Tag: M.W=250-300

Rubio-Garrido, Marina; Reina, Gabriel; Ndarabu, Adolphe; Rodriguez-Galet, Ana; Valades-Alcaraz, Ana; Barquin, David; Carlos, Silvia; Holguin, Africa published the artcile< High drug resistance levels could compromise the control of HIV infection in pediatric and adolescent population in Kinshasa, the Democratic Republic of Congo>, Application In Synthesis of 112-63-0, the main research area is human HIV infection drug resistance pediatric adolescent population Congo.

The inadequacy of HIV viremia and resistance monitoring in Africa leads to uncontrolled circulation of HIV strains with drug resistance mutations (DRM), compromising antiretroviral therapy (ART) effectiveness. This study describes the DRM prevalence and its therapeutic impact in HIV-infected pediatric patients from Kinshasa (Democratic Republic of Congo, DRC). From 2016-2018, dried blood were collected from 71 HIV-infected children and adolescents under ART in two hospitals in Kinshasa for HIV-1 DRM pol anal., predicted ARV-susceptibility by Stanford and phylogenetic characterization. HIV-1 sequences were recovered from 55 children/adolescents with 14 years of median-age. All had received nucleoside and non-nucleoside reverse transcriptase inhibitors (NRTI, NNRTI), 9.1% protease inhibitors (PI) and only one integrase inhibitor (INI). Despite the use of ART, 89.1% showed virol. failure and 67.3% carried viruses with major-DRM to one (12.7%), two (47.3%), or three (5.5%) ARV-families. Most children/adolescents harbored DRM to NNRTI (73.5%) or NRTI (61.2%). Major-DRM to PI was present in 8.3% and minor-DRM to INI in 15%. Dual-class-NRTI+NNRTI resistance appeared in 53.1% of patients. Viruses presented high/intermediate resistance to nevirapine (72.9% patients), efavirenz (70.9%), emtricitabine/lamivudine (47.9%), rilpivirine (41.7%), etravirine (39.6%), doravidine (33.3%), zidovudine (22.9%), among others. Most participants were susceptible to INI and PI. Great diversity of variants was found, with a high rate (40%) of unique recombinants. The high DRM prevalence observed among HIV-infected children and adolescents in Kinshasa could compromise the 95-95-95-UNAIDS targets in the DRC. It also reinforces the need for routine resistance monitoring for optimal rescue therapy election in this vulnerable population to control the spread of resistant HIV in the country.

PLoS One published new progress about Adolescent, mammalian. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peralta Muniz Moreira, Rodrigo; Li Puma, Gianluca published the artcile< CFD modeling of pharmaceuticals and CECs removal by UV/H2O2 process in helical microcapillary photoreactors and evaluation of OH radical rate constants>, Computed Properties of 112-63-0, the main research area is CFD modeling pharmaceutical contaminants removal UV hydrogen peroxide process; helical microcapillary photoreactors evaluation hydroxyl radical rate constant.

Process intensification by tailored secondary flow in helical microcapillary film (MCF) photoreactors was unveiled by computational fluid dynamics, and it was revealed for the removal of six common contaminants of emerging concern CECs (the antiviral Acyclovir, the antiretrovirals Stavudine and Zidovudine, and the biocidal antifungal agents Methylisothiazolinone, Benzisothiazolinone and Isoxazole) in water by UV hydrogen peroxide. The MCF photoreactors consisted of fluoropolymer films containing 10 microchannels with diameter varying from 100 to 1000μm coiled around a UVC lamp. In contrast to a MCF with straight channels, mixing intensification by secondary flow (Dean vortices) caused by the helical shape of the microcapillary strongly enhanced the radial fluid mixing, further supplementing the transport of the reacting species by Taylor-Aris dispersion. The intensity of the Dean vortices formed was correlated to the Dean (De) and Schmidt (Sc) numbers through a new correlation for the radial Peclet, which established that these become significant when De1.94Sc > 67. Thus, the second-order reaction rate constant of the six CECs with OH• radicals (kOH) determined in a helical MCF photoreactor increased (4.4% up to 37.9%) in comparison to those determined assuming a MCF photoreactor with plug flow. In addition, the helical shape of the MCF significantly diminished mass transfer limitations and decreased the CECs Elec. Energy per Order Reduction (EEO), paving the way for scaling-up of helical microcapillary photoreactor technol. This study shows how micromixing can be successfully exploited to design more efficient microcapillary photoreactors.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xiang, Jing; Ma, Lin; Gu, Zheng; Jin, Hongjun; Zhai, Hongbin; Tong, Jianfei; Liang, Tianjiao; Li, Juan; Ren, Qiushi; Liu, Qi published the artcile< A Boronated Derivative of Temozolomide Showing Enhanced Efficacy in Boron Neutron Capture Therapy of Glioblastoma>, Application In Synthesis of 112-63-0, the main research area is binary radiation therapy; boron delivery agents; boron neutron capture therapy; glioblastoma.

There is an incontestable need for improved treatment modality for glioblastoma due to its extraordinary resistance to traditional chemoradiation therapy. Boron neutron capture therapy (BNCT) may play a role in the future. We designed and synthesized a 10B-boronated derivative of temozolomide, TMZB. BNCT was carried out with a total neutron radiation fluence of 2.4 ± 0.3 x 1011 n/cm2. The effects of TMZB in BNCT were measured with a clonogenic cell survival assay in vitro and PET/CT imaging in vivo. Then, 10B-boronated phenylalanine (BPA) was tested in parallel with TMZB for comparison. The IC50 of TMZB for the cytotoxicity of clonogenic cells in HS683 was 0.208 mM, which is comparable to the IC50 of temozolomide at 0.213 mM. In BNCT treatment, 0.243 mM TMZB caused 91.2% ± 6.4% of clonogenic cell death, while 0.239 mM BPA eliminated 63.7% ± 6.3% of clonogenic cells. TMZB had a tumor-to-normal brain ratio of 2.9 ± 1.1 and a tumor-to-blood ratio of 3.8 ± 0.2 in a mouse glioblastoma model. BNCT with TMZB in this model caused 58.2% tumor shrinkage at 31 days after neutron irradiation, while the number for BPA was 35.2%. Therefore, by combining the effects of chemotherapy from temozolomide and radiotherapy with heavy charged particles from BNCT, TMZB-based BNCT exhibited promising potential for therapeutic applications in glioblastoma treatment.

Cells published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Huadi; Li, Hui; Lu, Shenyi; Shan, Shuangshuang; Guo, Yong published the artcile< Fuzheng Jiedu decoction induces apoptosis and enhances cisplatin efficacy in ovarian cancer cells in vitro and in vivo through inhibiting the PI3K/AKT/mTOR/NF-κB signaling pathway>, SDS of cas: 112-63-0, the main research area is ovarian cancer Fuzheng Jiedu decoction apoptosis cisplatin; PI3K AKT mTOR NFkB signaling pathway.

This study is aimed at investigating the anticancer activity of Fuzheng Jiedu decoction (FJD) alone or in combination with cisplatin in ovarian cancer (OC) models, as well as its underlying mechanisms of action. The anticancer activities of FJD, cisplatin, and the combination of the PI3K inhibitor (LY294002, LY) or activator (IGF-1) were evaluated in OC cell lines in vitro and in a SKOV3 xenograft mouse model in vivo. The cell proliferation and invasion ability were measured using MTT, EdU, and transwell assays, resp. The cell apoptosis was examined by flow cytometry and JC-1 assays. The expression levels of the Bcl-2 family and the PI3K/AKT/mTOR/NF-κB pathway-related proteins were analyzed by Western blot. The in vivo and in vitro studies showed that FJD administration could significantly inhibit cell proliferation and promote cell apoptosis in two OC cell lines SKOV3 and 3AO and partially decreased the tumor volumes and weights In addition, FJD could significantly downregulate the protein levels of p-PI3K/PI3K, p-AKT/AKT, p-mTOR/mTOR, NF-κB, p38, and Bcl-2 and upregulate the Bax, Cyt-C, and cleaved caspase-3 in OC tumor tissues and cells. FJD cotreatment increased the efficacy of cisplatin, including inhibiting OC cell proliferation and invasion, promoting cell apoptosis, and inhibiting the PI3K/AKT/ mTOR signaling pathway, while this enhancement was suppressed by IGF-1. Similarly, LY also enhanced the anticancer efficacy of cisplatin. This study indicated that FJD could improve the efficacy of cisplatin by inhibiting the PI3K/ AKT/mTOR/NF-κB signaling pathway. It is suggested that FJD may be a valuable adjuvant drug for the treatment of OC.

BioMed Research International published new progress about Acids Role: ANT (Analyte), BSU (Biological Study, Unclassified), PAC (Pharmacological Activity), THU (Therapeutic Use), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Hanyuan; Ma, Biao; Liu, Qi-Sheng; Wang, Mei-Ling; Wang, Zhen-Yu; Xu, Hui; Li, Ling-Jun; Wang, Xing; Dai, Hui-Xiong published the artcile< Transformations of Aryl Ketones via Ligand-Promoted C-C Bond Activation>, Computed Properties of 112-63-0, the main research area is aryl borate preparation ketoarene ligand promoted bond activation; C−C bond activation; Pd catalysis; aryl ketones; borylation.

The coupling of aromatic electrophiles (aryl halides, aryl ethers, aryl acids, aryl nitriles etc.) with nucleophiles is a core methodol. for the synthesis of aryl compounds Transformations of aryl ketones in an analogous manner via carbon-carbon bond activation could greatly expand the toolbox for the synthesis of aryl compounds due to the abundance of aryl ketones. An exploratory study of this approach is typically based on carbon-carbon cleavage triggered by ring-strain release and chelation assistance, and the products are also limited to a specific structural motif. Here we report a ligand-promoted β-carbon elimination strategy to activate the carbon-carbon bonds, which results in a range of transformations of aryl ketones, leading to useful aryl borates, and also to biaryls, aryl nitriles, and aryl alkenes. The use of a pyridine-oxazoline ligand is crucial for this catalytic transformation. A gram-scale borylation reaction of an aryl ketone via a simple one-pot operation is reported. The potential utility of this strategy is also demonstrated by the late-stage diversification of drug mols. probenecid, adapalene, and desoxyestrone, the fragrance tonalid as well as the natural product apocynin.

Angewandte Chemie, International Edition published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Yan; Song, Shuang; Li, Haitao; Wang, Xinyan; Song, Lianlian; Xue, Jianfei published the artcile< Polysaccharide from Ganoderma lucidum alleviates cognitive impairment in a mouse model of chronic cerebral hypoperfusion by regulating CD4+CD25+Foxp3+ regulatory T cells>, Application In Synthesis of 112-63-0, the main research area is Ganoderma cognitive impairment chronic CD4 CD25 Foxp3 regulatoryT cell.

Ganoderma lucidum (G. lucidum) is a kind of edible and medicinal mushroom. G. lucidum polysaccharide-1 (GLP-1) is one of the polysaccharides purified from crude GLP. Chronic cerebral hypoperfusion (CCH) as the common pathol. basis of various forms of dementia is an important cause of cognitive impairment. In this study, a step-down test was used to evaluate the cognitive ability of CCH mice. Flow cytometry was used to detect the proportion of CD4+CD25+Foxp3+ regulatory T (Foxp3+Treg) cells. ELISA anal. and western blot anal. were used to detect the transforming growth factor-β1 (TGF-β1) and Interleukin-10 (IL-10) levels that Foxp3+Treg cells secreted. Metabolomic anal. based on gas chromatog.-mass spectrometry (GC-MS) was used to evaluate the effect of GLP-1 on dysfunctional metabolism caused by inflammation. GLP-1 exhibited an alleviating cognitive impairment effect on CCH mice. The mechanism was related to GLP-1 by increasing Foxp3+Treg cell levels to increase levels of IL-10 and TGF-β1 and regulate abnormal energy metabolism These findings could provide preliminary results to exploit G. lucidum as a health care product or functional food for the adjuvant therapy of cognitive impairment of CCH.

Food & Function published new progress about Brain corpus callosum. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Halder, Mita; Bhanja, Piyali; Islam, Mominul Md.; Chatterjee, Sauvik; Khan, Aslam; Bhaumik, Asim; Islam, Sk. Manirul published the artcile< Porous organic polymer as an efficient organocatalyst for the synthesis of biofuel ethyl levulinate>, Quality Control of 112-63-0, the main research area is organocatalyst biofuel ethyl levulinate synthesis porous organic polymer.

Levulinic acid (LA), a lignocellulosic biomass-derived compound has been recognized as one of the versatile building blocks for the synthesis of commodity chems. having biofuel properties together with potential as precursor for the synthesis of several value-added pharmaceuticals and polymers. Herein, we report the synthesis of catalytically active functionalized porous organic polymer and its utilization as heterogeneous organocatalyst for the synthesis of EL from LA in very high yield. Here, sulfonic acid functionalized porous organic polymer SBZ@POP have been prepared via simple Friedel-Crafts alkylation of benzene with dimethoxymethane followed by sulfonation of the aromatic rings. The structure and properties of the material was examined through PXRD, N2 sorption, HR TEM, 13C CP-MAS NMR, NH3-TPD, TG-DTA and FTIR anal. Our characterization data suggested nanoscale porosity with high surface acidity in SBZ@POP. The effects of reaction time, catalyst loading, molar ratio of levulinic acid to ethanol and reaction temperature were studied thoroughly to optimize the catalytic activity of SBZ@POP. Under optimized reaction conditions EL yield of 88 % has been achieved with 1:15 molar ratio of LA to ethanol under refluxing conditions in 10 h. This porous organic polymer based organocatalyst displayed good recyclability for consecutive five reaction cycles suggesting the sustainable application potential of this acidic organocatalyst.

Molecular Catalysis published new progress about Density functional theory. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lanaya, Salaheddine; El Jemli, Yousra; Khallouk, Khadija; Abdelouahdi, Karima; Hannioui, Abdellah; Solhy, Abderrahim; Barakat, Abdellatif published the artcile< Sulfated Well-Defined Mesoporous Nanostructured Zirconia for Levulinic Acid Esterification>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is sulfated zirconia mesoporous nanostructure catalyst levulinic acid esterification.

Well-organized zirconia (ZrO2) nanoparticles forming mesoporous materials were successfully synthesized via a facile micelle-templating method using cetyltrimethylammonium bromide as a structure-directing template to control the nucleation/growth process and porosity. The systematic use of such a surfactant in combination with a microwave-assisted solvothermal (cyclohexane/water) reaction enabled the control of pore size in a narrow-size distribution range (3-17 nm). The effect of solvent mixture ratio on the porosity of the synthesized oxide was determined, and the controlled growth of zirconia nanoparticles was confirmed by means of powder X-ray diffraction, small-angle X-ray scattering, transmission electron microscopy, selected area electron diffraction, high-resolution transmission electron microscopy, XPS, thermogravimetric anal., and Fourier transform IR spectroscopy as well as N2 physisorption isotherm anal. Then, the as- prepared nanostructured zirconia oxides were treated with sulfuric acid to have sulfated samples. The catalytic performances of these mesoporous zirconia nanoparticles and their sulfated samples were tested for levulinic acid (LA) esterification by ethanol, with quant. conversions of LA to Et levulinate after 8 h of reaction.

ACS Omega published new progress about Binding energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Qiao-zhen; Xiao, Dong-guang published the artcile< Comparisons of different extraction fibers for analysis of aroma compounds in Litchi wine>, HPLC of Formula: 112-63-0, the main research area is extraction fiber aroma compound Litchi wine.

The aroma compounds of Litchi wine were analyzed by head space solid-phase micro-extraction (HS-SPME) coupled to gas chromatog.-mass spectrometry (GC-MS). Extraction characteristics of three different coating of extraction fibers were compared. The results indicated that the 65 μm PDMS/DVB was the best in the same exptl. conditions.

Tianjin Keji Daxue Xuebao published new progress about Fibers Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yu, Bo; Zhang, Hongye; Zhao, Yanfei; Chen, Sha; Xu, Jilei; Hao, Leiduan; Liu, Zhimin published the artcile< DBU-Based Ionic-Liquid-Catalyzed Carbonylation of o-Phenylenediamines with CO2 to 2-Benzimidazolones under Solvent-Free Conditions>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is DBU acetate ionic liquid catalyst carbonylation phenylenediamine carbon dioxide; benzimidazolone preparation.

2-Benzimidazolones were prepared via carbonylation of o-phenylenediamines with CO2 catalyzed by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)-based ionic liquids under solvent-free conditions. DBU acetate ([DBUH][OAc]) displayed high efficiency for catalyzing the reactions of CO2 with o-phenylenediamines, and a series of benzimidazolones were obtained in high yields. It was demonstrated that [DBUH][OAc] could serve as a bifunctional catalyst for these reactions with the cation activating CO2 and the anion activating o-phenylenediamines. This protocol provides an effective and environmentally friendly alternative route for production of benzimidazolones, and extends the chem. utilization of CO2 in organic synthesis as well.

ACS Catalysis published new progress about Aromatic diamines Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics