Tag: M.W=250-300

Wang, Ce; Zhang, Pingping; Chen, Zhenghong; Liu, Yang; Zhao, Li; Wang, Nan; Xu, Baocai published the artcile< Effects of fatty acyl chains on the interfacial rheological behaviors of amino acid surfactants>, HPLC of Formula: 112-63-0, the main research area is fatty acyl chain amino acid surfactant interfacial rheol behavior.

Amino acid surfactants derived from vegetable oils have attracted significant interest in the scientific community due to their excellent biocompatibility and low environmental impact. Because of the wide variety of vegetable oils, derived N-acyl amino acid surfactants may feature various fatty acyl groups and therefore offer diverse properties. According to the composition of commonly used vegetable oils, three main characteristics of fatty acyl structures, namely fatty acyl chain length, the number of C=C bonds, and hydroxyl substituent, were summarized in this paper and a series of N-fatty acyl glycinate surfactants were synthesized. The specific effects of these three structural factors on the surface tension and interfacial rheol. properties were systematically studied. In doing so, we found that an increase of fatty acyl chain length enhanced the interfacial activity and intermol. interactions of N-fatty acyl glycinate surfactants. Thus, glycinate surfactants with longer fatty acyls could generate more compact adsorption films with a higher dilational modulus. The cis C=C bonds in oleoyl and linoleoyl chains were found to bend the long hydrophobic tails, which might affect the compact arrangement of surfactant mols. and increased the viscoelasticity of interfacial films. In addition, the hydroxyl group on ricinoleoyl was found to inhibit the close packing of the hydrophobic tails and reduced intermol. interactions. As a result, more viscoelastic films were formed by sodium N-ricinoleoylglycinate. The obtained results gained insights into the relationships between fatty acyl structural characteristics and the interfacial arrangements of N-acyl amino acid surfactants, which present a theor. foundation for surfactant design and further application.

Journal of Molecular Liquids published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent) (N-acyl derivatives). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tsvetkov, Peter; Coy, Shannon; Petrova, Boryana; Dreishpoon, Margaret; Verma, Ana; Abdusamad, Mai; Rossen, Jordan; Joesch-Cohen, Lena; Humeidi, Ranad; Spangler, Ryan D.; Eaton, John K.; Frenkel, Evgeni; Kocak, Mustafa; Corsello, Steven M.; Lutsenko, Svetlana; Kanarek, Naama; Santagata, Sandro; Golub, Todd R. published the artcile< Copper induces cell death by targeting lipoylated TCA cycle proteins>, COA of Formula: C15H22N2O2, the main research area is copper cell death TCA cycle mitochondrial respiration homeostasis PDHA1.

Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How excess copper induces cell death, however, is unknown. Here, we show in human cells that copper-dependent, regulated cell death is distinct from known death mechanisms and is dependent on mitochondrial respiration. We show that copper-dependent death occurs by means of direct binding of copper to lipoylated components of the tricarboxylic acid (TCA) cycle. This results in lipoylated protein aggregation and subsequent iron-sulfur cluster protein loss, which leads to proteotoxic stress and ultimately cell death. These findings may explain the need for ancient copper homeostatic mechanisms.

Science (Washington, DC, United States) published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (DBT). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, COA of Formula: C15H22N2O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Madhusudan, Srinivasan; Smart, Fiona; Shrimpton, Paul; Parsons, Jason L.; Gardiner, Laurence; Houlbrook, Sue; Talbot, Denis C.; Hammonds, Timothy; Freemont, Paul A.; Sternberg, Michael J. E.; Dianov, Grigory L.; Hickson, Ian D. published the artcile< Isolation of a small molecule inhibitor of DNA base excision repair>, Application of C19H34O2, the main research area is inhibitor DNA base excision repair inhibitor CRT0044876 human antitumor; apurinic apyrimidinic endonuclease DNA damage repair inhibitor.

The base excision repair (BER) pathway is essential for the removal of DNA bases damaged by alkylation or oxidation A key step in BER is the processing of an apurinic/apyrimidinic (AP) site intermediate by an AP endonuclease. The major AP endonuclease in human cells (APE1, also termed HAP1 and Ref-1) accounts for >95% of the total AP endonuclease activity, and is essential for the protection of cells against the toxic effects of several classes of DNA damaging agents. Moreover, APE1 overexpression has been linked to radio- and chemo-resistance in human tumors. Using a newly developed high-throughput screen, several chem. inhibitors of APE1 have been isolated. Amongst these, CRT0044876 was identified as a potent and selective APE1 inhibitor. CRT0044876 inhibits the AP endonuclease, 3′-phosphodiesterase and 3′-phosphatase activities of APE1 at low micromolar concentrations, and is a specific inhibitor of the exonuclease III family of enzymes to which APE1 belongs. At non-cytotoxic concentrations, CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds This enhancement of cytotoxicity is associated with an accumulation of unrepaired AP sites. In silico modeling studies suggest that CRT0044876 binds to the active site of APE1. These studies provide both a novel reagent for probing APE1 function in human cells, and a rational basis for the development of APE1-targeting drugs for antitumor therapy.

Nucleic Acids Research published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tang, Feng; Yang, Chao; Li, Feng-Ping; Yu, Dong-Hu; Pan, Zhi-Yong; Wang, Ze-Fen; Li, Zhi-Qiang published the artcile< Palmitoyl transferases act as potential regulators of tumor-infiltrating immune cells and glioma progression>, Electric Literature of 112-63-0, the main research area is palmitoyl transferase tumor infiltrating immune cell glioma progression; MT: Bioinformatics; ZDHHCs; gliomas; immune-cell infiltration; post-translational modification; signaling pathway.

High immune-cell infiltration in glioblastomas (GBMs) leads to immunotherapy resistance. Emerging evidence has shown that zinc finger Asp-His-His-Cyc-type (ZDHHC) palmitoyl transferases participate in regulating tumor progression and the immune microenvironment. In the present study, a large cohort of patients with gliomas from The Cancer Genome Atlas (TCGA) and Rembrandt databases was included to perform omics anal. of ZDHHCs in gliomas. CCK-8, flow cytometry, quant. real-time PCR, western blotting, and transwell assays were performed to determine the effects of ZDHHC inhibition on glioma cells and microglia. We found that five (ZDHHC11, ZDHHC12, ZDHHC15, ZDHHC22, and ZDHHC23) out of 23 ZDHHCs were aberrantly expressed in gliomas and might play their roles through the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway. Further results indicated that inhibition of ZDHHCs with 2-bromopalmitate (2-BP) suppressed glioma-cell viability and autophagy, as well as promoted apoptosis. Targeting ZDHHCs also promoted the sensitivity of glioma cells to temozolomide (TMZ) chemotherapy. In addition, the inhibition of ZDHHCs weakened the migratory ability of microglia induced by glioma cells in vitro and in vivo. Taken together, our findings suggest that the inhibition of ZDHHCs suppresses glioma-cell viability and microglial infiltration. Targeting ZDHHCs may be promising for glioma treatments.

Molecular Therapy–Nucleic Acids published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (ZDHHC11). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Riand, J.; Chenon, M. T.; Lumbroso-Bader, N. published the artcile< Carbon-13 NMR study of substituent effects in the pyrimidine nucleus>, Synthetic Route of 112-63-0, the main research area is pyrimidine substituent effect NMR; carbon NMR pyrimidine.

Twenty-one pyrimidines were studied by 13C NMR, and the effect of Me and NH2 substituents on the chem. shifts determined Pair parameters derived from observed and calculated chem. shifts of disubstituted pyrimidines were used to calculate chem. shifts of tri- and tetrasubstituted pyrimidines.

Tetrahedron Letters published new progress about NMR (nuclear magnetic resonance). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Xizheng; Lei, Xiaofeng; Wang, Yong-Gang; Ding, Yi published the artcile< Prevention of Na Corrosion and Dendrite Growth for Long-Life Flexible Na-Air Batteries>, HPLC of Formula: 112-63-0, the main research area is flexible NAB dendrite growth corrosion gel electrolyte modified anode.

Rechargeable Na-air batteries (NABs) based on abundant Na resources are generating great interest due to their high energy d. and low cost. However, Na anode corrosion in ambient air and the growth of abnormal dendrites lead to insufficient cycle performance and safety hazards. Effectively protecting the Na anode from corrosion and inducing the uniform Na plating and stripping are therefore of vital importance for practical application. We herein report a NAB with in situ formed gel electrolyte and Na anode with trace residual Li. The gel electrolyte is obtained within cells through crosslinking Li ethylenediamine at the anode surface with tetraethylene glycol di-Me ether (G4) from the liquid electrolyte. The gel can effectively prevent H2O and O2 crossover, thus delaying Na anode corrosion and electrolyte decomposition Na dendrite growth was suppressed by the electrostatic shield effect of Li+ from the modified Li layer. Benefiting from these improvements, the NAB achieves a robust cycle performance over 2000 h in opened ambient air, which is superior to previous results. Gelation of the electrolyte prevents liquid leakage during battery bending, facilitating greater cell flexibility, which could lead to the development of NABs suitable for wearable electronic devices in ambient air. The Na-air batteries have been developed with in situ formed gel electrolyte on a Li modified Na anode. They display ultrastable cycle performance up to 2000 h in ambient air.

ACS Central Science published new progress about Battery anodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Merker, Philip C.; Vona, Joseph A. published the artcile< Use of pyridinium bromide perbromide for brominations>, Application of C19H34O2, the main research area is .

Directions are given for student preparation of butyl bromide, p-bromoacetanilide, bromobenzene, and the bromination of anethole.

Journal of Chemical Education published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Xingru; Guo, Rui; Zhao, Yaxuan; Liu, Danping; Chen, Jing; Miao, Ningning; Gao, Shujuan; Guo, Jixun; Zhang, Tao; Shi, Lianxuan published the artcile< Wild soybean resists the stress of low phosphorus by increasing nutrient reuse between the young and old leaves>, Electric Literature of 112-63-0, the main research area is Glycine leaf age nutrient phosphorus deficiency metabolomics.

Screening and identification of plant resources with high quality and multi resistance is important for crop breeding. In this study, ion content was determined by ion chromatog. and at. absorption spectrophotometer, and gas chromatog.-mass spectrometry (GC-MS)-based metabolomic anal. was carried out. Then metabolic pathways were constructed using the Kyoto Encyclopedia of Genes and Genomes and the MetaboAnalyst website to compare the changes and differences of young and old leaves of two wild soybean lines with different stress tolerance under low-phosphorus (LP) stress. The aim was to reveal the mechanism of wild soybean resistance to LP stress from insights concerning nutrient accumulation and mobilization. The results showed that in LP-tolerant wild soybean, Ca2+ accumulated and TCA, amino acid and organic acid metabolisms were enhanced in young and old leaves; disaccharide and trisaccharide metabolism was enhanced and phosphohexose metabolism was inhibited in old leaves; Mg2+, disaccharide and trisaccharide contents increased in young leaves, while inorganic P was relatively stable. Our experiment highlighted that LP-tolerant wild soybean adapted to LP stress by enhancing energy and material metabolisms and maintaining the growth and development of young leaves at the expense of old leaves, which is of great significance for the development and utilization of germplasm resources and the breeding of LP-tolerant soybean.

Plant Growth Regulation published new progress about Disaccharides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yuan, Huijun; Gao, Hua; Liu, Kun; Liu, Zhantao; Wang, Jian; Li, Wenjun published the artcile< Cycloadduct formation of α,β-unsaturated esters with azides catalyzed by NHC systems>, Electric Literature of 112-63-0, the main research area is cycloaddition unsaturated ester azide preparation triazole dihydropyrazole organocatalyst NHC.

1,2,3-Triazoles and aminomethylpyrazoles were prepared by 1,3-cycloaddition of azides with α,β-unsaturated esters organocatalyzed by N-heterocyclic carbenes, formed in situ from imidazolium and 1,2,4-triazolium salts. NHC-catalyzed cycloadduct formation of α,β-unsaturated esters with azides has been developed. This strategy could generate 1,2,3-triazoles and dihydropyrazoles with high yields and regioselectivities in the presence of an N-heterocyclic carbene catalyst. The broad substrate scope and mechanistic survey of this process are also presented.

Organic & Biomolecular Chemistry published new progress about Azides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Garuti, Laura; Roberti, Marinella; De Clercq, Erik published the artcile< Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles>, Reference of 112-63-0, the main research area is benzimidazolyl sulfone antiviral antiproliferative preparation.

Some benzimidazolyl sulfones were synthesized and evaluated for their antiviral and antiproliferative properties. I (R = CHMe2) displayed significant and selective activity against human cytomegalovirus (CMV), I (R = 3-NO2-C6H4) showed activity against varicella zoster virus (VZV). The compounds were further evaluated for inhibitory effect on the proliferation of murine leukemia cells and human T-lymphocyte cells. Marked cytotoxicity was noted with different derivatives Some structure-activity relationships are discussed.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics