115314-17-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Estep, Kimberly G. published the artcileSynthesis and Structure-Activity Relationships of 6-Heterocyclic-Substituted Purines as Inactivation Modifiers of Cardiac Sodium Channels, Quality Control of 115314-17-5, the publication is Journal of Medicinal Chemistry (1995), 38(14), 2582-95, database is CAplus and MEDLINE.

Purine-based analogs of SDZ 211-500 were prepared and evaluated as inactivation modifiers of guinea pig or human cardiac sodium (Na) channels expressed in Xenopus oocytes. Substances which remove or slow the Na channel inactivation process in cardiac tissue are anticipated to prolong the effective refractory period and increase inotropy and thus have potential utility as antiarrhythmic agents. Heterocyclic substitution at the 6-position of the purine ring resulted in compounds with increased Na activity and potency, with 5-membered heterocycles being optimal. Only minor modifications to the benzhydrylpiperazine side chain were tolerated. Selected compounds which delayed the inactivation of Na channels were found to increase refractoriness and contractility in a rabbit Langendorff heart model, consistent with the cellular mechanism. Activity in both the oocyte and rabbit heart assays was specific to the S-enantiomers. Preliminary in vivo activity has been demonstrated following i.v. infusion. The most promising compound on the basis of in vitro data is the formylpyrrole (S)-I, which is 25-fold more potent than DPI 201-106 in the human heart Na channel assay.

Journal of Medicinal Chemistry published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Quality Control of 115314-17-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Shuang published the artcileProtonic ionic liquids as efficient phase-separation catalysts for esterification of trimethylolpropane and acrylic acid, Product Details of C15H20O6, the publication is Journal of Molecular Liquids (2022), 119403, database is CAplus.

Trimethylolpropane acrylate (TMPTA) is becoming an important organic chem. intermediate, but it’s synthesis through the acid-catalyzed esterification of trimethylolpropane and acrylic acid is a challenge due to the poor activity and catalyst separation problems. In this work, a series of 1,3-propanesultone (PS)-functionalized imidazole ionic liquids (ILs) are prepared and evaluated as the acid catalysts for this reaction, including the catalytic performance comparison, optimization of reaction conditions, and the catalytic reusability. The obtained H₂SO₄-based IL ([IMPSH]HSO₄) caused a phase-separation catalytic process (reacted as a homogeneous catalyst, but precipitated at the end of reaction like a heterogeneous catalyst), presenting the best trimethylolpropane conversion (100%) and TMPTA selectivity (86.4%). Such catalytic performance is even better than that of homogeneous H₂SO₄. Moreover, the catalyst can be steadily reused at least four times without obvious change in activity and its structure. The highly efficient and environmentally benign performance of [IMPSH]HSO₄-catalyzed esterification of trimethylolpropane and acrylic acid make it possible to achieve industrial applications.

Journal of Molecular Liquids published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Product Details of C15H20O6.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Liu, Xuesheng published the artcileIn situ Growth of UiO-66 with Its Particle Size Reduced by 90% into Porous Polyacrylate: Experiments and Applications, Application In Synthesis of 15625-89-5, the publication is Industrial & Engineering Chemistry Research (2022), 61(23), 7902-7910, database is CAplus.

In this study, we successfully synthesized a novel composite material UiO-66/polyacrylate (UiO/PA) by suspension polymerization and in situ growth of metal-organic frameworks (MOFs). Due to the control of heterogeneous nucleation and firm growth, nano-UiO-66 with a diameter of only 400 nm has been reduced by about 90%, resulting in lower transfer resistance, effective separation of photogenerated carriers, and more catalytic active sites exposed. Under visible light irradiation, UiO/PA with 48.7% loading can almost completely degrade rhodamine B (RhB) in 120 min and the corresponding degradation rate constant of RhB reached 0.0203 min^-1 from 0 min^-1. After easy filtration and five cycles, the degradation rate is still above 85%. This study can provide new insights into effectively improving the photocatalytic performance of MOFs.

Industrial & Engineering Chemistry Research published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Application In Synthesis of 15625-89-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hwangbo, Hyeonwoo published the artcileDigital light processing 3D printing of multi-materials with improved adhesion using resins containing low functional acrylates, Formula: C15H20O6, the publication is Korean Journal of Chemical Engineering (2022), 39(2), 451-459, database is CAplus.

Abstract: Digital light processing (DLP) 3D printing has received increasing attention due to high-resolution printing capability, mass productivity, and cheap equipment cost. Most of all, the layer resolution less than 50μm overwhelms 200-300μm layer resolution of its competitive technol., filament deposition modeling (FDM) 3D printing. One of the easiest ways to improve mech. property is the use of multi-materials that complement each other’s weak property However, DLP 3D printing of multi-material printouts with reliable adhesion has been largely unexplored. In this study, we compared the mech. properties of four pairs of multi-materials consisting of two different materials of the same thickness. A composition with highest modulus and ultimate strength was fixed as the first half layer, and the acrylate of the composition for the other half layer was modulated with a monomer having a functionality between 1 and 3. If the acrylate monomer’s functionality for the other half layer was less than three, the multi-material printout showed nearly averaged mech. property of each material. We speculate that low functional acrylate with lower viscosity allows sufficient polymerization at the interface, enabling reliable adhesion. This approach that enables successful multi-material printing with improved adhesion and complementary mech. properties will extend the use of DLP 3D printing in a broad range of industrial application that requires both sophisticated shape and mech. strength.

Korean Journal of Chemical Engineering published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Formula: C15H20O6.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Conway, Walter D. published the artcileSolvent selection for countercurrent chromatography by rapid estimation of partition coefficients and application to polar conjugates of p-nitrophenol, Computed Properties of 6217-68-1, the publication is Journal of Liquid Chromatography (1984), 7(2), 275-89, database is CAplus.

A rapid and moderately precise technique to measure partition coefficients of UV-absorbing solutes in solvent systems for countercurrent chromatog. is described and applied to p-nitrophenol and its conjugates with glucose, H₂SO₄ and glucuronic acid. It involves equilibration of 1 mL of each phase with solute in a narrow test tube, removal of the entire lower phase, dilution with MeOH and calculation of the partition coefficient as the ratio of the absorbance values of each dilution at any suitable wavelength. The polar conjugates of p-nitrophenol can be separated by countercurrent chromatog. by using EtOAc as mobile phase and aqueous KH₂PO₄ as stationary phase.

Journal of Liquid Chromatography published new progress about 6217-68-1. 6217-68-1 belongs to esters-buliding-blocks, auxiliary class Salt,Nitro Compound,Sulfonate,Benzene, name is Potassium 4-nitrophenyl sulfate, and the molecular formula is C6H4KNO6S, Computed Properties of 6217-68-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Shinagawa, Yuko published the artcileDiscovery of a Potent and Short-Acting Oral Calcilytic with a Pulsatile Secretion of Parathyroid Hormone, Product Details of C9H9NO6S, the publication is ACS Medicinal Chemistry Letters (2011), 2(3), 238-242, database is CAplus and MEDLINE.

Short-acting oral calcilytics, calcium-sensing receptor (CaSR) antagonists, have been considered as alternatives for parathyroid hormone (PTH), an injectable bone anabolic drug used in the treatment of osteoporosis. Previously, we identified aminopropandiol 1, which transiently stimulated endogenous PTH secretion in rats. However, the inhibition of cytochrome P 450 (CYP) 2D6 and the low bioavailability of 1 remain to be solved. Attempts to change the physicochem. properties of the highly lipophilic amine 1 by introduction of a carboxylic acid group as well as further structural modifications led to the discovery of the highly potent biphenylcarboxylic acid 15 (I), with a markedly reduced CYP2D6 inhibition and a significantly improved bioavailability. Compound 15 evoked a rapid and transient elevation of endogenous PTH levels in rats after oral administration in a dose-dependent manner at a dose as low as 1 mg/kg. The PTH secretion pattern correlated with the pharmacokinetic profile and agreed well with that of the exogenous PTH injection which exerts a bone anabolic effect.

ACS Medicinal Chemistry Letters published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C15H12O6, Product Details of C9H9NO6S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Shinagawa, Yuko published the artcileNew aminopropanediol derivatives as orally available and short-acting calcium-sensing receptor antagonists, Synthetic Route of 115314-17-5, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(12), 3809-3813, database is CAplus and MEDLINE.

Synthesis and structure-activity relationship studies on new aminopropanediol derivatives I (R¹ = Ph, R² = H, Me, H₂C:CHCH₂, t-Bu, cyclopentyl, Ph, etc.; R¹ = 2-pyridyl, 1-naphthyl, 2-naphthyl, R² = Me; etc.) as calcium-sensing receptor antagonists are described. Modification of the phenolic moiety of a calcilytic compound NPS 2143 led to the identification of an orally available compound (R,R)-I (R¹ = 2-MeC₆H₄; R² = cyclopropyl) which demonstrated a rapid and transient stimulation of PTH release in rats.

Bioorganic & Medicinal Chemistry Letters published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C19H14O2, Synthetic Route of 115314-17-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Takaya, Jun published the artcileFluorine-controlled C-H borylation of arenes catalyzed by a PSiN-pincer platinum complex, COA of Formula: C14H18BFO4, the publication is Chemical Communications (Cambridge, United Kingdom) (2015), 51(100), 17662-17665, database is CAplus and MEDLINE.

An efficient, regioselective synthesis of fluorine-substituted arylboronic esters was achieved through fluorine-controlled C-H borylation of arenes with diboron catalyzed by a PSiN-platinum complex. The promising utility of the PSiN-platinum catalyst and its unique regioselectivity were demonstrated for the first time, which would complement the well-developed Ir-catalyzed C-H borylation.

Chemical Communications (Cambridge, United Kingdom) published new progress about 757982-31-3. 757982-31-3 belongs to esters-buliding-blocks, auxiliary class Boronic acid and ester,Boronic acid and ester, name is Methyl 4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate, and the molecular formula is C34H33ClN6O7, COA of Formula: C14H18BFO4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics