Tag: M.W=250-300

Chernov, Alexandr N.; Filatenkova, Tatiana A.; Glushakov, Ruslan I.; Buntovskaya, Alexandra S.; Alaverdian, Diana A.; Tsapieva, Anna N.; Kim, Alexandr V.; Fedorov, Evgeniy V.; Skliar, Sofia S.; Matsko, Marina V.; Galimova, Elvira S.; Shamova, Olga V. published the artcile< Anticancer Effect of Cathelicidin LL-37, Protegrin PG-1, Nerve Growth Factor NGF, and Temozolomide: Impact on the Mitochondrial Metabolism, Clonogenic Potential, and Migration of Human U251 Glioma Cells>, Category: esters-buliding-blocks, the main research area is ECAR; OCR; cathelicidin LL-37; clonogenicity; human glioma U251; metabolism of mitochondria; migration; nerve growth factor NGF; protegrin PG-1; temozolomide.

Glioblastoma (GBM) is one of the most aggressive and lethal malignancy of the central nervous system. Temozolomide is the standard of care for gliomas, frequently results in resistance to drug and tumor recurrence. Therefore, further research is required for the development of effective drugs in order to guarantee specific treatments to succeed. The aim of current study was to investigate the effects of nerve growth factor (NGF), human cathelicidin (LL-37), protegrin-1 (PG-1), and temozolomide on bioenergetic function of mitochondria, clonogenicity, and migration of human U251 glioma cells. Colony formation assay was used to test the ability of the glioma cells to form colonies in vitro. The U251 glioma cells migration was evaluated using wound-healing assay. To study the mitochondrial metabolism in glioma cells we measured oxygen consumption rates (OCR) and extracellular acidification rates (ECAR) using a Seahorse XF cell Mito stress test kit and Seahorse XF cell Glycolysis stress kit, resp. We revealed that LL-37, NGF, and TMZ show strong anti-tumorigenic activity on GMB. LL-37 (4 μM), TMZ (155 μM), and NGF (7.55 x 10-3 μM) inhibited 43.9%-60.3%, 73.5%-81.3%, 66.2% the clonogenicity of glioma U251 cells for 1-2 days, resp. LL-37 (4 μM), and NGF (7.55 x 10-3 μM) inhibited the migration of U251 glioma cells on the third and fourth days. TMZ also inhibited the migration of human glioma U251 cells over 1-3 days. In contrast, PG-1 (16 μM) stimulated the migration of U251 glioma cells on the second, fourth, and sixth days. Anti-mitogenic and anti-migration activities of NGF, LL-37, and TMZ maybe are relation to their capacity to reduce the basal OCR, ATP-synthetase, and maximal respiration of mitochondria in human glioma U251 cells. Glycolysis, glycolytic capacity and glycolytic spare in glioma U251 cells haven’t been changed under the effect of NGF, LL-37, PG-1, and TMZ in regard to control level. Thus, LL-37 and NGF inhibit migration and clonogenicity of U251 glioma cells, which may indicate that these compounds have anti-mitogenic and anti-migration effects on human glioma cells. The study of the mechanisms of these effects may contribute in the future to the use of NGF and LL-37 as therapeutic agents for gliomas.

Molecules published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ravindra, Manasa; Wallace-Povirk, Adrianne; Karim, Mohammad A.; Wilson, Mike R.; O’Connor, Carrie; White, Kathryn; Kushner, Juiwanna; Polin, Lisa; George, Christina; Hou, Zhanjun; Matherly, Larry H.; Gangjee, Aleem published the artcile< Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis>, Synthetic Route of 112-63-0, the main research area is pyrrolopyrimidine synthesis antitumor folate receptor purine nucleotide.

Tumor-targeted specificities of 6-substituted pyrrolo[2,3-d]pyrimidine analogs of 1, where the Ph side-chain is replaced by 3′,6′ (5, 8), 2′,5′ (6, 9), and 2′,6′ (7, 10) pyridyls, were analyzed. Proliferation inhibition of isogenic Chinese hamster ovary (CHO) cells expressing folate receptors (FRs) α and β were in rank order, 6 > 9 > 5 > 7 > 8, with 10 showing no activity, and 6 > 9 > 5 > 8, with 10 and 7 being inactive, resp. Antiproliferative effects toward FRα- and FRβ-expressing cells were reflected in competitive binding with [3H]folic acid. Only compound I was active against proton-coupled folate receptor (PCFT)-expressing CHO cells (∼4-fold more potent than 1) and inhibited [3H]methotrexate uptake by PCFT. In KB and IGROV1 tumor cells, I showed <1 nM IC50, ∼ 2-3-fold more potent than 1. Compound I inhibited glycinamide ribonucleotide formyltransferase in de novo purine biosynthesis and showed potent in vivo efficacy toward s.c. IGROV1 tumor xenografts in SCID mice. Journal of Medicinal Chemistry published new progress about Antifolates. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

E. V., Rashmi; K. P., Vijayalakshmi; Balachandran, Nisha; Mathew, Dona; Kumar K. S., Santhosh published the artcile< Soft-segment Free Polyurethanes and their Self-healable Films>, Category: esters-buliding-blocks, the main research area is polyurethane self healable film thermomech morphol property.

Introducing non-covalent interactions into polymeric chains can result in supramol. polymers with interesting properties and dynamic features. In this work, a functional polyurethane (FPU) and non-functional polyurethane (NFPU) were synthesized from phloroglucinol and hexamethylene diisocyanate monomers by tuning their stoichiometry. Both the PUs featured spherical morphol. as observed in FESEM images and exhibited surface dynamics with time. The PUs led to self-standing films but their properties are significantly different. Temperature dependent FTIR and NMR gave strong evidence for the presence of multiple H-bonding. Computational studies (B3 LYP/6-31G** level DFT method) highlighted considerable interaction for FPU than NFPU due to enhanced H-bonding between chains. The FPU was further made into self-healable film by incorporating another polyurethane (MPU) (self-healing efficiency >80%). The mechanism of self-healing lies on the gradual growth of H-bonding between FPU and MPU at ambient conditions which is corroborated with glycerol-embedded self-healing film.

Progress in Organic Coatings published new progress about Contact angle. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bikman, Benjamin T.; Shimy, Kim J.; Apovian, Caroline M.; Yu, S.; Saito, Erin R.; Walton, Chase M.; Ebbeling, Cara B.; Ludwig, David S. published the artcile< A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is adipose tissue mitochondrial respiration diet rate.

Adipocyte mitochondrial respiration may influence metabolic fuel partitioning into oxidation vs. storage, with implications for whole-body energy expenditure. Although insulin has been shown to influence mitochondrial respiration, the effects of dietary macronutrient composition have not been well characterized. The aim of this exploratory study was to test the hypothesis that a high-carbohydrate diet lowers the oxygen flux of adipocyte mitochondria ex vivo. Among participants in a randomized-controlled weight-loss maintenance feeding trial, those consuming a high-carbohydrate diet (60% carbohydrate as a proportion of total energy, n = 10) had lower rates of maximal adipose tissue mitochondrial respiration than those consuming a moderate-carbohydrate diet (40%, n = 8, p = 0.039) or a low-carbohydrate diet (20%, n = 9, p = 0.005) after 10 to 15 wk. This preliminary finding may provide a mechanism for postulated calorie-independent effects of dietary composition on energy expenditure and fat deposition, potentially through the actions of insulin on fuel partitioning.

European Journal of Clinical Nutrition published new progress about Adipose tissue. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fujii, Shingo; Sobol, Robert W.; Fuchs, Robert P. published the artcile< Double-strand breaks: When DNA repair events accidentally meet>, Category: esters-buliding-blocks, the main research area is review temozolomide double strand break DNA repair; Alkylation; Base excision repair; Cell death; Futile cycle; MGMT; Mismatch repair.

A review. The cellular response to alkylation damage is complex, involving multiple DNA repair pathways and checkpoint proteins, depending on the DNA lesion, the cell type, and the cellular proliferation state. The repair of and response to O-alkylation damage, primarily O6-methylguaine DNA adducts (O6-mG), is the purview of O6-methylguanine-DNA methyltransferase (MGMT). Alternatively, this lesion, if left un-repaired, induces replication-dependent formation of the O6-mG:T mis-pair and recognition of this mis-pair by the post-replication mismatch DNA repair pathway (MMR). Two models have been suggested to account for MMR and O6-mG DNA lesion dependent formation of DNA double-strand breaks (DSBs) and the resulting cytotoxicity – futile cycling and direct DNA damage signaling. While there have been hints at crosstalk between the MMR and base excision repair (BER) pathways, clear mechanistic evidence for such pathway coordination in the formation of DSBs has remained elusive. However, using a novel protein capture approach, Fuchs and colleagues have demonstrated that DSBs result from an encounter between MMR-induced gaps initiated at alkylation induced O6-mG:C sites and BER-induced nicks at nearby N-alkylation adducts in the opposite strand. The accidental encounter between these two repair events is causal in the formation of DSBs and the resulting cellular response, documenting a third model to account for O6-mG induced cell death in non-replicating cells. This graphical review highlights the details of this Repair Accident model, as compared to current models, and we discuss potential strategies to improve clin. use of alkylating agents such as temozolomide, that can be inferred from the Repair Accident model.

DNA Repair published new progress about Alkylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Okamoto, Yoshiki; Iwamoto, Narimasa; Takamuku, Setsuo published the artcile< Photochemical carbon-phosphorus bond cleavage of nitro-substituted benzylphosphonic acids>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is carbon phosphorous bond cleavage nitrobenzylphosphonate.

Upon UV irradiation, the C-P bond of p-nitrobenzylphosphonate was more readily cleaved to give a monomeric m-phosphate anion as intermediate than those of o- and m- derivatives

Journal of the Chemical Society, Chemical Communications published new progress about C-P bond cleavage. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Baochao; Wen, Guoen; Zhang, Quan; Hou, Min; He, Haibing; Gao, Shuanhu published the artcile< Asymmetric Total Synthesis and Biosynthetic Implications of Perovskones, Hydrangenone, and Hydrangenone B>, COA of Formula: C19H34O2, the main research area is asym total synthesis biosynthesis perovskone hydrangenone; photoenolization Diels Alder icetexane synthesis; bioinspired Diels Alder perovskatone D ocimene perovskone synthesis.

Perovskones and hydrangenones are a family of structurally complex triterpenoids that were mainly isolated from the genus Salvia medicinal plants. These isoprenoids exhibit a broad range of biol. activities, such as antitumor and antiplasmodial activities. Here, we report the collective total synthesis of perovskone (I), perovskones C (II), D (III), F (IV), hydrangenone (V), and hydrangenone B (VI). The key strategies in this work include the following: (1) an asym. photoenolization/Diels-Alder reaction was developed to construct a tricyclic ring bearing three contiguous quaternary centers, which was used to build the core icetexane skeleton; (2) a bioinspired Diels-Alder reaction of perovskatone D with trans-α-ocimene was applied to stereospecifically generate perovskones; (3) late-stage oxidations and ring forming steps were developed to synthesize perovskones and hydrangenones. Our synthetic work suggests that (1) perovskatone D may serve as the precursor of the biosynthesis of perovskones and (2) the formation of hydrangenone and hydrangenone B, containing a five-membered D ring, may involve an oxidative ring cleavage and ring regeneration process.

Journal of the American Chemical Society published new progress about Acetalization (1-pot stereoselective Diels-Alder/hemiacetalization cascade). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kumar, Deepak; Singh, Hema; Maurya, Mehilal; Nguyen, Van-Huy; Vo, Dai-Viet N.; Sharma, Ajit; Banerjee, Shaibal published the artcile< Novel evaluation enhancement role of poly (1-(3-nitrophenyl)-1H-1,2,3-triazol-4-yl) acrylate materials for propellant composite formulation>, Computed Properties of 112-63-0, the main research area is propellant composite nitrophenyl triazolyl acrylate enhancement.

The performance of solid propellants is often tailored by incorporating energetic materials such as novel oxidizers, energetic binders, and ballistic modifiers. Metal oxide nanoparticles are known for their persuasive nature to modify burning rate of ammonium perchlorate based composite propellants. In the present work, nano iron oxide and poly (1-(3-nitrophenyl)-1H-1,2,3-triazol-4-yl) acrylate are incorporated in the composite propellant formulation by partly replacing coarse ammonium perchlorate (AP) as well as hydroxy terminated polybutadiene (HTPB), resp., and different properties were evaluated. The mech. properties data revealed that on increasing the percentage of polymer in the composition by partly replacing HTPB, there is an increase in tensile strength while decreasing elongation percentage. The data of ballistic properties revealed that on incorporation of nano iron oxide in the composition enhances the burning rate while on partial replacement of HTPB with polymer there is a decrease in burning rate from 11.95 mm s-1 to 8.75 mm s-1, resp. was observed

Materials Letters published new progress about Combustion. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Rui; Lei, Chao; Chen, Liang; He, Liqing; Guo, Haixun; Zhang, Xiang; Feng, Wenke; Yan, Jun; McClain, Craig J.; Deng, Zhongbin published the artcile< Alcohol-driven metabolic reprogramming promotes development of RORγt-deficient thymic lymphoma>, Computed Properties of 112-63-0, the main research area is thymic lymphoma RORgammat alc metabolism.

RORγt is a master regulator of Th17 cells. Despite evidence linking RORγt deficiency/inhibition with metastatic thymic T cell lymphomas, the role of RORγt in lymphoma metabolism is unknown. Chronic alc. consumption plays a causal role in many human cancers. The risk of T cell lymphoma remains unclear in humans with alc. use disorders (AUD) after chronic RORγt inhibition. Here we demonstrated that alc. consumption accelerates RORγt deficiency-induced lymphomagenesis. Loss of RORγt signaling in the thymus promotes aerobic glycolysis and glutaminolysis and increases allocation of glutamine carbon into lipids. Importantly, alc. consumption results in a shift from aerobic glycolysis to glutaminolysis. Both RORγt deficiency- and alc.-induced metabolic alterations are mediated by c-Myc, as silencing of c-Myc decreases the effects of alc. consumption and RORγt deficiency on glutaminolysis, biosynthesis, and tumor growth in vivo. The ethanol-mediated c-Myc activation coupled with increased glutaminolysis underscore the critical role of RORγt-Myc signaling and translation in lymphoma.

Oncogene published new progress about Alcoholism. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rogers, Gary A.; Parsons, Stanley M.; Anderson, D. C.; Nilsson, Lena M.; Bahr, Ben A.; Kornreich, Wayne D.; Kaufman, Rose; Jacobs, Robert S.; Kirtman, Bernard published the artcile< Synthesis, in vitro acetylcholine-storage-blocking activities, and biological properties of derivatives and analogs of trans-2-(4-phenylpiperidino)cyclohexanol (vesamicol)>, Electric Literature of 112-63-0, the main research area is vesamicol analog preparation acetylcholine blocking; phenylpiperidinocychlohexanol analog preparation; piperidinocyclohexanol; structure activity vesamicol analog acetylcholine blocking.

Eighty-four analogs, e.g., I [R = (un)substituted Ph, cyclohexyl, PhCH2, Ph(CH2)3] and derivatives of the acetylcholine storage-blocking drug trans-2-4(4-phenylpiperidino)cyclohexanol (vesamicol) were synthesized, and their potencies were evaluated with the acetylcholine active-transport assay utilizing purified synaptic vesicles from Torpedo elec. organ. The parent drug exhibits enantioselectivity, with (-)-vesamicol being 25-fold more potent than (+)-vesamicol. The mol. structure and absolute configuration of (+)-vesamicol were determined by x-ray crystallog. The absolute configuration of (-)-vesamicol is (1R,2R). Structure-activity evidence indicates that (-)-vesamicol does not act as an acetylcholine analog. Alterations to all three rings can have large effects on potency. Unexpectedly, analogs locking the alc. and ammonium groups trans-diequatorial or trans-diaxial both exhibit good potency. A potent benzovesamicol family was discovered that is suitable for facile elaboration of the sort useful in affinity labeling and affinity chromatog. applications. A good correlation was found between potencies as assessed by the acetylcholine transport assay and LD50 values in mouse.

Journal of Medicinal Chemistry published new progress about Cholinergic receptors Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics