Tag: M.W=250-300

Yin, Jiameng; Lin, Yajun; Fang, Weiwei; Zhang, Xin; Wei, Jie; Hu, Gang; Liu, Pu; Niu, Jie; Guo, Jun; Zhen, Yongzhan; Li, Jian published the artcile< Tetrandrine citrate suppresses breast cancer via depletion of glutathione peroxidase 4 and activation of nuclear receptor coactivator 4-mediated ferritinophagy>, Application In Synthesis of 347174-05-4, the main research area is tetrandrine citrate glutathione peroxidase nuclear receptor coactivator breast cancer; breast cancer; ferroptosis; glutathione peroxidase 4; nuclear receptor coactivator 4; tetrandrine citrate.

Tetrandrine citrate (TetC), a novel tetrandrine salt with high water solubility, demonstrates a potent antitumor activity in chronic myeloid leukemia. Studies have indicated an important role of ferroptosis in breast cancer (BC). However, whether TetC inhibits BC progression via ferroptosis has never been explored. In the present study, we showed that TetC had a significant inhibitory effect on the proliferation and migration of MCF7 and MDA-MB-231 cells. Then, we combined TetC with different inhibitors to determine which form of cell death could be driven by TetC. MTT assay showed that ferrostatin (Fer-1) demonstrated the most potent effect on improving TetC-induced cell death in contrast to other inhibitors. TetC was also shown to significantly increase the mRNA level of prostaglandinendoperoxide synthase 2 (Ptgs2), a ferroptosis marker. Further studies showed that TetC significantly suppressed the expression of glutathione peroxidase 4 (GPX4) and ferritin heavy chain 1 (FTH1) but increased the expression of nuclear receptor coactivator 4 (NCOA4) in MCF7 and MDA-MB-231 cells even in the presence of erastin or Ras-selective lethal 3 (RSL3). Collectively, we showed novel data that ferroptosis was a major form of TetC-induced cell death. Moreover, TetC-induced ferroptotic cell death was achieved via suppressing GPX4 expression and activating NCOA4-mediated ferritinophagy in BC cells.

Frontiers in Pharmacology published new progress about Autophagosome. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Application In Synthesis of 347174-05-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xue, Dong; Chen, Ying-Chun; Wang, Qi-Wei; Cun, Ling-Feng; Zhu, Jin; Deng, Jin-Gen published the artcile< Asymmetric Direct Vinylogous Michael Reaction of Activated Alkenes to Nitroolefins Catalyzed by Modified Cinchona Alkaloids>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is malononitrile alkylidene stereoselective vinylogous Michael addition nitroalkene cinchona alkaloid; alkylidene malononitrile nitroalkyl asym synthesis.

The first organocatalytic and asym. direct vinylogous Michael reaction of electron-deficient alkylidene malononitriles, e.g. I (X = CH2, O, S), as the nucleophilic species with nitroalkenes RCH:CHNO2 (R = Ph, 4-MeOC6H4, 4-ClC6H4, 2-furyl, 2-thienyl, etc.) has been reported. The novel transformations exhibit exclusive γ-selectivity and high diastereo- and enantioselectivity and afford the multifunctional products with two vicinal chiral centers, e.g. II, in 85-95% yields.

Organic Letters published new progress about Alkenes, electron-deficient Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Lan; Xian, Yan-Fang; Hu, Zhen; Loo, Steven King Fan; Ip, Siu Po; Chan, Wood Yee; Lin, Zhi-Xiu; Wu, Justin Che Yuen published the artcile< Efficacy and action mechanisms of a Chinese herbal formula on experimental models of atopic dermatitis>, Synthetic Route of 112-63-0, the main research area is Chinese herbal formula exptl model atopic dermatitis; Atopic dermatitis; Chinese herbal formula; Epidermal barrier; NF-κB pathway; Skin inflammation; Th1/Th2 balance.

Atopic dermatitis (AD) is a skin inflammatory disease characterized by erythema, eruption, lichenification and pruritus. Shi Zhen Formula (SZF), an empirical Chinese herbal preparation, has clin. efficacy in relieving the symptoms of AD patients. However, the underlying mol. mechanisms of SZF remained unclear. We aimed to investigate the anti-AD effects of SZF and elucidate its underlying mol. mechanisms using in vitro and in vivo models of AD. High-performance liquid chromatog. anal. was performed for quality control of SZF extract The anti-inflammatory effect of SZF was investigated through evaluating the levels of nitric oxide (NO), chemokines and pro-inflammatory cytokines in the lipopolysaccharide (LPS) stimulated RAW264.7 cells. AD-like skin lesions in female BALB/c mice were induced by 2,4-dinitrochlorobenzene (DNCB). SZF (3.15, 6.30 and 9.45 g/kg) and dexamethasone (5 mg/kg) were administered by gavage daily for 15 consecutive days. The body weight, skin thickness, skin dermatitis severity and scratching behaviors were recorded throughout the study. Histol. anal., reverse transcription-quant. polymerase chain reaction (RT-PCR), western blot (WB) and ELISA anal. were used to illuminate the mol. targets associated with the anti-AD effects of SZF. SZF markedly decreased the epidermal thickening and infiltration of mast cells in the ears and dorsal skin of the 2,4-dinitrochlorobenzene (DNCB)-treated mice. SZF not only suppressed the levels of IgE (IgE), histamine, thymic stromal lymphopoietin (TSLP) and IL-4 in the serum but also suppressed the over-production of IL-4 and IL-6 and gene expressions of IL-4, IL-13, IL-31 and TSLP in the dorsal skin. Moreover, SZF improved epidermal barrier by increasing the protein expressions of filaggrin, involucrin and loricrin and inhibited the activation of NF-κB p65 pathway in the dorsal skin of the DNCB-treated mice. SZF alleviates DNCB induced AD-like skin lesions in mice through regulating Th1/Th2 balance, improving epidermal barrier and inhibiting skin inflammation. Our research findings provide scientific footing on the use of this Chinese herbal formula for the treatment of AD.

Journal of Ethnopharmacology published new progress about Atopic dermatitis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Hua; Liu, Liangliang; Liu, Xiao; Jia, Yu; Zhang, Peng; Zhang, Yong published the artcile< Greatly promoted oxygen reduction reaction activity of solid catalysts by regulating the stability of superoxide in metal-O2 batteries>, Application of C19H34O2, the main research area is superoxide solid catalyst stability oxygen battery reduction reaction activity.

Oxygen reduction reactions (ORRs) with one- or two-electron-transfer pathways are the essential process for aprotic metal-oxygen batteries, in which the stability of superoxide intermediates/products (O2-, LiO2, NaO2, etc.) mainly dominates the ORR activity/stability and battery performance. However, little success in regulating the stability of the superoxides has been achieved due to their highly reactive characteristics. Herein, we identified and modulated the stability of superoxides by introducing anthraquinone derivatives as cocatalysts which functioned as superoxide trapper adsorbing the superoxides generated via surface-mediated ORR and then transferring them from the solid catalyst surface into electrolyte. Among the studied trappers, 1,4-difluoroanthraquinone (DFAQ) with electron-withdrawing groups showed the highest adsorption towards superoxides and could efficiently stabilize LiO2 in electrolyte, which greatly promoted the surface-mediated ORR rate and stability. This highlighted the magnitude of adsorption between the trapper and LiO2 on the ORR activity/stability. Using an aprotic Li-O2 battery as a model metal-O2 battery, the overall performance of the cell with DFAQ was substantially improved in terms of cell capacity, rate capability and cyclic stability. These results represent a significant advance in the understanding of ORR mechanisms and promoting the performance of metal-O2 batteries.

Science China Materials published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Duan, Ju; Wang, Wenting; Zou, Degui; Liu, Jing; Li, Na; Weng, Junying; Xu, Li-ping; Guan, Ying; Zhang, Yongjun; Zhou, Pengfei published the artcile< Construction of a Few-Layered COF@CNT Composite as an Ultrahigh Rate Cathode for Low-Cost K-Ion Batteries>, Category: esters-buliding-blocks, the main research area is covalent organic framework carbon nanotube potassium ion battery cathode; cathode materials; covalent organic frameworks; few-layered; potassium-ion batteries; ultrahigh rate performance.

Potassium-ion batteries (PIBs) are attracting great interest for large-scale energy storage owing to the abundant resources and low redox potential of K+/K. However, the large volume changes and slow kinetics caused by the larger ionic radius of K+ for cathode materials remain a critical challenge for PIBs. Herein, we construct few-layered covalent organic frameworks integrated with carboxylated carbon nanotubes (DAAQ-COF@CNT) as cathode materials for PIBs. The synthesized DAAQ-COF@CNT features numerous active sites, a stable conductive framework, and an appropriate surface area with nanopores, which can render high elec. conductivity, shorten the ion/electron diffusion distance, and accelerate K+ diffusion. In consequence, the DAAQ-COF@CNT delivers a high reversible capacity of 157.7 mAh g-1 at 0.1 A g-1, an excellent rate capability of 111.2 mAh g-1 at 1 A g-1, and a long cycling stability of 77.6% capacity retention after 500 cycles at 0.5 A g-1. The integrated characterization of ex situ XPS, Fourier transform IR spectroscopy, and theor. simulation discloses that the storage mechanism of DAAQ-COF@CNT is based on the reversible reaction between electroactive C=O groups and K+ during two successive steps. This work provides a promising high-performance cathode material for PIBs and encourages the development of new types of covalent organic frameworks for PIBs.

ACS Applied Materials & Interfaces published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Childers, Wayne E. Jr.; Havran, Lisa M.; Asselin, Magda; Bicksler, James J.; Chong, Dan C.; Grosu, George T.; Shen, Zhongqi; Abou-Gharbia, Magid A.; Bach, Alvin C. III; Harrison, Boyd L.; Kagan, Natasha; Kleintop, Teresa; Magolda, Ronald; Marathias, Vasilios; Robichaud, Albert J.; Sabb, Annmarie L.; Zhang, Mei-Yi; Andree, Terrance H.; Aschmies, Susan H.; Beyer, Chad; Comery, Thomas A.; Day, Mark; Grauer, Steven M.; Hughes, Zoe A.; Rosenzweig-Lipson, Sharon; Platt, Brian; Pulicicchio, Claudine; Smith, Deborah E.; Sukoff-Rizzo, Stacy J.; Sullivan, Kelly M.; Adedoyin, Adedayo; Huselton, Christine; Hirst, Warren D. published the artcile< The Synthesis and Biological Evaluation of Quinolyl-piperazinyl Piperidines as Potent Serotonin 5-HT1A Antagonists>, Application In Synthesis of 112-63-0, the main research area is quinolinyl piperazinyl piperidine derivative preparation serotonin 5HT1A antagonist.

As part of an effort to identify 5-HT1A antagonists that did not possess typical arylalkylamine or keto/amido-alkyl aryl piperazine scaffolds, prototype compound I was identified from earlier work in a combined 5-HT1A antagonist/SSRI program. This quinolyl-piperazinyl piperidine analog displayed potent, selective 5-HT1A antagonism but suffered from poor oxidative metabolic stability, resulting in low exposure following oral administration. SAR studies, driven primarily by in vitro liver microsomal stability assessment, identified compound II, which displayed improved oral bioavailability and lower intrinsic clearance. Further changes to the scaffold resulted in a loss in potency. Compound II displayed cognitive enhancing effects in a number of animal models of learning and memory, enhanced the antidepressant-like effects of the SSRI fluoxetine, and reversed the sexual dysfunction induced by chronic fluoxetine treatment.

Journal of Medicinal Chemistry published new progress about 5-HT1A receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hollenhorst, Marie A.; Bumpus, Stefanie B.; Matthews, Megan L.; Bollinger, J. Martin; Kelleher, Neil L.; Walsh, Christopher T. published the artcile< The Nonribosomal Peptide Synthetase Enzyme DdaD Tethers Nβ-Fumaramoyl-L-2,3-diaminopropionate for Fe(II)/α-Ketoglutarate-Dependent Epoxidation by DdaC during Dapdiamide Antibiotic Biosynthesis. [Erratum to document cited in CA153:612347]>, Quality Control of 77215-54-4, the main research area is erratum peptide synthetase DdaD epoxidation DdaC DdaF dapdiamide; Pantoea nonribosomal peptide synthetase DdaD epoxidation erratum.

On Supporting Information page S5, the addition of one equivalent of N-methlymorpholine was omitted from the methods for preparation of amides 2a and 2b. The reagent was added prior to cooling the solutions to -10 °C. On Supporting Information page S7, the wording of the method section ‘G. DdaC/D Enzymic Assays with Anaerobically Purified Ddac’ was altered to make it more clear. This material is available free of charge via the Internet at http://pubs.acs.organic

Journal of the American Chemical Society published new progress about Antibiotics (dapdiamide). 77215-54-4 belongs to class esters-buliding-blocks, and the molecular formula is C12H24N2O4, Quality Control of 77215-54-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Garzio, Kayla; McElroy, Kelly; Grossman, Stuart; Holdhoff, Matthias; Ozer, Byram; Yankulina, Olga published the artcile< Safety of temozolomide use in adult patients with renal dysfunction>, Electric Literature of 112-63-0, the main research area is Glioblastoma; High grade glioma; Primary central nervous system lymphoma; Renal impairment; Temozolomide.

Abstract: Purpose: Temozolomide (TMZ), a cytotoxic DNA alkylating agent, is the main chemotherapy used for the treatment of high grade astrocytomas. The active alkylator, methylhydrazine, is not recovered in urine and thus renal function is not expected to affect clearance. Prescribing information for TMZ states pharmacokinetics have not been studied in adults with poor renal function, eGFR < 36 mL/min/1.73 m2. We reviewed our clin. experience with TMZ in patients with impaired renal function to evaluate safety of administering full dose TMZ. Methods: The primary endpoint was to characterize the incidence and severity of thrombocytopenia in patients with eGFR < 60 mL/min/1.73 m2 who received TMZ for treatment of high grade gliomas (HGG) or primary CNS lymphoma (PCNSL). Secondary endpoints included incidence and severity of neutropenia, lymphopenia hepatotoxicity, and number of TMZ cycles administered. Medical records of patients with HGG or PCNSL treated with TMZ from Oct. 1, 2016-Sept. 30, 2019 were accessed to identify cases for this study. Results: Thirty-two patients were eligible for this study. Of the seven patients with eGFR < 36 mL/min/1.73m2, 38/39 cycles (97%) were completed without grade 3-4 thrombocytopenia. No patients experienced grade 3-4 neutropenia, and grade 3-4 lymphopenia occurred in 5 cycles (15%). One patient discontinued TMZ 7 days prior to completion of radiation due to thrombocytopenia. Conclusion: Hematol. toxicity in patients with severe renal dysfunction, eGFR < 36 mL/min/1.73m2, is similar to that of patients with normal renal function. Severe renal impairment does not preclude use of temozolomide, but cautious monitoring of blood counts is warranted. Journal of Neuro-Oncology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Aiqin; Li, Jing; Fan, Haojun; Xiang, Jun; Wang, Li; Yan, Jun published the artcile< Effect of mechanical properties on the self-healing behavior of waterborne polyurethane coatings>, Quality Control of 112-63-0, the main research area is waterborne polyurethane coating mech property effect self healing behavior.

The effect of structural parameters such as hard segment content and crosslinking degree on the mech. properties of waterborne self-healing polyurethane and the effect of tensile strength, self-healing conditions (temperature, time) on the self-healing properties were investigated. These results demonstrated that as the increasing of the content of hard segments/the crosslinking agent, the tensile strength of the sample increased and the self-healing performance exhibited a downward trend. When the tensile strength reached 40 MPa, it could hardly healed, even if prolonging the self-healing time or increasing the self-healing temperature Mechanism study demonstrated that the self-healing ability was attributed to the dynamic exchange of disulfide bonds and the thermal reversibility of hydrogen bonds in the system. Hydrogen bonding could provide the initial self-healing force and promote the dynamic exchange reaction of disulfide bonds, while high hydrogen bonding is not conducive to the movement of macromol. segments, causing a decrease in the self-healing efficiency.

Journal of Applied Polymer Science published new progress about Crack (fracture). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alker, D.; Swanson, A. G. published the artcile< Formation, synthetic utility and structure elucidation of a 2-(bromomethyl)-1,4-dihydropyridine>, Application In Synthesis of 112-63-0, the main research area is bromomethyldihydropyridine derivative preparation nucleophile substitution; pyridine bromomethyldihydro preparation nucleophile substitution.

The structure of the product obtained by reacting the 1,4-dihydropyridine I (R = H) with pyridinium bromide perbromide has been confirmed by NMR spectroscopy as the 2-bromomethyl derivative I (R = Br) (II). The reaction of II with a range of nucleophiles is reported.

Tetrahedron Letters published new progress about Nucleophilic substitution reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics