Tag: M.W=250-300

Shah, Muddaser; Murad, Waheed; Ur Rehman, Najeeb; Mubin, Sidra; Al-Sabahi, Jamal Nasser; Ahmad, Manzoor; Zahoor, Muhammad; Ullah, Obaid; Waqas, Muhammad; Ullah, Saeed; Kamal, Zul; Almeer, Rafa; Bungau, Simona G.; Al-Harrasi, Ahmed published the artcile< GC-MS Analysis and Biomedical Therapy of Oil from n-Hexane Fraction of Scutellaria edelbergii Rech. f.: In Vitro, In Vivo, and In Silico Approach>, Synthetic Route of 112-63-0, the main research area is hexane oil scutellaria edelbergii biomedical therapy; GC-MS analysis; analgesic assay; anti-diabetics; anti-inflammatory; antibacterial activity; antioxidants.

The current study aimed to explore the crude oils obtained from the n-hexane fraction of Scutellaria edelbergii and further analyzed, for the first time, for their chem. composition, in vitro antibacterial, antifungal, antioxidant, antidiabetic, and in vivo anti-inflammatory, and analgesic activities. For the phytochem. composition, the oils proceeded to gas chromatog.-mass spectrometry (GC-MS) anal. and from the resultant chromatogram, 42 bioactive constituents were identified. Among them, the major components were linoleic acid Et ester (19.67%) followed by Et oleate (18.45%), linolenic acid Me ester (11.67%), and palmitic acid Et ester (11.01%). Tetrazolium 96-well plate MTT assay and agar-well diffusion methods were used to evaluate the isolated oil for its min. inhibitory concentrations (MIC), min. bactericidal concentration (MBC), half-maximal inhibitory concentrations (IC50), and zone of inhibitions that could determine the potential antimicrobial efficacy閳ョç? Anti-glucosidase potential was visualized through mol. docking simulations where ten compounds of the oil were found to be the leading inhibitors of the selected enzyme based on interactions, binding energy, and binding affinity. The oil from the n-hexane fraction of S. edelbergii contained valuable bioactive constituents that can act as in vitro biol. and in vivo pharmacol. agents. However, further studies are needed to uncover individual responsible compounds of the observed biol. potentials which would be helpful in devising novel drugs.

Molecules published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Erika L. Ponce A; Ochoa-Herrera, Valeria; Quintanilla, Francisco; Egas, David A.; Mora, Jose R. published the artcile< Optimization of a Gas Chromatography Methodology for Biodiesel Analysis>, Formula: C19H34O2, the main research area is fatty acid methyl ester biodiesel gas chromatog optimization transesterification.

Biodiesel from four different renewable resources was produced. An optimization of the reference methodol. by gas chromatog. was conducted based on the construction of calibration curves for each biodiesel during fatty acid Me esters (FAME) quantification. Therefore, in the proposed optimized methodol., pure com. standards are not necessary. Consequently, a reduction in the research expenses is achieved, making this methodol. a cost-effective alternative for FAME quantification. The calibration curves obtained for each biodiesel presented slope values between 0.5-0.7 and regression coefficients (R2) > 0.98 in all cases. These results were compared to those obtained by the conventional methodol. With respect to the validation of the optimized methodol., a comparison of the results obtained by this proposed methodol. and the reference one is presented. Finally, a robust and promising technique to quantify FAME present in biodiesel was successfully developed in this study.

Journal of Analytical Chemistry published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kimura, Toshihiro; Kamata, Keigo; Mizuno, Noritaka published the artcile< Bifunctional Tungstate Catalyst for Chemical Fixation of CO2 at Atmospheric Pressure>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is aromatic diamine propargylic alc carbon dioxide fixation tungstate catalyst; heterocycle cyclic urea carbonate quinazolinedione preparation reaction mechanism.

The authors report the first example of tungstate-based catalytic fixation of carbon dioxide (CO2). A simple monomeric tungstate, TBA[WO4] (TBA = n-Bu4N+) acts as a highly efficient homogeneous catalyst for chem. fixation of CO2 with aromatic diamines, 2-aminobenzonitriles, and propargylic alcs. to give urea derivatives quinazoline-2,4(1H,3H)-diones, and cyclic carbonates, resp. The 1H and 13C NMR spectra show the specific interaction of the tungsten-oxo moiety in TBA[WO4] with both CO2 and the substrate. This study also shows the importance of developing bifunctional catalysts which can activate both CO2 and a nucleophile (amines, alcs., etc.).

Angewandte Chemie, International Edition published new progress about Alcohols, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhai, Shiyang; Zhang, Huimin; Chen, Rui; Wu, Jiangxia; Ai, Daiqiao; Tao, Shunming; Cai, Yike; Zhang, Ji-Quan; Wang, Ling published the artcile< Design, synthesis and biological evaluation of novel hybrids targeting mTOR and HDACs for potential treatment of hepatocellular carcinoma>, SDS of cas: 112-63-0, the main research area is hepatocellular carcinoma mTOR HDAC1 antiproliferative drug deign mol docking; HDACs; Hepatocellular carcinoma; Hybrids; mTOR.

Hepatocellular carcinoma (HCC) is a major contributor to global cancer incidence and mortality. Many pathways are involved in the development of HCC and various proteins including mTOR and HDACs have been identified as potential drug targets for HCC treatment. In the present study, two series of novel hybrid mols. targeting mTOR and HDACs were designed and synthesized based on parent inhibitors (MLN0128 and PP121 for mTOR, SAHA for HDACs) by using a fusion-type mol. hybridization strategy. In vitro antiproliferative assays demonstrated that these novel hybrids with suitable linker lengths exhibited broad cytotoxicity against various cancer cell lines, with significant activity against HepG2 cells. Notably, DI06, an MLN0128-based hybrid, exhibited antiproliferative activity against HepG2 cells with an IC50 value of 1.61娓璏, which was comparable to those of both parent drugs (MLN0128, IC50 = 2.13娓璏 and SAHA, IC50 = 2.26娓璏). In vitro enzyme inhibition assays indicated that DI06, DI07 and DI17 (PP121-based hybrid) exhibited nanomolar inhibitory activity against mTOR kinase and HDACs (e.g., HDAC1, HDAC2, HDAC3, HADC6 and HADC8). Cellular studies and western blot analyses uncovered that in HepG2 cells, DI06 and DI17 induced cell apoptosis by targeting mTOR and HDACs, blocked the cell cycle at the G0/G1 phase and suppressed cell migration. The potential binding modes of the hybrids (DI06 and DI17) with mTOR and HDACs were investigated by mol. docking. DI06 displayed better stability in rat liver microsomes than DI07 and DI17. Collectively, DI06 as a novel mTOR and HDACs inhibitor presented here warrants further investigation as a potential treatment of HCC.

European Journal of Medicinal Chemistry published new progress about Acetylated histone H3 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Jin; Yang, Ruhan; Zhang, Li; Chen, Ying; Sheng, Xinxin; Zhang, Xinya published the artcile< Robust, transparent, and self-healable polyurethane elastomer via dynamic crosslinking of phenol-carbamate bonds>, Related Products of 112-63-0, the main research area is transparent self healable polyurethane elastomer crosslinking phenol carbamate bond.

Intrinsic self-healing materials designed through the incorporation of noncovalent interactions or dynamic covalent bonds are prized for their ability to recover from mech. damages. However, they often suffer from deteriorated mech. property due to the increased chain mobility. In this work, we reported a high-strength, colorless transparent self-healing polyurethane elastomer through dynamic crosslinking of reversible phenol-carbamate bonds. Tetrabromobisphenol A (TBBPA) and Pr gallate (PG) were used as the dynamic chain extender and dynamic crosslinking agent, resp. They both can be effectively deblocked at mild temperatures ensuring that the self-healing efficiency is not affected by the material formulation. The mech. properties can be tailored in a wide range by varying the crosslink d. and hard segment content, and their combination uniquely determines the material formulation. The phenol-carbamate based polyurethane (PPU) with a hard segment of 60% and a crosslink d. ç’?of 0.5 mmol cm-3 exhibited a tensile strength up to 46.4 MPa at the break strain of 615% and displayed high elastic resilience. In the meantime, it could be fully healed (鐣忚ç†?= 93%) with 2 h of heating at 100鎺矯 after completely cut off. After recycled three times, it still maintained 80% of its original tensile strength. The structural rigidity of the crosslinker PG and the highly reversible phenol-carbamate bond play a crucial role in strengthening the mech. strength while maintaining the self-healing efficiencies at elevated temperatures This work provides a feasible strategy to prepare mech. robust crosslinked polyurethane elastomer with high self-healing efficiency in a cost-effective manner.

Polymer published new progress about Complex modulus, tan � 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mikosch, W.; Dorfmuller, Th.; Eimer, W. published the artcile< Rotational motion of charged molecules in aqueous solutions. A change in the diffusion mechanism>, Computed Properties of 112-63-0, the main research area is rotational motion charged mol aqueous solution; viscosity fluorescence charged mol aqueous solution; diffusion Stokes Einstein Debye equation.

The rotational motion of the anions polyphenyl 2 (PP2) and pyrene tetrasulfonate (PTS) was studied as a function of the solvent viscosity by time-resolved fluorescence depolarization spectroscopy using the single photon counting technique. The viscosity was varied by changing the temperature and the composition of the water-glycerol mixtures, resp. At low viscosity the reorientational behavior of PP2 and PTS is well described by the Stokes-Einstein-Debye (SED) equation under stick boundary conditions. With increasing viscosity (��25 cP) however the rotational motion did no longer follow the SED predictions. Instead, we observed a much faster relaxation time, approaching an asymptotic value at very high viscosities. In the high viscosity regime microscopic collisional effects rather than the macroscopic hydrodynamics drag of the solvent determines the reorientational dynamics of the solute mols.

Journal of Chemical Physics published new progress about Diffusion. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Santschi, Nico; Matthey, Coraline; Schwenk, Rino; Otth, Elisabeth; Togni, Antonio published the artcile< On the Effect of Backbone Modifications in 3,3-Dimethyl-1-(trifluoromethyl)-3H-1æµ?,2-benziodaoxole>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is dimethyl trifluoromethyl benziodaoxole.

We report on the effect of small side-chain modifications to the structure of 3,3-dimethyl-1-(trifluoromethyl)-3H-1æµ?,2-benziodaoxole (1b) on its reactivity, as expressed by the initial rate v0 in a model reaction, and show how the latter can be successfully correlated to an easily determined phys. parameter p, a 13C NMR chem. shift. The relationship v0 é–?p is already present in the simplest starting material devoid of the hypervalent bond and the iodine core and, therefore, presents an interesting approach towards the future scaffold-optimization of this class of reagents.

European Journal of Organic Chemistry published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Khalifa, Muhammad M.; Philkhana, Satish Chandra; Golden, Jennifer E. published the artcile< Synthesis of Ring-Fused, N-Substituted 4-Quinolinones Using pKa-Guided, Base-Promoted Annulations with Isatoic Anhydrides: Total Synthesis of Penicinotam>, Category: esters-buliding-blocks, the main research area is isatoic anhydride ketone base promoted anionic annulation; quinolinone preparation; penicinotam total synthesis.

An anionic annulation strategy employing isatoic anhydrides and a wide assortment of enolizable partners was developed to afford over 80 novel ring-fused, N-substituted 4-quinolinones, an underrepresented privileged template. Multiple factors governing the efficiency of the transformation were determined, resulting in a reliable and tunable synthetic platform applicable for a broad range of substrates with variable deprotonation susceptibility, such as tetramic and tetronic acids, cyclic 1,3-diketones, and cycloalkanones. Application to the synthesis of bioactive, pyrrolizine-fused 4-quinolinone, penicinotam I, resulted in the most brief and highest yielding total synthesis of the alkaloid in three steps and a 36% overall yield.

Journal of Organic Chemistry published new progress about Cyclization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lipshutz, Bruce H.; Frieman, Bryan A.; Unger, John B.; Nihan, Danielle M. published the artcile< Thermally accelerated asymmetric hydrosilylations using ligated copper hydride>, Application In Synthesis of 112-63-0, the main research area is thermally microwave accelerated asym hydrosilylation ligated copper hydride catalyst; prochiral substrate asym hydrosilylation ligated copper hydride catalyst.

Exposure of a variety of prochiral substrates to [(R)-(-)-DTBM-SEGPHOS]CuH + PMHS under microwave or conventionally heated conditions reduces reaction times for these hydrosilylations from hours to minutes without significant erosion in ee in most cases. Thus, microwave assisted hydrosilylation of isophorone with poly(methylhydrosiloxane) at 60�for 60 min gave 100% (R)-3,3,5-trimethylcyclohexanone.

Canadian Journal of Chemistry published new progress about Hydrosilylation catalysts, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Baddeley, Kate L.; Cook, Matthew J. published the artcile< A highly selective Bi(OTf)3 mediated fragmentation-contraction of �ortholactones. A facile route to functionalized �lactones>, SDS of cas: 4098-06-0, the main research area is lactone preparation pyranyl ortholactone fragmentation acetate migration ring contraction.

A very selective method for the formation of ç»?lactones from pyranyl ortholactones has been developed which occurs via a fragmentation-acetate migration-ring contraction process. The reaction is very functional group tolerant, providing functionalized ç»?lactones as a single isomeric product following the ring contraction. Mechanistic studies indicate the reaction is mediated by triflic acid liberated from Bi(OTf)3 in a slow and controlled manner providing excellent chemo and regioselectivity. We propose the triflic acid acts as both a proton and a nucleophile source with triflate anion mediating the fragmentation process.

Tetrahedron published new progress about Fragmentation reaction. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, SDS of cas: 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics