Tag: M.W=250-300

Thomson, Jennifer E.; Kyle, Andrew F.; Gallagher, Katherine A.; Lenden, Philip; Concellon, Carmen; Morrill, Louis C.; Miller, Andrew J.; Joannesse, Caroline; Slawin, Alexandra M. Z.; Smith, Andrew D. published the artcile< N-Heterocyclic carbene catalysed oxygen-to-carbon carboxyl transfer of indolyl and benzofuranyl carbonates>, Electric Literature of 112-63-0, the main research area is indolyl carbonate carboxyl transfer nitrogen heterocyclic carbene catalyst; benzofuranyl carbonate carboxyl migration nitrogen heterocyclic carbene catalyst; indolecarboxylate hydro preparation; benzofurancarboxylate hydro preparation.

The ability of N-heterocyclic carbenes to promote O-to-C carboxyl transfer on a range of indolyl and benzofuranyl carbonates is examined, and the scope and limitations of this process are delineated.

Synthesis published new progress about Carbenes (methylene derivatives) Role: CAT (Catalyst Use), USES (Uses) (nitrogen-heterocyclic). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

He, Li; Chen, Yanhua; Zhang, Haitian; Wang, Hui; Chen, Shujuan; Liu, Shuliang; Liu, Aiping; Li, Qin; Ao, Xiaolin; Liu, Yaowen published the artcile< Isolation and identification of Lactobacillus and yeast species and their effect on the quality of fermented rice cakes>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Lactobacillus Saccharomyces isolation fermented rice cake quality.

In this study, microbes were isolated from the rice slurry of a fermented rice cake to obtain lactic acid bacteria and yeast species. These species were identified using microbial physiol. and gene sequence analyses. As the growth of the lactic acid bacterial strain R-2b and the yeast J-3a strains were found to be the best, a composite starter comprising these microbes was used for the preparation of fermented rice cakes. Based on single factor and orthogonal experiments, when the proportion of Lactobacillus plantarum, Saccharomyces cerevisiae, and Candida humilis was 1:3:6, the optimal fermentation conditions were addition of sugar and starter amounts of 20% and 6%, resp., a fermentation temperature of 32°C, and fermentation time of 8 h. The fermented rice cake with this optimum ratio had the most abundant volatile components and qualified physicochem. and microbial indexes. Addnl., the overall quality was better than that of com. available products.

Innovative Food Science & Emerging Technologies published new progress about Bakery cakes (fermented rice). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Collett, Christopher J.; Massey, Richard S.; Maguire, Oliver R.; Batsanov, Andrei S.; O’Donoghue, AnnMarie C.; Smith, Andrew D. published the artcile< Mechanistic insights into the triazolylidene-catalysed Stetter and benzoin reactions: role of the N-aryl substituent>, Category: esters-buliding-blocks, the main research area is triazolylidene catalyzed Stetter benzoin reaction aryl substituent effect mechanism.

The in situ observation, isolation and reversible formation of intermediate 3-(hydroxybenzyl)azolium salts derived from NHC addition to a range of substituted benzaldehydes is probed. Equilibrium constants for the formation of these 3-(hydroxybenzyl)azolium salts, as well as rate constants of hydrogen-deuterium exchange (kex) at C(α) of these intermediates for a range of N-aryl triazolinylidenes is reported. These combined studies give insight into the preference of N-pentafluorophenyl NHCs to participate in benzoin and Stetter reaction processes.

Chemical Science published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cordon, Marie B.; Jacobsen, Kristian M.; Nielsen, Cecilie S.; Hjerrild, Per; Poulsen, Thomas B. published the artcile< Forward Chemical Genetic Screen for Oxygen-Dependent Cytotoxins Uncovers New Covalent Fragments that Target GPX4>, Safety of Ethyl 3-amino-4-(cyclohexylamino)benzoate, the main research area is oxygen gPX chem geneticscreen cytotoxin covalent fragment; GPX4; covalent fragments; ferroptosis; hypoxia; phenotypic screening.

The identification of growth inhibitory compounds with the ability to selectively target the cellular oxygenation state may be of therapeutic interest. Here, a phenotypic screen of a covalent fragment library revealed diverse compounds containing propiolamide warheads with selective toxicity for liver cancer cells in normoxic conditions. Target identification and validation through CETSA and direct pulldown experiments demonstrated that several compounds target glutathione peroxidase 4 (GPX4) and induce ferroptotic cell death. Although being an oxidative cell death mechanism, ferroptosis can be induced also under hypoxic conditions. Prompted by the selective toxicity discovered in the screen, we mapped the oxygen-dependence of several ferroptosis-inducing compounds across three different cell lines. These studies revealed combinations with notable reductions in sensitivity under hypoxic conditions. These observations are mechanistically interesting and may be relevant for the use of ferroptosis-inducers as anti-cancer agents.

ChemBioChem published new progress about Antitumor agents. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Safety of Ethyl 3-amino-4-(cyclohexylamino)benzoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Topczewski, Joseph J.; Kuder, Craig H.; Neighbors, Jeffrey D.; Hohl, Raymond J.; Wiemer, David F. published the artcile< Fluorescent schweinfurthin B and F analogs with anti-proliferative activity>, HPLC of Formula: 112-63-0, the main research area is schweinfurthin fluorescent analog synthesis antiproliferative anticancer cytotoxicity.

The natural tetracyclic schweinfurthins are potent and selective inhibitors of cell growth in the National Cancer Institute’s 60 cell-line screen. At this time, the mechanism or cellular target that underlies this activity has not yet been identified, and efforts to illuminate the schweinfurthins’ mode of action would benefit from development of potent fluorescent analogs that could be readily visualized within cells. This report described the synthesis of fluorescent analogs, such as I [R = H, R1 = OH, R2 = NO2; R = H, R1 = OMe, R2 = NO2, NH2; R = OH, R1 = OMe, R2 = NO2, NH2], of schweinfurthins B and F, and demonstrated that these compounds retain the potent and differentially toxic activities against select human cancer cells that are characteristic of the natural schweinfurthins. In addition, the synthesis of control compounds that maintain parallel fluorescent properties, but lack the potent activity of the natural schweinfurthin was described. Use of fluorescence microscopy showed differences between the localization of the active and relatively inactive schweinfurthin analogs. The active compounds localized in peripheral puncta which may identify the site(s) of activity.

Bioorganic & Medicinal Chemistry published new progress about Antiproliferative agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Jing; Ma, Shengtao; Lin, Meiqing; Tang, Jian; Yue, Congcong; Zhang, Zhang; Yu, Yingxin; An, Taicheng published the artcile< New mixed bromine/chlorine transformation products of tetrabromobisphenol A: Synthesis and identification in dust samples from an e-waste dismantling site>, Application In Synthesis of 112-63-0, the main research area is mixed bromine chlorine transformation product tetrabromobisphenol A dust ewaste.

The large-scale production and usage of tetrabromobisphenol A (TBBPA) and its analogs have caused widespread contamination, raising concern about their potential endocrine disruption effects on both humans and ecosystems. In the present study, debromination and unknown mixed bromine/chlorine transformation products of TBBPA (X-BBPA) were screened in dust samples from an e-waste dismantling site. Five monochloro products (2-chloro-2′,6,6′-TriBBPA, 2-chloro-2′,6-DiBBPA, 2-chloro-2′,6′-DiBBPA, 2-chloro-2′-MoBBPA, and 2-chloro-6-MoBBPA) and two dichloro products (2,2′-dichloro-6,6′-DiBBPA and 2,2′-dichloro-6-MoBBPA) were successfully synthesized and structurally identified. TBBPA and its transformation products were detected by comparison of their mass spectra and retention times with those of synthetic standards The mean concentration of X-BBPA was 1.63 x 104 ng/g in e-waste dismantling workshop dust samples based on dry weight, which was at a similar level to TBBPA. However, it was 1 order of magnitude lower than the concentrations of the debromination congeners. Thus, both debromination and chlorine-bromine exchange may be important reactions during the thermal processing of e-waste. The results on mixed chlorinated/brominated TBBPA transformation products provided new insights into TBBPA transformation. The elevated levels of the transformation products of TBBPA suggested that these products should be targeted to avoid underestimation of possible health risks.

Environmental Science & Technology published new progress about Air pollution. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dumitrescu, Dan; Legrand, Yves-Marie; Petit, Eddy; van der Lee, Arie; Barboiu, Mihail published the artcile< Adaptive binding and selection of compressed 1,ω-diammonium-alkanes via molecular encapsulation in water>, Quality Control of 112-63-0, the main research area is crystal structure water guanidinium pyrenetetrasulfonate aminoalkane.

Guest mols. confined inside hollow mol. assemblies and thus protected from their environment can show unexpected structural behavior or special reactivity compared to their behavior in a bulk, unprotected environment. A special case is the coiling behavior of variable-length alkane chains in rigid hydrogen-bonded mol. cages. It has been found before that coiling may occur in such circumstances, but no exptl. evidence concerning the exact conformation of the chains has yet been presented. Self-assembly of a mol. cage in water and the crystalline state from three distinct components in which linear 1,ω-diammonium-alkanes chains are confined with different degrees of compression are reported. The exact coiling behavior is determined from at. resolution X-ray diffraction showing crenel-like conformations in the compressed state. Chem. selection can be obtained from mixtures of alkane chains via the encapsulation of kinetically stable conformations observed during the encapsulation of pure components. Moreover, it was found that uncompressed and compressed chains can be competitively trapped inside the capsule. These findings may provide insight in areas to a better understanding of biol. processes, such as the fatty acid metabolism

Chemical Science published new progress about COSY spectroscopy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Jianhua; Jiang, Chao published the artcile< Palladium-Catalyzed C-H Silylation of Aliphatic Ketones Using an Aminooxyamide Auxiliary>, Application In Synthesis of 112-63-0, the main research area is palladium catalyzed silylation aliphatic ketone aminooxyamide auxiliary; beta silyl ketone preparation.

A Pd-catalyzed β-C(sp3)-H silylation of aliphatic ketones with disilanes to afford β-silyl ketones is reported. The aminooxyamide auxiliary is critical for the C-H activation and silylation. The reaction tolerates a number of functional groups and shows good selectivity in silylating β-C(sp3)-H bonds in the company of C(sp2)-H bonds and acidic α-C(sp3)-H bonds. The reaction is scalable, and the aminooxyamide auxiliary is readily removed to give β-silyl ketones, which could serve as useful building blocks for organic synthesis. Late-stage diversification using this protocol is demonstrated in the silylation of santonin with good yield.

Organic Letters published new progress about Aliphatic ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kavouridis, Vasileios K.; Ligon, Keith L.; Wen, Patrick Y.; Iorgulescu, J. Bryan published the artcile< Survival outcomes associated with MGMT promoter methylation and temozolomide in gliosarcoma patients>, Synthetic Route of 112-63-0, the main research area is Chemotherapy; Glioblastoma; Gliosarcoma; MGMT promoter methylation; Temozolomide.

Abstract: Purpose: Gliosarcoma is an uncommon glioblastoma subtype, for which MGMT promoter methylation′s relationship with response to temozolomide chemotherapy is unclear. We therefore examined this question using a national cohort. Methods: The National Cancer Database was queried for patients histopathol. diagnosed with gliosarcoma between 2010 and 2019. The associations between MGMT promoter methylation, first-line single-agent chemotherapy-presumed to be temozolomide herein-and overall survival (OS) were examined using log-rank tests and Cox regression, with correction for multiple testing (p < 0.01 was significant). Results: 580 newly-diagnosed gliosarcoma patients with MGMT status were available, among whom 33.6% were MGMT promoter methylated. Median OS for gliosarcoma patients that received standard-of-care temozolomide and radiotherapy was 12.1 mo (99% confidence interval [CI] 10.8-15.1) for MGMT promoter unmethylated and 21.4 mo (99% CI 15.4-26.2) for MGMT promoter methylated gliosarcomas (p = 0.003). In multivariable anal. of gliosarcoma patients-which included the potential confounders of age, sex, maximal tumor size, extent of resection, and radiotherapy-receipt of temozolomide was associated with improved OS in both MGMT promoter methylated (hazard ratio [HR] 0.23 vs. no temozolomide, 99% CI 0.11-0.47, p < 0.001) and unmethylated (HR 0.50 vs. no temozolomide, 99% CI 0.29-0.89, p = 0.002) gliosarcomas. MGMT promoter methylation was associated with improved OS among temozolomide-treated gliosarcoma patients (p < 0.001), but not in patients who did not receive chemotherapy (p = 0.35). Conclusion: In a national anal. of gliosarcoma patients, temozolomide was associated with prolonged OS irresp. of MGMT status. These results provide support for the current practice of trimodal therapy for gliosarcoma. Journal of Neuro-Oncology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Morgan, Alexander B.; Jurs, Joshua L.; Tour, James M. published the artcile< Synthesis, flame-retardancy testing, and preliminary mechanism studies of nonhalogenated aromatic boronic acids: a new class of condensed-phase polymer flame-retardant additives for acrylonitrile-butadiene-styrene and polycarbonate>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is aromatic boronic acid flame retardant preparation; polycarbonate benzenediboronic acid fire resistance; ABS aromatic boronic acid flame retardancy mechanism.

This study describes the syntheses and thermal properties of aromatic boronic acids and their use as flame retardants. The possible flame-retardancy mechanisms are also discussed. The materials were synthesized from aromatic bromides using one of two procedures. The first procedure involved traditional approaches to boronic acids, using lithium-halogen exchange and quenching with trimethylborate followed by hydrolysis. The second procedure used a nickel catalyst and a dialkoxy borane to generate aromatic dialkoxyboronates that were converted to boronic acids by acid hydrolysis. The thermal properties of these aromatic boronic acids were studied using differential scanning calorimetry (DSC) and thermal gravimetric anal. (TGA). These materials were blended into acrylonitrile-butadiene-styrene (ABS) and polycarbonate (PC) resins and tested for ignition resistance, using the UL-94 flame test. A 10 wt % loading of 1,4-benzenediboronic acid in polycarbonate gave a UL-94 V-0 result. This same diboronic acid showed flame retardancy and char formation in ABS, but this result was not quantifiable by the UL-94 test. Burn times for the ABS samples often exceeded 5 min, thereby showing unusual resistance to consumption by fire.

Journal of Applied Polymer Science published new progress about Catalysts. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics