Tag: M.W=250-300

Anand, Namrata; Koley, Suvajit; Ramulu, B. Janaki; Singh, Maya Shankar published the artcile< Metal-free aerobic one-pot synthesis of substituted/annulated quinolines from alcohols via indirect Friedlander annulation>, Synthetic Route of 112-63-0, the main research area is quinoline preparation green chem; aminobenzyl alc aminobenzophenone alc tandem oxidation Friedlander annulation.

Metal-free, operationally simple, and highly efficient one-pot aerobic process for the synthesis of functionalized/annulated quinolines e.g., I is devised from easily available 2-aminobenzyl alc./2-aminobenzophenones and alkyl/aryl alcs. for the first time. The process involves two sequential reactions, namely in situ aerial oxidation of alcs. to the corresponding aldehydes/ketones followed by Friedlander annulation.

Organic & Biomolecular Chemistry published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peeters, Emiel; Van Hal, Paul A.; Meskers, Stefan C. J.; Janssen, Rene A. J.; Meijer, E. W. published the artcile< Photoinduced electron transfer in a mesogenic donor-acceptor-donor system>, COA of Formula: C19H34O2, the main research area is photoinduced electron transfer mesogenic oligophenylenevinylene; liquid crystalline mesogenic oligophenylenevinylene photoinduced electron transfer.

A novel donor-acceptor-donor mol. consisting of two oligo(p-phenylene vinylene) (OPV4) units attached to a central perylene bisimide (PERY) core is described. This OPV4-PERY-OPV4 is the first mesogenic mol. that incorporates both p- and n-type semiconducting properties and possesses a liquid-crystalline mesophase, in which donor and acceptor functionalities self-assemble into an ordered material. Upon photoexcitation of the donor, a subpicosecond electron-transfer reaction occurs in OPV4-PERY-OPV4, both in solution and in (ordered) thin solid films. The lifetime of the charge-separated state is significantly longer in (ordered) thin films than in solution as a result of a reduction of geminate recombination by migration and spatial separation of charges in the film.

Chemistry – A European Journal published new progress about Electrooptical effect. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Demiray, Hatice; Estep, Alden S.; Tabanca, Nurhayat; Becnel, James J.; Demirci, Betul published the artcile< Chemical constituents from Rheum ribes shoots and its insecticidal activity against Aedes aegypti>, Category: esters-buliding-blocks, the main research area is methyl linoleate insecticidal Rheum Aedes.

A phytochem. investigation of hexane extract of Rheum ribes L., Polygonaceae, shoots was analyzed by gas chromatog. with flame ionization dection and mass specrometry and revealed seven components including Me hexadecanoate (Me palmitate) (2.4%), (Z)-9-Me octadecenoate (Me oleate) (2.9%), (Z,Z,Z)-9,12,15-Me octadecatrienoate (Me linolenate) (3.5%), 1-octadecanol (4.3%), (Z,Z)-9,12-Me octadecadienoate (Me linoleate) (5.7%), heptacosane (13.5%), and hexadecanoic acid (palmitic acid) (67.7%). The hexane extract was bioassayed for larvicidal and adult topical activity against an insecticide susceptible strain of Aedes aegypti, the yellow fever mosquito. Results demonstrated a 90% mortality against adults at 5μg/mosquito and first instar larvae at 1μg/μl. The major compound hexadecanoic acid showed 20% mortality at 6.25 ppm against adults whereas the compound provided 100% mortality at the highest screening dose of 1000 ppm against 1st instar larvae. The mosquitocidal activity of the analyzed plant material may be related to a specific combination of compounds present in the hexane extract Graphical abstract

Revista Brasileira de Farmacognosia published new progress about Aedes aegypti. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sherin, D. R.; Manojkumar, T. K. published the artcile< Exploring the selectivity of guanine scaffold in anticancer drug development by computational repurposing approach>, Computed Properties of 112-63-0, the main research area is exploring selectivity guanine scaffold anticancer drug development computational repurposing.

Drug repurposing is one of the modern techniques used in the drug discovery to find out the new targets for existing drugs. Insilico methods have a major role in this approach. We used 60 FDA approved antiviral drugs reported in the last 50 years to screen against different cancer cell receptors. The thirteen compounds selected after virtual screening are analyzed for their druggability based on ADMET parameters and found the selectivity of guanine derivatives-didanosine, entecavir, acyclovir, valganciclovir, penciclovir, ganciclovir and valacyclovir as suitable candidates. The pharmacophore model, AARR, suggested based on the common feature alignment, shows that the two fused rings as in guanine and two acceptors-one from keto-oxygen (A5) and other from the substituent attached to nitrogen of imidazole ring (A4) give the druggability to the guanine derivatives The NBO anal. on N9 is indicative of charge distribution from the ring to substituents, which results in delocalization of neg. character in most of the ligands. The mol. dynamics simulations also pointed out the importance of guanine scaffold, which stabilizes the ligands inside the binding pocket of the receptor. All these results are indicative of the selectivity of guanine scaffold in anticancer drug development, especially as PARP1 inhibitors in breast, ovarian and prostate cancer. As these seven mols. are already approved by FDA, we can safely go for further preclin. trials.

Scientific Reports published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xie, Zhenxing; Xu, Mang; Xie, Jie; Liu, Tao; Xu, Xie; Gao, Wei; Li, Zhanfei; Bai, Xiangjun; Liu, Xinghua published the artcile< Inhibition of ferroptosis attenuates glutamate excitotoxicity and nuclear autophagy in a CLP septic mouse model>, Computed Properties of 347174-05-4, the main research area is ferroptosis glutamate excitotoxicity nuclear autophagy sepsis associated encaphalopathy.

Sepsis-associated encephalopathy (SAE) often manifests in severe diffuse cerebral dysfunction due to an aberrant systemic immune response to infection. The underlying pathophysiol. of SAE is not entirely understood but is likely a multifactorial process that involves disruption in cell death mechanism. Ferroptosis is a novel formof programmed cell death characterized by iron accumulation and lipid peroxidation, leading to inflammatory cascade and glutamate release. We hypothesized that ferroptosis is involved in the glutamate-mediated excitotoxic neuron injury during the uncontrolled neural inflammatory process of SAE. Inhibiting ferroptosis with ferrostatin-1 (Fer-1) could alleviate glutamate excitotoxicity and reduce neuron death of SAE, potentially improving prognosis. We found that in the cecal ligation and puncture (CLP) sepsis model, ferroptosis occurred increasingly in the cerebrum, characterized by glutathione-dependent antioxidant enzyme glutathione peroxidase 4 (GPX4) inactivation, transferrin upregulation, mitochondria shrink and malondialdehyde (MDA) increased. Fer-1 treatment downregulated cerebral ferroptosis and alleviated glutamate excitotoxicity via dampening system xc-(SXC) and glutamate receptor N-methyl-D-asperate receptor subunit 2. Combined with an observed reduction in calcium transporter PLCG and PLCB activation, these processes ultimately protected the integrities of synapses and neurons during SAE. Fer-1 treatment also rescued sepsis-induced nuclear autophagy and improved the behaviors of tail suspension test and novel object recognition test in septic mice. Conclusively, our results suggested that inhibition of ferroptosis could attenuate glutamate excitotoxicity and SAE outcomes.

Shock published new progress about AMPA receptors, GluR1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Computed Properties of 347174-05-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kotschi, Stefan; Jung, Anna; Willemsen, Nienke; Ofoghi, Anahita; Proneth, Bettina; Conrad, Marcus; Bartelt, Alexander published the artcile< NFE2L1-mediated proteasome function protects from ferroptosis>, Product Details of C15H22N2O2, the main research area is NFE2L1 proteasome function protect ferroptosis; Brown adipose tissue; Ferroptosis; GPX4; Lipids; Proteasome; Ubiquitin.

Ferroptosis continues to emerge as a novel modality of cell death with important therapeutic implications for a variety of diseases, most notably cancer and degenerative diseases. While susceptibility, initiation, and execution of ferroptosis have been linked to reprogramming of cellular lipid metabolism, imbalances in iron-redox homeostasis, and aberrant mitochondrial respiration, the detailed mechanisms of ferroptosis are still insufficiently well understood.Here we show that diminished proteasome function is a new mechanistic feature of ferroptosis. The transcription factor nuclear factor erythroid-2, like-1 (NFE2L1) protects from ferroptosis by sustaining proteasomal activity. In cellular systems, loss of NFE2L1 reduced cellular viability after the induction of both chem. and genetically induced ferroptosis, which was linked to the regulation of proteasomal activity under these conditions. Importantly, this was reproduced in a Sedaghatian-type Spondylometaphyseal Dysplasia (SSMD) patient-derived cell line carrying mutated glutathione peroxidase-4 (GPX4), a critical regulator of ferroptosis. Also, reduced proteasomal activity was associated with ferroptosis in Gpx4-deficient mice. In a mouse model for genetic Nfe2l1 deficiency, we observed brown adipose tissue (BAT) involution, hyperubiquitination of ferroptosis regulators, including the GPX4 pathway, and other hallmarks of ferroptosis.Our data highlight the relevance of the NFE2L1-proteasome pathway in ferroptosis. Manipulation of NFE2L1 activity might enhance ferroptosis-inducing cancer therapies as well as protect from aberrant ferroptosis in neurodegeneration, general metabolism, and beyond.

Molecular Metabolism published new progress about Brown adipose tissue. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Product Details of C15H22N2O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Koenig, Wilfried A.; Benecke, Ingrid; Sievers, Susanne published the artcile< New results in the gas chromatographic separation of enantiomers of hydroxy acids and carbohydrates>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is chiral phase enantiomer gas chromatog; hydroxyisopentanoic acid packing gas chromatog; hydroxyoctanoic acid packing gas chromatog; phenylethylamine packing gas chromatog enantiomer; valinephenylethylamide packing gas chromatog enantiomer; amino acid modified polysiloxane packing; amine enantiomer separation gas chromatog; amino acid enantiomer gas chromatog; hydroxy acid enantiomer gas chromatog; carbohydrate enantiomer gas chromatog.

New chiral stationary phases for gas chromatog. separation of the enantiomers of amines, amino alcs., hydroxy acids and carbohydrates are described. Hydroxy acids were separated on stationary phases prepared from S-2-hydroxyisopentanoic acid and S-2-hydroxyoctanoic acid by coupling with S-α-phenylethylamine. For the first time, separation of carbohydrate enantiomers was achieved on a stationary phase obtained by connecting L-valine-S-α-phenylethylamide to the functionalized cyanoethyl side-chains of the polysiloxane XE-60.

Journal of Chromatography published new progress about Amines. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Zhigang; Ayaz, Muhammad; Cappelli, Alexandra A.; Hulme, Christopher published the artcile< General One-pot, Two-Step Protocol Accessing a Range of Novel Polycyclic Heterocycles with High Skeletal Diversity>, Reference of 112-63-0, the main research area is Ugi three component coupling cyclodehydration; benzimidazole polycyclic heterocycle preparation skeletal diversity.

An Ugi one-pot three-component four-center reaction was coupled with a subsequent acid mediated cyclodehydration step to furnish a multitude of unique scaffolds having in common an embedded or attached benzimidazole and often a ring system formed through lactamization, e.g. I. Using combinations of tethered Ugi inputs typically via tethered acid-ketone inputs and supporting reagents containing masked internal nucleophiles, such scaffolds were produced in good to excellent yields in an operationally friendly manner.

ACS Combinatorial Science published new progress about Cyclocondensation reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xie, Hui; Zeng, Lili; Zeng, Shaogao; Lu, Xin; Zhang, Guicheng; Zhao, Xin; Cheng, Na; Tu, Zhengchao; Li, Zhiyuan; Xu, Hongjiang; Yang, Ling; Zhang, Xiquan; Huang, Min; Zhao, Junling; Hu, Wenhui published the artcile< Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization>, Reference of 112-63-0, the main research area is pyrrolopyrimidine analog peptidase DPPIV inhibitor preparation structure pharmacokinetics antidiabetic.

We previously reported a highly potent DPP-IV inhibitor 6 with low in vivo efficacy. While trying to maintain consistent in vitro and in vivo biol. activity, we initiated a pharmacokinetic property-driven optimization to improve the metabolic stability and permeability of inhibitor 6. A simple scaffold replacement of thienopyrimidine with pyrrolopyrimidine (21a) led to significantly improved metabolic stability (4% vs. 65% remaining). Further modification of the pyrrolopyrimidine scaffold to produce compound 21j resulted in much better oral bioavailability than 6. Importantly, compound 21j exhibits greater in vivo efficacy than does 6 and Alogliptin and is worthy of further development.

European Journal of Medicinal Chemistry published new progress about Antidiabetic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kaur, Sukhdeep; Sharma, Priyanka; Bains, Aarti; Chawla, Prince; Sridhar, Kandi; Sharma, Minaxi; Inbaraj, Baskaran Stephen published the artcile< Antimicrobial and Anti-Inflammatory Activity of Low-Energy Assisted Nanohydrogel of Azadirachta indica Oil>, Formula: C19H34O2, the main research area is Azadirachta indica oil nanohydrogel antimicrobial antiinflammatory activity; GC–MS; HPLC; anti-inflammatory; bactericidal; fungicidal; minimum inhibitory concentration; phenolic compounds.

Plant-based bioactive compounds have been utilized to cure diseases caused by pathogenic microorganisms and as a substitute to reduce the side effects of chem. synthesized drugs. Therefore, in the present study, Azadirachta indica oil nanohydrogel was prepared to be utilized as an alternate source of the antimicrobial compound The total phenolic compound in Azadirachta indica oil was quantified by chromatog. anal. and revealed gallic acid (0.0076 ppm), caffeic acid (0.077 ppm), and syringic acid (0.0129 ppm). Gas chromatog.-mass spectrometry anal. of Azadirachta indica oil revealed the presence of bioactive components, namely hexadecenoic acid, heptadecanoic acid, c-linolenic acid, 9-octadecanoic acid (Z)-Me ester, methyl-8-methyl-nonanoate, eicosanoic acid, Me ester, and 8-octadecane3-ethyl-5-(2 ethylbutyl). The nanohydrogel showed droplet size of 104.1 nm and -19.3 mV zeta potential. The nanohydrogel showed potential antimicrobial activity against S. aureus, E. coli, and C. albicans with min. inhibitory, bactericidal, and fungicidal concentrations ranging from 6.25 to 3.125 (μg/mL). The nanohydrogel showed a significantly (p < 0.05) higher (8.40 log CFU/mL) value for Gram-neg. bacteria E. coli compared to Gram-pos. S. aureus (8.34 log CFU/mL), and in the case of pathogenic fungal strain C. albicans, there was a significant (p < 0.05) reduction in log CFU/mL value (7.79-6.94). The nanohydrogel showed 50.23-82.57% inhibition in comparison to standard diclofenac sodium (59.47-92.32%). In conclusion, Azadirachta indica oil nanohydrogel possesses great potential for antimicrobial and anti-inflammatory activities and therefore can be used as an effective agent. Gels published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics