Tag: M.W=250-300

Mitsuzuka, Masahiko; Kinbara, Yuho; Fukuhara, Mizuki; Nakahara, Maki; Nakano, Takashi; Takarada, Jun; Wang, Zhongkui; Mori, Yoshiki; Kageoka, Masakazu; Tawa, Tsutomu; Kawamura, Sadao; Tajitsu, Yoshiro published the artcile< Relationship between photoelasticity of polyurethane and dielectric anisotropy of diisocyanate, and application of high-photoelasticity polyurethane to tactile sensor for robot hands>, Product Details of C19H34O2, the main research area is polyurethane diisocyanate tactile sensor robot hand photoelasticity dielec anisotropy; dielectric anisotropy; photoelasticity; polyurethane; tactile sensor.

Eight types of polyurethane were synthesized using seven types of diisocyanate. It was found that the elasto-optical constant depends on the concentration of diisocyanate groups in a unit volume of a polymer and the magnitude of anisotropy of the dielec. constant of diisocyanate groups. It was also found that incident light scattered when bending stress was generated inside photoelastic polyurethanes. A high sensitive tactile sensor for robot hands was devised using one of the developed polyurethanes with high photoelasticity.

Polymers (Basel, Switzerland) published new progress about Complex modulus, tan δ. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Menon, Archita Venugopal; Liu, Jing; Tsai, Hanting Phoebe; Zeng, Lingxue; Yang, Seungjeong; Asnani, Aarti; Kim, Jonghan published the artcile< Excess heme upregulates heme oxygenase 1 and promotes cardiac ferroptosis in mice with sickle cell disease>, Name: Ethyl 3-amino-4-(cyclohexylamino)benzoate, the main research area is heme oxygenase cardiac ferroptosis sickle cell disease.

Sickle cell disease (SCD) is characterized by increased hemolysis, which results in plasma heme overload and ultimately cardiovascular complications. Here, we hypothesized that increased heme in SCD causes upregulation of heme oxygenase 1 (Hmox1), which consequently drives cardiomyopathy through ferroptosis, an iron-dependent non-apoptotic form of cell death. First, we demonstrated that the Townes SCD mice had higher levels of hemopexin-free heme in the serum and increased cardiomyopathy, which was corrected by hemopexin supplementation. Cardiomyopathy in SCD mice was associated with upregulation of cardiac Hmox1, and inhibition or induction of Hmox1 improved or worsened cardiac damage, resp. Because free iron, a product of heme degradation through Hmox1, has been implicated in toxicities including ferroptosis, we evaluated the downstream effects of elevated heme in SCD. Consistent with Hmox1 upregulation and iron overload, levels of lipid peroxidation and ferroptotic markers increased in SCD mice, which were corrected by hemopexin administration. Moreover, ferroptosis inhibitors decreased cardiomyopathy, whereas a ferroptosis inducer erastin exacerbated cardiac damage in SCD and induced cardiac ferroptosis in nonsickling mice. Finally, inhibition or induction of Hmox1 decreased or increased cardiac ferroptosis in SCD mice, resp. Together, our results identify ferroptosis as a key mechanism of cardiomyopathy in SCD.

Blood published new progress about Blood serum. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Name: Ethyl 3-amino-4-(cyclohexylamino)benzoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Xi; Hu, Sumeng; Li, Lingqiao; Torkelson, John M. published the artcile< Dynamic Covalent Polyurethane Networks with Excellent Property and Cross-Link Density Recovery after Recycling and Potential for Monomer Recovery>, Synthetic Route of 112-63-0, the main research area is dynamic covalent polyurethane network crosslink density recovery recycling; tensile polyurethane recycling alcoholysis.

Dynamic urethane chem., which involves both associative and dissociative mechanisms, can be used to achieve reprocessability in cross-linked polyurethane (PU) networks. We discovered that property recovery and thermal stability of dynamic covalent PU networks can be enhanced by incorporating excess free hydroxyl groups, and thus performing polymerization reactions at slight stoichiometric imbalance of hydroxyl and isocyanate groups, and by increasing the crosslinker functionality from three to four. While free hydroxyl groups suppress the reversion of urethane links and minimize side reactions associated with liberated isocyanate groups under reprocessing conditions, tetrafunctional crosslinkers help to maintain network integrity in the presence of small levels of side reactions. Using these strategies, we developed a PU network that, within exptl. error, exhibits 100% recovery of crosslink d. and tensile properties after multiple reprocessing steps, which has not been reported before. We also demonstrated the potential of recovering monomer from PU networks by alcoholysis under relatively mild conditions. Our study not only offers a solution to the long-standing issue of PU network recycling, but also provides simple strategies to improve property recovery of reprocessable networks.

ACS Applied Polymer Materials published new progress about Complex modulus, tan δ. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jain, Suman L.; Sharma, Vishal B.; Sain, Bir published the artcile< Highly efficient and selective oxidation of secondary alcohols to ketones under organic solvent and transition metal free conditions>, SDS of cas: 112-63-0, the main research area is oxidation secondary alc ketone organic solvent transition metal free; secondary alc oxidation ketone solid oxidant green chem.

The aqueous HBr/H2O2 was found to be highly efficient and green catalytic system for the selective oxidation of the secondary alcs. to ketones in excellent yields under organic solvent free conditions. The results of the oxidation of the secondary alcs. with solid alternatives of the aqueous hydrogen peroxide like SPC or SPB are also described.

Tetrahedron published new progress about Green chemistry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Yongkang; Chi, Shuyan; Zhang, Shuang; Dong, Xiaohui; Yang, Qihui; Liu, Hongyu; Tan, Beiping; Xie, Shiwei published the artcile< Evaluation of Methanotroph (Methylococcus capsulatus, Bath) bacteria meal on body composition, lipid metabolism, protein synthesis and muscle metabolites of Pacific white shrimp (Litopenaeus vannamei)>, Reference of 112-63-0, the main research area is Methylococcus body composition protein lipid metabolism.

A feeding trial was conducted to evaluate a new dietary protein Methanotroph (Methylococcus capsulatus, Bath) bacteria meal (BPM) on nutritional profile of Litopenaeus vannamei. The basal diet was formulated to contain 25% fish meal and then 15%, 30% and 45% of fish meal protein were replaced with BPM in three exptl. diets, which were labeled FM, BPM15, BPM30, and BPM45, resp. A total of 480 uniform-sized shrimp were equally distributed to four groups with three replicates and fed exptl. diets four times daily for seven weeks. Results showed that dietary BPM had no significant effect on the growth performance of shrimp (P > 0.05) but significantly reduced the crude lipid content of the whole body in shrimp fed the BPM30 diet compared to the FM diet (P < 0.05). Total cholesterol and triglyceride in the hemolymph fell significantly with the increase BPM substitution (P < 0.05). Expression of fas (fatty acid synthetase) significantly decreased with increasing BPM substitution, but the expression of cpt-1 (carnitine palmitoyltransferase) significantly increased in shrimp fed BPM30 (P < 0.05). Expression of tor (target of rapamycin) significantly decreased in hepatopancreas, while an opposite change was exhibited in the intestine of shrimp fed BPM45 (P < 0.05). Results of metabolomics indicated that dietary BPM affected the TCA cycle, ascorbate and aldarate metabolism, and glutathione metabolism in shrimp. In conclusion, BPM is an alternative to FM as a novel protein source for shrimp feed, but the changes in whole body composition, lipolysis and fatty acid synthesis, and protein synthesis and muscle metabolites of L.vannamei are noted. Aquaculture published new progress about Fish meal. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sohn, Jiwon; Hwang, Jaehoon; Park, Soo Young; Lee, Geon Joon published the artcile< Carbazole-based photorefractive organic glass showing high diffraction efficiency at low external electric field>, Formula: C19H34O2, the main research area is carbazole photorefractive organic glass diffraction efficiency elec field.

Photorefractive organic glass, 9-(2-ethylhexyl)-3-[2-(4-nitrophenyl)vinyl]-9H-carbazole (EHCN), showing large coupling gain and high diffraction efficiency at low external elec. field was synthesized and characterized. EHCN showed the glass transition at 25° and the good thermal stability up to 400°. Photorefractivity of EHCN was studied by using 100 μm thick films (S1, S2, S3) doped with 0%, 0.5%, and 1% 2,4,7-trinitrofluorenone (TNF), resp. Two-beam coupling net gain of 50.8 cm-1 was obtained for the 0.5% TNF-doped EHCN sample (S2) at 40 V/μm field. The highest internal diffraction efficiency, obtained from the degenerate four-wave mixing at 30 V/μm field, reached 90% for the 1% TNF-doped EHCN sample (S3).

Japanese Journal of Applied Physics, Part 1: Regular Papers, Short Notes & Review Papers published new progress about Charge transfer complexes Role: FMU (Formation, Unclassified), PEP (Physical, Engineering or Chemical Process), PRP (Properties), TEM (Technical or Engineered Material Use), FORM (Formation, Nonpreparative), PROC (Process), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dello Russo, Cinzia; Scott, Kathryn Anne; Pirmohamed, Munir published the artcile< Dimethyl fumarate induced lymphopenia in multiple sclerosis: A review of the literature>, Electric Literature of 112-63-0, the main research area is review sclerosis lymphopenia dimethyl fumarate; Dimethyl fumarate; Lymphopenia; Microbiome; Monomethyl fumarate; Multiple Sclerosis; Pharmacogenetics; Pharmacokinetics; Psoriasis.

A review. Di-Me fumarate (DMF) is a first line medication for multiple sclerosis. It has a favorable safety profile, however, there is concern regarding the occurrence of moderate-severe and sustained lymphopenia and the associated risk of progressive multifocal leukoencephalopathy. We carried out an extensive literature review to understand the mol. mechanisms underlying this adverse reaction. Dynamic changes in certain components of the immune system are likely to be important for the therapeutic effects of DMF, including depletion of memory T cells and decrease in activated T cells together with expansion of naive T cells. Similar modifications were reported for the B cell components. CD8+ T cells are particularly susceptible to DMF-induced cell death, with marked reductions observed in lymphopenic subjects. The reasons underlying such increased sensitivity are not known, nor it is known how expansion of other lymphocyte subsets occurs. Understanding the mol. mechanisms underlying DMF action is challenging: in vivo DMF is rapidly metabolized to monomethyl fumarate (MMF), a less potent immunomodulator in vitro. Pharmacokinetics indicate that MMF is the main active species in vivo. However, the relative importance of DMF and MMF in toxicity remains unclear, with evidence presented in favor of either of the compounds as toxic species. Pharmacogenetic studies to identify genetic predictors of DMF-induced lymphopenia are limited, with inconclusive results.

Pharmacology & Therapeutics published new progress about CD8-positive T cell. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Schoenfeld, Ryan C.; Bourdet, David L.; Brameld, Ken A.; Chin, Elbert; de Vicente, Javier; Fung, Amy; Harris, Seth F.; Lee, Eun K.; Le Pogam, Sophie; Leveque, Vincent; Li, Jim; Lui, Alfred S.-T.; Najera, Isabel; Rajyaguru, Sonal; Sangi, Michael; Steiner, Sandra; Talamas, Francisco X.; Taygerly, Joshua P.; Zhao, Junping published the artcile< Discovery of a Novel Series of Potent Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B>, Application In Synthesis of 112-63-0, the main research area is hepatitis C virus NS5B nonnucleoside inhibitor preparation SAR.

Hepatitis C virus (HCV) is a major global public health problem. While the current standard of care, a direct-acting antiviral (DAA) protease inhibitor taken in combination with pegylated interferon and ribavirin, represents a major advancement in recent years, an unmet medical need still exists for treatment modalities that improve upon both efficacy and tolerability. Toward those ends, much effort has continued to focus on the discovery of new DAAs, with the ultimate goal to provide interferon-free combinations. The RNA-dependent RNA polymerase enzyme NS5B represents one such DAA therapeutic target for inhibition that has attracted much interest over the past decade. Herein, we report the discovery and optimization of a novel series of inhibitors of HCV NS5B, through the use of structure-based design applied to a fragment-derived starting point. Issues of potency, pharmacokinetics, and early safety were addressed to provide a clin. candidate in fluoropyridone (I).

Journal of Medicinal Chemistry published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Wen; Hao, Jiatong; Wu, Yanliang; Liu, Chang; Shimizu, Kuniyoshi; Li, Renshi; Zhang, Chaofeng published the artcile< Protective effects of heterophyllin B against bleomycin-induced pulmonary fibrosis in mice via AMPK activation>, Reference of 112-63-0, the main research area is heterophyllin B AMPK pulmonary fibrosis; AMPK activation; Heterophyllin B; Pulmonary fibrosis; STING.

Pulmonary fibrosis (PF) is a chronic interstitial lung disease with unknown etiol. In the present study, we evaluated the anti-fibrotic effects of heterophyllin B, a natural product from Radix Pseudostellariae having anti-inflammatory and tyrosinase inhibitory activities. In bleomycin (BLM)-induced PF mouse model, heterophyllin B treatments (5 or 20 mg/kg/d) significantly attenuated BLM-induced alveolar cavity collapse, inflammatory cell infiltration, alveolar wall thickening and collagen deposition. When compared to model group, heterophyllin B treatments also increased AMP (AMP)-activated protein kinase (AMPK) phosphorylation levels by 359% (P < 0.001) and reduced the expression of stimulator of interferon genes (STING) by 73% (P < 0.001). Furthermore, co-administration of heterophyllin B with AMPK inhibitor dorsomorphin (Compound C) significantly blocked the improvement effects of heterophyllin B on BLM-damaged lung tissue, and also increased the protein expression of STING which was inhibited by heterophyllin B in fibrotic lungs (P < 0.001). It is known that alveolar epithelia and lung fibroblasts exert prominent roles in the fibrosis progression. In the present study we found that, in vitro, heterophyllin B significantly inhibited alveolar epithelial mesenchymal transition (EMT) and lung fibroblast transdifferentiation. We also found that the inhibition of heterophyllin B on lung fibroblast transdifferentiation and STING expression was reversed by Compound C. To summarize, heterophyllin B exhibited protective effects on BLM-induced lung fibrosis potentially by inhibiting TGF-Smad2/3 signalings and AMPK-mediated STING signalings. European Journal of Pharmacology published new progress about Analysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ree, Brian J.; Mato, Yoshinobu; Xiang, Li; Kim, Jehan; Isono, Takuya; Satoh, Toshifumi published the artcile< Topologically controlled phase transitions and nanoscale film self-assemblies of cage poly(ε-caprolactone) and its counterparts>, Related Products of 112-63-0, the main research area is polycaprolactone film phase transition counterpart thermal property.

Here we report the first quant. investigation of nanoscale film morphologies of a cage-shaped poly(ε-caprolactone) (cg-PCL9k) and its counterparts in star, cyclic, and linear topologies (st-PCL9k, cy-PCL6k, and l-PCL6k) with consideration of topol. influence through synchrotron grazing incidence X-ray scattering anal. The folded crystalline layer thickness lc is found to be in the increasing order of: st-PCL9k < l-PCL6k < cy-PCL6k< cg-PCL9k. Addnl. structural parameters, such as lamellar orientation, crystallinity, and orientation of orthorhombic lattice in nanoscale film, exhibit intricate dependencies on their mol. topologies and steric influences from the mol. joints and end groups. Nevertheless, all topol. PCLs form lamellar structures based on the orthorhombic crystal lattice in nanoscale films. In addition, crystallization temperature Tc and crystal melting temperature Tm of all PCLs in bulk are highly dependent on the mol. topol.; both Tc and Tm follow the same increasing trend of: st-PCL9k < l-PCL6k< cy-PCL6k < cg-PCL9k. Phase transition characteristics such as heat of fusion and crystallinity in bulk state, and thermal stability also depend upon the topol. and steric influences. Polymer Chemistry published new progress about Branched polymers, star-branched Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics