Tag: M.W=250-300

Yoon, Chong-Bok; Shim, Hong-Ku published the artcile< New second-order nonlinear optical (NLO) epoxy polymer treated by sol-gel processing>, Electric Literature of 112-63-0, the main research area is nonlinear optical epoxy resin preparation.

The authors have demonstrated a novel approach to achieve a stable second-order NLO polymer by incorporating NLO moieties into a processable epoxy polymer and hardening with crosslinkable sol-gel technique. The crosslinked polymer showed high nonlinearity (d33 = 41 pm/V) and better thermal stability compared to the prepolymer, which maintained its nonlinearity up to 100° without significant loss of NLO activity.

Macromolecular Chemistry and Physics published new progress about Epoxy resins Role: PRP (Properties), SPN (Synthetic Preparation), TEM (Technical or Engineered Material Use), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fattore, Luigi; Malpicci, Debora; Milite, Ciro; Castellano, Sabrina; Sbardella, Gianluca; Botti, Gerardo; Ascierto, Paolo A.; Mancini, Rita; Ciliberto, Gennaro published the artcile< Reverse transcriptase inhibition potentiates target therapy in BRAF-mutant melanomas: effects on cell proliferation, apoptosis, DNA-damage, ROS induction and mitochondrial membrane depolarization>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is melanoma BRAF reverse transcriptase target therapy apoptosis DNA damage; DSBs; Drug resistance; Melanoma; Mitochondrial membrane depolarization; Reverse transcriptase inhibitors; Target therapy.

Abstract: Target therapies based on BRAF and MEK inhibitors (MAPKi) have changed the therapeutic landscape for metastatic melanoma patients bearing mutations in the BRAF kinase. However, the emergence of drug resistance imposes the necessity to conceive novel therapeutic strategies capable to achieve a more durable disease control. Their activation can be efficiently controlled with reverse transcriptase inhibitors (RTIs) frequently used in the treatment of AIDS. These drugs have demonstrated anti-proliferative effects in several cancer models, including also metastatic melanoma. However, to our knowledge no previous study investigated the capability of RTIs to mitigate drug resistance to target therapy in BRAF-mutant melanomas. In this short report we show that the non-nucleoside RTI, SPV122 in combination with MAPKi strongly inhibits BRAF-mutant melanoma cell growth, induces apoptosis, and delays the emergence of resistance to target therapy in vitro. Mechanistically, this combination strongly induces DNA double-strand breaks, mitochondrial membrane depolarization and increased ROS levels. Our results shed further light on the mol. activity of RTI in melanoma and pave the way to their use as a novel therapeutic option to improve the efficacy of target therapy. [media not available: see fulltext] Graphical abstract: [graphic not available: see fulltext].

Cell Communication and Signaling published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kuwano, Ryoichi; Ikeda, Ryuhei; Hirasada, Kazuki published the artcile< Catalytic asymmetric hydrogenation of quinoline carbocycles: unusual chemoselectivity in the hydrogenation of quinolines>, Application of C19H34O2, the main research area is chiral ruthenium catalyst stereoselective hydrogenation quinoline; tetrahydroquinoline stereoselective preparation.

The reduction of quinolines selectively took place on their carbocyclic rings to give 5,6,7,8-tetrahydroquinolines, when the hydrogenation was conducted in the presence of a Ru(η3-methallyl)2(cod)-PhTRAP catalyst. The chiral ruthenium catalyst converted 8-substituted quinolines into chiral 5,6,7,8-tetrahydroquinolines with up to 91 : 9 er.

Chemical Communications (Cambridge, United Kingdom) published new progress about Enantioselective synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Karami, Afshin; Hossienpour, Maryam; Mohammadi Noori, Ehsan; Rahpyma, Mehdi; Najafi, Khadijeh; Kiani, Amir published the artcile< Synergistic Effect of Gefitinib and Temozolomide on U87MG Glioblastoma Angiogenesis>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is gefitinib temozolomide glioblastoma angiogenesis synergistic effect.

One of the most common and deadly brain tumors is Glioblastoma multiforme (GBM). Due to recent advances in angiogenesis and its related key factors, this process as a hallmark in glioblastoma has attracted more consideration from the research community. Temozolomide (TMZ) as the first-line treatment used to treat GBM but, resistance to TMZ limits its effectiveness and the need for better treatments is still felt. Therefore, we aimed to examine the Synergistic effects of Gefitinib (GFI) in combination with Temozolomide on VEGF and MMPs in glioma cell line (U87MG). Our results displayed that GFI could induce cytotoxic effects in U87MG with IC50 values of 11 μM. U87MG cells produced large amounts of VEGF without any stimuli, and the results showed that GFI in combination with TMZ caused a significant decrease in VEGF production in these cells. In this study, we demonstrated that after treating with TMZ and GFI, there was more decrease in the levels of MMP 2 and 9 secretions in cells than treatment with GFI and TMZ doses alone. This study indicates synergistic effects of GFI plus TMZ against glioma are mediated by the potentiated anti-angiogenesis. Therefore, it can be considered as a promising plan for future studies.

Nutrition and Cancer published new progress about Angiogenesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Huan-Ming; Bellotti, Peter; Erchinger, Johannes E.; Paulisch, Tiffany O.; Glorius, Frank published the artcile< Radical Carbonyl Umpolung Arylation via Dual Catalysis>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is aryl benzoate preparation; aldehyde aryl bromide carbonyl umpolung arylation nickel catalyst photoredox.

A series of aryl benzoates I [R = iPr, tBu, cyclohexyl, etc.; R1 = 4-NCC6H4, 2-NCC6H4, 2-pyridyl, etc.] via dual nickel and photoredox catalyzed radical carbonyl umpolung arylation of aldehydes and aryl bromides was reported. This redox-neutral approach provided a complementary method to construct Grignard-type products from (hetero)aryl bromides and aliphatic aldehydes, without the need for prefunctionalization. Sequential activation, hydrogen atom transfer and halogen atom transfer process could directly converted aldehydes to the corresponding ketyl radicals, which further react with aryl-nickel intermediates in an overall polarity-reversal process. This radical strategy tolerated-among others-acidic functional groups, heteroaryl motifs and sterically hindered substrates and was applied in the late-stage modification of drugs and natural products.

Journal of the American Chemical Society published new progress about Aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bezerra, Rita de Cassia de Freitas; Rodrigues, Francisco Eduardo Arruda; Arruda, Tathilene Bezerra Mota Gomes; Moreira, Francisca Belkise de Freitas; Chaves, Pedro Oribio Bastos; Assuncao, Joao Carlos da Costa; Ricardo, Nagila Maria Pontes Silva published the artcile< Babassu-oil-based biolubricant: Chemical characterization and physicochemical behavior as additive to naphthenic lubricant NH-10>, SDS of cas: 112-63-0, the main research area is oil naphthenic lubricant additive physicochem behavior.

In the search of new bioproducts, which could substitute petroleum derivatives and with capability to attend industrial demand, the present research reports the synthesis of babassu-oil-based biolubricant (Orbignya speciosa M), its characterization, and the impact in mineral lubricant properties when the biolubricant was used as additive. The botanical species was submitted to chromatog. anal., and the oil content was predominantly saturated Spectroscopy anal. confirmed the success of the reaction, and the biolubricant consisted of a mixture of mono, di and tri esters of trimethylolpropane. The thermogravimetric behavior of the babassu biolubricant was also studied. The gaseous products evolved during the process were analyzed by IR spectroscopy and the volatilization and combustion process could be described. Blends between babassu biolubricant and mineral basic oil NH-10 were prepared in the proportions of 3, 5 and 10% volume/volume, and physicochem. properties as specific mass, kinematic viscosity at 40 and 100 °C, and flow point were evaluated. For the proportions used in the evaluation, babassu biolubricant could be pointed as a secure additive for mineral oil lubricant NH-10. The characterization of babassu biolubricant, the thermogravimetric behavior, and spectroscopy anal. of the gaseous products evolved, as well as the use as a possible additive and points to a possible use for biolubricants.

Industrial Crops and Products published new progress about Attalea speciosa. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Crispino, Gerard A.; Jeong, Kyu Sung; Kolb, Hartmuth C.; Wang, Zhi Min; Xu, Daqiang; Sharpless, K. Barry published the artcile< Improved enantioselectivity in asymmetric dihydroxylations of terminal olefins using pyrimidine ligands>, Synthetic Route of 112-63-0, the main research area is enantioselectivity dihydroxylation olefin pyrimidine ligand; asym dihydroxylation olefin pyrimidine ligand; diol asym synthesis.

A new class of cinchona alkaloid derivatives, 2,5-diphenyl-4,6-bis(9-O-dihydroquinidyl)pyrimidine and its pseudoenantiomer 2,5-diphenyl-4,6-bis(9-O-dihydroquinyl)pyrimidine, was found to give improved enantioselectivity in the osmium catalyzed asym. dihydroxylation of mono-substituted terminal olefins. Mol. modeling and ligand structural variation studies were carried out in an attempt to understand the high enantioselectivities observed

Journal of Organic Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Ming; Gao, Bin; Yao, Ying; Xue, Yingwen; Inyang, Mandu published the artcile< Synthesis, characterization, and environmental implications of graphene-coated biochar>, Computed Properties of 112-63-0, the main research area is synthesis characterization graphene coated biochar.

The biochar technol. was combined with the emerging graphene technol. to create a new engineered graphene-coated biochar from cotton wood. The biomass feedstock was 1st treated with graphene/pyrene-derivative and was then annealed at 600° in a quartz tube furnace under N environment. Laboratory characterization with different microscopy and spectrometry tools showed that the graphene sheets were soldered by the pyrene mols. on the biochar surface during the annealing process. Thermogravimetric anal. showed that the graphene skin could improve the thermal stability of the biochar, making the engineered biochar a better C sequester for large scale land applications. Batch sorption exptl. results indicated that the graphene-coated biochar has excellent adsorption ability of polycyclic aromatic hydrocarbons (PAHs) with a maximum Methylene Blue adsorption capacity of 174 mg/g, which is >20 times higher than that of the unmodified cotton wood biochar and comparable to those of some phys. or chem. activated carbons. The enhanced adsorption of Methylene Blue on the graphene-coated biochar is mainly controlled by the strong π-π interactions between aromatic mols. and the graphene sheets on biochar surface. It is anticipated that this novel, facile, and low-cost method can be expanded to other C-rich materials to create engineered biochar for various environmental applications.

Science of the Total Environment published new progress about Adsorptive wastewater treatment. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sehaki, Chabha; Jullian, Nathalie; Choque, Elodie; Dauwe, Rebecca; Fontaine, Jean Xavier; Molinie, Roland; Ayati, Fadila; Fernane, Farida; Gontier, Eric published the artcile< Profiling of Essential Oils from the Leaves of Pistacia lentiscus Collected in the Algerian Region of Tizi-Ouzou: Evidence of Chemical Variations Associated with Climatic Contrasts between Littoral and Mountain Samples>, Electric Literature of 112-63-0, the main research area is Pistacia lentiscus leaf essential oil chem variation; Pistacia lentiscus; antioxidant activity; essential oil; fatty acid.

Leaves of Pistacia lentiscus were collected from two Algerian sites in the mountains and the littoral of the Tizi-Ouzou region. The harvest was conducted in four consecutive seasons on the same selected set of trees. Essential oils (EOs) were extracted by hydrodistillation; then, they were analyzed by gas chromatog. coupled mass spectrometry (GC-MS). Forty-seven constituents could be detected and quantified, including α-pinene (2-13%), β-caryophyllene (8-25%), β-myrcene (0.3-19%), bornyl acetate (0.8-7%), δ-cadinene (3-8%), bisabolol (1-9%), β-pinene (0.9-7%), caryophyllene oxide (4-9%), and α-cadinol (3-11%). Antioxidant (AOx) activities of the EOs were assessed by ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and 2,2 ‘-azino-bis (3-ethylbenzothiazoline)-6-sulfonic acid (ABTS) assays. Significant differences in EO composition and AOx activities appeared dependent on the season and the site. Variations of AOx activities were significant for the FRAP and ABTS tests but not for DPPH. Characterization of the leaf fatty acyl (FA) profiles was performed by GC-MS. Variability appeared according to season and altitude. Polyunsaturated fatty acids levels were high (27-55%) at the coldest date and place. The levels of linolenic acyl in the leaves were significantly correlated with bisabolol levels in the EOs (Spearman’s correlation coefficient: 0.818). Such results will be useful for the sustainable local valorization of wild P. lentiscus. These data also open new routes for further studies on terpenoid biosynthesis using correlation networks and fluxomic approaches.

Molecules published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Zhi-Min; Zhang, Qing-Wei; Chen, Zhi-Hua; Li, Hui; Tu, Yong-Qiang; Zhang, Fu-Min; Tian, Jin-Miao published the artcile< Organocatalytic Asymmetric Halogenation/Semipinacol Rearrangement: Highly Efficient Synthesis of Chiral α-Oxa-Quaternary β-Haloketones>, Electric Literature of 112-63-0, the main research area is dihydropyranyl diarylmethanol cinchona alkaloid diastereoselective enantioselective halogenation semipinacol rearrangement; beta haloketone chiral halotetrahydropyranyl ketone stereoselective preparation; diastereoselective enantioselective halogenation semipinacol rearrangement catalyst cinchona alkaloid.

A novel asym. halogenation/semipinacol rearrangement reaction catalyzed by cinchona alkaloid derivatives was developed. Two types of β-haloketones (X = Br, Cl) were obtained with up to 95% yield and 99% enantiomeric excess. The desired (+) and (-) enantiomers of the β-haloketones were readily obtained.

Journal of the American Chemical Society published new progress about Aralkyl alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (dihydropyranyl). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics