Tag: M.W=250-300

Feng, Chuchu; Wu, Yu; Chen, Yantao; Xiong, Xilin; Li, Peng; Peng, Xiaomin; Li, Chunmou; Weng, Wenjun; Zhu, Yafeng; Zhou, Dunhua; Li, Yang published the artcile< Arsenic trioxide increases apoptosis of SK-N-BE (2) cells partially by inducing GPX4-mediated ferroptosis>, Application In Synthesis of 347174-05-4, the main research area is arsenic trioxide anticancer agent ferroptosis neuroblastoma; Arsenic trioxide; Ferroptosis; GPX4; Neuroblastoma; Quantitative proteomic analysis.

Neuroblastoma (NB) is the most common extracranial tumor in central nervous system threatening childrens health with limited therapeutic options. Arsenic trioxide (ATO) has been identified the cytotoxicity in NB cells but the potential mechanism remains unclear. In this study, we attempted to obtain some insight into the mechanisms of cell death induced by ATO in NB cells. Proteomic analyses found that ATO can affect the signaling pathway associated with ferroptosis, including the upregulation of iron absorption (FTL, FTH1, HO-1), ferritinophagy (LC3, P62, ATG7, NCOA4) and modifier of glutathione synthesis (GCLM); downregulation of glutamine synthetase (GS) and GPX4, which was the critical inhibitor of ferroptosis. Western blot anal. revealing GPX4 expression in SK-N-BE (2) cells decreased after treatment with ATO (7.3μM), resulting in a loss of GPX4 activity. Furthermore, Ferroptosis inhibitor ferrostatin-1 partially blocked ATO-induced cell death. Our study revealed that ATO may induce ferroptosis in neuroblastoma cell SK-N-BE (2) by facilitating the downregulation of GPX4, ultimately resulting in iron-dependent oxidative death.

Molecular Biology Reports published new progress about Antitumor agents. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Application In Synthesis of 347174-05-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hashimoto, Kei; Tatara, Ryoichi; Ueno, Kazuhide; Dokko, Kaoru; Watanabe, Masayoshi published the artcile< Design of polymer network and Li+ solvation enables thermally and oxidatively stable, mechanically reliable, and highly conductive polymer gel electrolyte for lithium batteries>, Application of C19H34O2, the main research area is design polymer network li solvation enables thermally oxidatively stable.

Herein, we demonstrate that design of polymer network and Li+-ion solvation enables the fabrication of thermally and oxidatively stable, mech. reliable, and highly conductive polymer gel electrolytes for lithium batteries. Polymer gel electrolytes have been used for Li-ion batteries (LIB) due to their quasi-solid natures and flexible shapes. However, they frequently suffer from the high vapor pressures of the incorporated solvents, low oxidative stabilities, and poor mech. properties. To overcome these drawbacks, we fabricated a tough gel electrolyte comprising a tetra-arm poly(ethylene glycol) (TPEG) homogeneous polymer network, in which a tetraglyme(G4)-based solvate ionic liquid (SIL) was incorporated. It was intriguing to find that the solvation of Li+ ion by oxygen atoms (within G4 and TPEG), represented as [O]/[Li], governed the thermal and oxidative stabilities of the gel electrolyte, while the homogeneous network contributed to the mech. reliability and high ionic conductivity At [O]/[Li] = 5, the TPEG-based gel electrolyte with no free solvent simultaneously exhibited high thermal (>200°C) and oxidative stabilities (>4.4 V), high stretchability, and high ionic conductivity (~1 mS cm-1 at 30°C). These favorable properties of the gel electrolyte resulted in reversible charge/discharge of a 4-V-class high-voltage cathode (LiNi0.6Mn0.2Co0.2O2, NMC622).

Journal of the Electrochemical Society published new progress about Battery cathodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

El-Rafie, Hanaa Mohamed; Zahran, Magdy K.; Raoof, Gehan F. Abdel published the artcile< Cotton bandages finished with microcapsules of volatile organic constituents of marine macro-algae for wound healing>, Reference of 112-63-0, the main research area is Cotton bandage microcapsulevolatile organic constituent marine macroalgae wound healing; Algal volatile constituents; Cotton fabric finishing; Gas chromatography/Mass spectrometry; Marine macroalgae; Microencapsulation; Wound healing.

Microencapsulation is an innovative technique having a growing application in textile finishing. Besides, marine macroalgae contain plenty of phytoconstituents used in various fields especially textile finishing. This work imparts the property of wound healing finish to cotton fabrics producing a bandage from eco-friendly algal volatile organic constituents (VOCs). VOCs extracted from Digenea simplex, Lurencea papillosa, Galaxurea oblongata, and Turbenaria decurrens Egyptian marine macroalgae scattered along the coastline of the Red sea were 0.52, 0.9, 0.87, and 0.62% (v/w), resp. These VOCs as well as their microencapsulated (VOM) forms were finished onto cotton fabrics by a conventional pad-dry cure technique using sodium alginate (SA) as a shell wall material. The VOCs of each alga were extracted and chem. investigated using gas chromatog. coupled with mass spectrometry (GC-MS). The results indicate, in addition to the identification of 125 volatile compounds, the diversity and outstanding differences in volatile composition among the 4 algae. Wound healing activities of the finished fabrics were evaluated. VOCs microcapsules-finished (VOMF) fabrics were more effective compared to VOCs-finished (VOF) fabrics and almost comparable to mebo-ointment (standard drug)-finished (MoF) fabrics. The differences in VOCs efficiencies may be attributable to the diversity in type and amount of volatiles found in the four algae. Therefore, this is a low-cost, convenient, reproducible, and scalable way to obtain encapsulated VOCs for the application in textile wound healing.

Bioprocess and Biosystems Engineering published new progress about Acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Haode; Tian, Yu; Wang, Wenxuan; Jian, Zelang; Chen, Wen published the artcile< Organic Ammonium Ion Battery: A New Strategy for a Nonmetallic Ion Energy Storage System>, HPLC of Formula: 112-63-0, the main research area is ammonium battery charge carrier nonmetallic ion energy storage system; Ammonium-Ion Batteries; Electrochemistry; Organic Electrolytes; Prussian White Analogues.

Nonmetallic ammonium (NH4+) ion batteries are promising candidates for large-scale energy storage systems, which have the merit of low molar mass, sustainability, non-toxicity and non-dendrite. Herein, for the first time, we introduce the novel organic ammonium ion batteries (OAIBs). Significantly, a manganese-based Prussian white analog (noted as MnHCF) as cathode exhibits a reversible capacity of 104 mAh g-1 with 98% retention over 100 cycles. We further demonstrate the electrochem. performance of the NH4+ ion full cell, which delivers a reversible capacity of 45 mAh g-1 with a broad electrochem. window. Combining ex situ XPS, ex situ XRD results and electrochem. properties, the NH4+ ion storage mechanism of MnHCF in a non-aqueous electrolyte is clearly revealed. This work verifies the feasibility of employing NH4+ ions as charge carriers in organic energy storage systems and provides new insights for designing organic nonmetallic ion batteries with broad electrochem. windows and high energy d.

Angewandte Chemie, International Edition published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hejmanowska, Joanna; Albrecht, Lukasz published the artcile< Organocatalytic asymmetric approach to spirocyclic tetrahydrothiophenes containing either a butenolide or an azlactone structural motif>, Quality Control of 112-63-0, the main research area is spirocyclic tetrahydrothiophene preparation enantioselective; mercaptoacetaldehyde butenolide azlactone Michael addition aldol organocatalyst.

In this manuscript a new organocatalytic approach to spirocyclic tetrahydrothiophenes bearing either a butenolide or an azlactone moiety is described. The developed methodol. is based on the cascade reactivity of 2-mercaptoacetaldehyde (generated in situ from 1,4-dithiane-2,5-diol) with α,β-unsaturated butenolides or azlactones, that consists of a thio-Michael addition followed by an intramol. aldol reaction. Chiral bases derived from cinchona alkaloids are used as a catalyst promoting the cascade and controlling its stereochem. outcome.

ARKIVOC (Gainesville, FL, United States) published new progress about Aldol addition, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ye, Lupeng; Park, Jonathan J.; Peng, Lei; Yang, Quanjun; Chow, Ryan D.; Dong, Matthew B.; Lam, Stanley Z.; Guo, Jianjian; Tang, Erting; Zhang, Yueqi; Wang, Guangchuan; Dai, Xiaoyun; Du, Yaying; Kim, Hyunu R.; Cao, Hanbing; Errami, Youssef; Clark, Paul; Bersenev, Alexey; Montgomery, Ruth R.; Chen, Sidi published the artcile< A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy>, Category: esters-buliding-blocks, the main research area is breast cancer proline metabolism CAR T therapy CRISPR; CAR-T; PRODH2; T cell CRISPR activation screen; T cell GOF screen; antitumor efficacy; dead-guide RNA; metabolism; mitochondria; proline metabolism.

Chimeric antigen receptor (CAR)-T cell-based immunotherapy for cancer and immunol. diseases has made great strides, but it still faces multiple hurdles. Finding the right mol. targets to engineer T cells toward a desired function has broad implications for the armamentarium of T cell-centered therapies. Here, we developed a dead-guide RNA (dgRNA)-based CRISPR activation screen in primary CD8+ T cells and identified gain-of-function (GOF) targets for CAR-T engineering. Targeted knockin or overexpression of a lead target, PRODH2, enhanced CAR-T-based killing and in vivo efficacy in multiple cancer models. Transcriptomics and metabolomics in CAR-T cells revealed that augmenting PRODH2 expression reshaped broad and distinct gene expression and metabolic programs. Mitochondrial, metabolic, and immunol. analyses showed that PRODH2 engineering enhances the metabolic and immune functions of CAR-T cells against cancer. Together, these findings provide a system for identification of GOF immune boosters and demonstrate PRODH2 as a target to enhance CAR-T efficacy.

Cell Metabolism published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (Ccnb1i.p.1). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Yinhua; Chan, Guo Hao; Chiba, Shunsuke published the artcile< Amide-Directed C-H Sodiation by a Sodium Hydride/Iodide Composite>, Synthetic Route of 112-63-0, the main research area is amide aryl sodium hydride iodide sodiation transformation; arene preparation; C−H activation; amides; arenes; metalation; sodium hydride.

A new protocol for amide-directed ortho and lateral C-H sodiation is enabled by sodium hydride (NaH) in the presence of either sodium iodide (NaI) or lithium iodide (LiI). The transient organosodium intermediates could be transformed into functionalized aromatic compounds

Angewandte Chemie, International Edition published new progress about Alkali metal organometallic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (organosodium). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Abdel Karim, M.; Naima, E.; Sima, A. published the artcile< GC-MS Analysis and Antimicrobial Activity of Cissus quadrangularis Oil>, Formula: C19H34O2, the main research area is antimicrobial activity Cissus quadrangularis oil GC MS analysis.

This study was planned to identify and quantify the oil from Sudanese Cissus quadrangularis and to evaluate the antimicrobial activity of the extracted oil. Cissus quadrangularis is a perennial climber widely used in Sudanese ethnomedicine. This plant grows in warm tropics and may propagate through stem cutting. Cissus quadrangularis possesses digestive, anthelmintic and tonic properties. The plant is rich in ascorbic acid, calcium and carotene. It also contains flavonoids, steroids and terpenoids. GC- MS anal. of Cissus quadrangularis oil revealed the presence of the following major components: E,E,Z-1,3,12-nonadecatriene-5,14-diol (22.11%); (R)-(-)- 14-methyl-8-hexadecyn-1-ol (15.44%); trilinolein (12.17%); 9,12-octadecadienoyl chloride, (Z,Z)- (11.02%) and 9,12-octadecadienoic acid (Z,Z)-, Me ester (8.67%). The oil was evaluated for its antimicrobial activity against five standard human pathogens. It showed moderate activity against Staphylococcus aureus and Pseudomonas aeruginosa.

Pharmaceutical and Chemical Journal published new progress about Anthelmintics. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xue, Dao-jin; Zhen, Zheng; Wang, Ke-xin; Zhao, Jia-lin; Gao, Yao; Chen, Yu-peng; Shen, You-bi; Peng, Zi-zhuang; Guan, Dao-gang; Huang, Tao published the artcile< Uncovering the potential mechanism of Xue Fu Zhu Yu Decoction in the treatment of intracerebral hemorrhage>, Category: esters-buliding-blocks, the main research area is sphingosine herbal medicine intracerebral hemorrhage; Chinese herbal medicine (CHM); Important gene network model; Integrated pharmacology; Intracerebral Hemorrhage (ICH); Mechanism.

Chinese herbal medicine (CHM) is characterized by “”multi- compounds, multi-targets and multi-pathway””, which has advanced benefits for preventing and treating complex diseases, but there still exists unsolved issues, mainly include unclear material basis and underlying mechanism of prescription. Integrated pharmacol. is a hot cross research area based on system biol., mathematics and poly-pharmacol. It can systematically and comprehensively investigate the therapeutic reaction of compounds or drugs on pathogenic genes network, and is especially suitable for the study of complex CHM systems. Intracerebral Hemorrhage (ICH) is one of the main causes of death among Chinese residents, which is characterized with high mortality and high disability rate. In recent years, the treatment of ICH by CHM has been deeply researched. Xue Fu Zhu Yu Decoction (XFZYD), one of the commonly used prescriptions in treating ICH at clinic level, has not been clear about its mechanism. Here, we established a strategy, which based on compounds-targets, pathogenetic genes, network anal. and node importance calculation Using this strategy, the core compounds group (CCG) of XFZYD was predicted and validated by in vitro experiments The mol. mechanism of XFZYD in treating ICH was deduced based on CCG and their targets. The results show that the CCG with 43 compounds predicted by this model is highly consistent with the corresponding Compound-Target (C-T) network in terms of gene coverage, enriched pathway coverage and accumulated contribution of key nodes at 89.49%, 88.72% and 90.11%, resp., which confirmed the reliability and accuracy of the effective compound group optimization and mechanism speculation strategy proposed by us. Our strategy of optimizing the effective compound groups and inferring the mechanism provides a strategic reference for explaining the optimization and inferring the mol. mechanism of prescriptions in treating complex diseases of CHM.

BMC Complementary Medicine and Therapies published new progress about Algorithm, reliability. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Jun; He, Bin-Qing; Wang, Peng-Zi; Yu, Xiao-Ye; Zhao, Quan-Qing; Chen, Jia-Rong; Xiao, Wen-Jing published the artcile< Photoinduced, Copper-Catalyzed Radical Cross-Coupling of Cycloketone Oxime Esters, Alkenes, and Terminal Alkynes>, HPLC of Formula: 112-63-0, the main research area is oxime ester alkene alkyne copper photoinduced radical cross coupling; cyanoalkyl containing propargylic preparation.

A photoinduced, copper-catalyzed three-component radical cross-coupling of cycloketone oxime esters, alkenes, and terminal alkynes is described for the first time. Key to the success of this process was the integration of photoinduced iminyl radical-mediated C-C bond cleavage with the conceptual simplicity of copper-catalyzed radical cross-coupling. This protocol provides access to cyanoalkyl-containing propargylic compounds in good yields.

Organic Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics