Tag: M.W=250-300

Zolla, Lello; Ceci, Marcello published the artcile< Plasma Metabolomics Profile of ′′Insulin Sensitive′′ Male Hypogonadism after Testosterone Replacement Therapy>, Product Details of C19H34O2, the main research area is insulin sensitive male hypogonadism plasma metabolomic testosterone replacement therapy; Cori cycle; hypogonadism; insulin sensitivity; testosterone therapy.

Male hypogonadism is a disorder characterized by low levels of testosterone, but patients can either show normal insulin (insulin-sensitive (IS)) or over time they can become insulin-resistant (IR). Since the two groups showed different altered metabolisms, testosterone replacement therapy (TRT) could achieve different results. In this paper, we analyzed plasma from 20 IS patients with low testosterone (<8 nmol/L) and HOMAi < 2.5. The samples, pre- and post-treatment with testosterone for 60 days, were analyzed by UHPLC and mass spectrometry. Glycolysis was significantly upregulated, suggesting an improved glucose utilization. Conversely, the pentose phosphate pathway was reduced, while the Krebs cycle was not used. Branched amino acids and carnosine metabolism were pos. influenced, while β-oxidation of fatty acids (FFA) was not activated. Cholesterol, HDL, and lipid metabolism did not show any improvements at 60 days but did so later in the exptl. period. Finally, both malate and glycerol shuttle were reduced. As a result, both NADH and ATP were significantly lower. Interestingly, a significant production of lactate was observed, which induced the activation of the Cori cycle between the liver and muscles, which became the main source of energy for these patients without involving alanine. Thus, the treatment must be integrated with chems. which are not restored in order to reactivate energy production International Journal of Molecular Sciences published new progress about Blood plasma. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Moali, Catherine; Brollo, Maurice; Custot, Julien; Sari, Marie-Agnes; Boucher, Jean-Luc; Stuehr, Dennis J.; Mansuy, Daniel published the artcile< Recognition of α-Amino Acids Bearing Various C:NOH Functions by Nitric Oxide Synthase and Arginase Involves Very Different Structural Determinants>, Recommanded Product: (S)-tert-Butyl 3-amino-2-((tert-butoxycarbonyl)amino)propanoate, the main research area is hydroxyguanidine amino acid preparation arginase recognition; amidoxime amino acid preparation nitric oxide synthase recognition; amino acid recognition arginase nitric oxide synthase.

Several α-amino acids bearing a C:NOH function separated from the Cα carbon by two to five atoms have been synthesized and tested as substrates or inhibitors of recombinant nitric oxide synthases (NOS) I and II and as inhibitors of rat liver arginase (RLA). These include four N-hydroxyguanidines, Nω-hydroxy-L-arginine (NOHA) and its analogs homo-NOHA, nor-NOHA, and dinor-NOHA, two amidoximes bearing the -NH-C(CH3):NOH group, and two amidoximes bearing the -CH2-C(NH2):NOH group. Their behavior toward NOS and RLA was compared to that of the corresponding compounds bearing a C:NH function instead of the C:NOH function. The results obtained clearly show that efficient recognition of these α-amino acids by NOS and RLA involves very different structural determinants. NOS favors mols. bearing a -NH-C(R):NH motif separated from Cα by three or four CH2 groups – such as arginine itself – with the necessary presence of δ-NH and ω-NH groups and a more variable R substituent. The corresponding mols. with a C:NOH function exhibit a much lower affinity for NOS. On the contrary, RLA best recognizes mols. bearing a C:NOH function separated from Cα by three or four atoms, the highest affinity being observed in the case of three atoms. The presence of two ω-nitrogen atoms is important for efficient recognition, as in the two best RLA inhibitors, Nω-hydroxynorarginine and Nω-hydroxynorindospicine, which exhibit IC50 values at the micromolar level. However, contrary to what was observed in the case of NOS, the presence of a δ-NH group is not important. These different structural requirements of NOS and RLA may be directly linked to the position of crucial residues that have been identified from crystallog. data in the active sites of both enzymes. Thus, binding of arginine analogs to NOS particularly relies on strong interactions of their δ-NH and ω-NH2 groups with glutamate 371 (of NOS II), whereas binding of C:NOH mols. to RLA is mainly based on interactions of their terminal OH group with the binuclear Mn(II)···Mn(II) cluster of the enzyme and on possible addnl. bonds between their ω-NH2 group with histidine 141, glutamate 277, and one Mn(II) ion. The different modes of interaction displayed by both enzymes depend on their different catalytic functions and provide interesting opportunities to design useful mols. for selective regulation of NOS and arginase.

Biochemistry published new progress about Enzyme functional sites, active. 77215-54-4 belongs to class esters-buliding-blocks, and the molecular formula is C12H24N2O4, Recommanded Product: (S)-tert-Butyl 3-amino-2-((tert-butoxycarbonyl)amino)propanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sobhi, Rania; Farag, Nahla A.; Khalid, Haidy published the artcile< Lead discovery of new antiviral entities through the generation of 3D-QSAR pharmacophore hypothesis virtual screening and molecular docking study>, Application of C19H34O2, the main research area is QSAR pharmacophore hypothesis mol docking antiviral entity.

Sofosbuvir (Sovaldi) is the most successful clin. used antiviral agent targeted for the treatment of Hepatitis C. The study is aiming to discover new lead entities acting as specific inhibitors of the NS5B RNA-dependent RNA polymerase that is essential for viral replication. The recent approach of computer-aided drug design is a challenge nowadays in drug discovery. We generate a 3D-QSAR pharmacophore model from a training set of 17 nucleoside analog inhibitors including Sofosbuvir with congeneric structures and known (IC50) for each antiviral agent. A valid 3D- QSAR pharmacophore model has been successfully generated to identify the binding features responsible for the biol. activity using Discovery Studio software version The generated hypothesis is used for virtual screening of 3D databases which reveals 73 nucleoside analogs as coded compounds of expected nucleoside inhibitor antiviral activity. Followed by Mol. Docking of the compounds of highest fit values to the prepared HCV RNA dependent RNA polymerase NS5B enzyme which is downloaded from the protein data bank (4WTG) with its natural inhibitor SOFOSBUVIR DIPHOSPHATE GS-607596 to estimate the binding affinity and the geometrical orientation of the proposed compound in the HCV RNA dependent RNA polymerase NS5B binding site.

World Journal of Pharmacy and Pharmaceutical Sciences published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Artyukhin, Alexander B.; Bakajin, Olgica; Stroeve, Pieter; Noy, Aleksandr published the artcile< Layer-by-Layer Electrostatic Self-Assembly of Polyelectrolyte Nanoshells on Individual Carbon Nanotube Templates>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is carbon nanotube surface functionalization layer self assembly polyelectrolyte; polystyrene sulfonate sodium self assembly polydiallyldimethylammonium chloride nanotube.

A general procedure was implemented for modification of carbon nanotubes, based on polyelectrolyte layer-by-layer assembly. Multilayer structures were built around individual carbon nanotube bridges by first modifying the nanotube surface with a pyrene derivative followed by layer-by-layer deposition of polyelectrolyte macro-ions on the nanotube. Nanotubes were grown by the chem. vapor deposition (CVD) method using pyrolyzed ethylene as a carbon source. The polyelectrolytes used are poly(styrenesulfonate) sodium salt (PSS) and poly(diallyldimethylammonium chloride) (PDDA). The TEM and scanning confocal fluorescence microscopy images confirm the formation of nanometer-thick amorphous polymer nanoshells around the nanotubes. These multilayer polyelectrolyte shells on individual carbon nanotubes introduce nearly unlimited opportunities for the incorporation of various functionalities into nanotube devices, which, in turn, opens up the possibility of building more complex multicomponent structures.

Langmuir published new progress about Anionic polyelectrolytes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ma, Xiaotian; Zhang, Yao; Song, Zijia; Yu, Kun; He, Changliu; Zhang, Xu published the artcile< Enzyme-catalyzed synthesis and properties of polyol ester biolubricant produced from Rhodotorula glutinis lipid>, SDS of cas: 112-63-0, the main research area is Rhodotorula glutinis polyol ester biolubricant lipid enzyme catalysis.

Biolubricants do not cause the environmental pollution resulting from the manufacturing and use of mineralbased lubricants, but the commonly adopted chem. method of preparing biolubricants using expensive vegetable oils as raw materials is still environmentally and economically unsatisfactory. In this study, R. glutinis lipid with a high oleic-acid content was esterified with trimethylolpropane (TMP) by using the Candida sp. 99-125 enzyme in a solvent-free system, and the effect of the microbial oil with the high oleic-acid content on the performance of resulting biolubricants was investigated. The purpose of this study was to solve the problems of pollution caused by the chem. synthesis of biolubricants and of the uneconomical use of vegetable oils as raw materials. Further, this study aimed to improve the performance of biolubricants by using the microbial lipid with a high oleic-acid content. As a result of optimization of the reaction conditions, the yield of trimethylolpropane fatty acid triester (TFAT) reached 89.5%. The synthesized biolubricants had excellent low-temperature lubrication performance (pour point = – 45°C), and the physicochem. performance reached the ISOVG-46 grade. The results of the high-frequency reciprocating friction test (HRFT) show that the products have better tribol. properties than mineral-based lubricants of the same viscosity grade (friction coefficient = 0.085; average wear scar diameter = 187μm).

Biochemical Engineering Journal published new progress about Biorheology. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Safri, Ahmad Yanuar; Gaff, Jessica; Octaviana, Fitri; Setiawan, Denise Dewanto; Imran, Darma; Cherry, Catherine L.; Laws, Simon M.; Price, Patricia published the artcile< Brief Report: Demographic and Genetic Associations With Markers of Small and Large Fiber Sensory Neuropathy in HIV Patients Treated Without Stavudine>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is demog genetic association fiber sensory neuropathy HIV Stavudine.

Neurotoxic antiretroviral therapy (ART) such as stavudine has been now replaced with safer therapies, reducing the prevalence of neuropathy from 34% to 15% in HIV+ Indonesians. However, it is unclear whether the residual cases display damage to small or large nerve fibers and whether both are influenced by known risk factors, including alleles of CAMKK2 associated with neuropathy in HIV patients. The encoded protein influences the growth and repair of nerve fibers. HIV-pos. adults on ART for >12 mo without exposure to stavudine were screened for neuropathy using the AIDS Clin. Trials Group Brief Peripheral Neuropathy Screen (BPNS). Large fiber neuropathy was assessed by nerve conduction (NC) and small fiber neuropathy using stimulated skin wrinkling (SSW) applied to the fingers. CAMKK2 alleles were assessed by TaqMan OpenArray technol. Neuropathy diagnoses were more common with SSW than BPNS (49/173 vs 26/185, X2; P = 0.0009), with poor alignment between these outcomes (P = 0.60). NC and BPNS diagnosed neuropathy at similar frequencies (29/151 vs 26/185; P = 0.12) and were aligned (P < 0.0001). In bivariate analyzes, all diagnoses were associated with patients' age and persistent HIV replication, with minor effects from CD4 T-cell counts and time on ART. CAMKK2 alleles associated with neuropathy diagnosed with BPNS and SSW but not NC. Multivariable analyzes confirmed the importance of age and HIV replication, with distinct CAMKK2 polymorphisms affecting BPNS and SSW. Paradoxically, height was protective against skin wrinkling. Overall the data link CAMKK2 genotypes with small rather than large fiber damage. SSW may reflect pathol. distinct from that identified using BPNS. JAIDS, Journal of Acquired Immune Deficiency Syndromes published new progress about Homo sapiens. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lu, Gang; Liu, Richard Y.; Yang, Yang; Fang, Cheng; Lambrecht, Daniel S.; Buchwald, Stephen L.; Liu, Peng published the artcile< Ligand-Substrate Dispersion Facilitates the Copper-Catalyzed Hydroamination of Unactivated Olefins>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is unactivated olefin copper catalyzed hydroamination ligand substrate dispersion interaction.

The current understanding of ligand effects in transition metal catalysis is mostly based on the anal. of catalyst-substrate through-bond and through-space interactions, with the latter commonly considered to be repulsive in nature. The dispersion interaction between the ligand and the substrate, a ubiquitous type of attractive noncovalent interaction, is seldom accounted for in the context of transition-metal-catalyzed transformations. Herein we report a computational model to quant. analyze the effects of different types of catalyst-substrate interactions on reactivity. Using this model, we show that in the copper(I) hydride (CuH)-catalyzed hydroamination of unactivated olefins, the substantially enhanced reactivity of copper catalysts based on bulky bidentate phosphine ligands originates from the attractive ligand-substrate dispersion interaction. These computational findings are validated by kinetic studies across a range of hydroamination reactions using structurally diverse phosphine ligands, revealing the critical role of bulky P-aryl groups in facilitating this process.

Journal of the American Chemical Society published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guggisberg, Yves; Faigl, Ferenc; Schlosser, Manfred published the artcile< Optional ortho or alpha hydroxymethylation of alkylarenes>, Synthetic Route of 112-63-0, the main research area is regioselective hydroxymethylation alkylarene; alkanol aryl; benzyl alc alkyl.

Treatment of arenes carrying Me or primary alkyl groups, e.g., EtPh, in THF with potassium tert-butoxide activated butyllithium followed by reaction with formaldehyde gives 2-arylalkanols, e.g., PhCHMeCH2OH. In contrast, if prior to the addition of the electrophile a stoichiometric amount of magnesium dibromide is added then the regioisomeric 2-alkylbenzyl alcs., e.g., 2-EtC6H4CH2OH, are formed.

Journal of Organometallic Chemistry published new progress about Regiochemistry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Ying; Zhang, Ling; Yang, Chao; Han, Jinsong; Wang, Chongqing; Zheng, Canhui; Zhou, Youjun; Lv, Jiaguo; Song, Yunlong; Zhu, Ju published the artcile< Discovery of benzenesulfonamide derivatives as potent PI3K/mTOR dual inhibitors with in vivo efficacies against hepatocellular carcinoma>, Product Details of C19H34O2, the main research area is benzene sulfonamide derivative preparation dual PI3K mTOR inhibitor hepatoma; Antitumor; Benzenesulfonamide derivatives; Dual inhibitors; Hepatocellular carcinoma; Mammalian target of rapamycin (mTOR); Phosphoinositide 3-kinase (PI3K).

The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway is related to cellular activities. Abnormalities of this signaling pathway were discovered in various cancers, including hepatocellular carcinoma (HCC). The PI3K/mTOR dual inhibitors were proposed to have enhanced antitumor efficacies by targeting multiple points of the signaling pathway. We synthesized a series of propynyl-substituted benzenesulfonamide derivatives as PI3K/mTOR dual inhibitors. Compound 7k (NSC781406) was identified as a highly potent dual inhibitor, which exhibited potent tumor growth inhibition in the hepatocellular carcinoma BEL-7404 xenograft model. Compound 7k may be a potential therapeutic drug candidate for HCC.

Bioorganic & Medicinal Chemistry published new progress about Antiproliferative agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ziemczonek, Piotr; Gosecka, Monika; Gosecki, Mateusz; Marcinkowska, Monika; Janaszewska, Anna; Klajnert-Maculewicz, Barbara published the artcile< Star-Shaped Poly(furfuryl glycidyl ether)-Block-Poly(glyceryl glycerol ether) as an Efficient Agent for the Enhancement of Nifuratel Solubility and for the Formation of Injectable and Self-Healable Hydrogel Platforms for the Gynaecological Therapies>, HPLC of Formula: 112-63-0, the main research area is PFGE block PGGE hydrogel nifuratel solubility gynaecol therapy; Trichomonas infections; candidiasis; drug delivery system; hydrophobic drug; nifuratel; poly(furfuryl glycidyl ether); poly(glyceryl glycerol ether); unimolecular copolymer micelle; vulvovaginitis.

In this paper, we present novel well-defined unimol. micelles constructed a on poly(furfuryl glycidyl ether) core and highly hydrophilic poly(glyceryl glycerol ether) shell, PFGE-b-PGGE. The copolymer was synthesized via anionic ring-opening polymerization of furfuryl glycidyl ether and (1,2-isopropylidene glyceryl) glycidyl ether, resp. MTT assay revealed that the copolymer is non-cytotoxic against human cervical cancer endothelial (HeLa) cells. The copolymer thanks to furan moieties in its core is capable of encapsulation of nifuratel, a hydrophobic nitrofuran derivative, which is a drug applied in the gynaecol. therapies that shows a broad antimicroorganism spectrum. The study shows high loading capacity of the copolymer, i.e., 146 mg of nifuratel per 1 g of copolymer. The load unimol. micelles were characterized using DLS and TEM microscopy and compared with the reference glyceryl glycerol ether homopolymer sample. The presence of numerous 1,2-diol moieties in the shell of PFGE-b-PGG macromols. enabled the formation of reversible crosslinks with 2-acrylamidephenylboronic acid-based polyacrylamide. The obtained hydrogels were both injectable and self-healable, which was confirmed with a rheol. study.

International Journal of Molecular Sciences published new progress about Anionic ring-opening polymerization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics