Tag: M.W=250-300

Zhang, Xiaoyang; Hou, Yaqin; Peng, Cheng; Wang, Chu; Wang, Xiang; Liang, Zhigang; Lu, Jing; Chen, Baian; Dai, Jiapei; Liu, Boli; Cui, Mengchao published the artcile< Oligoethyleneoxy-Modified 99mTc-Labeled β-Amyloid Imaging Probes with Improved Brain Pharmacokinetics for Single-Photon Emission Computed Tomography>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is technetium oligoethyleneoxy amyloid SPECT imaging brain pharmacokinetics.

An oligoethyleneoxy linker was introduced for conjugation between 99mTc/Re-bis(aminoethanethiol) (BAT) and β-amyloid (Aβ) binding scaffolds. Rhenium complexes exhibited high to moderate binding affinity to Aβ1-42 aggregates and efficient fluorescent staining to Aβ plaques in brain tissue. After radiolabeling, the 99mTc-labeled probes revealed improved brain pharmacokinetics in normal ICR mice. Probe [99mTc]15 with potent binding affinity (Ki = 13.4 nM) and the highest initial brain uptake (2.10% ID/g at 2 min) in normal ICR mice was evaluated further. In vitro autoradiog. showed specific labeling of Aβ plaques by [99mTc]15 in transgenic (Tg) mouse brain tissue. Ex vivo autoradiog. further demonstrated its efficient labeling of Aβ plaques in a living Tg mouse. In vivo single photon emission computed tomog. (SPECT)/CT imaging in six rhesus monkeys revealed remarkably improved brain uptakes (1.94-2.63% ID within 20 min) of [99mTc]15, making it highly potential to be used in humans for Aβ plaques imaging in the brain.

Journal of Medicinal Chemistry published new progress about Brain. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wadsworth, D. H.; Schupp, III O. E.; Sous, E. J.; Ford, Jr. J. A. published the artcile< The stereochemistry of the phosphonate modification of the Wittig reaction>, COA of Formula: C19H34O2, the main research area is .

A number of olefins prepared by the phosphonate carbanion modification of the Wittig reaction were shown to have trans configurations.. Vapor phase chromatography of the intact reaction mixtures showed, at most, only trace amounts of cis isomers. To determine the degree of stereospecificity of the reaction under adverse circumstances, several experiments were devised with systems which, based on the generally accepted reaction mechanism, should be more favorable for the preparation of cis olefins. In only one case, however, was a significant amount of a cis isomer formed [6.4% cis-1,2-(1,1′-dinaphthyl)ethylene in a 1:10 cis-trans mixture], demonstrating the great stereospecific tendency of the reaction. Possible interpretations of the observed differences in stereospecificity of olefin formation from phosphonate carbanions and phosphorus ylides are discussed.

Journal of Organic Chemistry published new progress about NMR (nuclear magnetic resonance). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bai, Zhang-Zhen; Ni, Jing; Tang, Jun-Man; Sun, Dao-Yang; Yan, Zhen-Guo; Zhang, Jing; Niu, Li-Xin; Zhang, Yan-Long published the artcile< Bioactive components, antioxidant and antimicrobial activities of Paeonia rockii fruit during development>, COA of Formula: C19H34O2, the main research area is transresveratrol benzoic acid paeoniflorin luteolin Paeonia antioxidant antimicrobial activity; Albiflorin (PubChem CID: 24868421); Antibacterial activity; Antioxidant activity; Benzoic acid (PubChem CID: 243); LC-ESI-QqQ-MS; Luteolin (PubChem CID: 5280445); Methyl gallate (PubChem CID: 7428); Monoterpene glycosides; OPLS-DA; PCA; Paeonia rockii fruit; Paeoniflorin (PubChem CID: 442534); Phenolic compounds; Trans-resveratrol (PubChem CID: 445154).

In last ten years, much attention focused on tree peony fruit (TPF) for edible oil production despite other potential utilization. The present study identified and quantified 29 bioactive components by liquid chromatog.-electrospray ionization-triple quadrupole-mass spectrometry (LC-ESI-QqQ-MS) targeted approach during the development of TPF. Trans-resveratrol, benzoic acid, luteolin, and Me gallate were selected as predominant chem. markers between seeds and pods through principal component anal. (PCA) and orthogonal partial least square-discriminant anal. (OPLS-DA). Extremely high levels of paeoniflorin (1893 mg/100 g) and trans-resveratrol (1793 mg/100 g) were observed at stage 2 (S2) and S6 in seeds, resp. Antioxidant activities determined by ABTS+·, DPPH·, and FRAP assays showed significant correlations with total phenolic content (TPC) and total flavonoid content (TFC). The strongest antibacterial effects of pod and seed against Staphylococcus aureus and Proteus vulgaris occurred at initial stages and maturation stages. TPF could be a potential source of bioactive compounds with functional properties.

Food Chemistry published new progress about Antimicrobial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Temburnikar, Kartik W.; Zimmermann, Sarah C.; Kim, Nathaniel T.; Ross, Christina R.; Gelbmann, Christopher; Salomon, Christine E.; Wilson, Gerald M.; Balzarini, Jan; Seley-Radtke, Katherine L. published the artcile< Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is antiproliferative activity cancer fungus halogenated thienopyrimidine structure; Antifungal; Apoptosis; Cytostatic; Heterocyclic chemistry; Thieno[3,2-d]pyrimidine.

The in vitro evaluation of thieno[3,2-d]pyrimidines identified halogenated compounds 1 and 2 with antiproliferative activity against three different cancer cell lines. A structure activity relation study indicated the necessity of the chlorine at the C4-position for biol. activity. The two most active compounds 1 and 2 were found to induce apoptosis in the leukemia L1210 cell line. Addnl., the compounds were screened against a variety of other microbial targets and as a result, selective activity against several fungi was also observed The synthesis and preliminary biol. results are reported herein.

Bioorganic & Medicinal Chemistry published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Matousek, Vaclav; Pietrasiak, Ewa; Schwenk, Rino; Togni, Antonio published the artcile< One-Pot Synthesis of Hypervalent Iodine Reagents for Electrophilic Trifluoromethylation>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is preparation hypervalent iodine reagent; electrophilic trifluoromethylation.

Simplified syntheses suited for large scale preparations of the two hypervalent iodine reagents I and II for electrophilic trifluoromethylation are reported. In both cases, the stoichiometric oxidants sodium metaperiodate and tert-Bu hypochlorite have been replaced by trichloroisocyanuric acid. Reagent I is accessible in a one-pot procedure from 2-iodobenzoic acid in 72% yield. Reagent II was prepared via fluoroiodane III in a considerably shorter reaction time and with no need of an accurate temperature control.

Journal of Organic Chemistry published new progress about Iodanes Role: IMF (Industrial Manufacture), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Xingdong; Hou, Jinjun; Zhang, Zijia; Chen, Lingmin; Ni, Hui; Qian, Yong; Wu, Wenyong; Long, Huali; Zhang, Linlin; Li, FeiFei; Lei, Min; Huang, Yong; Guo, Dean; Wu, Wanying published the artcile< In-depth exploration and comparison of chemical constituents from two Lilium species through offline two-dimensional liquid chromatography combined with multimode acquisition of high-resolution mass spectrometry>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Lilium compound 2D LC HRMS; Comparative components; Lilium; Offline 2D LC; Phenylpropanoid derivatives; Steroidal saponins.

Lilium lancifolium and Lilium brownii viridulum were two common cultivars of Lilium in China, which have been used as a source of food in ancient China, and as a traditional herbal medicine in most northern hemispheres countries continues today. However, only a few secondary metabolites in Lilium closely related to human health have been reported. In this research, an offline two-dimensional (HILIC and RP C18) separation system combined with multimode high-resolution mass spectrometry data acquisition was established for in-depth exploration and comparison of the chem. components in Lilium. In total, 331 components were identified, among which phenylpropanoid derivatives and steroidal saponins were the most abundant components. Furthermore, sulfur derivatives and steroidal alkaloids were systematically characterized in Lilium for the first time. These results provided valuable information for in-depth differentiating types of components characterization, which may be applied to assess and improve the edible and medicinal values of Lilium.

Journal of Chromatography A published new progress about Homo sapiens. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kost, A. N.; Minkin, V. I.; Sagitullin, R. S.; Gorbunov, V. I.; Sadekov, I. D. published the artcile< Transfer of substituent effects across the indole ring>, Reference of 112-63-0, the main research area is charge transfer indoles; indoles charge transfer.

The pK values and σ constants (Taft, Hammett, Webster, and Dewar constants) were determined for substituted indole-2-carboxylic acids (I). The transfer of the elec. charges in this ring system is weaker than in carbocyclic systems. The electron-donating groups have very little effect. The relation of structure with the pK of I is best expressed in terms of the Dewar theory.

Zhurnal Organicheskoi Khimii published new progress about Ionization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Maity, Asim; Hyun, Sung-Min; Powers, David C. published the artcile< Oxidase catalysis via aerobically generated hypervalent iodine intermediates>, Reference of 112-63-0, the main research area is hypervalent iodine reagent preparation oxidase catalysis aryl iodide.

The development of sustainable oxidation chem. demands strategies to harness O2 as a terminal oxidant. Oxidase catalysis, in which O2 serves as a chem. oxidant without necessitating incorporation of oxygen into reaction products, would allow diverse substrate functionalization chem. to be coupled to O2 reduction Direct O2 utilization suffers from intrinsic challenges imposed by the triplet ground state of O2 and the disparate electron inventories of four-electron O2 reduction and two-electron substrate oxidation Here, we generate hypervalent iodine reagents-a broadly useful class of selective two-electron oxidants-from O2. This is achieved by intercepting reactive intermediates of aldehyde autoxidation to aerobically generate hypervalent iodine reagents for a broad array of substrate oxidation reactions. The use of aryl iodides as mediators of aerobic oxidation underpins an oxidase catalysis platform that couples substrate oxidation directly to O2 reduction We anticipate that aerobically generated hypervalent iodine reagents will expand the scope of aerobic oxidation chem. in chem. synthesis.

Nature Chemistry published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fushimi, Nobuhiko; Fujikura, Hideki; Shiohara, Hiroaki; Teranishi, Hirotaka; Shimizu, Kazuo; Yonekubo, Shigeru; Ohno, Kohsuke; Miyagi, Takashi; Itoh, Fumiaki; Shibazaki, Toshihide; Tomae, Masaki; Ishikawa-Takemura, Yukiko; Nakabayashi, Takeshi; Kamada, Noboru; Ozawa, Tomonaga; Kobayashi, Susumu; Isaji, Masayuki published the artcile< Structure-activity relationship studies of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia>, SDS of cas: 112-63-0, the main research area is preparation structure benzyl pyrazolyl glucopyranoside derivative SGLT1 inhibitor hyperglycemia.

Sodium glucose co-transporter 1 (SGLT1) plays a dominant role in the absorption of glucose in the gut and is considered a promising target in the development of treatments for postprandial hyperglycemia. A series of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyranoside derivatives have been synthesized, and its inhibitory activity toward SGLTs has been evaluated. By altering the substitution groups at the 5-position of the pyrazole ring, and every position of the Ph ring, we studied the structure-activity relationship (SAR) profiles and identified a series of potent and selective SGLT1 inhibitors. Representative derivatives showed a dose-dependent suppressing effect on the escalation of blood glucose levels in oral mixed carbohydrate tolerance tests (OCTT) in streptozotocin-nicotinamide-induced diabetic rats (NA-STZ rats).

Bioorganic & Medicinal Chemistry published new progress about Antidiabetic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Balannik, Victoria; Wang, Jun; Ohigashi, Yuki; Jing, Xianghong; Magavern, Emma; Lamb, Robert A.; De Grado, William F.; Pinto, Lawrence H. published the artcile< Design and Pharmacological Characterization of Inhibitors of Amantadine-Resistant Mutants of the M2 Ion Channel of Influenza A Virus>, Related Products of 112-63-0, the main research area is spiroundecane preparation influenza virus M2 channel blockade SAR.

The A/M2 proton channel of influenza A virus is a target for the anti-influenza drugs amantadine and rimantadine, whose effectiveness was diminished by the appearance of naturally occurring point mutants in the A/M2 channel pore, among which the most common are S31N, V27A, and L26F. We have synthesized and characterized the properties of a series of compounds, originally derived from the A/M2 inhibitor BL-1743. A lead compound emerging from these investigations, spiro[5.5]undecan-3-amine, is an effective inhibitor of wild-type A/M2 channels and L26F and V27A mutant ion channels in vitro and also inhibits replication of recombinant mutant viruses bearing these mutations in plaque reduction assays. Differences in the inhibition kinetics between BL-1743, known to bind inside the A/M2 channel pore, and amantadine were exploited to demonstrate competition between these compounds, consistent with the conclusion that amantadine binds inside the channel pore. Inhibition by all of these compounds was shown to be voltage-independent, suggesting that their charged groups are within the N-terminal half of the pore, prior to the selectivity filter that defines the region over which the transmembrane potential occurs. These findings not only help to define the location and mechanism of binding of M2 channel-blocking drugs but also demonstrate the feasibility of discovering new inhibitors that target this binding site in a number of amantadine-resistant mutants.

Biochemistry published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics