Tag: M.W=250-300

Li, Lin; Wang, Hui; Zhao, Shuping; Zhao, Yuan; Chen, Yongping; Zhang, Jiuyan; Wang, Chuqiao; Sun, Ning; Fan, Honggang published the artcile< Paeoniflorin ameliorates lipopolysaccharide-induced acute liver injury by inhibiting oxidative stress and inflammation via SIRT1 / FOXO1a / SOD2 signaling in rats>, HPLC of Formula: 112-63-0, the main research area is inflammation oxidative stress paeoniflorin ameliorates lipopolysaccharide acute liver injury; NLRP3 inflammasome; Paeoniflorin; SIRT1/FOXO1a/SOD2 signaling; acute liver injury; mitochondrial ROS.

Acute liver injury (ALI) is a poor prognosis and high mortality complication of sepsis. Paeoniflorin (PF) has remarkable anti-inflammatory effects in different disease models. Here, we explored the protective effect and underlying mol. mechanisms of PF against lipopolysaccharide (LPS)-induced ALI. Sprague-Dawley rats received i.p. (i.p.) injection of PF for 7 days, 1 h after the last administration, and rats were injected i.p. 10 mg/kg LPS. PF improved liver structure and function, reduced hepatic reactive oxygen species (ROS) and methane dicarboxylic aldehyde (MDA) levels, and increased superoxide dismutase (SOD) activity. Western blot anal. suggested that PF significantly inhibited expression of inflammatory cytokines (TNF-α, IL-1β, and IL-18) and inhibited activation of the NLRP3 inflammasome. PF or mitochondrial ROS scavenger (mito-TEMPO) significantly improved liver mitochondrial function by scavenging mitochondrial ROS (mROS), restoring mitochondrial membrane potential loss and increasing level of ATP and enzyme activity of complex I and III. In addition, PF increased expression of sirtuin-1 (SIRT1), forkhead box O1 (FOXO1a) and manganese superoxide dismutase (SOD2), and increased FOXO1a nuclear retention. However, the inhibitor of SIRT1 (EX527) abolished the protective effect of PF. Taken together, PF promotes mROS clearance to inhibit mitochondrial damage and activation of the NLRP3 inflammasome via SIRT1/FOXO1a/SOD2 signaling.

Phytotherapy Research published new progress about Acute liver failure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Quek, Lake-Ee; van Geldermalsen, Michelle; Guan, Yi Fang; Wahi, Kanu; Mayoh, Chelsea; Balaban, Seher; Pang, Angel; Wang, Qian; Cowley, Mark J.; Brown, Kristin K.; Turner, Nigel; Hoy, Andrew J.; Holst, Jeff published the artcile< Glutamine addiction promotes glucose oxidation in triple-negative breast cancer>, Reference of 112-63-0, the main research area is breast cancer glucose oxidation glutamine addiction.

Glutamine is a conditionally essential nutrient for many cancer cells, but it remains unclear how consuming glutamine in excess of growth requirements confers greater fitness to glutamine-addicted cancers. By contrasting two breast cancer subtypes with distinct glutamine dependencies, we show that glutamine-indispensable triple-neg. breast cancer (TNBC) cells rely on a non-canonical glutamine-to-glutamate overflow, with glutamine carbon routed once through the TCA cycle. Importantly, this single-pass glutaminolysis increases TCA cycle fluxes and replenishes TCA cycle intermediates in TNBC cells, a process that achieves net oxidation of glucose but not glutamine. The coupling of glucose and glutamine catabolism appears hard-wired via a distinct TNBC gene expression profile biased to strip and then sequester glutamine nitrogen, but hampers the ability of TNBC cells to oxidise glucose when glutamine is limiting. Our results provide a new understanding of how metabolically rigid TNBC cells are sensitive to glutamine deprivation and a way to select vulnerable TNBC subtypes that may be responsive to metabolic-targeted therapies.

Oncogene published new progress about Amino acid transporter ASCT2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Russo, Vincenzo; Tesser, Riccardo; Rossano, Carmelina; Cogliano, Tommaso; Vitiello, Rosa; Leveneur, Sebastien; Di Serio, Martino published the artcile< Kinetic study of Amberlite IR120 catalyzed acid esterification of levulinic acid with ethanol: From batch to continuous operation>, COA of Formula: C19H34O2, the main research area is levulinic acid ethanol esterification cation exchanger kinetics ethyl levulinate.

Levulinic acid (LA) is 1 of the most important platform chems. as it is a versatile building block for a variety of high value-added products, fine chems. and pharmaceutical intermediates. Catalytic esterification of LA with alkyl alcs. leads to levulinate esters which can be used as fragrances, flavoring agents and fuel additives. The kinetics of the levulinic acid esterification with EtOH in the presence of Amberlite IR120 was studied in a batch reactor. The collected exptl. data were interpreted with a reliable model taking into account also for the mass transfer phenomena involved in the reaction network. The kinetic model was further validated by conducting experiments in a fixed bed reactor. The reactor was characterized in terms of fluid-dynamics and the collected kinetic data were interpreted with a reliable reactor model, considering the extent of the reaction and fluid-solid mass transfer limitation.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Density. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Garcia de Jalon, Elvira; Ruiz de Garibay, Gorka; Haug, Bengt Erik; McCormack, Emmet published the artcile< CytoCy5S, a compound of many structures. in vitro and in vivo evaluation of four near-infrared fluorescent substrates of nitroreductase (NTR)>, SDS of cas: 112-63-0, the main research area is nitroreductase fluorescent probe imaging.

CytoCy5S, a quenched, red-shifted fluorescent probe, has been used to exploit the imaging potential of the nitroreductase (NTR) reporter gene platform. Its use has been reported in a number of publications, however there are discrepancies in both the reported structure and its physicochem. properties. Herein, we aim to highlight these discrepancies and to define the best candidate of the four substrates under study for preclin. work in NTR reporting by optical applications. We report the synthesis, purification and characterization of four NTR substrates, including alternately described structures currently referred by the name CytoCy5S. A comparative NTR enzymic assay was performed to assess the spectroscopic characteristics of the different reductively activated probes. The NTR expressing triple-neg. breast carcinoma cell line, MDA-MB-231 NTR+, was employed to compare, both in vitro and in vivo, the suitability of these fluorescent probes as reporters of NTR activity. Comparison of the reporting properties was achieved by flow cytometry, fluorescence microscopy and optical imaging, both in vivo and ex vivo. This study evaluated the different spectroscopic and biol. characteristics of the four substrates and concluded that substrate 1 presents the best features for oncol. in vivo preclin. optical imaging.

Dyes and Pigments published new progress about Fluorescence imaging. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kandpal, Charu; Pandey, J. D.; Dey, Ranjan; Singh, Arvind Kumar; Singh, Vinod Kumar published the artcile< Comparative study of viscosity, diffusion coefficient, thermal conductivity and Gibbs free energy for binary liquid mixtures at varying temperatures>, HPLC of Formula: 112-63-0, the main research area is dynamic viscosity diffusion coefficient thermal conductivity free energy.

Comparative evaluation of useful transport properties (viscosity, thermal conductivity, diffusion coefficient) and Gibbs free energy has been carried out at 298.15 K and 323.15 K. Fourteen different approaches have been employed to compute the viscosity coefficient for ether-alkane mixtures with self-associated alcs. Thermal conductivity (λ) has been computed using six different models. Diffusion coefficient and Gibbs free energy has also been elucidated by fourteen approaches. The calculated values obtained from this work have been compared. The aim of this investigation is to check the variations occurred for ether-alkane mixtures due to application of different models at different temperatures and to get better understanding of the nature of the intermol. interactions in the mixture

Journal of Molecular Liquids published new progress about Binary mixtures. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Xiao; Song, Xiaosheng; Guo, Zhijie; Bian, Tengfei; Zhang, Jin; Zhao, Yong published the artcile< Biphasic Electrolyte Inhibiting the Shuttle Effect of Redox Molecules in Lithium-Metal Batteries>, Product Details of C19H34O2, the main research area is lithium metal battery shuttle effect biphasic electrolyte; biphasic electrolytes; lithium redox flow batteries; lithium-oxygen batteries; redox mediators; shuttle effects.

Redox mols. (RMs) as electron carriers have been widely used in electrochem. energy-storage devices (ESDs), such as lithium redox flow batteries and lithium-O2 batteries. Unfortunately, migration of RMs to the lithium (Li) anode leads to side reactions, resulting in reduced coulombic efficiency and early cell death. Our proof-of-concept study utilizes a biphasic organic electrolyte to resolve this issue, in which nonafluoro-1,1,2,2-tetrahydrohexyl-trimethoxysilane (NFTOS) and ether (or sulfone) with lithium bis(trifluoromethane)sulfonimide (LiTFSI) can be separated to form the immiscible anolyte and catholyte. RMs are extracted to the catholyte due to the enormous solubility coefficients in the biphasic electrolytes with high and low polarity, resulting in inhibition of the shuttle effect. When coupled with a lithium anode, the Li-Li sym., Li redox flow and Li-O2 batteries can achieve considerably prolonged cycle life with biphasic electrolytes. This concept provides a promising strategy to suppress the shuttle effect of RMs in ESDs.

Angewandte Chemie, International Edition published new progress about Cell cycle. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Altarawneh, Ibrahem; Altarawneh, Mohammednoor; Rawadieh, Saleh published the artcile< Theoretical study on thermochemical parameters and IR spectra of chlorinated isomers of nitrobenzene>, HPLC of Formula: 112-63-0, the main research area is theor thermochem parameter IR spectra nitrobenzene chlorinated isomer.

Thermochem. and geometrical parameters and internal rotation barriers of all chlorinated nitrobenzene isomers were calculated with the G3MP2B3 composite method. Standard entropies, standard Gibbs free energies of formation, standard enthalpies of formation, and heat capacities were calculated and compared with their corresponding available exptl. data. Our calculated enthalpy values agree well with the corresponding exptl. data. The temperature dependence of entropy and heat capacity has been analyzed. All isomers with ortho-chlorine substituents were found to be less stable than other corresponding isomers. Rotational barriers and distortions of the benzene rings were incorporated in the calculations of values for entropy and heat capacity. The IR spectra were calculated and found to be in reasonable agreement with the exptl. spectra.

Canadian Journal of Chemistry published new progress about Bond angle. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Peng-Cheng; Wang, Sheng-Xin; Yan, Xiang-Li; He, Ying-Ying; Wang, Min-Chun; Zheng, Hao-Zhen; Shi, Xu-Guang; Tan, Yong-Heng; Wang, Li-Sheng published the artcile< Combination of paeoniflorin and calycosin-7-glucoside alleviates ischaemic stroke injury via the PI3K/AKT signalling pathway>, Electric Literature of 112-63-0, the main research area is HT22 cells; Ischaemia/reperfusion injury; OGD/R injury; neuroprotective effects; synergistic enhancement; synergistic interaction.

ContextPaeoniflorin (PF) and calycosin-7-glucoside (CG, Paeonia lactiflora Pall. extract) have demonstrated protective effects in ischemic stroke. ObjectiveTo investigate the synergistic effects of PF + CG on ischemia/reperfusion injury in vivo and in vitro. Materials and methodsMale Sprague-Dawley rats were subjected to the middle cerebral artery occlusion/reperfusion (MCAO/R). After MCAO/R for 24 h, rats were randomly subdivided into 5 groups: sham, model (MCAO/R), study treatment (PF + CG, 40 + 20 mg/kg), LY294002 (20 mg/kg), and study treatment + LY294002. Males were given via intragastric administration; the duration of the in vivo experiment was 8 days. Neurol. deficits, cerebral infarction, brain edoema, and protein levels were assessed in vivo. Hippocampal neurons (HT22) were refreshed with glucose-free DMEM and placed in an anaerobic chamber for 8 h. Subsequently, HT22 cells were reoxygenated in a 37 °C incubator with 5% CO2 for 6 h. SOD, MDA, ROS, LDH and protein levels were measured in vitro. ResultsPF + CG significantly reduced neurobehavioral outcomes (21%), cerebral infarct volume (44%), brain edoema (1.6%) compared with the MCAO/R group. Moreover, PF + CG increased p-PI3K/PI3K (4.69%, 7.4%), p-AKT/AKT (6.25%, 60.6%) and Bcl-2/BAX (33%, 49%) expression in vivo and in vitro, and reduced GSK-3β (10.5%, 9.6%) expression. In vitro, PF + CG suppressed apoptosis in HT22 cells and decreased ROS and MDA levels (20%, 50%, resp.). ConclusionsPF + CG showed a synergistic protective effect against ischemic brain injury, potentially being a future treatment for ischemic stroke.

Pharmaceutical Biology (Abingdon, United Kingdom) published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aimi, Takahiro; Meguro, Tomohiro; Kobayashi, Akihiro; Hosoya, Takamitsu; Yoshida, Suguru published the artcile< Nucleophilic transformations of azido-containing carbonyl compounds via protection of the azido group>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is azido alc preparation; carbonyl compound azido nucleophile nucleophilic transformation.

Nucleophilic transformations of azido-containing carbonyl compounds, e.g., 4-(4-azidophenyl)benzaldehyde are discussed. The phosphazide formation from azides and di(tert-butyl)(4-(dimethylamino)phenyl)phosphine (Amphos) enabled transformations of carbonyl groups with nucleophiles such as lithium aluminum hydride and organometallic reagents RMgX (R = Et, Ph, 2-thienyl, etc.; X = Cl, Br). The good stability of the phosphazide moiety allowed to perform consecutive transformations of a diazide like 3-azido-5-(azidomethyl)benzaldehyde through triazole I formation and the Grignard reaction.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Karabanova, L. V.; Honcharova, L. A.; Shtompel, V. I. published the artcile< Structure and Properties of the POSS-Containing Nanocomposites Based on Polyurethane Matrix>, Category: esters-buliding-blocks, the main research area is polyurethane polyhedral oligomeric silsesquioxane nanocomposite structure property.

Nanocomposites based on Polyurethane (PU) matrix and 1,2-propanediolisobutyl-POSS (POSS) nanoparticles were prepared and investigated. POSS nanoparticles were incorporated into PU matrix in the process of PU synthesis. The structure peculiarities, the dynamic mech. and thermal properties, the morphol. of the nanocomposites have been investigated. Overall, it was found that POSS nanoparticles are capable to be incorporated into PU polymer chain by a chem. reaction between hydroxyl groups of POSS and diisocyanate groups of PU. The incorporation of the POSS nanoparticles into PU matrix leads to the formation of a more ordered structure, the POSS acts as a nanostructuring agent in the system. The introduction of the POSS nanoparticles into PU matrix significantly affects the thermal properties of the nanocomposites: the increasing in thermal stability was found. Investigation by WAXS/SAXS methods has shown that nanofiller POSS slightly affects the amorphous structure of PU. However, to a greater extent, the nanofiller POSS affects the microphase structure of PU. By dynamic mech. anal., it was detected that the storage moduli of PU/POSS nanocomposites exceeds the storage modulus of PU. But Mn/Mo changes non-monotonically with POSS content. The storage modulus of the nanocomposites increases in 1, 5 times compared to the native PU for the nanocomposites contained from 1 to 5 weight% of POSS. From the morphol. investigation, it is obvious that POSS introduced into PU matrix acts as nanostructuring agent. As a result, the nanocomposites with more ordered structure are formed thus leading to materials with improved thermal stability.

Springer Proceedings in Physics published new progress about Complex modulus, tan δ. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics