Tag: M.W=250-300

Hou, Wen; Wei, Bao; Liu, Hong Sheng published the artcile< The protective effect of Panax notoginseng mixture on hepatic ischemia/reperfusion injury in mice via regulating NR3C2, SRC, and GAPDH>, COA of Formula: C19H34O2, the main research area is Panax hepatic ischemia reperfusion injury NR3C2 SRC GAPDH; glyceraldehyde-3-phosphate dehydrogenase liver; hepatic ischemia/reperfusion injury; mineralocorticoid receptor; notoginseng mixture; tyrosine-protein kinase.

Panax notoginseng mixture (PNM) has the characteristics of multicomponent, multitarget, and multieffect, which can cope with the multidirectional and multidimensional complex pathol. process caused by hepatic ischemia/reperfusion injury (HIRI). Our animal experiments showed that PNM composed of notoginseng, dogwood, and white peony root could significantly reduce the level of aspartate transaminase and alanine aminotransferase in the blood of mice with HIRI, indicating that this preparation had a protective effect on HIRI in mice. Therefore, on this basis, the mol. mechanism of PNM intervention in HIRI was further explored by network pharmacol. First, target genes corresponding to active components and HIRI were obtained through databases such as TCMSP, Pharm Mapper, Swiss Target Prediction, GeneCards, and so on. All target genes were standardized by Uniprot database, and a total of 291 target genes with their intersection were obtained. Then, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and biol. processes (BPs) of 291 target genes were obtained through the online public platform of DAVID. A total of 177 KEGG pathways and 337 BPs were obtained by setting p < 0.01 and false discovery rate <0.05. The network mapping map of components and disease targets was drawn by Cytoscape, and the top 10 Hub target genes related to HIRI were obtained. At the same time, the String database was used to obtain the proteinaprotein interaction dataset, which was imported into Cytoscape, and the first 10 Hub target genes were obtained. The Hub target genes obtained by the above two methods were mol. docking with their corresponding small mol. compounds through DockThor online tool. The results showed that the docking of paeoniflorin with glyceraldehyde 3-phosphate dehydrogenase (GAPDH), paeoniflorin and loganin with SRC, ginsenoside Rb1 with NR3C2, ursolic acid and oleanolic acid with IL-6, paeoniflorin docking VEGFA, and MMP9. Finally, NR3C2, SRC, and GAPDH were identified as target genes in this study by referring to relevant literature reports. After verification by immunohistochem. experiments, compared with the sham group, the above three target genes were highly expressed in the HIRI group (p < 0.01). Compared with the HIRI group, the expression of three target genes in the PNM + HIRI group was significantly decreased (p < 0.01). The results showed that PNM could protect mouse HIRI by decreasing the expression of NR3C2, SRC, and GAPDH. Frontiers in Pharmacology published new progress about Adenosine A2A receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Prathiba, S.; Vaishnavi, A.; Saranya, R.; Chandrasatheesh, C.; Jayapriya, J. published the artcile< Synthesis of hydroxyl ether based biolubricant from poultry waste and to evaluate the friction performance with titania nanoparticles>, Category: esters-buliding-blocks, the main research area is hydroxyl ether biolubricant poultry waste friction titania nanoparticle.

Low-cost chicken waste fat, with a high content of palmitic acid (saturated fatty acid) and oleic acid (unsaturated fatty acid) was used for biolubricant production The effects of different reaction parameters on the fat transesterification reaction using potassium hydroxide to form fatty acid Me esters were investigated. In this study, the Me esters from chicken waste fat were chem. modified to produce hydroxyl ethers (biolubricants) through epoxidation, followed by the ring-opening reaction of the epoxides with isoamyl alc. in the molar ratio of 3:1 (alc.:methyl esters) using the acid catalyst p-toluene sulfonic acid. The biolubricant obtained after the ring-opening of the Me epoxides exhibited higher oxidative stability (OS) (18 h) than that of the biodiesel (3.85 h). The viscosity index of the biolubricant was found to be 295.32. The tribol. performance of the biolubricant was enhanced by the addition of TiO2 (0.05% w/v). The biolubricant with 0.05% TiO2 led to a 25% reduction in friction coefficient and also enhanced the viscosity by 1.1-fold. Thus, TiO2 is suggested as a good antifriction property enhancer and viscosity modifier for the chicken waste lubricant. In summary, the chicken waste fat can be considered a feasible alternative to formulate biolubricants that match the physicochem. and low-temperature properties of com. hydraulic oils.

Chemical Engineering Research and Design published new progress about Alcohols Role: PRP (Properties), TEM (Technical or Engineered Material Use), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Acemoglu, Murat; Allmendinger, Thomas; Calienni, John; Cercus, Jacques; Loiseleur, Olivier; Sedelmeier, Gottfried H.; Xu, David published the artcile< Synthesis of new N-aryl oxindoles as intermediates for pharmacologically active compounds>, Category: esters-buliding-blocks, the main research area is phenylacetic acid arylamino preparation; oxindole aryl preparation ring opening.

Various new N-aryl oxindoles I (R1 = Me, Et; R2 = 2-Cl-6-FC6H3, 2,3,6-F3C6H2, 2,6-Cl2-4-MeC6H2, etc.) were synthesized as intermediates for the preparation of pharmacol. active 2-(N-arylamino)phenylacetic acids II. Two novel approaches were explored for the construction of diarylamine and N-aryl oxindole core structures, in addition to Buchwald arylamination and Smiles rearrangement. Condensation of anilines with 2-oxo-cyclohexylidene-acetic acid derivatives and subsequent dehydrogenation is a new and viable method for the preparation of N-aryl oxindoles.

Tetrahedron published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bolscher, Jan G. M.; Brevoord, Judith; Nazmi, Kamran; Ju, Tongzhong; Veerman, Enno C. I.; van Wijk, Joanna A. E.; Cummings, Richard D.; van Die, Irma published the artcile< Solid-phase synthesis of a pentavalent GalNAc-containing glycopeptide (Tn antigen) representing the nephropathy-associated IgA hinge region>, Application In Synthesis of 112-63-0, the main research area is Tn antigen glycopeptide IgA nephropathy.

Incomplete or aberrant glycosylation leading to Tn antigen (GalNAcα1-Ser/Thr) expression on human glycoproteins is strongly associated with human pathol. conditions, including tumors, certain autoimmune diseases, such as the idiopathic IgA nephropathy, and may modulate immune homeostasis. In addition, the Tn antigen is highly expressed by certain pathogens and plays a role in host-pathogen interactions. To enable exptl. approaches to study interactions of the Tn antigen with the immune system and analyze anti-Tn antibody responses in infection or disorders, we generated a Tn-expressing resource that can be used for high-throughput screening. In consideration of IgA nephropathy in which the hinge region is incompletely glycosylated, we used this hinge sequence that encodes five potential glycosylation sites as the ideal template for the synthesis of a Tn antigen-expressing glycopeptide. Inclusion of an N-terminal biotin in the peptide enabled binding to streptavidin-coated ELISA plates as monitored using Helix pomatia agglutinin or anti-Tn monoclonal antibody. We also found that the biotinylated IgA-Tn peptide is a functional acceptor for β1-3-galactosylation using recombinant T-synthase (β1-3-galactosyltransferase). Besides its immunochem. functionality as a possible diagnostic tool for IgA nephropathy, the peptide is an excellent substrate for glycan elongation and represents a novel template applicable for glycan-antigen-associated diseases.

Carbohydrate Research published new progress about Agglutinins and Lectins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Yanlin; Ma, Songqi; Li, Qiong; Wang, Sheng; Huang, Kaifeng; Xu, Xiwei; Wang, Binbo; Zhu, Jin published the artcile< Dynamic transfer auto-catalysis of epoxy vitrimers enabled by the carboxylic acid/epoxy ratio based on facilely synthesized trifunctional monoesterified cyclic anhydrides>, Computed Properties of 112-63-0, the main research area is epoxy vitrimer trifunctional ester cyclic anhydride crosslinking.

Vitrimers based on transesterification exhibit reprocessable and amendable features, but highly rely on external catalyst to accelerate the stress relaxation and network rearrangement. Here we prepared reprocessable auto-catalyzed epoxy vitrimers via introducing dynamic transferrable monoesterified cyclic anhydrides into cross-linked networks. Two trifunctional monoesterified cyclic anhydrides MT and ST were facilely synthesized by catalyst-free melting reaction of maleic anhydride and succinic anhydride with trimethylolpropane, resp., and were utilized to cure the bisphenol A epoxy DER 331. The excess monoesterified anhydrides (containing catalytic carboxyl groups) grafted in the crosslinked networks could undergo dynamic reversible reactions to transfer from one site to another, as a result, the transesterification at different sites of the networks could be effectively catalyzed. The dynamic transfer of catalytic group followed two mechanisms:(i) removal-monoesterification of cyclic anhydrides and (ii) transesterification of monoesterified cyclic anhydrides with hydroxyl group. In addition to the excellent reprocessability and rapid stress relaxation, the auto-catalyzed epoxy vitrimers presented high glass transition temperatures of ∼110°C, Young’s modulus of ∼3103 MPa and tensile strength of ∼70.6 MPa. This dynamic transfer catalysis will provide a new idea to accelerate the stress relaxation and network rearrangement of vitrimers.

European Polymer Journal published new progress about Absorption (water). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wiedemann, Stefan; Frank, Daniel; Winsel, Harald; de Meijere, Armin published the artcile< Primary 1-Arylcyclopropylamines from Aryl Cyanides with Diethylzinc and Titanium Alkoxides>, Computed Properties of 112-63-0, the main research area is aryl nitrile diethyl zinc cyclopropanation; cyclopropanation catalyst titanium alkoxide; amine cyclopropyl preparation.

1-Aryl-substituted primary cyclopropylamines, e.g., I, are conveniently prepared from aromatic nitriles and diethylzinc. The yields range from 40 to 56% for donor-substituted (five examples) to 62-82% for non- and acceptor-substituted substrates (nine examples).

Organic Letters published new progress about Amines Role: SPN (Synthetic Preparation), PREP (Preparation) (cyclopropyl). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tikhomirov, Yu. P.; Kuznetsova, L. V.; Getmanenko, E. N. published the artcile< Sanitary and hygienic assessment of household polymers on the basis of acryl monomers>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Metaplast volatile compound release toxicity; Akriel’ emulsion volatile compound release.

The release of volatile substances from Metaplast and Akriel’ emulsion was negligible when used indoors with an air exchange of 1 vol/h. Thus, the products are suitable for the manufacture of goods for general use.

Gigiena i Sanitariya published new progress about Health hazard. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bayer, Edward A.; Viswanatha, T.; Wilchek, Meir published the artcile< The use of a homologous series of affinity labeling reagents in the study of the biotin transport system in yeast cells>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is biotin homolog yeast uptake; transport biotin homolog yeast; affinity label biotin transport.

A homologous series of 9 biotin-containing affinity labels, in which the reactive p-nitrophenyl ester group is located at increasing distances from the biol.-active ureido moiety, were synthesized. Cells, harvested from growth cultures of Saccharomyces cerevisiae, were suspended in K phosphate solution (pH 4.0) and treated with an EtOH solution containing 1 of the affinity labeled homologs. The cells then were washed, resuspended in phosphate solution containing glucose, and biotin-14C was added. Aliquots were taken at intervals, the cells collected by filtration, and the radioactivity was determined The percent inhibition of biotin uptake was greatest with the shorter-length affinity labels, and the inhibition decreased with increasing chain length. With some exceptions, the inhibited cells could be reactivated by adding mercaptoethanol. The relation of the structure of the homologs to the mechanism of biotin transport was discussed.

FEBS Letters published new progress about Biological transport. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Park, Robin; Amin, Manik; Trikalinos, Nikolaos A. published the artcile< Temozolomide duration and secondary hematological neoplasms: A literature review and implications for patients with neuroendocrine neoplasms>, COA of Formula: C19H34O2, the main research area is MDS; capecitabine; leukemia; myelodysplastic syndrome; myelotoxicity.

Evidence-based recommendations for the optimal duration and sequencing of temozolomide-based treatments in advanced neuroendocrine neoplasms are lacking. Here, we conducted a systematic review of the literature for a descriptive anal. of temozolomide-associated myelodysplasias and leukemias to guide treatment planning. A database search of PubMed and Embase was conducted to identify case reports and/or case series reporting secondary myelodysplasias or leukemias in the setting of temozolomide therapy. Key data items extracted from the studies were the temozolomide dose and duration, latency to hematol. disorder, type of secondary malignancy and cytogenetics. Reported cases were summarized graphically. A total of 16 studies with 27 patient cases of therapy-related hematol. neoplasms were identified, all of which were case reports or case series. The median treatment duration and cumulative dose were 19 mo and 18,000 mg/m2, resp. Most patients (21/27) were diagnosed on, or after, 12 mo, while only one patient was diagnosed before 6 mo of treatment. Most of the patients were diagnosed, while still on treatment with temozolomide. Graphically, cases clustered around a cumulative dose of 10,000 to 30,000 mg/m2 and a latency period of 10 to 40 mo which translates to an approx. treatment duration of 12.5 to 37.5 mo. Taken together, most reported treatment-related hematol. neoplasms appear to develop on or beyond the 12-mo mark, while patients are still on treatment with temozolomide. For patients with neuroendocrine neoplasms, where sequencing of multiple therapies is important, we suggest an approach to optimizing treatment duration by establishing disease response at 6 mo before continuing further treatment and restricting treatment to or establishing closer vigilance beyond 12 mo.

Journal of Neuroendocrinology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tobisu, Mamoru; Yasutome, Ayaka; Yamakawa, Ken; Shimasaki, Toshiaki; Chatani, Naoto published the artcile< Ni(0)/NHC-catalyzed amination of N-heteroaryl methyl ethers through the cleavage of carbon-oxygen bonds>, Computed Properties of 112-63-0, the main research area is Nickel catalyzed amination heteroaryl ether cleavage carbon oxygen bond.

Ni(0)/NHC-based catalyst system can promote the amination of N-heteroaryl Me ethers via the cleavage of normally unreactive carbon-oxygen bonds. Electron-deficient N-heteroarenes including pyridine, quinoline, isoquinoline, and quinoxaline undergo amination to afford aminopyridine and related heteroarenes, which constitute an important class of compounds

Tetrahedron published new progress about Amination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics