Tag: M.W=250-300

Douglas, James; Ling, Kenneth B.; Concellon, Carmen; Churchill, Gwydion; Slawin, Alexandra M. Z.; Smith, Andrew D. published the artcile< NHC-Mediated Chlorination of Unsymmetrical Ketenes: Catalysis and Asymmetry>, Related Products of 112-63-0, the main research area is chlorination asym unsaturated ketene nitrogen heterocyclic carbene catalyst.

NHCs promote the efficient chlorination of unsym. disubstituted ketenes with a range of chlorinating agents; chiral NHCs display promising levels of asym. induction in the chlorination process with up to 61 % ee observed using 2,3,4,5,6,6-hexachlorocyclohexa-2,4-dienone.

European Journal of Organic Chemistry published new progress about Chlorination catalysts (stereoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Yi-Yang; You, Jin-Hai; Zhang, Shao-Jian; Lin, Hua; Ren, Wen-Feng; Deng, Li; Pan, Si-Yu; Huang, Ling; Zhou, Yao; Li, Jun-Tao; Sun, Shi-Gang published the artcile< Li0.5PAA domains filled in porous sodium alginate skeleton: A 3D bicontinuous composite network binder to stabilize micro-silicon anode for high-performance lithium ion battery>, COA of Formula: C19H34O2, the main research area is lithium PAA domain filled porous sodium alginate skeleton; bicontinuous composite network binder silicon anode lithium battery.

An important strategy to improve energy d. of Li-ion batteries is to substitute the traditional graphite anode by Si-based anode which is endowed with ultra-high theor. specific capacity. However, the commercialization of Si anodes is hindered by its huge volume variation that results in electrode pulverization. In the current study, the authors fill up the pores of Na alginate (SA) network with lithiated polyacrylic acid (LixPAA) to form a cross-linked bicontinuous composite network binder (b-Li0.5PAA@SA), in which the pores of the SA skeleton are dominated with the Li0.5PAA domains; within such composite the SA and Li0.5PAA interlock tightly each other via extensive interfacial ester bonding. The resulting b-Li0.5PAA@SA network binder can effectively buffer the volume variation of Si microparticles (m-Si) during repeating cycling and prevent pulverization of the electrode, which is evidenced by a cycling capacity of 2762 mAh g-1 in the 1st cycle and a retention of 1584 mAh g-1 after 150 cycles. As a comparison, the m-Si electrode with only SA binder suffers from fatal capacity degradation after merely 20 cycles under the same conditions. Also, since the Li0.5PAA domains are ionic conductive and significantly reduce the porosity of the SA network, the b-Li0.5PAA@SA network binder could also enable a stable solid electrolyte interphase (SEI) film and fast electron/ion transfer, leading to an enhanced rate capability of the m-Si anodes.

Electrochimica Acta published new progress about Battery anodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Babushkina, T. A.; Robas, V. I.; Semin, G. K. published the artcile< Temperature dependences of the nuclear quadrupole resonance frequencies in molecular crystals>, Related Products of 112-63-0, the main research area is temperature nuclear quadrupole resonances; nuclear quadrupole resonances temperature; quadrupole resonances nuclear temperature; resonances nuclear quadrupole temperature; benzenes halo derivative; halobenzenes; nitrobenzenes.

About 90 temperature dependences of the nuclear quadrupole resonance frequencies (ω) of the nuclei 35Cl, 79Br, and 127I in mol. crystals of different aliphatic and C6H6 halogen derivatives were studied. The chief contribution to the temperature dependence of ω comes from torsional vibrations of the mols. in the crystal. In the temperature region 77-295°., ω is a linear function of temperature; hence, measurements at 3 temperatures (77, 195, and 295°K.) were sufficient. An exception was nitrohalogen derivatives of C6H6 (Br and I) and m-F2C6Br4 where the point of inflection of the temperature curve takes place on the side opposite that predicted by the Baeyer theory. Values of ω were measured for the compounds EtSiCl3 and CCl2(NO2)2 which had phase transformations. Although the relative changes in ω for CCl2(NO2)2 during phase transformations do not exceed 1.5%, T1 was equal to 130, 12, and 2.5 msec. for the α, β, and γ phases, resp., at 77°K. A statistical treatment of crystal shifts (∼600 splittings) showed that the most probable splitting values were in the range of 0.2-0.3% of the signal frequency.

Radiospektrosk. Tverd. Tela published new progress about Nuclear quadrupole resonance. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Skrastins, I.; Kastrons, V.; Duburs, G.; Mazeika, I.; Kadis, V. published the artcile< Preparation of furo- and difuro-1,4-dihydropyridines via bromination of 2,6-dimethyl-3,5-bis(methoxycarbonyl)-4-(o-nitrophenyl)-1,4-dihydropyridines>, Category: esters-buliding-blocks, the main research area is furopyridine dihydro; difuropyridine dihydro; pyridine furo difuro.

Furo- and difuro-1,4-dihydropyridines I and II were prepared by bromination of 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(o-nitrophenyl)-1,4-dihydropyridine with mild brominating agents, e.g., pyridine hydrogen tribromide, dioxane dibromide and NBS, followed by oxidation with 3N HNO3.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Robichaud, Joeel; Bayly, Christopher I.; Black, W. Cameron; Desmarais, Sylvie; Leger, Serge; Masse, Frederic; McKay, Daniel J.; Oballa, Renata M.; Paquet, Julie; Percival, M. David; Truchon, Jean-Francois; Wesolowski, Gregg; Crane, Sheldon N. published the artcile< β-Substituted cyclohexanecarboxamide cathepsin K inhibitors: Modification of the 1,2-disubstituted aromatic core>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is cyclohexanecarboxamide preparation cathepsin K inhibitor SAR.

Further SAR study around the central 1,2-disubstituted Ph of the previously disclosed Cat K inhibitor (-)-1 (I) has demonstrated that the solvent exposed P2-P3 linker can be replaced by various 5- or 6-membered heteroaromatic rings. While some potency loss was observed in the 6-membered heteroaromatic series (IC50 = 1 nM for pyridine-linked 4 vs 0.5 nM for phenyl-linked (±)-1), several inhibitors showed a significantly decreased shift in the bone resorption functional assay (10-fold for pyridine 4 vs 53-fold for (-)-1). Though this shift was not reduced in the 5-membered heteroaromatic series, potency against Cat K was significantly improved for thiazole 9 (IC50 = 0.2 nM) as was the pharmacokinetic profile of N-Me pyrazole 10 over our lead compound (-)-1.

Bioorganic & Medicinal Chemistry Letters published new progress about Bone resorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Moonsik; Yoo, Jihwan; Chang, Jong Hee; Kim, Se Hoon published the artcile< Association of MGMT gene promoter methylation with clinicopathological parameters in patients with wild-type IDH glioblastoma>, Application In Synthesis of 112-63-0, the main research area is isocitrate dehydrogenase MGMT gene promoter methylation clinicopathol glioblastoma human; ATRX loss; MGMT; glioblastoma; hypermethylation; low methylation; methylation status; temozolomide chemotherapy; wild-type IDH.

The methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter plays a key role in response to temozolomide chemotherapy and disease prognosis in patients with wild-type isocitrate dehydrogenase (IDH) glioblastoma (GBM). The MGMT promoter methylation status and its association with clinicopathol. parameters were retrospectively analyzed in a cohort of 316 patients with GBM with wild-type IDH. MGMT methylation was significantly associated with ATRX chromatin remodeler (ATRX) loss and completion of the standard Stupp protocol. The median durations of overall and progression-free survival for the unmethylated, low-methylated (10-39%), and hypermethylated (≥40%) groups were 15, 23, and 30 mo and 11, 18, and 21 mo, resp. However, the improvement in the survival of the hypermethylated group was not statistically significant. We suggest a possible association between MGMT methylation status and ATRX mutations in GBM with wild-type IDH.

Anticancer Research published new progress about Age groups. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cioffi, Christopher L.; Racz, Boglarka; Varadi, Andras; Freeman, Emily E.; Conlon, Michael P.; Chen, Ping; Zhu, Lei; Kitchen, Douglas B.; Barnes, Keith D.; Martin, William H.; Pearson, Paul G.; Johnson, Graham; Blaner, William S.; Petrukhin, Konstantin published the artcile< Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis>, Application of C19H34O2, the main research area is RBP4 antagonist preparation hepatic steatosis.

Retinol-binding protein 4 (RBP4) serves as a transporter for all-trans-retinol (1) in the blood, and it has been proposed to act as an adipokine. Elevated plasma levels of the protein have been linked to diabetes, obesity, cardiovascular diseases, and nonalcoholic fatty liver disease (NAFLD). Recently, adipocyte-specific overexpression of RBP4 was reported to cause hepatic steatosis in mice. We previously identified an orally bioavailable RBP4 antagonist that significantly lowered RBP4 serum levels in Abca4-/- knockout mice with concomitant normalization of complement system protein expression and reduction of bisretinoid formation within the retinal pigment epithelium. We describe herein the discovery of novel RBP4 antagonists 48 and 59, which reduce serum RBP4 levels by >80% in mice upon acute oral dosing. Furthermore, 59 demonstrated efficacy in the transgenic adi-hRBP4 murine model of hepatic steatosis, suggesting that RBP4 antagonists may also have therapeutic utility for the treatment of NAFLD.

Journal of Medicinal Chemistry published new progress about Complement Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Miranda, Renata Rank; Oliveira, Anny Carolline Silva; Skytte, Lilian; Rasmussen, Kaare Lund; Kjeldsen, Frank published the artcile< Proteome-wide analysis reveals molecular pathways affected by AgNP in a ROS-dependent manner>, Application In Synthesis of 112-63-0, the main research area is proteome ROS bend3 NRF2 cytotoxicity; N-Acetyl L-cysteine; Silver nanoparticles; metal uptake; oxidative stress; proteomics.

The use of mass spectrometry-based proteomics has been increasingly applied in nanomaterials risk assessments as it provides a proteome-wide overview of the mol. disturbances induced by its exposure. Here, we used this technique to gain detailed mol. insights into the role of ROS as an effector of AgNP toxicity, by incubating Bend3 cells with AgNP in the absence or presence of an antioxidant N-acetyl L-cystein (NAC). ROS generation is a key player in AgNP-induced toxicity, as cellular homeostasis was kept in the presence of NAC. By integrating MS/MS data with bioinformatics tools, in the absence of NAC, we were able to pinpoint precisely which biol. pathways were affected by AgNP. Cells respond to AgNP-induced ROS generation by increasing their antioxidant pool, via NRF2 pathway activation. Addnl., cell proliferation-related pathways were strongly inhibited in a ROS-dependent manner. These findings reveal important aspects of the AgNP mechanism of action at the protein level.

Nanotoxicology published new progress about BEN domain-containing protein 3 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yu, Jin-Sheng; Noda, Hidetoshi; Shibasaki, Masakatsu published the artcile< Exploiting β-amino acid enolates in direct catalytic diastereo- and enantioselective C-C bond-forming reactions>, SDS of cas: 112-63-0, the main research area is hybrid dipeptide synthesis spiro compound Shibasaki catalyst alkaloid; isoxazolidinone synthon beta amino acid enolate synthesis solvent effect; enantioselective diastereoselective catalytic synthesis Mannich adduct coupling amino ketoacid; amino acids; asymmetric catalysis; organocatalysis; peptides; spiro compounds.

In contrast to the widespread use of α-amino acid-equivalent enolates for the preparation of non-natural amino acids, the utilization of β-amino-acid counterparts has been limited. This deficit has resulted in a short supply of β2, 2-amino acids bearing two substituents at the α-carbon, especially for peptide synthesis. Herein, racemic 4-substituted isoxazolidin-5-ones were used as precursors of β2-amino acid enolates in the direct catalytic diastereo- and enantioselective C-C bond-forming reactions, constructing two adjacent stereocenters in a highly stereoselective fashion. The obtained adducts were smoothly coupled with α-amino acid-derived α-ketoacids to afford α/β2, 2-hybrid dipeptides suitable for 9-fluorenylmethoxycarbonyl (Fmoc)-based solid-phase peptide synthesis (Fmoc = 9-fluorenylmethoxycarbonyl). Moreover, the Mannich adducts obtained from isatin-derived imines were converted to spirocyclic β-lactams, which have recently received increased attention due to their unique biol. activities and conformational preferences.

Chemistry – A European Journal published new progress about Alkaloids Role: CAT (Catalyst Use), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Guo-Hui; Zheng, Hanliang; Li, Xin; Cheng, Jin-Pei published the artcile< Asymmetric Synthesis of Axially Chiral Phosphamides via Atroposelective N-Allylic Alkylation>, Application In Synthesis of 112-63-0, the main research area is atroposelective allylic alkylation MBH carbonate phosphamide; axially chiral phosphamide preparation crystal structure; mol structure axially chiral phosphamide; linear free energy relationship axially chiral phosphamide.

Axially chiral anilide compounds are an emerging but scarcely studied class of stereogenic mols. with potential applications as biol. active scaffolds. Because of the lower rotation barriers, the synthesis of these compounds is a challenging task. Also, the status of the limited structure type of chiral anilide constrains the latent capacity of the C-N axis as a chiral source in the application of asym. synthesis. Herein, the authors disclose an efficient protocol for the construction of the rationally designed axially chiral phosphamides via atroposelective N-allylic alkylation reaction of MBH carbonates and phosphamides. The simple hydroquinidine catalyst proves to be most efficient in this artroposelective strategy, delivering the desired axially chiral phosphamides in good yields and high enantioselectivities. A phosphamide compound, which contains both P-stereogenic center and C-N axial chirality, can be obtained by this method through a kinetic resolution process. Because of the large steric diaryl phosphoryl group, the synthesized axially chiral anilide has a large rotational barrier. As a demonstration, current studied axially chiral ortho-I substituted phosphamides could act as efficient chiral hypervalent I(III) catalysts for the asym. oxidative dearomatization of phenols. Also, a speculative model, which can explain the enantiocontrol, is proposed based on the exptl. observation and theor. calculation

ACS Catalysis published new progress about Alkylation catalysts (chiral sulfonamides). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics