Tag: M.W=250-300

Gadekar, Santosh C.; Dhayalan, Vasudevan; Nandi, Ashim; Zak, Inbal L.; Mizrachi, Meital Shema; Kozuch, Sebastian; Milo, Anat published the artcile< Rerouting the Organocatalytic Benzoin Reaction toward Aldehyde Deuteration>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is aldehyde deuteration rerouting organocatalytic benzoin reaction.

Herein, studies aimed at stabilizing reactive intermediates in the N-heterocyclic carbene (NHC) catalytic cycle was described, which enabled the full shutdown of the known benzoin coupling pathway, while rerouting its intermediates toward deuteration. The reversible nature of NHC catalysis and the selective stabilization of reaction intermediates facilitated clean hydrogen-deuterium exchange reactions of aromatic aldehydes by D2O, even for challenging electron-withdrawing substrates. In several cases, the addition of catalytic amounts of Ph boronic acid was used to further stabilize highly reactive intermediates and mitigate the formation of benzoin coupling byproducts. The mechanistic understanding at the foundation of this work resulted in unprecedented mild conditions with base and catalyst loadings as low as 0.1 mol %, and a scalable deuteration reaction applicable to a broad substrate scope with outstanding functional group tolerance. More importantly, adopting this approach enabled the construction of a guideline for identifying the appropriate catalyst and conditions for different substrates. Exptl. studies combined with machine learning and computational methods shed light on the nontrivial mechanistic underpinnings of this reaction.

ACS Catalysis published new progress about Aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thio, Joanne P.; Liang, Christopher; Bajwa, Alisha K.; Wooten, Dustin W.; Christian, Bradley T.; Mukherjee, Jogeshwar published the artcile< Synthesis and evaluation of mefway analogs as ligands for serotonin 5HT1A receptors>, Reference of 112-63-0, the main research area is mefway analog preparation serotonin 5HT1A receptor ligand; Mefway; PET imaging; Serotonin.

18F-Mefway (N-{2-[4-(2′-methoxyphenyl)piperazinyl]ethyl}-N-(2-pyridyl)-N-(4′-18F-fluoro-methylcyclohexane)carboxamide) (I) was developed and evaluated for use as a PET ligand for imaging 5-HT1A receptors. Ongoing studies of 18F-Mefway have shown it to be an effective PET radiotracer. We have synthesized isomers of Mefway by changing the position of the Me group in attempts to evaluate stability for imaging purposes. 2-Methyl-, 3-methyl-, and 4-methyl-cyclohexane-1-carboxylic acids and 3-carbomethoxy-, 4-carbomethoxycyclohexane-1-carboxylic acids were coupled with WAY-100634 to provide the methylcyclohexyl derivatives (2-, 3-, and 4-methyl). Mefway and 3-Mefway analogs were prepared by reduction of carbomethoxy- derivatives followed by fluorination. In vitro binding affinities for the methylated derivatives in rat brain homogenates were found to be 10.4 nM (2-methyl), 77 nM (3-methyl), and 21.5 nM (4-methyl). Binding affinity of 3-Mefway and 4-Mefway was found to be 17.4 nM and 6.26 nM, resp. Our results suggest that 3-methyl/3-fluoromethyl substituent has approx. threefold lower affinities compared to the 4-methyl/4-fluoromethyl substituent.

Medicinal Chemistry Research published new progress about 5-HT1A receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Dan; Cheng, Shiping; Zou, Guoming; Ding, Xiongfei published the artcile< Paeoniflorin inhibits proliferation and migration of psoriatic keratinocytes via the lncRNA NEAT1/miR-3194-5p/Galectin-7 axis>, COA of Formula: C19H34O2, the main research area is keratinocyte proliferation migration paeoniflorin lncRNA NEAT1 microRNA3194 5p Galectin7.

To investigate the mechanism underlying the effect of paeoniflorin (PF) on the proliferation and migration of psoriatic keratinocytes. The expressions of long noncoding RNA NEAT1, miR-3194-5p and Galectin-7 in skin tissues from psoriatic patients and healthy controls were detected. Psoriatic HaCat cells were used to investigate the function of NEAT1 and Galectin-7 as well as the effect and mechanism of PF in psoriasis. MTT, colony formation and scratch assays were used to assess the proliferation and migration of psoriatic HaCat cells. Dual-luciferase reporter assay was used to validate the interactions among NEAT1, miR-3194-5p and Galectin-7. NEAT1 and Galectin-7 were lowly expressed and miR-3194-5p was highly expressed in psoriatic patients. PF suppressed the proliferation and migration of psoriatic HaCat cells by elevating the expressions of NEAT1 and Galectin-7. NEAT1 pos. mediated the expression of Galectin-7 by targeting miR-3194-5p. PF controls the proliferation and migration of psoriatic HaCat cells via the NEAT1/miR-3194-5p/Galectin-7 axis.

Anti-Cancer Drugs published new progress about Cell migration. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Meng, Fan-Bing; Zhou, Li; Li, Jia-Jia; Li, Yun-Cheng; Wang, Meng; Zou, Long-Hua; Liu, Da-Yu; Chen, Wei-Jun published the artcile< The combined effect of protein hydrolysis and Lactobacillus plantarum fermentation on antioxidant activity and metabolomic profiles of quinoa beverage>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Lactobacillus plantarum fermentation antioxidant activity metabolomic profiles quinoa beverage; Antioxidant activity; Lactobacillus plantarum fermentation; Nontargeted metabolomics; Protein hydrolysis; Quinoa beverage.

Lactic acid bacteria fermentation is a commonly applied technique to produce nutritional, functional, and organoleptic enhanced foods. In the present study, protein hydrolysis and Lactobacillus plantarum fermentation were coupled to develop quinoa beverages. Protein hydrolysis effectively promoted the growth and fermentation of L. plantarum. Fermentation alone did not significantly improve antioxidant activity, but the combined use of protein hydrolysis and L. plantarum fermentation significantly improved the antioxidant activity of the quinoa beverage. Nontargeted metabolomics based on UHPLC-Q Exactive HF-X/MS and multivariate statistical anal. were performed to reveal the metabolite profile alterations of the quinoa beverage by different processing methods. A total of 756 metabolites were identified and annotated, which could be categorized into 12 different classes. The significant differentially abundant metabolites were mainly involved in primary metabolite metabolism and secondary metabolite biosynthesis. Many of these metabolites were proven to be vitally important to the function and taste formation of the quinoa beverage. Most importantly, the coupled use of protein hydrolysis and L. plantarum fermentation significantly increased some functional ingredients compared with protein hydrolysis and L. plantarum fermentation alone. The above results indicate that protein hydrolysis coupled with L. plantarum fermentation is an effective strategy to develop functional quinoa beverages.

Food Research International published new progress about Amino acids Role: FFD (Food or Feed Use), BIOL (Biological Study), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bila, Jose L.; Pijeat, Joffrey; Ramorini, Andrea; Fadaei-Tirani, Farzaneh; Scopelliti, Rosario; Baudat, Emilie; Severin, Kay published the artcile< Porous networks based on iron(II) clathrochelate complexes>, Related Products of 112-63-0, the main research area is iron boronate ester clathrochelate polymer preparation microporosity; crystal structure iron boronate ester clathrochelate.

Microporous networks based on boronate ester-capped iron(II) clathrochelate complexes are described. The networks were obtained by covalent crosslinking of tetrabrominated clathrochelate complexes via Suzuki-Miyaura polycross-coupling reactions with diboronic acids, or by Sonogashira-Hagihara polycross-coupling of clathrochelate complexes with terminal alkyne functions and 1,3,5-tribromobenzene. The networks display permanent porosity with apparent Brunauer-Emmett-Teller surface areas of up to SABET = 593 m2 g-1. A clathrochelate complex based on an enantiopure dioximato ligand was used to prepare chiral networks. One of these networks was shown to preferentially absorb D-tryptophan over L-tryptophan.

Dalton Transactions published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Jia-Sheng; Liu, Yuan; Shi, Rong; Lu, Xiong; Ma, Yue-Ming; Cheng, Neng-Neng published the artcile< Effects of combinations of Xiexin decoction constituents on diabetic nephropathy in rats>, Synthetic Route of 112-63-0, the main research area is xiexin decoction constituent diabetic nephropathy effect renoprotectant natural pharmaceutical; Baicalein (PubChem CID: 5281605); Baicalin (PubChem CID: 64982); Berberine (PubChem CID: 2353); Coptisine (PubChem CID: 72322); Diabetic nephropathy; Jatrorrhizine (PubChem CID: 72323); Palmatine (PubChem CID: 19009); Rats; Xiexin decoction.

Xiexin decoction (XXD) has been used as a treatment for diabetes mellitus for more than 1300 years. XXD constituents with protective effects against diabetic nephropathy (DN) include Rhizoma Coptidis alkaloids (RA), Radix et Rhizoma Rhei polysaccharides (RP), and Radix Scutellaria flavones (RF). The aim of the study is to investigate the effects of combinations of RA, RP, and RF on DN and their mechanisms of action. In vitro, high glucose-induced rat mesangial cells were treated with RA, RP, RF, and combinations thereof. Cell proliferation and levels of inflammatory factors were measured. In vivo, high-fat diet and streptozotocin-induced diabetic rats were treated with different combinations of RA, RP, and RF once per day for 12 wk. Blood and urine biochem. parameters, renal tissue morphol., and inflammation were investigated. In vitro, the combination of the three groups of components inhibited mesangial cell proliferation and reduced the levels of monocyte chemotactic protein-1 (MCP-1) and collagen IV. The effects of the three constituent groups in combination were stronger than those of each group alone or combinations of two groups. In diabetic rats, combinations of the three groups of herb components ameliorated blood glucose, urinary albumin excretion and decreased renal mesangial matrix expansion and basement membrane thickening. In addition, the combinations reduced renal tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) protein levels, down-regulated the expression of nuclear factor κB (NF-κB) and transforming growth factor beta 1 (TGF-β1), and up-regulated the expression of inhibitor of nuclear factor κB (IκB) protein. Among the three groups of herb components, RA produced the strongest effects, followed by RP, and then by RF. The combination of the three groups of herb components produced anti-DN effects through inhibition of inflammation mediated by NF-κB. Among the three groups of herb components, RA produced the strongest effect while RP and RF produced weaker effects.

Journal of Ethnopharmacology published new progress about Albumins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Weber, Simone Schneider; de Souza, Alessandra Carla Sampaio; Soares, Denise Caroline Luiz; Lima, Caroline Carvalho; de Moraes, Ana Carolina Rabello; Gkionis, Stephanie Viegas; Arenhart, Tanara; Rodrigues, Luiz Gustavo Goncalves; Ferreira, Sandra Regina Salvador; Pedrosa, Rozangela Curi; Silva, Denise Brentan; Paredes-Gamero, Edgar Julian; Perdomo, Renata Trentin; Parisotto, Eduardo Benedetti published the artcile< Chemical profile, antimicrobial potential, and antiaggregant activity of supercritical fluid extract from Agaricus bisporus>, COA of Formula: C19H34O2, the main research area is Agaricus chem profile antimicrobial antiaggregant anticoagulant.

Mushrooms are known for their medicinal value and health benefits, particularly the species Agaricus bisporus, which is rich in bioactive components. However, there are difficulties in determining bioactive compounds, as different extraction methods are rarely investigated and may yield extracts with different chem. profiles. For food and pharmaceutical applications, the toxicity of residual solvents must also be considered. This study aimed to (i) prepare A. bisporus extracts by supercritical fluid extraction (40 °C and 20 MPa-SFE1 or 30 MPa-SFE2) and conventional organic solvent extraction (COSE) with ethanol, (ii) compare the yield and chem. profile of extracts, and (iii) evaluate their antimicrobial, antiaggregant, and anticoagulant activities. The major compounds identified were two fatty acid Me esters (relative content greater than 40%): Me (E,E)-9,12-octadecadienoate (Me linoleate) and Me (Z)-9-octadecenoate (Me oleate). Me hexadecanoate and Me octadecanoate, two esters derived from palmitic acid, were also present in the extracts but at lower concentrations in terms of peak area percentage. Extracts obtained by SFE had low min. inhibitory concentrations (MIC) (75-500 μg/mL) against bacteria, being classified as strong inhibitors. On the other hand, MIC values of the extract obtained by COSE against Staphylococcus aureus and Staphylococcus epidermidis were higher than 2,000 μg/mL (weak inhibitor). COSE extract was not active against Gram-neg. bacteria. The antiplatelet aggregation effect of SFE extracts was higher than that of COSE extract In the face of ADP (ADP), COSE, SFE1, and SFE2 resulted in a 7%, 18%, and 12% decrease in platelet aggregation, resp. In the aggregation triggered by epinephrine, platelet aggregation decreased by 10%, 15%, and 18%, resp. Overall, A. bisporus extracts obtained by SFE showed the best performance in bioactive screening assays compared with the conventional ethanolic extract

Chemical Papers published new progress about Agaricus bisporus. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nguyen, L. H. B.; Picard, T.; Sergent, N.; Raynaud, C.; Filhol, J.-S.; Doublet, M.-L. published the artcile< Investigation of alkali and alkaline earth solvation structures in tetraglyme solvent>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is alkali alk earth ion solvation tetraglyme solvent DFT functional.

This study compares mol. calculations performed with mol. and periodic codes through an investigation of the solvation structures of alkali and alk. earth metal ions in tetraglyme solution The two codes are able to produce equivalent structural and energetic information at the same level of theory, and in the presence of the implicit solvation model or not. This comparison reveals that mol. optimizations can be performed with periodic codes and used directly as input models for interface or electrochem. calculations in order to preserve the solvent-solute interaction and the cavitation energy. By a rigorous comparison, we have demonstrated that equivalent energetic values can be obtained with the conventional PBE-D3 and the newly developed SCAN-rVV10 functionals. Nevertheless, as far as the vibrational features are concerned and when the mol. possesses a highly conjugated system, the SCAN-rVV10 functional is required to describe the vibrational modes properly. The computed IR/Raman spectra can thus be used as essential information to determine the first solvation shell of metal ions in glyme-based solutions In tetraglyme solution, the alkali and alk. earth metal ions exhibit a diverse solvation structure. Small ions like Li+ and Mg2+ tend to adopt a coordination number of five or six, while larger ions, Na+, K+, and Ca2+, prefer an eight-coordinated environment, and the metal-ligand interaction increases in the order K+-O < Na+-O < Li+-O < Ca2+-O < Mg2+-O. The solvation spheres play a significant role in the stability and the reactivity of the solvated ions, and can thus be used as input models to construct the solvation structure in more sophisticated electrolytes, such as polyethylene oxide, or perform electrochem. calculations Physical Chemistry Chemical Physics published new progress about Alkali metal ions. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Jun-lin; Hu, Ling-ling; Cai, Zeng-xuan; Li, Jin; Ren, Yi-ping published the artcile< Comparison and assessment of aflatoxins determination by ultra-pressure liquid chromatography>, Synthetic Route of 112-63-0, the main research area is UPLC trifluoroacetic acid aflatoxin purification food analysis contamination.

Objective: To compare and evaluate several methods for determination of aflatoxins by ultra- pressure liquid chromatog. (UPLC) combined with fluorescence detection (FLD). Methods: Samples were extracted by homogeneity (vortex) and ultrasound-assisted liquid-liquid extraction, and purified by immunoaffinity column and multifunctional column. Then the analytes were analyzed by UPLC-FLD with trifluoroacetic acid (TFA) pre-column derivation, photochem. post column derivation, iodine and bromine post column derivation, large volume flow cell and photochem. post column derivation tandem large volume flow cell. Results: The results showed each method was satisfying, and each method could fulfill the inspection requirements of common samples. Conclusion: The method of UPLC combined with fluorescence detector and large volume flow cell had the highest sensitivity among these methods. This method could not only raise the work efficiency, but also reduce a lot of poisonous and harmful organic solvent. Meanwhile, the method successfully fulfilled the min. limiting level requests according to the GB 2761-2011. Both acetonitnle aqueous solution and methanol aqueous solution could extract the aflatoxins from samples successfully. And the cleanup effect of immunoaffinity column achieved better results than that of multifunctional column.

Shipin Anquan Zhiliang Jiance Xuebao published new progress about Corn. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Ruonan; Shen, Chenlin; Xu, Qingqing; Liu, Yaru; Li, Bo; Huang, Cheng; Ma, Taotao; Meng, Xiaoming; Wu, Maomao; Li, Jun published the artcile< The permeability characteristics and interaction of main components from Si-Ni-San in a MDCK epithelial cell monolayer model>, Category: esters-buliding-blocks, the main research area is SiNiSan permeability main component interaction MDCK monolayer epithelial cell; MDCK cell; MRP2; P-gp; Si-Ni-San; efflux; tight junctions.

Si-Ni-San (SNS) possesses extensive therapeutic effects, however, the extent to which main components are absorbed and the mechanisms involved are controversial. In this study, MDCK cell model was used to determine the permeability characteristics and interaction between the major components of Si-Ni-San, including saikosaponin a, paeoniflorin, naringin and glycyrrhizic acid. The transport of the major components was concentration-dependent in both directions. Moreover, the transport of paeoniflorin, naringin and glycyrrhizic acid was significantly reduced at 4°C or in the presence of NaN3. Addnl., the efflux of paeoniflorin and naringin were apparently reduced in the presence of P-gp inhibitor verapamil. The transport of glycyrrhizic acid was clearly inhibited by the inhibitors of MRP2, indicating that MRP2 may be involved in the transport of glycyrrhizic acid. However, the results indicated that saikosaponin a was absorbed mainly by passive diffusion. Furthermore, the combined incubation of four major components had a powerful sorbefacient effect than a single drug used alone which may be regulated by tight junctions. Taken together, our study provides useful information for pharmacol. applications of Si-Ni-San and offers new insights into this ancient decoction for further researches, especially in drug synergism.

Xenobiotica published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics