Tag: M.W=250-300

Li, Chengwei; Prichard, Mark N.; Korba, Brent E.; Drach, John C.; Zemlicka, Jiri published the artcile< Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine>, Related Products of 112-63-0, the main research area is fluorinated methylenecyclopropane analog nucleoside preparation antiviral; fluoromethyl hydroxymethyl cyclopropylidene adenine guanine preparation antiviral structure.

Synthesis and antiviral activity of the title fluoromethylenecyclopropane analogs 15a, 15b, 16a, and 16b is described. Methylenecyclopropane carboxylate was first transformed to 2,2-bis-hydroxymethylmethylenecyclopropane. Selective monoacetylation followed by introduction of fluorine gave 2-acetoxymethyl-2-fluoromethylmethylenecyclopropane as the key intermediate. The synthesis of analogs 15a, 15b, 16a, and 16b then followed alkylation-elimination procedure as described previously for other methylenecyclopropane analogs. The adenine Z-isomer 15a was found to be a potent inhibitor of Epstein-Barr virus (EBV) in vitro with EC50/CC50 (μM) 0.5/55.7. Compounds 15b, 16a, and 16b were also active but at higher concentrations, EC50/CC50 (μM) 3.2-7.5/53.6-64.1. Analog 15a inhibited hepatitis C virus by virtue of its cytotoxicity and it moderately inhibited replication of the Towne strain of human cytomegalovirus (HCMV). The E-isomer 16a was a substrate for adenosine deaminase, whereas the Z-isomer 15a was not deaminated.

Bioorganic & Medicinal Chemistry published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Bin; Chansaenpak, Kantapat; Wu, Hongmiao; Zhu, Lin; Wang, Mengzhe; Li, Zibo; Lu, Hongjian published the artcile< Silver-promoted (radio)fluorination of unsaturated carbamates via a radical process>, Reference of 112-63-0, the main research area is oxazolidindione oxazinanone radiofluorinated oxazolidinone preparation; olefin acrylamide cyclization fluorination cascade silver radical.

The intramol. fluorocyclization of unsaturated carbamates is described here using a hypervalent iodine reagent in the presence of a silver catalyst. Both (hetero)aryl-substituted olefins and acrylamides can be utilized as effective substrates. Preliminary mechanistic investigations suggest that the reaction proceeds via a cyclization/1,2-(hetero)aryl migration/fluorination cascade involving an unusual radical process. Furthermore, starting from no-carrier-added [18F]TBAF, a simple one-pot, two-step cascade method was developed for the generation of 18F-labeled heterocycles with high radiochem. purity.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Yaohong; Qian, Yihua; Su, Wei; Chen, Xi published the artcile< Application of molecular probe to investigate surface structure of metal passivator on copper>, Formula: C19H34O2, the main research area is copper sulfide surface structure metal passivator investigative.

Copper sulfide (Cu2S) contaminant is semi-conductive. Its formation and migration to insulating paper and oil caused insulation breakdown. Addition of benzotriazole derivatives as metal passivator slows down the corrosion process, as the metal passivator produces a protective layer on the copper surface, which prevents the reaction between corrosive sulfur and copper. But the surface structure of this impermeable film is still unknown. Herein we reported our investigation on the orientation of metal-passivator complex on copper surface by means of mol. probe. Ageing exptl. study with different steric and electronic groups in benzotriazole skeleton indicated that the second position of the mol. was sensitive to steric effect, suggesting end-on orientation preferable. Subsequently, SEM-EDX revealed the relative amount of copper sulfide on copper surface. Moreover, FTIR represented the characteristic wavenumber of C=O, C=N moiety and benzene skeleton of passivator-copper complex. XPS anal. delivered the organic elemental composition of the protective layer.

IEEE Transactions on Dielectrics and Electrical Insulation published new progress about Corrosion. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zaleskaya, Marta; Dobrzycki, Lukasz; Romanski, Jan published the artcile< Highly efficient, tripodal ion-pair receptors for switching selectivity between acetates and sulfates using solid-liquid and liquid-liquid extractions>, Computed Properties of 112-63-0, the main research area is tripodal ion pair receptor acetate sulfate solid liquid extraction; anion recognition; cation recognition; crown ether; host-guest interactions; ion pair receptors; squaramide.

A tripodal, squaramide-based ion-pair receptor 1 was synthesized in a modular fashion, and 1H NMR and UV-vis studies revealed its ability to interact more efficiently with anions with the assistance of cations. The reference tripodal anion receptor 2, lacking a crown ether unit, was found to lose the enhancement in anion binding induced by presence of cations. Besides the ability to bind anions in enhanced manner by the “”single armed”” ion-pair receptor 3, the lack of multiple and prearranged binding sites resulted in its much lower affinity towards anions than in the case of tripodal receptors. Unlike with receptors 2 or 3, the high affinity of 1 towards salts opens up the possibility of extracting extremely hydrophilic sulfate anions from aqueous to organic phase. The disparity in receptor 1 binding modes towards monovalent anions and divalent sulfates assures its selectivity towards sulfates over other lipophilic salts upon liquid-liquid extraction (LLE) and enables the Hofmeister bias to be overcome. By changing the extraction conditions from LLE to SLE (solid-liquid extraction), a switch of selectivity from sulfates to acetates was achieved. X-ray measurements support the ability of anion binding by cooperation of the arms of receptor 1 together with simultaneous binding of cations.

International Journal of Molecular Sciences published new progress about Anions. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yamaguchi, Akihiro; Okazaki, Mitsuo published the artcile< Preparation of p-nitrostilbene derivatives by the modified Wittig reaction>, Application of C19H34O2, the main research area is Wittig reaction nitro stilbenes; stilbenes nitro Wittig reaction; nitro stilbenes Wittig reaction; trialkyl phosphite benzyl halide; phosphite trialkyl benzyl halide; benzyl halide trialkyl phosphite.

PhCH2Cl (70 g) and 100 g (EtO)3P (I) heated at 150-70° for 18 hr gave 107 g PhCH2PO(OEt)2 (II), b25 171-5°. Treating 46.0 g II with a mixture of 75 ml HNO3 (d. = 1.38) and 75 ml H2SO4 at -3 to 0° gave 0.58:1 o-O2NC6H4CH2P(OEt)2 (III)-p-NO2 isomer (IV). Nitration of I with fuming HNO3 yielded 0.2:98.2 III-IV. Treating p-O2NC6H4CH2Br and o-O2NC6H4CH2Br with I gave pure IV, b3 199-201°, n20D 1.5212, and III, b1 167-8°, n20D 1.5082, resp. III (2.7 g) treated with 0.35 g Na in 20 ml EtOH and then with p-O2NC6H4CHO gave 95.2% p-O2NC6H4CH:CHC6H4NO2-p, m. 295-6°. Similarly the following p-O2NC6H4CH:CHC6H4R-p were prepared (R, % yield, and m.p. given): CN, 96.8, 255-6°; CO2H, 65.5, 333-4°; Cl, 92.3, 186-7°; Br, 93.1, 201-1.5; H, 94.2, 156.5-7.5°; Me, 80.8, 150-50.5°; MeO, 92.5, 131-2°; Me2N, 85.5, 252°; AcNH, 90.4, 256-7°. Similarly p-O2NC6H4CH:CHC6H3(NO2)2-2,4, m. 142.5-43°, was prepared in 80.3% yield.

Nippon Kagaku Zasshi published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Qin; Rao, Nian; Liu, Li; Le, Yi; Yan, Longjia published the artcile< Development of 5-trifluoromethylpyrimidine derivatives as dual inhibitors of EGFR and SRC for cancer therapy>, Electric Literature of 112-63-0, the main research area is trifluoromethylpyrimidine derivative EGFR inhibitor antitumor mol docking.

In this paper, we reported a new series of 5-trifluoromethylpyrimidine derivatives (I [R = 4-methoxyphenyl, 2-fluorophenyl, 3-fluorophenyl, etc.], II [R = Pr, iso-Pr, hexyl, etc.]) for cancer therapy. They were tested for antitumor activity in vitro on four human cancer cell lines including A549, K562, HepG2, MCF-7 and two kinase including wild type epidermal growth factor receptor tyrosine kinase (EGFRwt-TK) and c-Src. The results suggested that some of the compounds (I [ R = 4-methoxyphenyl, 2-fluorophenyl, 3-fluorophenyl, 3,4-difluorophenyl], II [R = hexyl, Et acetate, iso-Pr, cyclopentyl, cyclohexyl, tetrahydropyran] 6b, 6d, 6e, 6f, 6g, 6h) performed well activities. Especially 2-((2-((4-((2-(Cyclohexylamino)-3,4-dioxocyclobut-1-en-1-yl)amino)phenyl)amino)-5-(trifluoro- methyl)pyrimidin-4-yl)amino)-N-methylbenzamide (6g) showed high antitumor activities against four cancer cell lines with 1.08 μM, 2.06 μM, 1.24 μM and 2.57 μM, resp. Furthermore, compound 2-((2-((4-((2-(cyclohexylamino)-3,4-dioxocyclobut-1-en-1-yl)amino)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-N-methylbenzamide inhibited EGFRwt and Src at the values of 0.75 μM and 0.15 μM.

Heterocycles published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Takagi, Toru; Itabashi, Yutaka; Tsuda, Takao published the artcile< High-performance liquid chromatographic separation of 2-hydroxy fatty acid enantiomers on a chiral slurry-packed capillary column>, Related Products of 112-63-0, the main research area is hydroxy fatty acid resolution HPLC; liquid chromatog resolution hydroxy fatty acid; nitrophenylurethane derivatization hydroxy fatty acid resolution.

Complete enantiomer separations of racemic 2-hydroxy fatty acids of C5-C16 as their 3,5-dinitrophenylurethane and Me ester derivatives were achieved by high-performance liquid chromatog. with a slurry-packed fused-silica capillary column (40 cm × 0.32 mm) inside diameter with a chiral phase, N-(S)-2-(4-chlorophenyl)isovaleroyl-p-phenylglycine ionically bonded to 5-μm silica gel. The anal. was optimized by using a ternary mobile phase, n-hexane-1,2-dichloroethane-ethanol, and UV detection at 226 nm.

Journal of Chromatographic Science published new progress about Chromatographic chiral resolution. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Lei; Hu, Hua-Ping; Chen, Xiao-Xiao; Xu, Guo-Yong; Liu, Jin-Song; Hu, Jiang-Miao; Wu, De-Ling; Xu, Feng-Qing published the artcile< Two new acetoisovanillone glycosides from the water-soluble fraction of Paeonia ostii>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Paeonia acetoisovanillone glycoside; Paeonia ostii T. Hong et J. X. Zhang; acetoisovanillone glycoside; water-soluble extraction.

The cortex root of Paeonia ostii, is used as a traditional Chinese medicine for treating female diseases. Phytochem. investigation of the water-soluble fraction of the plant led to the isolation of two new acetoisovanillone glycosides: acetoisovanillone-3-O-β-D-glucopyranoside (I) and 2-hydroxy-acetoisovanillone-3-O-β-D-glucopyranoside (II). Their structures were elucidated by extensive spectroscopic methods.

Natural Product Research published new progress about Bark (root). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dumitrescu, Dan; Dumitru, Florina; Legrand, Yves-Marie; Petit, Eddy; van der Lee, Arie; Barboiu, Mihail published the artcile< New ""Pyrene Box"" Cages for Adaptive Guest Conformations>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Pyrene box cage adaptive guest conformation crystallog.

The possibility of controlling the compression extent and the coiling shape of the 1,12-diammoniumdodecane guest is shown by changing the dimensions of the internal space of the host guanidinium 1,3,5,8 pyrene-tetrasulfonate PTS4- crystalline capsules by using guanidinium (G+), amino-guanidinium (AG+), and diaminoguanidinium (A2G+) cations.

Organic Letters published new progress about Amines Role: PEP (Physical, Engineering or Chemical Process), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent) (conjugate acids). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sorribes, Ivan; Wienhoefer, Gerrit; Vicent, Cristian; Junge, Kathrin; Llusar, Rosa; Beller, Matthias published the artcile< Chemoselective Transfer Hydrogenation to Nitroarenes Mediated by Cubane-Type Mo3S4 Cluster Catalysts>, Electric Literature of 112-63-0, the main research area is molybdenum sulfur cluster catalyst transfer hydrogenation nitro arene heteroarene; aromatic amine preparation.

Cubane-type Mo3S4 cluster compounds catalyzed transfer hydrogenation to nitro arenes or nitro heteroarenes to give aromatic amines. E.g., in presence of formic acid and NEt3 as the reducing agent, [Mo3S4H3(dmpe)2]BPh4 catalyzed the transfer hydrogenation of 4-O2NC6H4NH2 to give 90% p-phenylenediamine.

Angewandte Chemie, International Edition published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics