Tag: M.W=250-300

Dhanusha, G.; Sujith, S.; Nisha, Ar; Aathira, Kk; Haima, Js published the artcile< Cytotoxic and antiproliferative potential of methanolic extracts of Asparagus racemosus in MDAMB231 cells>, SDS of cas: 112-63-0, the main research area is cytotoxic antiproliferative potential methanolic extract Asparagus racemosus.

The present study was carried out to evaluate the cytotoxic and antiproliferative activity of methanolic extract of Asparagus racemosus in MDAB-231 cells. The qual. phytochem. anal. of the extract revealed the presence of steroids, alkaloids, flavonoids, glycosides, saponins and diterpenes. MDAMB-231 cells were maintained in RPMI media containing 10 per cent serum and 1 per cent antibiotic and antimycotic solution The cells were harvested and seeded to 96 well plate at 5 x 103 cells/mL, incubated for 24 h at 37°C with 5 per cent CO2. The cells were treated with 160, 80, 40, 20 and 10μg/mL of the extract for 24 h and viability was accessed using MTT Assay. Also cells were plated in 6 well plates at concentrations 3 x 105 cells/mL and exposed to 80, 40, 20 and 10μg/mL of the extract of Asparagus racemosus for acridine orange ethidium bromide (AO/EB) staining. There was a dose dependent decrease in viability of cells exposed to methanolic extracts of Asparagus racemosus with a viability of 15.55 ± 0.193 per cent for cells treated with 160μg/mL. The IC50 was found to be 91.36 ± 0.87μg/mL. The AO/EB staining revealed that most of the cells were dead in extract treated with 80μg/mL where more than 90 per cent of cells were live when treated with 10μg/mL of the extract

Pharma Innovation published new progress about Alkaloids Role: ANT (Analyte), ANST (Analytical Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wei, Siping; Liu, Bo; Zhao, Dongbing; Wang, Zhen; Wu, Jie; Lan, Jingbo; You, Jingsong published the artcile< Pyrido[1,2-c][1,2,4]triazol-3-ylidene: Reactivity and its application in organocatalysis and organometallic catalysis>, Application of C19H34O2, the main research area is pyridotriazolylidene preparation reaction catalyst.

The reactivity and catalytic performance of 2-ethylpyrido[1,2-c][1,2,4]-triazol-3-ylidene (I) have been comprehensively investigated. I shows unusual properties owing to the effect of the pyrido-annulation. While formohydrazide and hydrazine are obtained via the destruction of the triazole skeleton of the carbene, 3-((1Z,3E)-4-(1H-pyrrol-1-yl)buta-1,3-dienyl)-1-ethyl-1H-1,2,4-triazole is achieved through the cleavage of the C-N bond of the pyridine ring. I is also a powerful catalyst in a variety of organocatalyzed and Pd(II)-catalyzed transformations.

Organic & Biomolecular Chemistry published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liao, Hongdong; Wen, Xiangyu; Deng, Xuelei; Wu, Yonghong; Xu, Jianping; Li, Xin; Zhou, Shudong; Li, Xuefeng; Zhu, Chunhui; Luo, Feng; Ma, Yanqing; Zheng, Jingyuan published the artcile< Integrated proteomic and metabolomic analyses reveal significant changes in chloroplasts and mitochondria of pepper (Capsicum annuum L.) during Sclerotium rolfsii infection>, COA of Formula: C19H34O2, the main research area is pepper Capsicum annuum Sclerotium rolfsii infection chloroplast mitochondria analysis; Sclerotium rolfsii; chloroplasts; mitochondria; pepper; proteomics-metabonomics integrated analysis.

Infection by Sclerotium rolfsii will cause serious disease and lead to significant economic losses in chili pepper. In this study, the response of pepper during S. rolfsii infection was explored by electron microscopy, physiol. determination and integrated proteome and metabolome analyses. Our results showed that the stomata of pepper stems were important portals for S.rolfsii infection. The plant cell morphol. was significantly changed at the time of the fungal hyphae just contacting (T1) or surrounding (T2) the pepper. The chlorophyll, carotenoid, and MDA contents and the activities of POD, SOD, and CAT were markedly upregulated at T1 and T2. Approx. 4129 proteins and 823 metabolites were clearly identified in proteome and metabolome analyses, resp. A change in 396 proteins and 54 metabolites in pepper stem tissues was observed at T1 compared with 438 proteins and 53 metabolites at T2. The proteins and metabolites related to photosynthesis and antioxidant systems in chloroplasts and mitochondria were disproportionally affected by S. rolfsii infection, impacting carbohydrate and amino acid metabolism This study provided new insights into theresponse mechanism in pepper stems during S. rolfsii infection, which can guide future work on fungal disease resistance breeding in pepper.

Journal of Microbiology (Seoul, Republic of Korea) published new progress about Amino acid metabolism disorders. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Jiang; Zhao, Qunchao; Wilson, Thomas C.; Verhoog, Stefan; Lu, Long; Gouverneur, Veronique; Shen, Qilong published the artcile< Synthesis and Reactivity of α-Cumyl Bromodifluoromethanesulfenate: Application to the Radiosynthesis of [18F]ArylSCF3>, Product Details of C19H34O2, the main research area is aryl boronic pinacol ester cumyl bromodifluoromethanesulfenate copper bromodifluoromethylthiolation catalyst; bromodifluoromethylthiolated arene preparation fluorine18; fluorine18 labeled trifluoromethylthiolated arene preparation; PET; boron reagents; bromodifluoromethylthiolation; fluorine; radiolabeling.

A highly reactive electrophilic bromodifluoromethylthiolating reagent, α-cumyl bromodifluoro-methanesulfenate 1, was prepared to allow for direct bromodifluoromethylthiolation of aryl boron reagents. This coupling reaction takes place under copper catalysis, and affords a large range of bromodifluoromethylthiolated arenes. These compounds are amenable to various transformations including halogen exchange with [18F]KF/K222 , a process giving access to [18F]arylSCF3 in two steps from the corresponding aryl boronic pinacol esters.

Angewandte Chemie, International Edition published new progress about Aromatic hydrocarbons Role: SPN (Synthetic Preparation), PREP (Preparation) (bromodifluoromethylthiolated). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Xuan; Thummuri, Dinesh; Liu, Xingui; Hu, Wanyi; Zhang, Peiyi; Khan, Sajid; Yuan, Yaxia; Zhou, Daohong; Zheng, Guangrong published the artcile< Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity>, Electric Literature of 112-63-0, the main research area is preparation PROTAC apoptosis BCLxL degrader cancer platelet toxicity; Apoptosis; BCL-X(L); Degradation; PROTAC; Platelet.

Anti-apoptotic protein BCL-XL plays a key role in tumorigenesis and cancer chemotherapy resistance, rendering it an attractive target for cancer treatment. However, BCL-XL inhibitors such as ABT-263 cannot be safely used in the clinic because platelets solely depend on BCL-XL to maintain their viability. To reduce the on-target platelet toxicity associated with the inhibition of BCL-XL, we designed and synthesized PROTAC BCL-XL degraders that recruit CRBN or VHL E3 ligase because both of these enzymes are poorly expressed in human platelets compared to various cancer cell lines. We confirmed that platelet-toxic BCL-XL/2 dual inhibitor ABT-263 can be converted into platelet-sparing CRBN/VHL-based BCL-XL specific degraders. A number of BCL-XL degraders are more potent in killing cancer cells than their parent compound ABT-263. Specifically, XZ739, a CRBN-dependent BCL-XL degrader, is 20-fold more potent than ABT-263 against MOLT-4 T-ALL cells and has >100-fold selectivity for MOLT-4 cells over human platelets. Our findings further demonstrated the utility of PROTAC technol. to achieve tissue selectivity through recruiting differentially expressed E3 ligases.

European Journal of Medicinal Chemistry published new progress about Antitumor agents (low). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dupau, Philippe; Renouard, Thierry; Le Bozec, Hubert published the artcile< Straightforward synthesis of 4-formyl- and 4,4'-diformyl-2,2'-bipyridines: access to new dialkenyl substituted bipyridyl ligands>, Application of C19H34O2, the main research area is bipyridine formyl preparation; bipyridinecarboxaldehyde preparation; bipyridinedicarboxaldehyde preparation; Bredereck reagent formylation methylbipyridine.

4-Formyl-2,2′-bipyridines and 4,4′-diformyl-2,2′-bipyridines were prepared in two steps and in 52-71% overall yields via enamination of the corresponding 4-methyl-2,2′-bipyridines or 4,4′-dimethyl-2,2′-bipyridines. The synthesis of two 4,4′-dialkenyl-2,2′-bipyridyl ligands was also described. The treatment of 4,4′-dimethyl-2,2′-bipyridine with modified Bredereck’s reagent tert-butoxybis(dimethylamino)methane gave [2,2′-bipyridine]-4,4′-dicarboxaldehyde after oxidation of an intermediate [bipyridinedyl]propenamine.

Tetrahedron Letters published new progress about Formylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wijekoon, Champa; Netticadan, Thomas; Siow, Yaw L.; Sabra, Ali; Yu, Liping; Raj, Pema; Prashar, Suvira published the artcile< Potential Associations among Bioactive Molecules, Antioxidant Activity and Resveratrol Production in Vitis vinifera Fruits of North America>, Product Details of C19H34O2, the main research area is resveratrol Vitis vinifer bioactive mol antioxidant activity North America; antioxidant activity; bioactive molecules; grapes; resveratrol; stilbene synthase.

Grapes (Vitis vinifera L.) are rich in bioactive mols. contributing to health benefits. Consumption of grapes is linked to reduced incidence of cardiovascular diseases. Studies on table grape cultivars are limited although much attention in research was focused on the wine industry. Bioactive effects of grapes as anti-inflammatory, anticarcinogenic, cardioprotective, vasorelaxant, phytoestrogenic and neuroprotective have also been reported. For example, resveratrol is a natural food ingredient present in grapes, with high antioxidant potential. Here we conducted an exploratory study to investigate bioactive mols., antioxidant activity and the association between constitutive stilbene synthase (STS) gene expression and the resveratrol biosynthesis in selected table grape varieties in North America. The phenolic compounds, fatty acid composition and antioxidant activity of four grape varieties were compared. Red Globe variety was rich in unsaturated fatty acids as well as phenolic compounds such as caffeic acid, quercetin and resveratrol. Meanwhile, the constitutive expression of grape stilbene synthase gene was higher in Flame and Autumn Royal where resveratrol content of these cultivars was relatively low compared to the Red Globe variety. This study shows the potential links in grape antioxidant activity and resveratrol production, but more studies are necessary to show the association

Molecules published new progress about Anthocyanins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Shaozu; Wang, Yangyang; Chen, Lianxi; Chu, Mei; Dong, Yulin; Liu, Dan; Liu, Peng; Qu, Deyu; Duan, Junxin; Li, Xi published the artcile< MOF(Ni)/CNT composites with layer structure for high capacitive performance>, Application In Synthesis of 112-63-0, the main research area is metal orgnice framework nickel carbon nanotube composite electrochem property.

Metal-organic frameworks (MOFs) with high porosity and multivalent metal ion is a kind of prospective material for supercapacitor. However, the poor conductivity and stability degrade the capacitive performance of MOFs. Herein, a corrugated-layered-structure MOF(Ni)/carbon nanotube composite (MOF(Ni)/CNT) was prepared by solvothermal method. The corrugated-layered-structure of MOF(Ni) offers a sufficient electrolyte storage space and a fast ion diffusion channel, and 1D nanotube structure of CNT offers a good elec. conductivity and stability, which makes MOF(Ni)/CNT have an excellent capacitive performance. Compare to MOF(Ni), MOF(Ni)/CNT(w%) have a better electrochem. performance. Especially, MOF(Ni)/CNT(10%) not only has the highest specific capacitance, but also possesses an outstanding rate capacity (88.6% retention at 10 A g-1). Moreover, the asym. supercapacitor MOF(Ni)/CNT(10%)//AC can reach 97 F g-1 at 0.5 A g-1 and has 83.2% retention after 5000 cycles. It′s also shows a high energy d. of 32.6 Wh kg-1 at a power d. of 476.5 W kg-1. This work illustrates that layered MOFs are prospective materials for supercapacitor and provides a facile and effective way to boost the capacitive performance.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about Anodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bezzubets, M. K.; Rozina, V. S. published the artcile< Acidic derivatives of anthraquinone. I. Influence of substituents in the phenylamine radical of anthraquinone derivatives on their properties>, Category: esters-buliding-blocks, the main research area is .

Substitution of Br by PhNH in 1-amino-4-bromo-2-anthraquinonesulfonic acid (I) leads to a change of the orange color to blue (bathochromic effect); substitution within the PhNH group gives either a batho- or hypsochromic effect, insufficient, however, to change the visible color range, with Me giving the 1st effect and Cl giving the 2nd; their shift from the 4-position to the 2-position produces a hypsochromic effect. Stability of the dyes is improved by Me or Cl substitution in the PhNH group, with Cl giving the best effect; analogously, the solubility of Na salts drops. I (10 g., Na salt) in 200 ml. H2O and 16 ml. EtOH was heated 4 hrs. at 95° with 9.3 g. PhNH2, 5 g. Na2CO3, and 1 g. CuSO4, and, after steam distillation, the precipitated product was washed and recrystallized in the form of its Na salt, yielding 70% Na 1-amino-4-phenylamino-2-anthraquinonesulfonate, absorption maximum 605 mμ. o-Toluidine gave the corresponding 2′-Me derivative (75%), absorption maximum 610 mμ, while the 4′-analog had a maximum at 615 mμ. 2,4-Me2C6H3NH2 gave 65% of the 2′,4′-di-Me analog, maximum 620 mμ, while 2,4,5-Me3C6H2NH2 gave 73% of the 2′,4′,5′-tri-Me analog, maximum 630 mμ. 4-ClC6H4NH2 (9.6 g.) in 80 ml. H2O and 40 ml. EtOH was treated at 80-5° with 5 g. NaHCO3, 0.5 g. CuCl, and 10 g. I (Na salt) and refluxed 9 hrs.; after steam distillation the cooled filtrate yielded 64% Na 1-amino-4-(4-chlorophenylamino)-2-anthraquinonesulfonate (recrystallized from water), maximum 600 mμ; 2-ClC6H4NH2 gave 46% of the 2′-chloro analog, maximum 585 mμ; 2,5-Cl2C6H3NH2 gave 45% (after 25 hrs.’ reaction) of the 2,5′-di-Cl analog, maximum 580 mμ; the 3′,5′-di-Cl analog was similar; the 3,4,5-Cl3C6H2NH2 (I) gave 50% of the 3′,4′,5′-tri-Cl analog, maximum 575 mμ. Preparation of I: 50 g. p-nitroaniline in 300 ml. HCl and 150 ml. AcOH was chlorinated at 0°, yielding 78-80% 2,6,4-Cl2(O2N)C6H2NH2, m. 188.5-89° (from EtOH-AcOH); this (12 g.), diazotized, added at 90-5° to 300 ml. HCl and 30 g. CuCl paste, kept 1 hr. at 90°, and cooled, gave 3,4,5-trichloronitrobenzene (55%), m. 68-9° (from dilute AcOH); this (6.8 g.) added to hot 30 ml. H2O, 10 g. Fe shavings, and 1 ml. 40% AcOH, followed by steam distillation, gave I, m. 95-6°.

Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation) published new progress about Dyes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chamaraux-Tran, Thien-Nga; Muller, Marie; Pottecher, Julien; Diemunsch, Pierre A.; Tomasetto, Catherine; Namer, Izzie-Jacques; Dali-Youcef, Nassim published the artcile< Metabolomic impact of lidocaine on a triple negative breast cancer cell line>, SDS of cas: 112-63-0, the main research area is lidocaine human triple neg breast cancer cell metabolomics; anesthesia; cancer progression; cancer surgery; lidocaine; metabolomics; onco-anesthesia; perioperative period.

Metabolomics and onco-anesthesia are two emerging research fields in oncol. Metabolomics (metabolites anal.) is a new diagnostic and prognostic tool that can also be used for predicting the therapeutic or toxic responses to anticancer treatments. Onco-anesthesia studies assess the impact of anesthesia on disease-free and overall survival after cancer surgery. It has been shown that local anesthetics (LA), particularly lidocaine (LIDO), exert antitumor properties both in vitro and in vivo and may alter the biol. fingerprints of cancer cells. As LA are known to impair mitochondrial bioenergetics and byproducts, the aim of the present study was to assess the impact of LIDO on metabolomic profile of a breast cancer cell line. Breast cancer MDA-MB-231 cells were exposed for 4 h to 0.5 mM LIDO or vehicle (n = 4). The metabolomic fingerprint was characterized by high resolution magic angle spinning NMR spectroscopy (HRMAS). The multivariate technique using the Algorithm to Determine Expected Metabolite Level Alteration (ADEMA) (Cicek et al., PLoS Comput. Biol., 2013, 9, e1002859), based on mutual information to identify expected metabolite level changes with respect to a specific condition, was used to determine the metabolites variations caused by LIDO. LIDO modulates cell metabolites levels. Several pathways, including glutaminolysis, choline, phosphocholine and total choline syntheses were significantly downregulated in the LIDO group. This is the first study assessing the impact of LIDO on metabolomic fingerprint of breast cancer cells. Among pathways downregulated by LIDO, many metabolites are reported to be associated with adverse prognosis when present at a high titer in breast cancer patients. These results fit with the antitumor properties of LIDO and suggest its impact on metabolomics profile of cancer cells. These effects of LIDO are of clin. significance because it is widely used for local anesthesia with cutaneous infiltration during percutaneous tumor biopsy. Future in vitro and preclin. studies are necessary to assess whether metabolomics anal. requires modification of local anesthetic techniques during tumor biopsy.

Frontiers in Pharmacology published new progress about Anesthesia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics