Tag: M.W=250-300

Feng, Qian; Liu, Huan; Peng, Zhigang; Zheng, Yong published the artcile< Synthesis, characterization and evaluation of long-acting hyperbranched cationic polymer clay stabilizer used in water flooding>, Computed Properties of 112-63-0, the main research area is polymer clay stabilizer water flooding.

In the process of waterflooding development, it is of great importance to prevent the clay from hydration swelling and migration dispersion for protecting the formation and improving the water flooding efficiency. For those reasons, we successfully synthesized a cationic clay stabilizer (HBP-QAT) through melting polycondensation and cationic modification with maleic anhydride, diethanolamine, epichlorohydrin, triethylamine, and trimethylolpropane as monomers and p-toluene sulfonic acid as a catalyst. The chem. structure, cation degree, and mol. weight of HBP-QAT were studied by using FTIR, 1H NMR, sodium tetraphenylborate (STBP) back titration, and gel permeation chromatog. (GPC). The obtained results showed that HBP-QAT was a hyperbranched unsaturated polyester amide with a low mol. weight and a high cation degree, with corresponding values of 28400, and 44.2%, resp. The clay stability and durability of HBP-QAT were evaluated by linear anti-swelling, water flushing, and cutting rolling recovery tests. The obtained results showed that HBP-QAT has an excellent anti-washing capacity and a long-term inhibition effect. The initial anti-swelling rate of 1.0 wt% HBP-QAT reached 92.37%, and the anti-swelling rate of 1.0 wt% HBP-QAT also remained at 85% after flushing 10 times with water. Besides, the two cutting rolling recoveries exceed 72%. Most importantly, the inhibition mechanism of HBP-QAT was studied by zeta potential, X-ray diffraction (XRD), XPS, scanning electron microscope (SEM), and contact angles analyses, and thus we proposed an inhibition mechanism, presenting as follows. HBP-QAT inhibited the clay hydration swelling by neutralizing neg. charges on the surface of the clay particles to compress the elec. double layer, strongly adsorbing on the surface of the clay particles, and forming a waterproof polymer membranes, restraining water of intrusion into the clay interlayer.

Polymer Testing published new progress about Contact angle. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ueno, Daiki; Vasquez, Juan C; Sule, Amrita; Liang, Jiayu; van Doorn, Jinny; Sundaram, Ranjini; Friedman, Sam; Caliliw, Randy; Ohtake, Shinji; Bao, Xun; Li, Jing; Ye, Huihui; Boyd, Karla; Huang, Rong Rong; Dodson, Jack; Boutros, Paul; Bindra, Ranjit S; Shuch, Brian published the artcile< Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy.>, Application of C19H34O2, the main research area is FH; PARP inhibitor; SDHB; renal cell carcinoma; temozolomide.

Loss-of-function mutations in genes encoding the Krebs cycle enzymes Fumarate Hydratase (FH) and Succinate Dehydrogenase (SDH) induce accumulation of fumarate and succinate, respectively and predispose patients to hereditary cancer syndromes including the development of aggressive renal cell carcinoma (RCC). Fumarate and succinate competitively inhibit αKG-dependent dioxygenases, including Lysine-specific demethylase 4A/B (KDM4A/B), leading to suppression of the homologous recombination (HR) DNA repair pathway. In this study, we have developed new syngeneic Fh1- and Sdhb-deficient murine models of RCC, which demonstrate the expected accumulation of fumarate and succinate, alterations in the transcriptomic and methylation profile, and an increase in unresolved DNA double-strand breaks (DSBs). The efficacy of poly ADP-ribose polymerase inhibitors (PARPis) and temozolomide (TMZ), alone and in combination, was evaluated both in vitro and in vivo. Combination treatment with PARPi and TMZ results in marked in vitro cytotoxicity in Fh1- and Sdhb-deficient cells. In vivo, treatment with standard dosing of the PARP inhibitor BGB-290 and low-dose TMZ significantly inhibits tumor growth without a significant increase in toxicity. These findings provide the basis for a novel therapeutic strategy exploiting HR deficiency in FH and SDH-deficient RCC with combined PARP inhibition and low-dose alkylating chemotherapy.

Oncotarget published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Abraham, Michael H. published the artcile< Hydrogen bonding. XXVII. Solvation parameters for functionally substituted aromatic compounds and heterocyclic compounds, from gas-liquid chromatographic data>, HPLC of Formula: 112-63-0, the main research area is solvation parameter calculation aromatic compound chromatog; gas chromatog determination solute polarizability parameter; hydrogen bond solvation parameter gas chromatog; heterocyclic compound solvation parameter gas chromatog; retention equation gas chromatog aromatic compound; nonpolar stationary phase gas chromatog retention; linear free energy relationship gas chromatog.

The truncated solvation equation log SP = c + rR2 + l(log L16) was applied to a very large number of sets of gas-liquid chromatog. data on nonpolar stationary phases. The parameter log SP (SP = a solvation parameter) can be log VG (specific retention volume at the column temperature) or can be the retention index I; R2 is the excess molar refraction of the solute and c, r and l are constants A set of solutes of known log L16 values is used to construct the equation, and then further values of log L16 can be obtained for any solute of known log SP value. In this way, new log L16 values for > 1000 solutes were obtained. Known log L16 and R2 values are substituted into the equation log SP = c + rR2 + sπH2 + l(log L16) (s is a constant) so that it can be applied to GLC data on polar non-acidic stationary phases, and the dipolarity/polarizability parameter πH2 is determined in a similar fashion. Values of πH2 for > 700 compounds are reported, including those for functionally substituted aromatic compounds and heterocyclic compounds The πH2 parameter is a blend of dipolarity/polarizability, and cannot be calculated simply from solute dipole moments.

Journal of Chromatography published new progress about Alcohols, unsaturated Role: PRP (Properties). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Joshi, Anuradha S.; Shah, Rajvi K.; Suthar, Mona H.; Keharia, Unnati H. published the artcile< Evaluation of rationality of antimicrobial and antidiarrheal fixed dose combination available in Indian market>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is tenofovir antimicrobial fixed dose combination.

Literature reports growing concern on ever-burgeoning list of irrational fixed dose combinations (FDCs) flooding the Indian market. Current study addresses availability and rationality of two most common group of FDC used clin., i.e., antimicrobial (AM) and antidiarrheal (AD). Anal. of rationality of AM and AD, FDCs, and available in Indian market. AM and AD, FDCs listed in Indian Drug Review 2017 and 2018, were analyzed using a validated eight- point criteria tool. Out of 138 FDCs, 102 (73.91%) belonged to AM group and 36 (26.08%) belonged to AD group. Out of 102 AM FDC′s, 46 (45.09%) were rational and 56 (54.90%) were irrational. Out of 36 AD, FDCs, 10 (27.77%) were rational and 26 (72.22%) were irrational. Mean rationality score of AM and AD, FDC′s, was (7.72 ± 0.33) and (7.5 ± 0.78), resp. Anal. reveals that a number of FDCs available in Indian market is irrational.

National Journal of Physiology, Pharmacy and Pharmacology published new progress about Antimicrobial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wei, Yi; Zhang, Heng-Xia; Zeng, Jun-Liang; Nie, Jing; Ma, Jun-An published the artcile< Organocatalytic Asymmetric Decarboxylative Amination of β-Keto Acids: Access to Optically Active α-Amino Ketones and 1,2-Amino Alcohols>, Application of C19H34O2, the main research area is asym decarboxylative amination keto acid; amino ketone preparation; preparation amino alc.

An organocatalytic asym. decarboxylative amination reaction of β-keto acids is described. Under mild reaction conditions, a series of chiral α-amino ketones were obtained in good to high yields (up to 99%) and enantioselectivities (up to 95% ee). A chiral 1,2-amino alc. was synthesized from the corresponding decarboxylative amination product in several steps without loss of enantioselectivity.

Organic Letters published new progress about Amination (decarboxylative). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Defachelles, Anne-Sophie; Bogart, Emilie; Casanova, Michela; Merks, Johannes H M; Bisogno, Gianni; Calareso, Giuseppina; Melcon, Soledad Gallego; Gatz, Susanne Andrea; Le Deley, Marie-Cécile; McHugh, Kieran; Probst, Alicia; Rocourt, Nathalie; van Rijn, Rick R; Minard-Colin, Véronique; Chisholm, Julia C published the artcile< Reply to H. B et al.>, Category: esters-buliding-blocks, the main research area is .

There is no abstract available for this document.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Fengxiang; Graham, Emily T.; Naowarojna, Nathchar; Shi, Zhennan; Wang, Yuqi; Xie, Guanglei; Zhou, Lili; Salmon, Wendy; Jia, Jie-Min; Wang, Xi; Huang, Yuwei; Schreiber, Stuart L.; Zou, Yilong published the artcile< PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ>, Recommanded Product: Ethyl 3-amino-4-(cyclohexylamino)benzoate, the main research area is tumor tissues stratifying ferroptosis sensitivity PALP rapid imaging technique; cancer; ferroptosis sensitivity stratification; imaging; in situ quantitation; lipid peroxidation; polyunsaturated lipid.

Ferroptosis is an emerging cancer suppression strategy. However, how to select cancer patients for treating with ferroptosis inducers remains challenging. Here, we develop photochem. activation of membrane lipid peroxidation (PALP), which uses targeted lasers to induce localized polyunsaturated fatty acyl (PUFA)-lipid peroxidation for reporting ferroptosis sensitivity in cells and tissues. PALP captured by BODIPY-C11 can be suppressed by lipophilic antioxidants and iron chelation, and is dependent on PUFA-lipid levels. Moreover, we develop PALPv2, for studying lipid peroxidation on selected membranes along the z axis in live cells using two-photon microscopes. Using PALPv1, we detect PUFA-lipids in multiple tissues, and validate a PUFA-phospholipid reduction during muscle aging as previously reported. Patterns of PALPv1 signals across multiple cancer cell types in vitro and in vivo are concordant with their ferroptosis susceptibility and PUFA-phospholipid levels. We envision that PALP will enable rapid stratification of ferroptosis sensitivity in cancer patients and facilitate PUFA-lipid research.

Cell Chemical Biology published new progress about Antioxidants. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Recommanded Product: Ethyl 3-amino-4-(cyclohexylamino)benzoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Min Kyoung; Park, Geonha; Hong, Seon-Pyo; Jang, Young Pyo published the artcile< Analytical quality by design methodology approach for simultaneous quantitation of paeoniflorin and decursin in herbal medicine by RP-HPLC analysis>, Electric Literature of 112-63-0, the main research area is paeoniflorin decursin herbal medicine RPHPLC quantitation.

Simultaneous quantification of multiple marker compounds in herbal medicine by high performance liquid chromatog. (HPLC) anal. is still a challenge due to the complexity in various parameters to be considered and co-existing multi-components. As a case study, a reliable HPLC method for simultaneous quantification of paeoniflorin from Paeoniae Radix and decursin from Angelicae Gigantis Radix in various com. herbal medicine was developed based on anal. quality by design (AQbD) strategy. As a first step, risk assessment was performed to select the critical method parameters (CMPs) which were decided as organic mobile phase ratio and column oven temperature In order to evaluate the effect of the CMPs on critical method attributes (CMAs) of peak resolution and tailing, central composite design (CCD) was employed. The final chromatog. conditions were optimized as follows: column- C18, 4.6 x 250 mm, 5μm particle size; mobile phase- A: acetonitrile, B: 0.1% acetic acid water; detection wavelength- 235 nm for paeoniflorin, 325 nm for decursin; column oven temperature- 25°C; flow rate- 1.0 mL/min; gradient mobile phase system as Time (min): % A, 0:14, 25:14, 30:50, 60:50, 61:100, 65:100, 66:14, 75:14. The method was successfully validated according to the International Conference on Harmonization (ICH) guidelines and piloted for ten com. herbal medicines.

Natural Product Sciences published new progress about Particle size. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cui, Jiawen; Zhou, Qin; Yu, Meijin; Liu, Yuhao; Teng, Xiaohua; Gu, Xianhong published the artcile< 4-tert-butylphenol triggers common carp hepatocytes ferroptosis via oxidative stress, iron overload, SLC7A11/GSH/GPX4 axis, and ATF4/HSPA5/GPX4 axis>, Recommanded Product: Ethyl 3-amino-4-(cyclohexylamino)benzoate, the main research area is Cyprinus hepatocyte ferroptosis oxidative stress iron 4tertbutylphenol SLC7A11 pollution; 4-tert-butylphenol; Environmental pollutant; Ferrostatin-1; Iron homeostasis; ROS.

4-Tert-butylphenol (4-tBP) is a toxic environmental pollutant with moderate bioaccumulation, environmental persistence, and long-term toxicity. Its toxicity to aquatic organisms has become an issue of concern. However, the mol. mechanism of 4-tBP toxicity to aquatic organisms remained unclear. Liver is a target organ for environmental pollutants. Here, we established 4-tBP-exposed toxicity model in vivo and primary hepatocyte model in vitro in common carp (Cyprinus carpio L.). We found increased hepatic-somatic index (HSI) and abnormal serum biochem. indexes (ALT, AST, and LDH) after 4-tBP exposure, indicating liver damage. We further revealed that 4-tBP damaged the structural integrity of the livers with typical features of ferroptosis. Based on toxicogenomics anal., we found ferroptosis is likely to be involved in the mechanism of 4-tBP-induced liver damage. Moreover, our in vivo and in vitro experiment provided evidences that 4-tBP-exposure led to excess oxidative stress, iron overload, decreased MMP, and abnormal expression of ferroptosis-related factors. Interestingly, ferrostatin-1 (Fer-1, a ferroptosis inhibitor) pretreatment alleviated above changes. In summary, we demonstrated that 4-tBP triggered hepatocytes ferroptosis via oxidative stress, iron overload, SLC7A11/GSH/GPX4 axis, and ATF4/HSPA5/GPX4 axis. For the first time, we discovered that Fer-1 can ameliorate the toxicity of 4-tBP, which needs more investigations. Our results provided a scientific basis of mol. mechanism of 4-tBP-induced fish poisoning.

Ecotoxicology and Environmental Safety published new progress about Activating transcription factor 4 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Recommanded Product: Ethyl 3-amino-4-(cyclohexylamino)benzoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Guangli; Li, Junjie; Li, Qing published the artcile< Biodegradable MnO2 nanosheet mediated hybridization chain reaction for imaging of human apurinic/apyrimidinic endonuclease 1 activity in living cells>, Related Products of 112-63-0, the main research area is apurinic apyrimidinic endonuclease manganese dioxide nanosheet biodegradable.

A highly sensitive enzyme-free amplification assay for the detection of apurinic/apyrimidinic endonuclease 1 activity was developed. By incorporating biodegradable MnO2 nanosheets, in situ light up intracellular APE 1 activity was achieved.

Nanoscale published new progress about Biodegradability. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics