Tag: M.W=250-300

Marquis, Robert W. published the artcileAntagonists of the Calcium Receptor I. Amino Alcohol-Based Parathyroid Hormone Secretagogues, Computed Properties of 115314-17-5, the publication is Journal of Medicinal Chemistry (2009), 52(13), 3982-3993, database is CAplus and MEDLINE.

Functional screening of the former SmithKline Beecham compound collection against the human calcium receptor (CaR) resulted in the identification of the amino alc.-based hit 2 (IC₅₀ = 11 μM). Structure-activity studies of 2 focused on the optimization of the right- and left-hand side aromatic moieties as well as the amino alc. linker region. Critical to the optimization of this antagonist template was the discovery that the chirality of the C-2 secondary alc. played a key role in enhancing both CaR potency as well as selectivity over the β-adrenergic receptor subtypes. These SAR studies ultimately led to the identification of 38 (NPS 2143; SB-262470A), a potent and orally active CaR antagonist. Pharmacokinetic characterization of 38 in the rat revealed that this mol. had a large volume of distribution (11 L/kg), which resulted in a prolonged systemic exposure, protracted increases in the plasma levels of PTH, and an overall lack of net bone formation effect in a rodent model of osteoporosis.

Journal of Medicinal Chemistry published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Computed Properties of 115314-17-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tsukamoto, Hirokazu published the artcilePalladium(II)-Catalyzed Annulation of Alkynes with ortho-Ester-Containing Phenylboronic Acids, COA of Formula: C15H21BO4, the publication is Organic Letters (2007), 9(21), 4227-4230, database is CAplus and MEDLINE.

Palladium(II) catalyzes annulation of internal alkynes with Me 2-boronobenzoate and (2-boronophenyl)acetate to provide 2,3-disubstituted indenones and 3,4-disubstituted 2-naphthols, resp. E.g., [1,2-bis(diphenylphosphino)ethane]palladium(II) ditrifluoroacetate catalyzed the reaction of 2-methoxycarbonylphenylboronic acid with bis(4-methoxyphenyl)acetylene to give 98% indenone I. The annulation reaction would proceed through transmetalation of Pd(II) with the boron reagents and insertion of the alkynes, followed by unprecedented 1,2-addition of the generated alkenylpalladium(II) species to the intramol. ester group.

Organic Letters published new progress about 956229-86-0. 956229-86-0 belongs to esters-buliding-blocks, auxiliary class Boronic acid and ester,Benzene,Ester,Boronate Esters,Boronic acid and ester, name is Methyl 2-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate, and the molecular formula is C20H17FO4S, COA of Formula: C15H21BO4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Cho, Youngsung published the artcileEffects of two silane surface modifications with different functional groups on the thermal conductivity and mechanical properties of UV-cured composites with high ceramic filler loading, Quality Control of 15625-89-5, the publication is Ceramics International, database is CAplus.

With rapid technol. advancements, efficient thermal management is becoming increasingly important to sustain the stable operation of electronic devices. In this study, aluminum nitride (AlN) fillers with various acrylate monomers were subjected to two types of silane surface treatments to prepare composites with a high loading of AlN filler (65 wt%). The acrylates-isobornyl acrylate (IBOA), 1,4-butanediol diacrylate (BDDA), and trimethylolpropane triacrylate (TMPTA)-were mixed with bisphenol A ethoxylate dimethacrylate (Bis-EMA) as an oligomer, and phenylbis (2,4,6-trimethylbenzoyl)phosphine oxide (BAPO) as a photo-initiator in different proportions to obtain resin matrixes. Pristine AlN and AlN functionalized with APTES and MPS were used as fillers. The effect of the acrylate functional group in silanes on the thermal and mech. properties of the acrylate resin was explored. The thermal conductivities of the IBOA/AlN/APTES and IBOA/AlN/TMPTA composites with a high loading of the filler functionalized with APTES and MPS were 1.34 and 1.57 W/(m•K), resp., 4.15 and 5.28 times higher than that of the composite with neat resin. The enhanced filler-matrix compatibility increased the tensile strength of the composites. The findings highlighted that silane functionalization of AlN can enhance the thermal conductivity and mech. properties of the composite.

Ceramics International published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Quality Control of 15625-89-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lee, Seok Lyul published the artcileOptically isotropic nano-size encapsulation of nematic liquid crystals with a high-filling factor, Application In Synthesis of 15625-89-5, the publication is Journal of Molecular Liquids (2022), 119254, database is CAplus.

The filling factor of LCs in the LC-polymer composite system is a crucial factor for the electro-optic performance of optically isotropic liquid crystal (OILC) devices. The polymerization-induced phase separation method is well-known method to fabricate the OILCs; however, this method spontaneously limits the filling factor by ∼ 40%, which is inadequately low, owing to low-LC concentration in the mixtures To overcome such intrinsic problem, we propose an encapsulated LC which is fabricated by means of oil-in-water encapsulation. Through this approach, the filling factor of LCs is effectively increased up to 67.8% because the capsules are closely packed. Consequently, we achieve a thin-composite film of nano-size LC encapsulation whose isotropic state is reliably switched to anisotropic state in response to an external elec. field with low-operation voltage (E_th = 1.4 V/μm and E_op = 4.6 V/μm), fast-response time (τ_on = 0.5 ms, τ_off = 2.2 ms), and hysteresis-free electro-optic behavior. The highly improved electro-optic performances of the proposed encapsulated LC device would give versatile applications in blooming free-form flexible displays and various tunable photonic systems.

Journal of Molecular Liquids published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Application In Synthesis of 15625-89-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Heo, Jeonghyeon published the artcileVersatile camouflage coating of photochromic pigments, Application of Trimethylolpropane triacrylate, the publication is Molecular Crystals and Liquid Crystals, database is CAplus.

Based on photochromism of a diarylethene species, we introduced an easy but highly effective bar-coating method of a photochromic ink including shell type of photochromic pigments and UV curable epoxy resin, reversibly presenting change color in response to UV light. By using mask patterns for bar-coating, different patterns were successfully coated on various types of surfaces such as wood, glass, general concrete wall and even curved surfaces. Besides, in order to increase mech. stability of the coating, thin layer including acrylate chems. is further coated on the patterns. Finally, camouflage coating applications for encryption display films were successfully demonstrated.

Molecular Crystals and Liquid Crystals published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Application of Trimethylolpropane triacrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hojatpanah, Mohammad Reza published the artcileConstruction and application of a novel electrochemical sensor for trace determination of uranium based on ion-imprinted polymers modified glassy carbon electrode, Recommanded Product: Trimethylolpropane triacrylate, the publication is Chemosphere (2022), 133435, database is CAplus and MEDLINE.

In the present work, a novel electrochem. sensor modified glassy carbon electrode with ion-imprinted polymers (IIP-GCE) was applied for uranyl ions (UO²⁺²) determination Surface modifier was synthesized through precipitation polymerization method, using acrylic acid as a monomer, benzoyl peroxide (BPO) as initiator, and trimethylolpropane triacrylate (TMPTA) as crosslinker. A new uranyl-trans-3-(3-pyridyl) acrylic acid complex was employed, serving as an active and specific site on the synthesized modifier. Next, the synthesized modifier was characterized using X-ray diffraction (XRD), SEM (SEM), and Fourier Transform IR Spectroscopy (FT-IR) techniques. UO²⁺² ions were detected using a differential pulse adsorptive anodic stripping voltammetry method. Under the optimized conditions (pH = 8.0, pre-concentration time = 10 min and pre-concentration potential = -0.30 V), the modified electrode exhibited linear behavior in the interval of 1.27-95.49μg.L^-1 with a limit of detection (LOD) of 0.43μg.L^-1. Also, the constructed ion-imprinted sensor showed a successful application for determining UO²⁺² ions with recovery range of 97.6-101% in real samples.

Chemosphere published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Recommanded Product: Trimethylolpropane triacrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Maier, Lukas published the artcileDiastereoselective Flexible Synthesis of Carbocyclic C-Nucleosides, Computed Properties of 1040281-86-4, the publication is Journal of Organic Chemistry (2017), 82(7), 3382-3402, database is CAplus and MEDLINE.

Carbocyclic C-nucleosides are quite rare. Our route enables flexible preparation of three classes of these nucleoside analogs from common precursors-properly substituted cyclopentanones, which can be prepared racemic (in six steps) or optically pure (in ten steps) from inexpensive norbornadiene. The methodol. allows flexible manipulation of individual positions around the cyclopentane ring, namely highly diastereoselective installation of carbo- and heterocyclic substituents at position 1′, orthogonal functionalization of position 5′, and efficient inversion of stereochem. at position 2′. Newly prepared carbocyclic C-analog of tubercidine I, profiled in MCF7 (breast cancer) and HFF1 (human foreskin fibroblasts) cell cultures, is less potent than tubercidine itself, but more selectively toxic toward the tumorigenic cells.

Journal of Organic Chemistry published new progress about 1040281-86-4. 1040281-86-4 belongs to esters-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Ester,Boronate Esters,Boronic Acids,Boronic acid and ester,Boronate Esters,, name is Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carboxylate, and the molecular formula is C12H17BO4S, Computed Properties of 1040281-86-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Mewshaw, Richard E. published the artcileNew Generation Dopaminergic Agents. 1. Discovery of a Novel Scaffold Which Embraces the D₂ Agonist Pharmacophore. Structure-Activity Relationships of a Series of 2-Aminomethyl Chromans, Related Products of esters-buliding-blocks, the publication is Journal of Medicinal Chemistry (1997), 40(26), 4235-4256, database is CAplus and MEDLINE.

A series of 2-(aminomethyl)chromans (2-AMCs) was synthesized and evaluated for their affinity and selectivity for both the high- and low-affinity agonist states (D₂^High and D₂^Low, resp.) of the dopamine (DA) D₂ receptor. The 7-hydroxy-2-(aminomethyl)chroman moiety was observed to be the primary D₂ agonist pharmacophore. The 2-methylchroman moiety was discovered to be an entirely novel scaffold which could be used to access the D₂ agonist pharmacophore. Attaching various simple alkyl and arylalkyl side chains to the 7-hydroxy 2-AMC nucleus had significant effects on selectivity for the D₂^High receptor vs the 5HT_1A and α₁ receptors. A novel DA partial agonist, (R)-(-)-2-[(benzylamino)methyl]chroman-7-ol was identified as having the highest affinity and best selectivity for the D₂^High receptor vs the α₁ and 5HT_1A receptors. Several regions of the 2-AMC nucleus were modified and recognized as potential sites to modulate the level of intrinsic activity. The global min. conformer of the 7-hydroxy-2-AMC moiety was identified as fulfilling the McDermed model D₂ agonist pharmacophore criteria and was proposed as the D₂ receptor-bound conformation. Structure-activity relationships gained from these studies have aided in the synthesis of D₂ partial agonists of varying intrinsic activity levels. These agents should be of therapeutic value in treating disorders resulting from hypo- and hyperdopaminergic activity, without the side effects associated with complete D₂ agonism or antagonism.

Journal of Medicinal Chemistry published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wu, Yinping published the artcileLarge-molecular-weight acyldiphenylphosphine oxides as low-mobility type I photoinitiator for radical polymerization, HPLC of Formula: 15625-89-5, the publication is European Polymer Journal (2022), 111380, database is CAplus.

In recent years, the light source for photopolymerization technol. is evolving from energy-hungry mercury lamps to the safer light-emitting diodes (LEDs), and it is urgent to develop new photoinitiator adapted to the photopolymerization system with LED light source. Some acyldiphenylphosphine oxide photoinitiators have been designed and developed for LED light source, but their application is severely limited in the fields of food packing, medical equipment, environmentally-friendly product, etc. due to their high mobility in photocured polymers. In this study, eight acyldiphenylphosphine oxide mols. (DAPO-1 ∼ DAPO-8) were synthesized by introducing large mol. weight groups and their UV-visible absorption, photodegradation quantum yield, photopolymerization properties, mobility and solubility in monomer were determined Thereinto, photoinitiators show lower mobility than TPO, the photoinitiator commonly used in industry, as well as good solubility in monomers and excellent photopolymerization performance. Therefore, they can serve as potential substitutes for com. TPO, especially in the application of low-migration photocurable system.

European Polymer Journal published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C17H18N3NaO3S, HPLC of Formula: 15625-89-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Takada, Hiroyuki published the artcileIdentification of 2,6-Disubstituted 3H-Imidazo[4,5-b]pyridines as Therapeutic Agents for Dysferlinopathies through Phenotypic Screening on Patient-Derived Induced Pluripotent Stem Cells, COA of Formula: C12H17BO4S, the publication is Journal of Medicinal Chemistry (2019), 62(20), 9175-9187, database is CAplus and MEDLINE.

Dysferlinopathies, which are muscular diseases caused by mutations in the dysferlin gene, remain serious medical problems due to the lack of therapeutic agents. Herein, the authors report the design, synthesis, and structure-activity relations of a 2,6-disubstituted 3H-imidazo[4,5-b]pyridine series, which was identified from the phenotypic screening of chems. that increase the level of dysferlin in myocytes differentiated from patient-derived induced pluripotent stem cells (iPSCs). Optimization studies with cell-based phenotypic assay led to the identification of a highly potent compound, 19, with dysferlin elevation effects at double-digit nanomolar concentrations In addition, the mol. target of the authors’ chem. series was identified as tubulin, through a tubulin polymerization assay and a competitive binding assay using a photoaffinity labeling probe.

Journal of Medicinal Chemistry published new progress about 1040281-86-4. 1040281-86-4 belongs to esters-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Ester,Boronate Esters,Boronic Acids,Boronic acid and ester,Boronate Esters,, name is Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carboxylate, and the molecular formula is C13H18BClO3, COA of Formula: C12H17BO4S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics