Tag: M.W=250-300

Salmanroghani, Hassan; Mirvakili, Massoud; Baghbanian, Mahmud; Salmanroghani, Roham; Sanati, Golshid; Yazdian, Pouria published the artcile< Efficacy and tolerability of two quadruple regimens: bismuth, omeprazole, metronidazole with amoxicillin or tetracycline as first-line treatment for eradication of helicobacter Pylori in patients with duodenal ulcer: a randomized clinical trial>, Related Products of 112-63-0, the main research area is .

Aim To evaluate the efficacy and tolerability of tetracycline vs. high-dose amoxicillin in bismuthbased quadruple therapy for Helicobacter pylori(H.pylori) eradication. Methods This randomized, open-label clin. trial included 228 patients with H.pylori infection and duodenal ulcer without a history of H.pylori treatment. Patients were randomly divided into two groups. The amoxicillin group received metronidazole 500mg, bismuth subcitrate 240mg, and amoxicillin 1000mg, all three times a day, plus omeprazole 20 mg twice a day, for 14 days. The tetracycline group received metronidazole 500mg three times a day; bismuth subcitrate240mg and tetracycline HCl 500mg, both four times a day; and omeprazole 20 mg twice a day, for 14 days. Evaluation for compliance and drug-relatedadverse effects were evaluated at the end of two weeks. Eight weeks after the end of treatment, the rate of H.pylori eradication was assessed by the C13urease breath test. Results There were no significant demog. differences between the two groups. Eradication rate was higher with the amoxicillin-containing regimen than the tetracycline-containing regimen: 105/110 (95.51%; 95% confidence interval, 91.5%-99.3%) vs. 88/105 (83.8%; 95% CI, 76.7%-90.8%) by per-protocol anal. (p = 0.005) and 92.9% (95%CI, 88.1%-97.6%) vs. 76.5% (95%CI, 68.7%-84.2%) by intention-to-treat anal. (ITT, p = 0.001). Adverse effects were significant higher in the tetracycline groupthan in the amoxicillin group (65.2% vs. 43.4%; p = 0.001). Conclusion Bismuth-based quadruple therapy including high-dose amoxicillin and metronidazole achieved an acceptable rate of H.pylori infection eradication with good tolerance in patients with duodenal ulcer. This regimen can overcome treatment resistance in areas with high prevalence of metronidazole and clarithromycin resistance.

PLoS One published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Wande; Wei, Shiqiang; Wang, Wenyao; Qu, Jingping; Wang, Baomin published the artcile< Catalytic asymmetric construction of C-4 alkenyl substituted pyrazolone derivatives bearing multiple stereoelements>, Electric Literature of 112-63-0, the main research area is alkenyl pyrazolone preparation regioselective enantioselective diastereoselective; alkynylnaphthol pyrazolone Michael addition organocatalyst.

An organocatalytic asym. process was reported for the sterically precise construction of C-4 alkenyl substituted pyrazolone derivatives I (R1 = Bn, Me, 1-naphthylmethyl, etc.; R2 = Et, Ph, 2-thienyl, etc.; R3 = H, Br; Ar = Ph, 2-bromophenyl, 2-thienyl, etc.) bearing multiple stereoelements. A series of interesting products featuring the union of a centrally chiral pyrazolone moiety and an axially chiral styrene unit were obtained in high yield with excellent diastereoselectivity and enantioselectivity (up to 99% ee, >20 : 1 dr). The process has the characteristics of mild reaction conditions, simple operation and broad substrate scope. The result of gram-scale reaction indicates that the reaction has good practicability.

Chemical Communications (Cambridge, United Kingdom) published new progress about Diastereoselective synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mondal, Biswarup; Parhi, Sidharth Sankar; Rangaiah, Gade Pandu; Jana, Amiya K. published the artcile< Nano-catalytic heterogeneous reactive distillation for algal biodiesel production: Multi-objective optimization and heat integration>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is algal biodiesel production reactive distillation optimization heat integration.

This work proposes a novel reactive distillation (RD) column for the production of algal biodiesel by the use of a heterogeneous nano-catalyst, Ca(OCH3)2. The elitist non-dominated sorting genetic algorithm (NSGA-II) is employed to optimize the design of this RD column to maximize biodiesel purity while minimizing total annual cost and CO2 emissions. The optimal point is recommended by a Pareto ranking method, namely, technique for order of preference by similarity to ideal solution (TOPSIS) with entropy information for the weighting of objectives. To improve biodiesel purity, a decanter is proposed to couple with the RD column at the bottom. Subsequently, performance of the optimal RD column is further improved by retrofitting it with the vapor recompression arrangement. In this proposed intensified configuration, a reactive stage is thermally integrated with the reboiler to constitute a side vapor recompressed RD (SVRRD) column. Finally, a comparative study is performed to quantify the performance improvement of the proposed SVRRD column over the conventional RD column. It is found that there is a 34.6% reduction in CO2 emissions with a payback period of 4.54 years for the vapor recompressor. Hence, the proposed SVRRD is attractive with better performance in terms of energetic, environmental and economic perspectives.

Energy Conversion and Management published new progress about Algae (oil). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Singh, Vandana; Johansson, Pegah; Lin, Yii-Lih; Hammarsten, Ola; Westerlund, Fredrik published the artcile< Shining light on single-strand lesions caused by the chemotherapy drug bleomycin>, Related Products of 112-63-0, the main research area is bleomycin shining light chemotherapy human; BER inhibition; DNA damage; Damage mechanism of drugs; Fluorescence microscopy; Personalizing chemotherapy; Single molecule imaging; Single-strand breaks.

Quantification of the DNA damage induced by chemotherapy in patient cells may aid in personalization of the dose used. However, assays to evaluate individual patient response to chemotherapy are not available today. Here, we present an assay that quantifies single-stranded lesions caused by the chemotherapeutic drug Bleomycin (BLM) in peripheral blood mononuclear cells (PBMCs) isolated from healthy individuals. We use base excision repair (BER) enzymes to process the DNA damage induced by BLM and then extend the processed sites with fluorescent nucleotides using a DNA polymerase. The fluorescent patches are quantified on single DNA mols. using fluorescence microscopy. Using the assay, we observe a significant variation in the in vitro induced BLM damage and its repair for different individuals. Treatment of the cells with the BER inhibitor CRT0044876 leads to a lower level of repair of BLM-induced damage, indicating the ability of the assay to detect a compromised DNA repair in patients. Overall, the data suggest that our assay could be used to sensitively detect the variation in BLM-induced DNA damage and repair in patients and can potentially be able to aid in personalizing patient doses.

DNA Repair published new progress about Chemotherapy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Zhi; Yuan, Hong published the artcile< An alumina-coated UiO-66 nanocrystalline solid superacid with high acid density as a catalyst for ethyl levulinate synthesis>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is sulfate impregnated zirconia alumina catalyst preparation property; glucose dehydration ethyl levulinate.

The zirconium-containing metal-organic framework (MOF) UiO-66 was used as a cell to synthesize SO42-/ZrO2@Al2O3, a high-d. superacid with relatively strong Bronsted acidity. The UiO-66 MOF was first coated with alumina to form ZrO2@Al2O3. Impregnation with ammonium sulfate and calcination at 500°C afforded the bimetallic composite solid superacid SO42-/ZrO2@Al2O3. RESULTS : Scanning and transmission electron microscopy images confirmed that UiO-66 was successfully coated with aluminum oxide, and its octahedral structure and uniform size (400-600 nm) were retained. SO42-/ZrO2@Al2O3 had a Brunauer-Emmett-Teller sp. surface area of 301-330 m2 g-1 and average pore diameter of 9.6-10.7 nm. XPS and Fourier transform IR anal. showed that SO42-/ZrO2@Al2O3 contained S6+ and Al3+. Temperature-programmed ammonia desorption anal. showed that SO42-/ZrO2@Al2O3 contained super-strong acid sites. The total volume of desorbed ammonia reached 90-109 cm3 g-1. IR spectra of adsorbed pyridine indicated that SO42-/ZrO2@Al2O3 contained mainly Lewis acid sites and was relatively rich in Bronsted acid sites. Thermogravimetric anal. showed that the thermal stability of SO42-/ZrO2@Al2O3 was high. SO42-/ZrO2@Al2O3-3M (the impregnation concentration of ammonium sulfate was 3 mol L-1) and glucose were used to synthesize Et levulinate (EL) in ethanol. The highest EL yield of 37.5 mol% was obtained after reacting the mixture at 200°C for 5 h. An EL yield of 28.8 mol% was obtained after four consecutive reuses of the SO42-/ZrO2@Al2O3-3M catalyst.

Journal of Chemical Technology and Biotechnology published new progress about Dehydration catalysts. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hunter, James H.; Prendergast, Lisa; Valente, Louis F.; Madin, Andrew; Pairaudeau, Garry; Waring, Michael J. published the artcile< High Fidelity Suzuki-Miyaura Coupling for the Synthesis of DNA Encoded Libraries Enabled by Micelle Forming Surfactants>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is DNA encoded biaryl library preparation micelle surfactant Suzuki coupling.

DNA encoded chem. libraries provide a highly efficient means of screening vast numbers of small mols. against an immobilized protein target. Their potential is currently restricted by the constraints of carrying out library synthesis in the presence of attached DNA tags, for which a limited number of reactions and substrates can be used. Even established reactions, such as Suzuki-Miyaura couplings, do not give efficient coupling reactions across a wide range of substrates and can lead to significant DNA degradation We developed an efficient protocol for carrying out Suzuki-Miyaura couplings on DNA tagged substrates that proceeds with unprecedented efficiency to the desired biaryl products (>98% on average with no detectable DNA degradation) across a wide range of drug-like substrates using a micellar promoted process with com. TPGS-750-M surfactant. We have demonstrated the applicability of this method in DEL synthesis by preparing a prototypical two-dimensional 36-member library employing the Suzuki-Miyaura coupling methodol. as the final library synthesis step. This work shows, for the first time, that standard micellar surfactants can promote reactions for encoded library synthesis, leading to libraries of exceptional fidelity, and demonstrates the potential to expand the range of accessible DNA compatible chem.

Bioconjugate Chemistry published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Crittall, MatthewR.; Rzepa, Henry S.; Carbery, David R. published the artcile< Design, Synthesis, and Evaluation of a Helicenoidal DMAP Lewis Base Catalyst>, Computed Properties of 112-63-0, the main research area is helical dimethylaminopyridine analog preparation Lewis base catalyst enantioselective esterification; alc benzylic secondary enantioselective esterification anhydride kinetic resolution.

The design, synthesis, and study of helical dialkylaminopyridine Lewis base catalysts (P)-I and (M)-I is reported. These catalysts displayed good to excellent levels of selectivity (S ≤ 116) in the kinetic resolution of chiral secondary alcs. R1CH(OH)R2 (R1 = Ph, R2 = Me, Et, t-Bu; R1 = 4-FC6H4, 2-MeC6H4, 2-naphthyl, 9-anthryl, etc., R2 = Me). Catalysts I displayed excellent reactivity with exceptionally low loadings of 0.05 mol.% effecting practical levels of selectivity in kinetic resolutions

Organic Letters published new progress about Aralkyl alcohols Role: PUR (Purification or Recovery), RCT (Reactant), SPN (Synthetic Preparation), PREP (Preparation), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Wei; Li, Weiyi; Qin, Song published the artcile< Origins of enantioselectivity in the chiral diphosphine-ligated CuH-catalyzed asymmetric hydrosilylation of ketones>, COA of Formula: C19H34O2, the main research area is chiral diphosphine copper hydride catalyzed asym hydrosilylation acetophenone DFT; optimized geometry copper hydride catalyzed asym hydrosilylation acetophenone DFT; silyl ether preparation.

Computational studies on the asym. hydrosilylation of acetophenone over ligated CuH catalysts were performed with the DFT method. The calculations predict that the catalytic reaction involves two steps: (1) CuH addition to the carbonyl group via a four-membered transition state (TS) with the formation of Cu-alkoxide intermediates; (2) regeneration of the ligated CuH catalyst by an external SiH4 through a metathesis process to yield the corresponding silyl ether. The calculations in the chiral diphosphine-ligated CuH systems suggest that the metathesis process is the rate-determining step (RDS). The CuH addition step is vital for the distribution of the racemic products and therefore represents the stereo-controlling step (SCT). In this step, the greater steric hindrance between the aromatic rings of the ligands and the substrate is identified as the major factor for enantioselectivity. The corresponding TS in the face-to-face mode, suffering less steric hindrance, is more stable than its analog in the edge-to-face mode. The enantioselectivities are related not only to the P-Cu-P bite angles in the stereo-controlling TSs, but also to the substituents at the P-aryl rings of the chiral ligands. In short, a larger P-Cu-P bite angle and suitably modified P-aryl rings together are necessary to achieve excellent ee values.

Organic & Biomolecular Chemistry published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Sung-Bae; Lee, Jin-Seok; Moon, Sung-Ok; Lee, Hwa-Dong; Yoon, Yoo-Sik; Son, Chang-Gue published the artcile< A standardized herbal combination of Astragalus membranaceus and Paeonia japonica, protects against muscle atrophy in a C26 colon cancer cachexia mouse model>, HPLC of Formula: 112-63-0, the main research area is albiflorin paeoniflorin formononetin Astragalus antiinflammatory agent muscle atrophy; Astragalus membranaceus; Cancer cachexia; Muscle atrophy; Paeonia japonica.

Astragalus membranaceus (Fisch.) and Bunge and Paeonia japonica (Makino)Miyabe & H. Takeda have been traditionally used to improve the poor quality of life such as weakness, lack of appetite, fatigue, and malaise which is considered with cachexia condition. We investigated anti-cachectic effects of a herbal formula composed of Astragalus membranaceus and Paeonia japonica (APX) and the mol. mechanisms of APX in C26 cancer-induced cachexia mice and TNF-a-treated C2C12 myotubes. Addnl. synergistic anti-cachectic effects of APX were compared to those of individual herbal extracts and megestrol acetate. The forty-two BALB/c mice were randomly divided into 6 groups: normal (nontreatment), control (C26 injection), AM (C26 injection with Astragalus membranaceus), PJ (C26 injection with Paeonia japonica), APX C26 injection with combination of Astragalus membranaceus and Paeonia japonica and MA (C26 injection with megestrol acetate). All mice were orally administered DW (normal and control groups) or 100 mg/kg AM, PJ, APX or MA for 10 days. In the animal model, several tissues were weighed, and muscle tissue and blood were used to measure pro-inflammatory cytokines. C2C12 myotubes were exposed to 100 ng/mL TNF- α with or without 10μg/mL of AM, PJ, APX or MA for 48 h. The cells were used to immunofluorescence staining and western blot analyses. C26 injection induced notable body and muscle weight loss while APX administration significantly attenuated these alterations and the decrease of muscle weights and strength. APX also significantly attenuated the abnormal elevations in the concentration of three muscle atrophy-inducible cytokines; serum and muscle TNF-α,muscle TWEAK and IL-6 in C26 tumor-bearing mice. In the TNF-α-treated C2C12 myotube model, TNF-α treatment notably decreased MyH but activated atrophic proteins (MuRF and Fbx32) along with p38 and NFκB while these mol. alterations were significantly ameliorated by APX treatment. These pharmacol. actions of APX were supported by the results of immunofluorescence staining to MyH expression and the translocation of NFκB into the nucleus in C2C12 myotubes. Our data indicate the potential of an herbal formula, APX as an anti-cachexia agent; the effect of APX was superior to that of megestrol acetate overall especially for muscle atrophy. The underlying mechanisms of this herbal formula may involve the modulation of muscle atrophy-promoting mols. including p38, NFκB, TNF-α and TWEAK.

Journal of Ethnopharmacology published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Huihua; Morshedi, Mahbod; Kodikara, Mahesh S.; Moxey, Graeme J.; Wang, Genmiao; Wang, Huan; Quintana, Cristobal; Stranger, Rob; Zhang, Chi; Cifuentes, Marie P.; Humphrey, Mark G. published the artcile< Synthesis, Optical, Electrochemical, and Theoretical Studies of Dipolar Ruthenium Alkynyl Complexes with Oligo(phenylenevinylene) Bridges>, Quality Control of 112-63-0, the main research area is dipolar ruthenium alkynyl oligophenylenevinylene bridged preparation crystal mol structure; electrochem redox quadratic nonlinear optical property alkynyl ruthenium oligophenylenevinylene; mol structure calculation alkynyl ruthenium oligophenylenevinylene bridged; computational chemistry; electrochemistry; nonlinear optics; organometallic chemistry; transition metals.

The syntheses of oligo(p-phenylenevinylene)s (OPVs) end-functionalized with a ligated ruthenium alkynyl unit as a donor and a nitro as acceptor, namely trans-[Ru{CC-1-C6H4-4-(E)-CH:CH-1-C6H2-2,5-Et2-4-(E)-CH:CH-1-C6H2-2,5-Et2-4-(E)-CH:CH-1-C6H4-4-NO2}Cl(dppe)2] (Ru4), trans-[Ru{CC-1-C6H4-4-(E)-CH:CH-1-C6H2-2,5-Et2-4-(E)-CH:CH-1-C6H2-2,5-Et2-4-(E)-CH:CH-1-C6H2-2,5-(n-hexyl)2-4-(E)-CH:CH-1-C6H2-2,5-(n-hexyl)2-4-(E)-CH:CH-1-C6H4-4-NO2}Cl(dppe)2] (Ru6), and trans-[Ru{CC-1-C6H4-4-(E)-CH:CH-1-C6H2-2,5-Et2-4-(E)-CH:CH-1-C6H2-2,5-Et2-4-(E)-CH:CH-1-C6H2-2,5-(n-hexyl)2-4-(E)-CH:CH-1-C6H2-2,5-(n-hexyl)2-4-(E)-CH:CH-1-C6H2-2,5-(2-ethyl-n-hexyl)2-4-(E)-CH:CH-1-C6H2-2,5-(2-ethyl-n-hexyl)2-4-(E)-CH:CH-1-C6H4-4-NO2}Cl(dppe)2] (Ru8), are reported, together with those of precursor alkynes. Their electrochem. properties were assessed by cyclic voltammetry (CV), their linear optical and quadratic nonlinear optical (NLO) properties assayed by UV/Vis-NIR spectroscopy and hyper-Rayleigh scattering studies at 1064 nm, resp., and their linear optical properties in the formally RuIII state examined by UV/Vis-NIR spectroelectrochem. Computational studies employing time-dependent d. functional theory were undertaken on model complexes to rationalize the optical observations.

ChemPlusChem published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics