Tag: M.W=250-300

Baum, H. published the artcileSulfatases. XXI. The anomalous kinetics of arylsulfatase A of human tissues: the anomalies, Synthetic Route of 6217-68-1, the publication is Biochemical Journal (1958), 567-72, database is CAplus and MEDLINE.

cf. C.A. 52, 14725h. Preparations of human arylsulfatase A exhibit anomalous time-activity curves when incubated with di-K 2-hydroxy-5-nitrophenylsulfate (I), K p-acetylphenylsulfate, and K p-nitrophenyl sulfate. The rate of the reaction increases with time, at a rate which varies with the enzyme concentration The rate is proportional to some value greater than the 1st power of the enzyme concentration, depending upon the length of incubation time. Increasing substrate concentration during the initial period of incubation results in an increase in the rate to a maximum, whereas with prolonged incubation with the substrate the rate passes through a maximum and falls at higher substrate concentrations During the early incubation period there are optima at pH 4.4 and 5.0, whereas as the period of incubation is extended the 2 peaks merge at pH 4.4, and then shift to 4.7. The time-activity curves obtained at 20.5 and 30.5° cross those obtained at 37.5 and 50.5°; this indicates that enzyme destruction is not an important factor. The anomalous kinetics appear to be a feature peculiar to mammalian arylsulfatase A and are not shown by human arylsulfatase B or the arylsulfatases of limpets (Patella vulgata), Alcaligenes metalcaligenes, Taka-Diastase, and Helix pomatia.

Biochemical Journal published new progress about 6217-68-1. 6217-68-1 belongs to esters-buliding-blocks, auxiliary class Salt,Nitro Compound,Sulfonate,Benzene, name is Potassium 4-nitrophenyl sulfate, and the molecular formula is C6H4KNO6S, Synthetic Route of 6217-68-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nasrallah, Houssein published the artcileNew Coupling Agent Structures for Preparing Filler-Polymer Hybrid Materials Under Soft Irradiation Conditions, Recommanded Product: Trimethylolpropane triacrylate, the publication is Macromolecules (Washington, DC, United States) (2022), 55(15), 6394-6404, database is CAplus.

Bifunctional coupling agents have become unavoidable products for preparing hybrid materials with enhanced properties. They are at the origin of the homogeneous dispersion of the filler in the polymerizable matrix and the strong chem. interactions between the composites during the thermal reticulation and vulcanization processes. However, only few structures can play this role in a photo-curable matrix, which is widely applied today in various manufacturing processes (3D printing, cosmetics, medicine, etc). Developing new structures capable of working under accurate irradiation conditions can extend the use of coupling agents for preparing hybrid photo-curable materials for various applications (e.g., membranes, masks, and 2D- and 3D-nano/micro-objects). Recently, a new SPI (SPI-1) was proposed by our group and has revealed a high efficiency for preparing filler-polymer hybrid materials. Despite its efficiency, its activity is the highest under UV-B irradiation but lower under UV-A and inactive under visible light. In this paper, new coupling agent structures (bifunctional silane-based photoinitiators; SPIs) are synthesized and tested under various irradiation conditions extensively used in the photocuring fields (365, 385, and 405 nm). All the new structures demonstrate higher performance than the first SPI generation (SPI-1) under diverse light sources. More particularly, SPI-4, 5, and 6 (triphenylamine-based SPI) demonstrate a remarkable activity for preparing filler-polymer hybrid materials under visible-light irradiation (LED 405 nm). The efficiency of the new structures in the photopolymerization as well as in the grafting of the silica particles (used as a filler model) is elucidated. Finally, the enhancement of the mech. properties of the hybrid composite films and the possible use of the new approach in photolithog. are also demonstrated.

Macromolecules (Washington, DC, United States) published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Recommanded Product: Trimethylolpropane triacrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Brown, F. Reber published the artcileParticle beam liquid chromatography/mass spectrometry of phenols and their sulfate and glucuronide conjugates, Product Details of C6H4KNO6S, the publication is ACS Symposium Series (1990), 232-44, database is CAplus.

The particle beam-liquid chromatog.-mass spectrometry of PhOH, 4-nitrophenol, and 1-naphthol and their glucuronide and sulfate conjugates in electron impact and pos. chem. ionization is described. The compounds were separated on a strong anion exchange (SAX) HPLC column with a pH 4.5 NH₄HCO₂-acetonitrile mobile phase. Mol. ions were not obtained for any of the conjugate structures due to decomposition, but the phenols were detected in all cases as the M⁺ or [M + H]⁺ ion. The phenol formed from each conjugate as a decomposition product could usually be identified by computerized library search. In single ion monitoring mode, limits of detection ranged from 0.25 ng for 4-nitrophenyl glucuronide to 51 ng for PhOH.

ACS Symposium Series published new progress about 6217-68-1. 6217-68-1 belongs to esters-buliding-blocks, auxiliary class Salt,Nitro Compound,Sulfonate,Benzene, name is Potassium 4-nitrophenyl sulfate, and the molecular formula is C6H4KNO6S, Product Details of C6H4KNO6S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Yuan published the artcileFormulation and Performance Characterization of Polymeric Dust Suppressants for Stockpiles, Name: Trimethylolpropane triacrylate, the publication is ACS Omega (2022), 7(11), 9891-9899, database is CAplus and MEDLINE.

With an aim at the dust problem of open dust sources in construction sites, open stockyards, mines, docks, and other areas, a polymer chem. dust inhibitor was developed in this study that is suitable for stockyards through theor. anal. and laboratory tests. Through a single-factor experiment and an orthogonal experiment, the viscosity value of dust suppressant and the hardness value of the crust taken as evaluation indexes, the optimal formula of dust suppressant for a pile was finally obtained after an anal. of range and variance: the optimum formulation of the dust suppressant for stockpiles was finally obtained by: 0.6%A + 0.2%B + 0.28%C + 0.7%D. The performance of the dust suppressant was characterized. The results showed that the longer the suppression time of suppressants, the better the weather resistance and environmental friendliness. Polymeric dust suppressants for stockpiles can effectively suppress the open dust, improve the air quality, protect the climate environment, and maintain people’s health and have a certain industrial application prospect.

ACS Omega published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C13H26N2, Name: Trimethylolpropane triacrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gautom, Trishnamoni published the artcileStructural basis of terephthalate recognition by solute binding protein TphC, Name: Potassium 4-nitrophenyl sulfate, the publication is Nature Communications (2021), 12(1), 6244, database is CAplus and MEDLINE.

Biol. degradation of Polyethylene terephthalate (PET) plastic and assimilation of the corresponding monomers ethylene glycol and terephthalate (TPA) into central metabolism offers an attractive route for bio-based mol. recycling and bioremediation applications. A key step is the cellular uptake of the non-permeable TPA into bacterial cells which has been shown to be dependent upon the presence of the key tphC gene. However, little is known from a biochem. and structural perspective about the encoded solute binding protein, TphC. Here, we report the biochem. and structural characterization of TphC in both open and TPA-bound closed conformations. This anal. demonstrates the narrow ligand specificity of TphC towards aromatic para-substituted dicarboxylates, such as TPA and closely related analogs. Further phylogenetic and genomic context anal. of the tph genes reveals homologous operons as a genetic resource for future biotechnol. and metabolic engineering efforts towards circular plastic bio-economy solutions

Nature Communications published new progress about 6217-68-1. 6217-68-1 belongs to esters-buliding-blocks, auxiliary class Salt,Nitro Compound,Sulfonate,Benzene, name is Potassium 4-nitrophenyl sulfate, and the molecular formula is C6H4KNO6S, Name: Potassium 4-nitrophenyl sulfate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gaiser, Birgit I. published the artcileProbing the Existence of a Metastable Binding Site at the β₂-Adrenergic Receptor with Homobivalent Bitopic Ligands, Recommanded Product: (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, the publication is Journal of Medicinal Chemistry (2019), 62(17), 7806-7839, database is CAplus and MEDLINE.

Herein, we report the development of bitopic ligands aimed at targeting the orthosteric binding site (OBS) and a metastable binding site (MBS) within the same receptor unit. Previous mol. dynamics studies on ligand binding to the β₂-adrenergic receptor (β₂AR) suggested that ligands pause at transient, less-conserved MBSs. We envisioned that MBSs can be regarded as allosteric binding sites and targeted by homobivalent bitopic ligands linking two identical pharmacophores. Such ligands were designed based on docking of the antagonist (S)-alprenolol into the OBS and an MBS and synthesized. Pharmacol. characterization revealed ligands with similar potency and affinity, slightly increased β₂/β₁AR-selectivity, and/or substantially slower β₂AR off-rates compared to (S)-alprenolol. Truncated bitopic ligands suggested the major contribution of the metastable pharmacophore to be a hydrophobic interaction with the β₂AR, while the linkers alone decreased the potency of the orthosteric fragment. Altogether, the study underlines the potential of targeting MBSs for improving the pharmacol. profiles of ligands.

Journal of Medicinal Chemistry published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Recommanded Product: (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Naidoo, Jacinth published the artcileDiscovery of a Neuroprotective Chemical, (S)-N-(3-(3,6-Dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with Improved Druglike Properties, Category: esters-buliding-blocks, the publication is Journal of Medicinal Chemistry (2014), 57(9), 3746-3754, database is CAplus and MEDLINE.

(-)-P7C3-S243 (I) is a neuroprotective aminopropyl carbazole with improved druglike properties compared with previously reported compounds in the P7C3 class. It protects developing neurons in a mouse model of hippocampal neurogenesis and protects mature neurons within the substantia nigra in a mouse model of Parkinson’s disease. A short, enantioselective synthesis provides the neuroprotective agent in optically pure form. It is nontoxic, orally bioavailable, metabolically stable, and able to cross the blood-brain barrier. As such, it represents a valuable lead compound for the development of drugs to treat neurodegenerative diseases and traumatic brain injury.

Journal of Medicinal Chemistry published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Valencia, L. M. published the artcileInduced damage during STEM-EELS analyses on acrylic-based materials for Stereolithography, SDS of cas: 15625-89-5, the publication is Polymer Degradation and Stability (2022), 110044, database is CAplus.

(Scanning) transmission electron microscopy, (S)TEM, offers a powerful characterization tool based on electron-matter interactions, highly valuable in materials science. However, the possible electron beam induced damage during (S)TEM measurements hinders the anal. of soft materials, such as acrylic resins. Importantly, acrylic resins offer an appealing playground for the development of novel composites with customized properties and convenient processing capabilities for 3D-printing technologies, including Stereolithog. (SLA). There are several factors preventing the optimal performance of TEM measurements applied to acrylic resins, among which we focus on the quality of the analyzed specimen (i.e., compromise between thickness and robustness, to achieve electron transparency while keeping the material integrity), particularly challenging when working with soft materials; the electrostatic charging/discharging effects, resulting in sample drift and related noise/artifacts; and the radiolysis and knock-on electron-induced damage, which directly degrade the material under study. We explore and compare different methodologies to obtain resin specimens suitable for (S)TEM anal., employed for the subsequent study of the electron-beam damage induced during STEM-EELS measurements. Furthermore, we propose likely underlying mechanisms explaining the acrylic resin degradation based on the different EELS monitored signals. On one hand, we assess the evolution of the carbon and oxygen content, as well as the material thinning as a function of the accumulated electron dose. On the other hand, we extract meaningful information from the spectral shape of carbon and oxygen K-edges upon increasing electron doses, unraveling likely degradation pathways. The earned understanding on the electron-beam induced damage and the determination of critical doses provide a useful framework for the implementation of (S)TEM techniques as useful tools to help in the smart engineering of acrylic-based composites for SLA.

Polymer Degradation and Stability published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C5H5BrN2, SDS of cas: 15625-89-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Rahman, Shahzad S. published the artcile1,3-Diaminopropan-2-ol Sulfonamides as potent and selective inhibitors of the glycine transporter type 1, HPLC of Formula: 115314-17-5, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(6), 1741-1745, database is CAplus and MEDLINE.

High throughput screening led to the discovery of a novel series of 1,3-diaminopropan-2-ol sulfonamides, e.g. I, as selective GlyT-1 inhibitors. Structure-activity relationships of this novel series and optimization of the initial hit that led to the identification of I, a potent and selective GlyT-1 inhibitor, are also presented.

Bioorganic & Medicinal Chemistry Letters published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, HPLC of Formula: 115314-17-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Narjes, Frank published the artcileDiscovery of (7R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus NS5B Polymerase, Recommanded Product: (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, the publication is Journal of Medicinal Chemistry (2011), 54(1), 289-301, database is CAplus and MEDLINE.

Infections caused by hepatitis C virus (HCV) are a significant world health problem for which novel therapies are in urgent demand. The polymerase of HCV is responsible for the replication of viral genome and has been a prime target for drug discovery efforts. Here, we report on the further development of tetracyclic indole inhibitors, binding to an allosteric site on the thumb domain. Structure-activity relationship (SAR) studies around an indolo-benzoxazocine scaffold led to the identification of compound 33 (MK-3281), an inhibitor with good potency in the HCV subgenomic replication assay and attractive mol. properties suitable for a clin. candidate. The compound caused a consistent decrease in viremia in vivo using the chimeric mouse model of HCV infection.

Journal of Medicinal Chemistry published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Recommanded Product: (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics