Tag: M.W=250-300

Lei, Yali; Zhou, Xu; Zhao, Yang; Zhang, Jianfa published the artcile< Effects of exogenous ATP on melanoma growth and tumor metabolism in C57BL/6 mice>, HPLC of Formula: 112-63-0, the main research area is ATP LDHA LDHB anticancer agent melanoma.

Altered energy metabolism (glucose, lipid, amino acid) is a hallmark of cancer growth that provides the theor. basis for the development of metabolic therapies as cancer treatments. ATP is one of the major biochem. constituents of the tumor microenvironment. ATP promotes tumor progression or suppression depending on various factors, including concentration and tumor type. Here we evaluated the antitumor effect of extracellular ATP on melanoma and the potential underlying mechanisms. A s.c. tumor model in mice was used to investigate the antitumor effects of ATP. Major lymphocyte cell changes and intratumoral metabolic changes were assessed. Metabolomic anal. (1H NMR spectroscopy) was performed on tumor samples. We measured the activities of lactate dehydrogenase A (LDHA) and LDHB in the excised tumors and serum and found that ATP and its metabolites affected the proliferation of and LDHA activity in B16F10 cells, a murine melanoma cell line. In addition, treatment with ATP dose-dependently reduced tumor size in melanoma-bearing mice. Moreover, flow cytometry anal. demonstrated that the antitumor effect of ATP was not achieved through changes in T-cell or B-cell subsets. Metabolomics anal. revealed that ATP treatment simultaneously reduced multiple intratumoral metabolites related to energy metabolism as well as serum and tumor LDHA activities. Furthermore, both ATP and its metabolites significantly suppressed both tumor cell proliferation and LDHA activity in the melanoma cell line. Our results in vivo and in vitro indicate that exogenous ATP inhibits melanoma growth in association with altered intratumoral metabolism

Comparative Medicine published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Koohgard, Mehdi; Hosseini-Sarvari, Mona published the artcile< Visible-light-mediated phosphonylation reaction: formation of phosphonates from alkyl/arylhydrazines and trialkylphosphites using zinc phthalocyanine>, HPLC of Formula: 112-63-0, the main research area is visible light mediated phosphonylation reaction phosphonate formation zinc phthalocyanine.

In this work, we developed a ligand- and base-free visible-light-mediated protocol for the photoredox syntheses of arylphosphonates and, for the first time, alkyl phosphonates. Zinc phthalocyanine-photocatalyzed Csp2-P and Csp3-P bond formations were efficiently achieved by reacting aryl/alkylhydrazines with trialkylphosphites in the presence of air serving as an abundant oxidant. The reaction conditions tolerated a wide variety of functional groups.

Organic & Biomolecular Chemistry published new progress about Air. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Sun; Wang, Lei; Chauhan, Pankaj; Peuronen, Anssi; Rissanen, Kari; Enders, Dieter published the artcile< Asymmetric Synthesis of Five-Membered Spiropyrazolones via N-Heterocyclic Carbene (NHC)-Catalyzed [3+2] Annulations>, Quality Control of 112-63-0, the main research area is spiropyrazolone preparation enantioselective diastereoselective; enal unsaturated pyrazolone annulation heterocyclic carbene catalyst.

A new synthetic strategy for the asym. synthesis of five-membered spiropyrazolones via N-heterocyclic carbene-catalyzed [3+2] annulations employing enals and unsaturated pyrazolones as substrates has been developed. The new protocol allows the flexible variation of all four substituents of the pharmaceutically important spiropyrazolones in moderate to very good yields and in most cases with excellent diastereoselectivities and good to excellent enantioselectivities.

Synthesis published new progress about Cyclization ([3+2]). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kazmierski, Wieslaw M.; McDermed, John published the artcile< Synthesis of the carbonic acid benzotriazol-1-yl-ester-(2-biotinylamino)-9H-fluoren-9-ylmethyl ester: a convenient transient-biotinylation reagent for use in affinity chromatography>, HPLC of Formula: 112-63-0, the main research area is biotinylaminofluorenylmethoxycarbonyl peptide protective group preparation; affinity chromatog biotinylated fluorenylmethoxycarbonyl peptide.

Stepwise synthesis of hydrophobic peptides frequently yields deletion products, which often require extensive purification and identification. A new transient-biotinylation reagent I was prepared, which was conveniently used in affinity chromatog. of crude products to afford pure peptides. Unlike conventional affinity chromatog., reagent I leads to free N-terminal peptides, which are thus amenable to further chem. manipulations.

Tetrahedron Letters published new progress about Affinity chromatography. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cote, Adrien P.; El-Kaderi, Hani M.; Furukawa, Hiroyasu; Hunt, Joseph R.; Yaghi, Omar M. published the artcile< Reticular Synthesis of Microporous and Mesoporous 2D Covalent Organic Frameworks>, HPLC of Formula: 112-63-0, the main research area is boronic acid derivative condensation triphenylene; covalent organic framework microporous organoborane preparation gas adsorption isotherm.

Three new crystalline microporous and mesoporous 2-dimensional covalent organic frameworks termed COF-6, -8, and -10 from boronic acid building blocks and 2,3,6,7,10,11-hexahydroxytriphenylene were synthesized and structurally characterized. These materials constructed of C2O2B rings form eclipsed layered structures with pore sizes ranging from 6.4 to 34.1 Å and have high thermal stability, low d., and high porosity as indicated by the surface areas of 980, 1400, and 2080 m2 g-1 for COF-6, -8, and -10, resp. The control of pore size and structure demonstrates the effectiveness of reticular chem. methods toward materials design.

Journal of the American Chemical Society published new progress about Boronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Roztocki, Kornel; Formalik, Filip; Bon, Volodymyr; Krawczuk, Anna; Goszczycki, Piotr; Kuchta, Bogdan; Kaskel, Stefan; Matoga, Dariusz published the artcile< Tuning Adsorption-Induced Responsiveness of a Flexible Metal-Organic Framework JUK-8 by Linker Halogenation>, Reference of 112-63-0, the main research area is pyridyl benzenedicarbohalohydrazide zinc oxydibenzoic carboxylate MOF preparation crystal structure; gas adsorption responsiveness flexible zinc metal organic framework; crystal mol structure pyridyl benzenedicarbohalohydrazide zinc oxydibenzoic carboxylate MOF.

Flexible stimuli-responsive metal-organic frameworks have become promising candidates for numerous applications in gas-related technologies; however, the methods of fine tuning their responses are still limited and sought after. In this work, authors demonstrate control over the adsorption properties of a flexible platform by incorporating halogen substituents (X = F, Cl, Br, I) into an eightfold interpenetrated isoreticular series [Zn(oba)(X-pip)]n (JUK-8X; X-pip = 4-pyridyl-functionalized benzene-1,3-dicarbo-5-halogenohydrazide; oba2- = 4,4′-oxydibenzoic carboxylate). The introduced halogen atoms allow for precise tuning of CO2 gate-opening pressures from p/p0 = 0.08 for the parental JUK-8 to 0.78 for the chlorine-functionalized JUK-8Cl. The presence of fluorine or chlorine substituent in the X-pip linker practically does not influence the maximum molar CO2 uptake as compared to JUK-8, whereas larger bromine or iodine atoms increase this uptake by 59 and 48%, resp. Utilizing in situ powder x-ray diffraction (PXRD) during CO2 adsorption for a model JUK-8F, they propose a detailed mechanism of phase transitions including positions of the adsorbed gas mols. for the two loaded phases. D. functional theory calculations supported by in situ PXRD measurements at a saturation pressure shed light on the unusual CO2 adsorption properties of JUK-8Br and JUK-8I. Overall, their report demonstrates the use of halogen interactions for the control of a gas-responsive system and provides insightful guidance for the further development of flexible, adaptable materials.

Chemistry of Materials published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Seo, Chang-Seob; Lee, Mee-Young published the artcile< Simultaneous Determination of Fourteen Marker Compounds in the Traditional Herbal Prescription, Geumgwesingihwan, Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry>, Formula: C19H34O2, the main research area is geumgwesingihwan traditional herbal prescription UPLCMS; Geumgwesingihwan; UPLC–MS/MS; simultaneous determination; traditional herbal prescription.

Geumgwesingihwan (GSH) is a traditional herbal prescription composed of eight medicinal herbs: Rehmannia glutinosa (Gaertn.) DC., Dioscorea japonica Thunb., Cornus officinalis Siebold and Zucc., Poria cocos Wolf, Paeonia suffruticosa Andrews, Alisma plantago-aquatica subsp. orientale (Sam.) Sam., Achyranthes bidentate Blume, and Plantago asiatica L. This study developed and validated an ultra-performance liquid chromatog.-tandem mass spectrometry (UPLC-MS/MS) method in the multiple reaction monitoring (MRM) mode for simultaneous determination of 14 compounds (allantoin, gallic acid, 5-(hydroxymethyl)furfural, geniposidic acid, oxypaeoniflorin, loganin, geniposide, paeoniflorin, ecdysterone, verbascoside, cornuside, benzoylpaeoniflorin, paeonol, and alisol B acetate) in GSH. The chromatog. separation of all marker analytes was carried out on an Acquity UPLC BEH C18 column (100 mm × 2.1 mm, 1.7μm) using gradient elution of a mobile phase of distilled water-acetonitrile containing 0.1% acetic acid. The newly established UPLC-MS/MS MRM method was validated by evaluating the linearity, the limits of detection and quantification, recovery, and precision. All markers were detected at concentrations of 6.94-4126.28 mg/kg. In addition, the recovery was 76.65-119.49% and the relative standard deviation value of the precision was 0.19-9.91%. The newly developed and validated UPLC-MS/MS assay will provide useful information for quality assessment of GSH.

Molecules published new progress about Achyranthes bidentata. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Lan-xiang; Zhang, Bao-hua; Zhang, Xing-chen published the artcile< Synthesis of 4-bromo-N,N-dimethylaniline>, Quality Control of 112-63-0, the main research area is bromo dimethylaniline preparation pyridinium tribromide.

A method for the synthesis of the title compound is reported here. In presence of pyridine, 4-bromo-N,N-dimethylaniline was synthesized by a substitution reaction starting from N,N-dimethylaniline and bromine. In this reaction, the easy-to-handle bromination agent pyridinium tribromide was formed and the regioselectivity of the substitution reaction was enhanced. The optimal molar ratio was n(C8H11N):n(Br2):n(C5H5N) = 1:1.1:1.1, the reaction was at 10-15° for 6 h (product yield 68%).

Hebei Shifan Daxue Xuebao, Ziran Kexueban published new progress about Bromination, regioselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sghaier, Randa; Nury, Thomas; Leoni, Valerio; Caccia, Claudio; Pais De Barros, Jean-Paul; Cherif, Ameur; Vejux, Anne; Moreau, Thibault; Limem, Khalifa; Samadi, Mohammad; Mackrill, John J.; Masmoudi, Ahmed Slaheddine; Lizard, Gerard; Zarrouk, Amira published the artcile< Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrial alterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol>, Category: esters-buliding-blocks, the main research area is oligodendrocyte oxiapoptophagy dimethyl monomethyl fumarate oxidative stress mitochondrial dysfunction; 158N cells; 7β-hydroxycholesterol; Apoptosis; Autophagy; Dimethyl fumarate; Lipid profile; Mitochondria; Monomethyl fumarate; Oxiapoptophagy; Oxidative stress; Peroxisome.

The cytoprotective effects of dimethylfumarate, used in the treatment of relapsing remitting multiple sclerosis and of MMF, its main metabolite, were evaluated on murine oligodendrocytes 158 N exposed to 7β-OHC (50μM, 24 h) with or without DMF or MMF (25μM). The activity of 7β-OHC in the presence or absence DMF or MMF was evaluated on several parameters: cell adhesion; plasma membrane integrity measured with PI, trypan blue and FDA assays; LDH activity; antioxidant enzyme activities ; generation of lipid peroxidation products (MDA, CDs) and CPs; ROS overproduction conducted with DHE and DHR123. Apoptosis and autophagy were characterized by staining with Hoechst 33,342, Giemsa and acridine orange, and with antibodies raised against caspase-3 and LC3. DMF and MMF attenuate 7β-OHC-induced cytotoxicity: cell growth inhibition; decreased cell viability; mitochondrial dysfunction (decrease of succinate dehydrogenase activity, loss of ΔΨm, increase of mitochondrial O·-2 production, alteration of the TCA cycle, and cardiolipins content); oxidative stress induction; changes in fatty acid and cholesterol metabolism; and cell death induction (caspase-3 cleavage, activation of LC3-I in LC3-II). Ultrastructural alterations of mitochondria and peroxisomes were prevented. These results demonstrate that DMF and MMF prevent major dysfunctions associated with neurodegenerative diseases: oxidative stress, mitochondrial dysfunction, apoptosis and autophagy.

Journal of Steroid Biochemistry and Molecular Biology published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rahman, Masum; Olson, Ian; Mansour, Moustafa; Carlstrom, Lucas P.; Sutiwisesak, Rujapope; Saber, Rehan; Rajani, Karishma; Warrington, Arthur E.; Howard, Adam; Schroeder, Mark; Chen, Sisi; Decker, Paul A.; Sananikone, Eliot F.; Zhu, Yi; Tchkonia, Tamar; Parney, Ian F.; Burma, Sandeep; Brown, Desmond; Rodriguez, Moses; Sarkaria, Jann N.; Kirkland, James L.; Burns, Terry C. published the artcile< Selective vulnerability of senescent glioblastoma cells to BCL-XL inhibition>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .

Glioblastoma (GBM) is a rapidly fatal malignancy typically treated with radiation and temozolomide (TMZ), an alkylating chemotherapeutic. These cytotoxic therapies cause oxidative stress and DNA damage, yielding a senescent-like state of replicative arrest in surviving tumor cells. Unfortunately, recurrence is inevitable and may be driven by surviving tumor cells eventually escaping senescence. A growing number of so-called “”senolytic”” drugs have been recently identified that are defined by their ability to selectively eliminate senescent cells. A growing inventory of senolytic drugs is under consideration for several diseases associated with aging, inflammation, DNA damage, as well as cancer. Ablation of senescent tumor cells after radiation and chemotherapy could help mitigate recurrence by decreasing the burden of residual tumor cells at risk of recurrence. This strategy has not been previously explored for GBM. We evaluated a panel of 10 previously described senolytic drugs to determine whether any could exhibit selective activity against human GBM persisting after exposure to radiation or TMZ. Three of the 10 drugs have known activity against BCL-XL and preferentially induced apoptosis in radiated or TMZ-treated glioma. This senolytic activity was observed in 12 of 12 human GBM cell lines. Efficacy could not be replicated with BCL-2 inhibition or senolytic agents acting against other putative senolytic targets. Knockdown of BCL-XL decreased survival of radiated GBM cells, whereas knockdown of BCL-2 or BCL-W yielded no senolytic effect. Implications: These findings imply that molecularly heterogeneous GBM lines share selective senescence-induced BCL-XL dependency increase the significance and translational relevance of the senolytic therapy for latent glioma.

Molecular Cancer Research published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics