Tag: M.W=250-300

Banerjee, Sanjukta; Ray, Ayusmita; Das, Debabrata published the artcile< Optimization of Chlamydomonas reinhardtii cultivation with simultaneous CO2 sequestration and biofuels production in a biorefinery framework>, SDS of cas: 112-63-0, the main research area is carbon dioxide Chlamydomonas biofuel biorefinery; Bioethanol; Biorefinery; CO(2) sequestration; Microalgae: Chlamydomonas reinhardtii; Parameter optimization.

Algal biomass is regarded as a sustainable energy feedstock for the future. Enhancement of the biomass and metabolite production of microalgae increases the economic feasibility of the biofuel production process. The present study encompasses on bioethanol production from Chlamydomonas reinhardtii through a biorefinery approach. The biomass and carbohydrate productivity of C. reinhardtii UTEX 90 and CC 2656 were enhanced by optimizing the physico-chem. parameters. The following conditions were found suitable for the improvement of biomass and metabolite content of C. reinhardtii: pH 6.5-7.0, incubation temperature 30鎺矯, initial acetate and ammonium chloride concentration of 1.56 g L-1 and 100-200 mg L-1, resp. Under the optimized operational condition biomass and carbohydrate productivity of C. reinhardtii UTEX 90 and CC 2656 were 512 mg L-1 d-1 & 266.24 mg L-1 d-1 and 364 mg L-1 d -1 & 163.80 mg L-1 d-1, resp. The amount of CO2 sequestered during the cultivation process by UTEX 90 and CC 2656 were 113 mg L-1 d-1 and 74.95 mg L-1 d-1, resp. The depigmented and defatted carbohydrate rich biomass was considered as raw material for bioethanol production The bioethanol yield range was 90-94% of the theor. yield using Saccharomyces cerevisiae INVSC-1 in a double jacket reactor. To improve the viability of the process, the spent media after ethanol fermentation was subsequently used for methane production using mixed microbial consortium. The energy recovery from the process was 40.39% and 39.7% for UTEX 90 and CC 2656, resp. when C. reinhardtii biomass was used as substrate for biofuel production The present investigation concedes with the potentiality of algae as a favorable 3rd generation feedstock to address the existing challenges of clean energy production with concomitant CO2 sequestration.

Science of the Total Environment published new progress about Autotrophic bacteria. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xiang, Jun; Lin, Jianxun; Wang, Zhonghui; Zhou, Shenglin; Wang, Zhenya; Yan, Qiang; Liu, Yidong; Fan, Haojun published the artcile< Sustainable and invisible anti-counterfeiting inks based on waterborne polyurethane and upconversion nanoparticles for leather products>, Related Products of 112-63-0, the main research area is leather polyurethane anticounterfeiting ink nanoparticle.

Counterfeit leather products infringe the intellectual property rights of the business, cause enormous economic loss, and neg. influence the business enthusiasm for innovation. However, traditional anti-counterfeiting materials for leather products suffer from complicated fabrication procedures, photobleaching, and high volatile organic compound (VOC) emissions. Here, a sustainable and invisible anti-counterfeiting ink composed of waterborne polyurethane and water-dispersible lanthanide-doped upconversion nanoparticles (UCNPs) featuring ease of preparation, high photostability, non-toxicity, low VOC emissions, and strong adhesion strength for leather products is designed and synthesized. After decorating on the surface of leather products, the obtained patterns are invisible under normal light conditions. Upon irradiation at 808 nm, the invisible patterns can be observed by naked eyes due to the visible light emitted by 808 nm excited UCNPs. Our approach described here opens a new pathway to realize the long-term, stable anti-counterfeiting function of leather products.

Journal of Leather Science and Engineering published new progress about Abrasion resistance. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rabal, Obdulia; Sanchez-Arias, Juan A.; Cuadrado-Tejedor, Mar; de Miguel, Irene; Perez-Gonzalez, Marta; Garcia-Barroso, Carolina; Ugarte, Ana; Estella-Hermoso de Mendoza, Ander; Saez, Elena; Espelosin, Maria; Ursua, Susana; Haizhong, Tan; Wei, Wu; Musheng, Xu; Garcia-Osta, Ana; Oyarzabal, Julen published the artcile< Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease>, Reference of 112-63-0, the main research area is histone deacetylase HDAC phosphodiesterase PDE5 inhibitor antialzheimer Alzheimer.

Simultaneous inhibition of phosphodiesterase 5 (PDE5) and histone deacetylases (HDAC) has recently been validated as a potentially novel therapeutic approach for Alzheimer’s Disease (AD). To further extend this concept, the authors designed and synthesized the first chem. series of dual acting PDE5 and HDAC inhibitors, and the authors validated this systems therapeutics approach. Following the implementation of structure- and knowledge-based approaches, initial hits were designed and were shown to validate the hypothesis of dual in vitro inhibition. Then, an optimization strategy was pursued to obtain a proper tool compound for in vivo testing in AD models. Initial hits were translated into mols. with adequate cellular functional responses (histone acetylation and cAMP/cGMP response element-binding (CREB) phosphorylation in the nanomolar range), an acceptable therapeutic window (>1 log unit) and the ability to cross the blood-brain barrier, leading to the identification of 7 as a candidate for in vivo proof-of-concept testing.

Journal of Medicinal Chemistry published new progress about Alzheimer disease. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Meng, Jinni; Zhu, Yafei; Ma, Huixia; Wang, Xiaobo; Zhao, Qipeng published the artcile< The role of traditional Chinese medicine in the treatment of cognitive dysfunction in type 2 diabetes>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is review traditional Chinese medicine treatment diabetic cognitive dysfunction; Central nervous system; Hyperglycemia; Insulin resistance; Mechanisms; TCM.

A review. Diabetic cognitive dysfunction (DCD) is mainly one of the complications of type 2 diabetes mellitus (T2DM) with complex and obscure pathogenesis. Extensive evidence has demonstrated the effectiveness and safety of traditional Chinese medicine (TCM) for DCD management. This review attempted to systematically summarize the possible pathogenesis of DCD and the current Chinese medicine on the treatment of DCD. We acquired information of TCM on DCD treatment from PubMed, Web of Science, Science Direct and CNKI databases. We then dissected the potential mechanisms of currently reported TCMs and their active ingredients for the treatment of DCD by discussing the deficiencies and giving further recommendations. Most TCMs and their active ingredients could improve DCD through alleviating insulin resistance, microvascular dysfunction, abnormal gut microbiota composition, inflammation, and the damages of the blood-brain barrier, cerebrovascular and neurons under hyperglycemia conditions. TCM is effective in the treatment of DCD with few adverse reactions. A large number of in vivo and in vitro, and clin. trials are still needed to further reveal the potential quality markers of TCM on DCD treatment.

Journal of Ethnopharmacology published new progress about Cognitive disorders (diabetic). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Eggers, Christian; Hoetelmans, Richard; Laeer, Stephanie published the artcile< Zidovudine and lamivudine reach higher concentrations in ventricular than in lumbar human cerebrospinal fluid>, Application In Synthesis of 112-63-0, the main research area is cerebrospinal fluid zidovudine lamivudine antiretroviral.

Objective: For the treatment of HIV-1-related brain disease and for the prevention of the brain becoming a viral reservoir, it is important that antiretroviral agents reach sufficient concentrations in the CNS. To date, human brain pharmacokinetic data are solely derived from lumbar cerebrospinal fluid (CSF) and mostly originate from single samples. Design: We determined concentrations of antiretroviral drugs in serial samples of ventricular CSF and compared these to the concentrations in serum and lumbar CSF of these patients. Methods: Two treatment-naive HIV-1-infected patients received external ventricular drainage for obstructive hydrocephalus. Starting with a combination antiretroviral regimen (cART), ventricular CSF, and subsequently lumbar CSF, with parallel serum, was frequently collected. Drug concentrations were determined and CSF-to-serum ratios were calculated Results: High concentrations, resulting in high CSF-to-serum ratios, were found in the ventricular CSF of the three substances zidovudine, lamivudine and indinavir, whereas this was not observed for stavudine, ritonavir, saquinavir and efavirenz. Concentrations of zidovudine and lamivudine were up to four times greater in CSF from the ventricles than in lumbar CSF of the same patient. The zidovudine concentrations in the ventricular CSF exceeded serum concentrations by a factor of 1.4. Conclusion: Unexpectedly high concentrations of some antiretrovirals in the ventricular CSF, the site close to the brain parenchyma where HIV is located, should be considered when the cART regimen is aiming at CNS viral replication.

AIDS (London, United Kingdom) published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Geary, Gemma C.; Hope, Eric G.; Singh, Kuldip; Stuart, Alison M. published the artcile< Electrophilic fluorination using a hypervalent iodine reagent derived from fluoride>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is hypervalent iodine fluoride preparation electrophilic fluorination reagent; keto ester electrophilic fluorination hypervalent iodine fluoride; diketone electrophilic fluorination hypervalent iodine fluoride.

The air- and moisture-stable fluoroiodane I, readily prepared on a 6 g scale by nucleophilic fluorination of the corresponding hydroxyiodane with TREAT-HF, was used as an electrophilic fluorinating reagent to monofluorinate 1,3-keto esters and difluorinate 1,3-diketones with good isolated yields.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wahyudi, Wahyudi; Nadjib, Muhammad; Novela, Mila C.; Aprilia, Ornelia D. published the artcile< The effect of palm biodiesel composition on the physical properties of Calophylluminophyllum-palm biodiesel mixture>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Calophyllum palm oil biodiesel phys property.

The increasing energy consumption and depletion of fossil fuels require the need for alternative source of fuels. Biodiesel is an alternative fuel developed and can replace or reduce the use of petroleum diesel. One of its development processes is to change fatty acid composition through the mixing of different raw materials namely Calophyllum inophyllum and palm oil. Calophylluminophyllum oil is a non-edible raw, while palm oil is an edible raw material which is abundantly produced. The research was carried out by processing palm and Calophylluminophyllum oil into biodiesel using transesterification. Furthermore, both kinds of biodiesel were mixed with 11 variations of the composition The results showed that mixing biodiesel Calophyllum inophyllum and palm oil produced pos. results with decreased viscosity and increased calorific value.

IOP Conference Series: Materials Science and Engineering published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Mahn Joo; Whitesides, George M. published the artcile< L-Lactate dehydrogenase: substrate specificity and use as a catalyst in the synthesis of homochiral 2-hydroxy acids>, Application In Synthesis of 112-63-0, the main research area is oxo carboxylate reduction lactate dehydrogenase; hydroxy acid preparation lactate dehydrogenase; butene oxide enzymic preparation.

Kinetic parameters (Km, kcat) are reported for reduction of é–?0 æµ?keto acids by L-lactate dehydrogenase (L-LDH; EC 1.1.1.27) from 5 sources (porcine heart, rabbit muscle, chicken liver, bovine heart, lobster tail). The L-LDH-catalyzed reduction reaction of 4 substrates representative of the range of activities observed was done on a preparative scale by using rabbit muscle L-LDH, and absolute configurations and values of enantiomeric excess (ee) of the products were determined: 2-hydroxybutanoic acid, ee > 99% S; 2-hydroxypentanoic acid, ee >99% S; cyclopropaneglycolic acid, ee >99% S; 3-phenyllactic acid, ee >99% S. This enzyme-catalyzed reduction provides a practical method for preparing 1-25-g quantities of a range of 2-hydroxy acids with high ee. To illustrate the value of these compounds as chiral synthons, (S)-2-hydroxybutanoic acid was converted to (S)-1-butene oxide having >98% ee on a 6-g scale.

Journal of the American Chemical Society published new progress about Chiral synthons. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Lihua; Ma, Baiquan; Wang, Changzhi; Chen, Xingyu; Ruan, Yong-Ling; Yuan, Yangyang; Ma, Fengwang; Li, Mingjun published the artcile< MdWRKY126 modulates malate accumulation in apple fruit by regulating cytosolic malate dehydrogenase (MdMDH5)>, Application In Synthesis of 112-63-0, the main research area is MdWRKY126 malate dehydrogenase apple fruit.

The content of organic acids greatly influences the taste and storage life of fleshy fruit. Our current understanding of the mol. mechanism of organic acid accumulation in apple (Malus domestica) fruit focuses on the aluminum-activated malate transporter 9/Ma1 gene. In this study, we identified a candidate gene, MdWRKY126, for controlling fruit acidity independent of Ma1 using homozygous recessive mutants of Ma1, namely Belle de Boskoop “”BSKP”” and Aifeng “”AF.”” Analyses of transgenic apple calli and flesh and tomato (Solanum lycopersicum) fruit demonstrated that MdWRKY126 was substantially associated with malate content. MdWRKY126 was directly bound to the promoter of the cytoplasmic NAD-dependent malate dehydrogenase MdMDH5 and promoted its expression, thereby enhancing the malate content of apple fruit. In MdWRKY126 overexpressing calli, the mRNA levels of malate-associated transporters and proton pump genes also significantly increased, which contributed to the transport of malate accumulated in the cytoplasm to the vacuole. These findings demonstrated that MdWRKY126 regulates malate anabolism in the cytoplasm and coordinates the transport between cytoplasm and vacuole to regulate malate accumulation. Our study provides useful information to improve our understanding of the complex mechanism regulating apple fruit acidity.

Plant Physiology published new progress about Acidity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Hesol; Lee, Sullim; Baek, Ji Yun; Seo, Chang-Seob; Yun, Hwayoung; Kim, Su-Nam; Kang, Ki Sung; Choi, You-Kyung published the artcile< Estrogenic activity of ethyl gallate and its potential use in hormone replacement therapy>, Product Details of C19H34O2, the main research area is ethyl gallate estrogen receptor component hormone replacement therapy; Estrogen receptor; Ethyl gallate; Hormone replacement therapy.

We aimed to compare the estrogenic activities of compounds isolated from Moutan Cortex Radicis (MRC, Paeonia suffruticosa Andrews) and identify their potential use in hormone replacement therapy. We quantified seven marker components (gallic acid, oxypaeoniflorin, paeoniflorin, Et gallate, benzoic acid, benzoylpaeoniflorin, and paeonol) in MRC using a high-performance liquid chromatog. simultaneous anal. assay. To investigate the estrogenic activity of MRC and the seven marker components, an E-screen assay was conducted using the estrogen receptor (ER)-pos. MCF-7 human breast cancer cell line. Among them, Et gallate caused cell proliferation in a concentration-dependent manner at concentrations above 25娓璏 and was clearly suppressed by combination treatment with the ER antagonist ICI 182,780. Therefore, Et gallate may be a compound of MRC that can increase the estrogenic effect in ER-pos. MCF-7 cells.

Bioorganic & Medicinal Chemistry Letters published new progress about Cell proliferation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics