Tag: M.W=250-300

Pinet, Sandra; Liautard, Virginie; Debiais, Megane; Pucheault, Mathieu published the artcile< Radical Metal-Free Borylation of Aryl Iodides>, Quality Control of 112-63-0, the main research area is radical borylation aryl iodide steric hindrance; boronic ester preparation.

A simple metal-free borylation of aryl iodides mediated by a fluoride sp 2-sp 3diboron adduct is described. The reaction conditions are compatible with various functional groups. Electronic effects of substituents do not affect the borylation while steric hindrance does. The reaction proceeds via a radical mechanism in which pyridine serves to stabilize the boryl radicals, generated in situ.

Synthesis published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pai, K. Usha S.; Bodke, Yadav D.; Manandhar, Suman; Pai, K. Sreedhara Ranganath published the artcile< In silico-Based Virtual Screening and Molecular Docking Analysis of Phytochemicals obtained from Methanolic Extract of Cleome viscosa Linn. by GC-MS Method for its Anticancer Activity>, COA of Formula: C19H34O2, the main research area is Cleome viscosa phytochem virtual screening mol docking anticancer activity.

Cleome viscosa belonging to the family Capparidaceae, is a weed with ethano-botanical value found in India. In the present investigation, methanolic extract of Cleome viscosa was analyzed by gas chromatog.-mass spectrometry (GC-MS) to identify the important phytochem. constituents. The GC-MS anal. of methanol from whole plant of Cleome viscosa detected the presence of 78 phytochem. compounds Quant. phytochem. evaluation of the methanolic extract of Cleome viscosa was performed. These identified compounds were analyzed for their anticancer activity through in silico mol. docking studies. Computation based in silico docking studies were done using maestro interface. Three protein, poly (ADP-ribose) polymerase-1 (PARP-1), epidermal growth factor receptor (EGFR), human papilloma virus (HPV) specific to different cancers were selected for screening of these phytochems. Phytomols. with better activity and binding were shortlisted after XP mode of docking. The dock score, glide energy and 2D binding interactions of the top five phytochems. with three selected proteins have been discussed. The identified hit could be a potent inhibitor these proteins that further requires exptl. validation.

Asian Journal of Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tibor Fekete, Janos; Gyorffy, Balazs published the artcile< A unified platform enabling biomarker ranking and validation for 1562 drugs using transcriptomic data of 1250 cancer cell lines>, Category: esters-buliding-blocks, the main research area is cancer biomarker ranking validation transcriptome; Chemotherapy; In vitro; Machine learning; Proliferation; RNAseq; Random forest; Receiver operator characteristics.

In vitro cell line models provide a valuable resource to investigate compounds useful in the systemic chemotherapy of cancer. However, the due to the dispersal of the data into several different databases, the utilization of these resources is limited. Here, our aim was to establish a platform enabling the validation of chemoresistance-associated genes and the ranking of available cell line models. We processed four independent databases, DepMap, GDSC1, GDSC2, and CTRP. The gene expression data was quantile normalized and HUGO gene names were assigned to have unambiguous identification of the genes. Resistance values were exported for all agents. The correlation between gene expression and therapy resistance is computed using ROC test. We combined four datasets with chemosensitivity data of 1562 agents and transcriptome-level gene expression of 1250 cancer cell lines. We have set up an online tool utilizing this database to correlate available cell line sensitivity data and treatment response in a uniform anal. pipeline. We employed the established pipeline to by rank genes related to resistance against afatinib and lapatinib, two inhibitors of the tyrosine-kinase domain of ERBB2. The computational tool is useful 1) to correlate gene expression with resistance, 2) to identify and rank resistant and sensitive cell lines, and 3) to rank resistance associated genes, cancer hallmarks, and gene ontol. pathways. The platform will be an invaluable support to speed up cancer research by validating gene-resistance correlations and by selecting the best cell line models for new experiments

Computational and Structural Biotechnology Journal published new progress about Acute lymphocytic leukemia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Feng, Qiang; Shen, Menglu; Zhu, Jiaming; Li, Jiang; Zhang, Jie; Guo, Shaoyun published the artcile< Realization of polyurethane/epoxy interpenetrating polymer networks with a broad high-damping temperature range using β-cyclodextrins as chain extenders>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is PU epoxy IPN damping material cyclodextrin chain expansion property.

Damping materials, especially high-damping (loss factor (tanδ) > 0.5 and above) materials, are widely applied for suppressing vibration and controlling noise in industrial field, but achieving a high tanδ over a wide temperature range is a challenging task. Herein, we report a novel polyurethane (PU)/epoxy (EP) interpenetrating polymer network (IPN) damping material by using 21-hydroxyl β-cyclodextrins (β-CDs) as PU chain extenders. At a high ratio of hydroxyls to isocyanate groups, every β-CD underwent a different degree of chain expansion. Then these β-CDs grafting different numbers of PU chains generated different-size hard segments, thus increasing the species of motion units and widening the damping temperature range. The unreacted hydroxyls on β-CDs provided a large quantity of hydrogen bonding protons, which could form hydrogen bonds with urethane groups, thus facilitating an increase in the tanδ value. Therefore, PU/EP IPNs with a broad high-damping temperature range were successfully prepared The results showed that PU/EP IPNs cured by β-CDs underwent a damping temperature range of 93.1 K (tanδ > 0.5), 82.4 K (tanδ > 0.7) and even 74.1 K (tanδ > 0.8), much better than the corresponding 32.9 K, 23.9 K and 20.5 K for traditional PU/EP IPNs cured by trihydroxyl trimethylolpropane (TMP).

Materials & Design published new progress about Epoxy resins Role: POF (Polymer in Formulation), PRP (Properties), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adams, Nicholas D.; Adams, Jerry L.; Burgess, Joelle L.; Chaudhari, Amita M.; Copeland, Robert A.; Donatelli, Carla A.; Drewry, David H.; Fisher, Kelly E.; Hamajima, Toshihiro; Hardwicke, Mary Ann; Huffman, William F.; Koretke-Brown, Kristin K.; Lai, Zhihong V.; McDonald, Octerloney B.; Nakamura, Hiroko; Newlander, Ken A.; Oleykowski, Catherine A.; Parrish, Cynthia A.; Patrick, Denis R.; Plant, Ramona; Sarpong, Martha A.; Sasaki, Kosuke; Schmidt, Stanley J.; Silva, Domingos J.; Sutton, David; Tang, Jun; Thompson, Christine S.; Tummino, Peter J.; Wang, Jamin C.; Xiang, Hong; Yang, Jingsong; Dhanak, Dashyant published the artcile< Discovery of GSK1070916, a Potent and Selective Inhibitor of Aurora B/C Kinase>, Application In Synthesis of 112-63-0, the main research area is aurora kinase inhibitor GSK1070916 structure activity antitumor antiproliferative.

The Aurora kinases play critical roles in the regulation of mitosis and are frequently overexpressed or amplified in human tumors. Selective inhibitors may provide a new therapy for the treatment of tumors with Aurora kinase amplification. Herein we describe our lead optimization efforts within a 7-azaindole-based series culminating in the identification of GSK1070916 (17k). Key to the advancement of the series was the introduction of a 2-aryl group containing a basic amine onto the azaindole leading to significantly improved cellular activity. Compound 17k is a potent and selective ATP-competitive inhibitor of Aurora B and C with Ki* values of 0.38 ± 0.29 and 1.5 ± 0.4 nM, resp., and is >250-fold selective over Aurora A. Biochem. characterization revealed that compound 17k has an extremely slow dissociation half-life from Aurora B (>480 min), distinguishing it from clin. compounds 1 and 2. In vitro treatment of A549 human lung cancer cells with compound 17k results in a potent antiproliferative effect (EC50 = 7 nM). I.p. administration of 17k in mice bearing human tumor xenografts leads to inhibition of histone H3 phosphorylation at serine 10 in human colon cancer (Colo205) and tumor regression in human leukemia (HL-60). Compound 17k is being progressed to human clin. trials.

Journal of Medicinal Chemistry published new progress about Antiproliferative agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Saticioglu, Izzet Burcin; Mulet, Magdalena; Duman, Muhammed; Altun, Soner; Gomila, Margarita; Lalucat, Jorge; Garcia-Valdes, Elena published the artcile< First occurrence and whole-genome comparison of Pseudomonas haemolytica isolated in farmed rainbow trout>, Category: esters-buliding-blocks, the main research area is rainbow trout Pseudomonas haemolytica occurrence whole genome comparison.

The isolation of Pseudomonas haemolytica from different habitats as well as its distribution over a wide geog. area, possible reservoir role for antibiotic resistance and zoonotic potential, all require the detailed characterization of P. haemolytica strains. In the present study, we describe 18 phenotypically similar strains isolated from the rainbow trout, Oncorhynchus mykiss (Walbaum, 1792). The strains were collected from seemingly healthy, symptomatic or moribund rainbow trout of all sizes, from fry to broodstock. The strains were morphol., phenotypically (API20 NE and VITEK 2) and chemotaxonomically characterized by their methyl-fatty acid content (FAME), and mass spectrometry (MALDI-TOF) by their protein profiles. The 16S rRNA sequence similarity values grouped them into the Pseudomonas fluorescens phylogenetic group of species. The 18 strains were compared to 6 other previously described P. haemolytica strains, 2 of which were isolated from milk products and 4 from chicken products. A multilocus sequence anal. was performed for all strains. Strain P45 was selected to represent the 18 new isolates for genomic comparisons by ANIb, and GGDC was used to confirm the identification at species level. The presence of genes related to antimicrobial resistance, secretion systems and virulence was also assessed using comparative genomic analyses. This is the first comprehensive report on P. haemolytica strains isolated from fish.

Aquaculture Research published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alves, Alanderson Arthu Araujo; de Medeiros, Lucas Henrique Gomes; Feitosa, Filipe Xavier; de Sant’Ana, Hosiberto Batista published the artcile< Thermodynamic Properties of Biodiesel and Petrodiesel Blends at High Pressure and High Temperature and a New Model for Density Prediction>, Formula: C19H34O2, the main research area is thermodn property biodiesel petrodiesel blend density modeling.

This paper presents a new model to predict the d. of biodiesel + petrodiesel mixtures at high pressure and high temperature (HPHT) based on the Murnaghan equation of state, as a function of temperature, pressure, volumetric composition, and petrodiesel and biodiesel densities. This model was validated by using exptl. data from the literature, along with a new exptl. data set for biodiesel (grape seed, corn, and linseed) + petrodiesel, at high pressure (0.10-100.00 MPa) and high temperature (293.15-413.15 K) in a composition range of 0, 20, 40, 60, 80, and 100%volume These exptl. data were correlated by using the Tammann-Tait equation. From these data, the following derivative properties were determined: isothermal compressibility (κT), isobaric thermal expansibility (αP), internal pressure (pint), and the difference between pressure and volume heat capacities (cp – cv). Deviations obtained from the model proposed in this work (%AARD) were less than 0.50% for biodiesel + petrodiesel d. data.

Journal of Chemical & Engineering Data published new progress about Acid number. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shakouri, Zahra; Nazockdast, Hossein; Sadeghi Ghari, Hedayatollah published the artcile< Effect of the geometry of cellulose nanocrystals on morphology and mechanical performance of dynamically vulcanized PLA/PU blend>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is cellulose nanocrystal vulcanized PLA polyurethane elastomer blend mech property.

Effects of the addition of single but geometrically different cellulose nanocrystals (CNCs) namely cylindrical CNCs (ultrasonic treated), spherical CNCs (chem. treated) and rod-like CNCs (com.) on microstructural development and mech. performance of the thermoplastic vulcanizates (TPVs) based on polylactic acid/polyurethane prepolymer (80/20) were studied. It was shown that a fraction of PLA mols. reacted with PU mols. during the dynamic crosslinking process. This was confirmed by the results of gel content measurements which showed an appreciable amount of addnl. gel content. This phenomenon together with the dynamic vulcanization process facilitated the development of a dual-continuous morphol. in the TPV sample which was confirmed by the melt viscoelastic results and TEM micrographs. Interestingly, the addition of spherical CNCs to the TPV led to a remarkable enhancement in its toughness. A similar effect but to a lesser extent was observed in the TPV sample filled with cylindrical CNCs. These results could be explained in terms of a 3D percolated or interconnected network microstructure formed between finely dispersed CNCs localized in PLA and/or between CNCs and the PLA matrix. This fact was evidenced by observation of strong liquid-solid transition in the melt viscoelastic results, as well as TEM and AFM micrographs. On contrary to other counterparts, the rod-like CNCs had a weakening effect on toughness of the TPV which was attributed to their poor dispersion and/or formation of their aggregates which could act as stress concentrators. Moreover, DMTA results showed an almost similar reinforcing effect for the three CNCs on increasing the modulus of the TPV below Tg of the PU and partially compensated the PU reducing effect on modulus in the temperature range between the Tg of PU and PLA.

Cellulose (Dordrecht, Netherlands) published new progress about Elongation at break. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Xiao-Le; Wang, Ya-Ting; Guo, Zhen-Yu; Zhang, Ning-Ning; Wang, Yuan-Yuan; Hu, Die; Wang, Zhen-Zhen; Zhang, Yi published the artcile< Efficacy of paeoniflorin on models of depression: A systematic review and meta-analysis of rodent studies>, Category: esters-buliding-blocks, the main research area is meta analysis Paeonia depression paeoniflorin human; Animal studies; Depression; Paeoniflorin; Systematic review; meta-Analysis.

Meta-anal. of paeoniflorin, a bioactive compound extracted from the traditional Chinese herb, Paeonia lactiflora Pall, has been demonstrated to possess efficient antidepressant activity in previous studies. Our systematic review and meta-anal. aimed to assess the effectiveness of paeoniflorin in relieving depressive-like behaviors in animal models. We searched for in vivo studies on the antidepressant effects of paeoniflorin in rodents using electronic databases from their inception to Apr. 2021. The measurements of animal behavioral tests, including the sucrose consumption, forced swimming, tail suspension, and open field tests, were regarded as the outcomes. Fourteen studies involving 416 animals met the inclusion criteria and were included in the meta-anal. Statistical anal. revealed remarkable differences between the paeoniflorin and control groups. Furthermore, the paeoniflorin group showed great efficiency in improving depressive-like symptoms of animals in the sucrose consumption, forced swimming, tail suspension, and open field tests. Our meta-anal. demonstrates that paeoniflorin can significantly improve depressive-like symptoms in animals and suggests that it can be a potential therapy for patients with depression in the future.

Journal of Ethnopharmacology published new progress about Depression. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hawkins, Joel M.; Meyer, Axel; Nambu, Mitch published the artcile< Asymmetric bisosmylation of fullerene C60: novel chiral π-systems>, HPLC of Formula: 112-63-0, the main research area is stereoselective regioselective bisosmylation fullerene; fullerene osmium complex chiral; cinchona alkaloid stereoselective biosmylation fullerene.

Two isomers of C60(OsO4py2)2 are chiral by virtue of the substitution pattern on the icosahedral carbon cluster. Treatment of C60 with two equiv of OsO4 and five equiv of cinchona alkaloid derivative, followed by exchange of the chiral ligands for pyridine, gives the chiral (C2) isomers of C60(OsO4py2)2 with optical rotations up to 3700° and CD spectra which reflect the novel chiral band-shaped π-systems of these compounds The regiochem. and stereochem. of the bisosmylation of C60 appear to be controlled by attractive electronic interactions between the arene components of the cinchona alkaloid ligands and the fullerene surface.

Journal of the American Chemical Society published new progress about Dihydroxylation, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics