Tag: M.W=250-300

Badali, Mohammad; Khalafy, Jabbar; Alidoost, Elnaz; Aghazadeh, Masomeh published the artcile< Ammonium hydrotribromide salts as convenient and selective brominating agents of aryl methyl ketones>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is aryl ketone ammonium hydrotribromide salt monobromination regioselective; bromo ketone preparation.

A simple and improved protocol for the α-monobromination of acetophenone and acetyl carbazole derivatives using different ammonium hydrotribromide salts under mild reaction condition was described.

Journal of the Chemical Society of Pakistan published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bradsher, C. K.; Gross, P. M.; Hobbs, M. E.; Kittila, R. S.; Rapoport, L.; Tarrant, P.; West, G. published the artcile< Chloro- and dichlorobis(trichloromethyl)benzenes>, Electric Literature of 112-63-0, the main research area is .

1,3-C6H4(CCl3)2 (I) (243 g.) and 0.25 g. Fe filings, chlorinated (5 hrs.) at 115-25°, give 73 g. 5-chloro-1,3-bis(trichloromethyl)benzene (II), m. 77-8°; hydrolysis gives 5,1,3-ClC6H3(CO2H)2, whose di-Me ester m. 79-80°. Dichlorination of I (10 hrs. at a temperature as high as 145°) or of II yields a di-Cl derivative, b9 184-9°, and a small quantity of 2,5,1,4-Cl2C6H2(CCl3)2, m. 191-2°. 2,1,3-ClC6H3Me2, chlorinated at 120-30° (Hg arc), gives 30% 2-chloro-1,3-bis(trichloromethyl)benzene (III), m. 136-7°. 4,1,3-ClC6H3Me2 yields 50% 4,1,3-ClC6H3(CCl3)2, b8.5 180-5°, and a small quantity of III. 4,1,3-FC6H3Me2 yields 82% 4-fluoro-1,3-bis(trichloromethyl)benzene, b11 157.5-9.5°. 2,1,4-ClC6H3Me2 yields 79% 2-chloro-1,4-bis(trichloromethyl)benzene, m. 78-80°.

Journal of the American Chemical Society published new progress about Chlorination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dong, Juan; Tian, Xin; Sun, Xiao-yi; Jiang, Wen-wei; Luo, Qin; Yang, Qin published the artcile< Study on synthesis technology of 4,6-dinitro-1,2,3-trichlorobenzene and waste acid recycling>, Reference of 112-63-0, the main research area is dinitrotrichlorobenzene waste acid recycling.

The nitration of 1,2,3-trichlorobenzene are studied in the binary system of sulfuric acid and nitric acid. The effect of molar ratio of raw materials, reaction temperature and reaction time on the yield are evaluated in the system of nitric acid/sulfuric acid. The optimum process parameters are selected in the system of 98% of sulfuric acid and 65% of nitric acid as follows: n(1,2,3-trichlorobenzene):n(sulfuric acid):n(nitric acid) = 1:11.3:2.3, reaction temperature 65°C and reaction time 4.5 h. The yield of 4,6-dinitro-1,2,3-trichlorbenzene is 93.95%. The concentration of waste acid can reach to about 95% by extracting and distilling in vacuo. Both the sulfuric acid and residue after recrystallization can be recycled as starting materials in another synthetic reaction of 4,6-dinitro-1,2,3-trichlorbenzene, the product is obtained in yields greater than about 94 mol percent with purity being greater than about 99w%, The structure of target product is characterized by IR, HPLC and Element anal.

Procedia Engineering published new progress about Nitrification. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Qian, Kun; Seifert, Soenke; Winans, Randall E.; Li, Tao published the artcile< Understanding Solvation Behavior of the Saturated Electrolytes with Small/Wide-Angle X-ray Scattering and Raman Spectroscopy>, Related Products of 112-63-0, the main research area is solvation behavior saturated electrolytes small wide angle XRS Raman.

Concentrated electrolytes are attracting significant attention because the solvation structures could stabilize the interface, encouraging novel electrolyte development for high-voltage and long-cycle-life batteries. Saturated electrolytes, which have the highest salt concentrations, have been rarely studied because of their shortcomings of high viscosity and low ionic conductivity Nevertheless, the exciting solvation structure in saturated solution is still worth studying, significantly broadening the comprehensive understanding of the solvation processes. In this work, we investigate the saturated lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) dissolved in seven different organic solvents, including propylene carbonate (PC), THF, acetonitrile (ACN), DMF, 1,2-dimethoxyethane (DME), diethylene glycol di-Me ether (Diglyme), and tetraethylene glycol di-Me ether (Tetraglyme). The combined small/wide-angle X-ray scattering and Raman spectroscopy are employed to study the global and local solvation structure. This work demonstrates a method for detecting the structure of liquids, which will facilitate the study of structure-performance relationships and the screening of new electrolytes.

Energy & Fuels published new progress about Batteries (high-voltage). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Giron-Callejas, Amalia; Garcia-Morales, Claudia; Mendizabal-Burastero, Ricardo; Meza, Rita I.; Sierra, Tomasa; Tapia-Trejo, Daniela; Perez-Garcia, Marissa; Quiroz-Morales, Veronica S.; Paredes, Mayte; Rodriguez, Alizon; Juarez, Sandra I.; Farach, Nasim; Videa, Geraldina; Lara, Bredy; Rodriguez, Edith; Ardon, Elvia; Sajquim, Edgar; Lorenzana, Rolando; Ravasi, Giovanni; Northbrook, Sanny; Reyes-Teran, Gustavo; Avila-Rios, Santiago published the artcile< High level of pre-treatment and acquired HIV drug resistance in Honduras: a nationally representative survey, 2016-17>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is nigh level pretreatment acquired HIV drug resistance.

Background: Pre-treatment HIV drug resistance (HIVDR) to NNRTIs has consistently increased in low-/middle-income countries during the last decade. Objectives: To estimate the prevalence of pre-treatment HIVDR and acquired HIVDR among persons living with HIV (PLHIV) on ART for 12 ± 3 mo (ADR12) and ≥48 mo (ADR48) in Honduras. Patients and methods: A nationwide cross-sectional survey with a two-stage cluster sampling was conducted from Oct. 2016 to Nov. 2017. Twenty-two of 54 total ART clinics representing >90% of the national cohort of adults on ART were included. HIVDR was assessed for protease and reverse transcriptase Sanger sequences using the Stanford HIVdb tool. Results: A total of 729 PLHIV were enrolled; 26.3% (95% CI 20.1%-33.5%) ART initiators reported prior exposure to antiretrovirals. Pre-treatment HIVDR prevalence was 26.9% (95% CI 20.2%-34.9%) to any antiretroviral and 25.9% (19.2%-33.9%) to NNRTIs. NNRTI pre-treatment HIVDR was higher in ART initiators with prior exposure to antiretrovirals (P = 0.001). Viral load (VL) suppression rate was 89.7% (85.1%-93.0%) in ADR12 and 67.9% (61.7%-73.6%) in ADR48. ADR12 to any drug among PLHIV with VL ≥1000 copies/mL was 86.1% (48.9%-97.6%); 67.1% (37.4%-87.5%) had HIVDR to both NNRTIs and NRTIs, and 3.8% (0.5%-25.2%) to PIs. ADR48 was 92.0% (86.8%-95.3%) to any drug; 78.1% (66.6%-86.5%) to both NNRTIs and NRTIs, and 7.3% (1.8%-25.1%) to PIs. Conclusions: The high prevalence of NNRTI pre-treatment HIVDR observed in Honduras warrants consideration of non-NNRTI-based first-line regimens for ART initiation. Programmatic improvements in HIVDR monitoring and adherence support may also be considered.

Journal of Antimicrobial Chemotherapy published new progress about Anti-HIV agents (anti-HIV-1 agents, anti-hiv-1 drugs). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dolan, Niamh; Gavin, Declan P.; Eshwika, Ahmed; Kavanagh, Kevin; McGinley, John; Stephens, John C. published the artcile< Synthesis, antibacterial and anti-MRSA activity, in vivo toxicity and a structure-activity relationship study of a quinoline thiourea>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is quinoline thiourea preparation antibacterial structure activity; Antibacterial; MRSA; Quinoline; Structure activity relationship; Thiourea.

We report the synthesis and antibacterial evaluation of a series of thiourea-containing compounds 1-[3,5-Bis(trifluoromethyl)phenyl]-[(quinuclidin-2-yl)methyl]thiourea I, was the most active against a range of Gram-pos. and Gram-neg. bacteria, and exhibited bacteriostatic activity against methicillin resistant Staphylococcus aureus (MRSA) comparable to that of the well-known antibacterial agent vancomycin. Quinoline thiourea I was subjected to a detailed structure-activity relationship study, with I and its derivatives evaluated for their bacteriostatic activity against both Gram-neg. and Gram-pos. bacteria. A number of structural features important for the overall activity of quinoline thiourea I have been identified. A selection of compounds, including I, was also evaluated for their in vivo toxicity using the larvae of the Greater wax moth, Galleria mellonella. Compound I, and a number of derivatives, were found to be non-toxic to the larvae of Galleria mellonella. A new class of antibiotic can result from the further development of this family of compounds

Bioorganic & Medicinal Chemistry Letters published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Charaschanya, Manwika; Maskrey, Taber S.; LaPorte, Matthew G.; Janjic, Jelena M.; Wipf, Peter published the artcile< Synthesis and optimization of nitroxide-based inhibitors of ferroptotic cell death in cancer cells and macrophages>, Computed Properties of 347174-05-4, the main research area is alkene peptide isostere synthesis nitroxide inhibitor ferroptotic cell death; peptide alkene enantioselective diastereoselective synthesis antitumor structure activity ferroptosis; vinylogous Mannich reaction cross metathesis drug desigh luminescence.

JP4-039 Is an alkene peptide isostere that acts as a low-micromolar inhibitor of erastin- and RSL-3-induced ferroptotic cell death in the HT-1080 cell line. In this work, we have developed new synthetic strategies that allow access to analogs of this lead structure. Enantioselective vinylogous Mannich or cross-metathesis reactions were key to the preparation of a series of analogs that culminated in the preparation of the ca. 30-fold more potent analog (I) (BOC = tert-butoxycarbonyl). Structure-activity relationship analyses used both HT-1080 cells and a luminescence-based ferroptosis assay in RAW 264.7 macrophages. In particular, α,α-disubstituted alkene peptide isosteres (Rα ≠ H) were found to exceed the potency of the corresponding glycine (Rα = H) derivatives

ACS Medicinal Chemistry Letters published new progress about Alkenes Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses) (peptides). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Computed Properties of 347174-05-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ohkubo, Mitsuru; Kuno, Atsushi; Nakanishi, Isao; Takasugi, Hisashi published the artcile< Studies on cerebral protective agents. VIII. Synthesis of 2-aminothiazoles and 2-thiazolecarboxamides with anti-anoxic activity>, Application of C19H34O2, the main research area is antianoxic aminothiazole thiazolecarboxamide structure cerebral protection; aminothiazole preparation antianoxic cerebral protection structure; thiazolecarboxamide preparation antianoxic cerebral protection structure.

Various 2-aminothiazoles and 2-thiazolecarboxamides, possessing a nitrogenous basic moiety at the C-2 position of the thiazole ring, were prepared and tested for anti-anoxic (AA) activity in mice. Among them, N-[2-(4-morpholinyl)ethyl]-4-(3-trifluoromethylphenyl)-2-thiazolecarboxyamide hydrochloride (FR108143) (min. EDs of 3.2 mg/kg i.p. and 10 mg/kg p.o., resp.) exhibited more potent AA activity than either FK360 or FR75039, each of which has a nitrogenous basic moiety at the C-5 position. The structure-activity relationships with regard to AA activity of this series of compounds are discussed, and the three-dimensional electrostatic potentials (3D-MEP) around the basic nitrogen atom of FK360 and the thiazole derivative (FR108143) are compared.

Chemical & Pharmaceutical Bulletin published new progress about Electrostatic potential. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Du, Zheng-Cai; Xia, Zhong-Shang; Huang, Yan-Feng; Peng, Yi; Cao, Bing-Bing; Li, Chun-Qi; Liang, Yun-Fei; Zhao, Fang-Hui; Zhang, Ming-Zhe; Chen, Zhang-Mei; Hou, Xiao-Tao; Hao, Er-Wei; Deng, Jia-Gang published the artcile< Cardiotoxicity induced by Cochinchina momordica seed extract in zebrafish>, Synthetic Route of 112-63-0, the main research area is zebrafish cardiotoxicity cochinchina momordica seed extract; CMSE; apoptosis; cardiotoxicity; inflammation; oxidative stress; zebrafish.

Momordica cochinchinensis (Lour.) Spreng is an indigenous South Asian edible fruit, and seeds of Momordica cochinchinensis have been used therapeutically in traditional Chinese medicine. Previous studies have shown that M. cochinchinensis seed (Momordicae Semen) has various pharmaceutical properties such as antioxidant and anti-ulcer effects as well as contains secondary metabolites with potential anticancer activities such as triterpenoids and saponins. Recent studies reported that water extract and ethanol extract of M. cochinchinensi seed were tested on mammals using an acute toxic classic method as OECD guidelines 420. No matter injected i.v. or i.m., animals died within several days. In this study, zebrafish embryos were exposed to various doses of Cochinchina momordica seed extract (CMSE) from 2 dpf (days post fertilization, dpf) to 3 dpf. CMSE-induced cardiotoxicity such as pericardial edema, cardiac apoptosis, increased ROS production, cardiac neutrophil infiltration, decreased blood flow velocity, and reduced expression of three marker genes of cardiac functions were found in zebrafish roughly in a dose-dependent manner. These results suggest that CMSE may induce cardiotoxicity through pathways involved in inflammation, oxidative stress, and apoptosis.

Journal of Applied Toxicology published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Demarchi, Gianina; Valla, Sofía; Perrone, Sofía; Chimento, Agustina; Bonadeo, Nadia; Vitale, Daiana Luján; Spinelli, Fiorella Mercedes; Cervio, Andrés; Sevlever, Gustavo; Alaniz, Laura; Berner, Silvia; Cristina, Carolina published the artcile< β-Catenin is reduced in membranes of human prolactinoma cells and it is inhibited by temozolomide in prolactin secreting tumor models.>, Electric Literature of 112-63-0, the main research area is Prolactinomas; Wnt; pituitary tumors; temozolomide; β-Catenin.

INTRODUCTION: Prolactinomas are the most frequent pituitary tumor subtype. Despite most of them respond to medical treatment, a proportion are resistant and become a challenge in clinical management. Wnt/β-Catenin pathway has been implicated in several cancers including pituitary tumors and other sellar region malignancies. Interestingly, Wnt/β-Catenin inhibition augments the cytotoxicity of the chemotherapeutic agent Temozolomide (TMZ) in different cancers. TMZ is now being implemented as rescue therapy for aggressive pituitary adenoma treatment. However, the molecular mechanisms associated with TMZ action in pituitary tumors remain unclear. OBJECTIVES: Our aims in the present study were to evaluate differential β-Catenin expression in human resistant prolactinomas and Wnt/β-Catenin signaling activation and involvement in Prolactin (PRL) secreting experimental models treated with TMZ. RESULTS: We first evaluated by immunohistochemistry β-Catenin localization in human resistant prolactinomas in which we demonstrated reduced membrane β-Catenin in prolactinoma cells compared to normal pituitaries, independently of the Ki-67 proliferation indexes. In turn, in vivo 15 mg/kg of orally administered TMZ markedly reduced PRL production and increased prolactinoma cell apoptosis in mice bearing xenografted prolactinomas. Intratumoral β-Catenin strongly correlated with Prl and Cyclin D1, and importantly, TMZ downregulated both β-Catenin and Cyclin D1, supporting their significance in prolactinoma growth and as candidates of therapeutic targets. When tested in vitro, TMZ directly reduced MMQ cell viability, increased apoptosis and produced G2/M cell cycle arrest. Remarkably, β-Catenin activation and VEGF secretion were inhibited by TMZ in vitro. CONCLUSIONS: We concluded that dopamine resistant prolactinomas undergo a β-Catenin relocalization in relation to normal pituitaries and that TMZ restrains experimental prolactinoma tumorigenicity by reducing PRL production and β-Catenin activation. Together, our findings contribute to the understanding of Wnt/β-Catenin implication in prolactinoma maintenance and TMZ therapy, opening the opportunity of new treatment strategies for aggressive and resistant pituitary tumors.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics