Tag: M.W=250-300

Huang, Shenlin; Voigtritter, Karl R.; Unger, John B.; Lipshutz, Bruce H. published the artcile< Asymmetric CuH-catalyzed 1,4-reductions in water at room temperature>, Application of C19H34O2, the main research area is Michael acceptor asym hydrosilylation copper hydride catalyst micelle water; alkene enantioselective reduction copper hydride catalyst micelle water.

Taking advantage of micellar catalysis in water, asym. hydrosilylation reactions of β,β-disubstituted Michael acceptors were conducted at ambient temperatures using water, and only water, as the global medium.

Synlett published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent) (Michael acceptors). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Boebel, Timothy A.; Hartwig, John F. published the artcile< Iridium-Catalyzed Preparation of Silylboranes by Silane Borylation and Their Use in the Catalytic Borylation of Arenes>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is iridium catalyzed silylborane preparation; silane borylation methoxy iridium cyclooctadiene butylbipyridine catalyzed; silylborane preparation catalytic borylation arene; arene carbon hydrogen bond activation.

Silylboranes are versatile reagents for transition metal-catalyzed reactions of unsaturated organic mols. These reagents are typically prepared by the addition of a silyl lithium species to a boron electrophile. However, the need to generate anionic silane reagents limits the scope of silylboranes that can be readily obtained. Here, the synthesis of trialkylsilylboranes by borylation of silanes catalyzed by iridium complexes is described. The reaction of trialkylhydrosilanes with B2pin2 catalyzed by the combination of [Ir(OMe)cod]2 and 4,4′-di-tert-butylbipyridine forms trialkylsilylboronic esters. In addition, these trialkylsilylboranes serve as boron sources for iridium-catalyzed borylation of aryl C-H bonds. In contrast to diboron reagents, the silylboranes react with methylarenes at both the aryl and Me C-H bonds.

Organometallics published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Campianl, Jian L.; Ghosh, Subhajit; Kapoor, Vaishali; Yan, Ran; Thotala, Sukrutha; Jash, Arijita; Hu, Tong; Mahadevan, Anita; Rifai, Kasem; Pagel, Logan; Lee, Byung Ha; Ferrando-Martinez, Sara; Wolfarth, Alexandra A.; Yang, Se Hwan; Hallahan, Dennis; Chhedau, Milan G.; Thotala, Dinesh published the artcile< Long-acting recombinant human interleukin-7, NT-17, increases cytotoxic CD8 T cells and enhances survival in mouse glioma models>, Category: esters-buliding-blocks, the main research area is temozolomide NT17 anticancer agent CD8 T cell glioblastoma.

Patients with glioblastoma (GBM) are treated with radiotherapy (RT) and temozolomide (TMZ). These treatments may cause prolonged systemic lymphopenia, which itself is associated with poor outcomes. NT-17 is a long-acting IL7 that expands CD4 and CD8 T-cell numbers in humans and mice. We tested whether NT-17 prevents sys- temic lymphopenia and improves survival in mouse models of GBM. Exptl. Design: C57BL/6 mice bearing intracranial tumors (GL261 or CT2A) were treated with RT (1.8 Gy/day x 5 days), TMZ (33 mg/kg/day x 5 days), and/or NT-17 (10 mg/kg on the final day of RT). We followed the mice for survival while serially analyzing levels of circulating T lymphocytes. We assessed regulatory T cells (Treg) and cytotoxic T lymphocytes in the tumor microenvironment, cervical lymph nodes, spleen, and thymus, and hematopoietic stem and progenitor cells in the bone marrow. GBM tumor-bearing mice treated with RT+NT-17 increased T lymphocytes in the lymph nodes, thymus, and spleen, enhanced Wily production, and decreased Tregs in the tumor which was associated with a significant increase in sur- vival. NT-17 also enhanced central memory and effector memory CD8 T cells in lymphoid organs and tumor. Depleting CD8 T cells abrogated the effects of NT-17. Furthermore, NT-17 treatment decreased progenitor cells in the bone marrow. In orthotopic glioma-bearing mice, NT-17 miti- gates RT-related lymphopenia, increases cytotoxic CD8 T lympho- cytes systemically and in the tumor, and improves survival. A phase I/II trial to evaluate NT-17 in patients with high-grade gliomas is ongoing (NCT03687957).

Clinical Cancer Research published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Qiu, Xiaoguang; Chen, Yidong; Bao, Zhaoshi; Chen, Li; Jiang, Tao published the artcile< Chemoradiotherapy with temozolomide vs. radiotherapy alone in patients with IDH wild-type and TERT promoter mutation WHO grade II/III gliomas: A prospective randomized study>, Reference of 112-63-0, the main research area is glioma temozolomide isocitrate dehydrogenase chemoradiotherapy radiotherapy mutation survival; Grade II/III glioma; IDH mutation; Radiotherapy; TERT promoter mutation; Temozolomide.

Patients with grade II/III diffuse glioma (lower grade glioma, LGG) with isocitrate dehydrogenase wild-type (IDH-wt) and telomerase reverse-transcriptase promoter mutation (TERTp-mut) experience shorter overall survival (OS) time than IDH mutant patients. The optimal treatment strategy for these patients is unclear. We compared the effects of radiotherapy (RT) alone vs. RT concurrent with temozolomide (TMZ) followed by adjuvant TMZ in these LGG patients.Thirty-seven LGG patients with IDH-wt and TERTp-mut were randomly allocated to either RT alone treatment (RT group, n = 18; 60 Gy in 30 daily fractions) or RT concurrent with TMZ (75 mg/m2/d, 7 d/wk) followed by adjuvant TMZ (CRT group, n = 19). The median follow-up duration was 17 mo. Log-rank test was used for OS and PFS comparisons.The 1-yr OS rate was 94.1[95confidence interval (CI) 82.9-100] in the CRT group and 74.6(95CI, 52.9-96.4) in the RT group. The median OS values in the CRT and RT groups were statistically different [25 vs. 17 mo, resp.; hazard ratio (HR) 0.271; 95CI, 0.092-0.793; P = 0.017], while PFS values were not (16 vs. 7 mo, resp.; HR, 0.917; 95CI, 0.397-2.120; P = 0.840). Multivariate anal. indicated that CRT treatment and female sex were associated with significantly longer OS (P = 0.001, P = 0.016, resp.).CRT treatment for IDH-wt/TERTp-mut grade II/III gliomas resulted in significantly longer OS than RT alone. Female sex was a significant favorable prognostic factor.

Radiotherapy and Oncology published new progress about Chemoradiotherapy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

De Angelis, Martina; Primitivo, Ludovica; Lucarini, Claudia; Agostinelli, Sonia; Sappino, Carla; Ricelli, Alessandra; Righi, Giuliana published the artcile< Stereocontrolled total synthesis of iminosugar 1,4-dideoxy-1,4-imino-D-iditol>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is alditol iminosugar potential antiviral antitumor antidiabetic antituberculosis antibacterial alkaloid; iminosugar deoxyiminoiditol alditol preparation stereoselective hydroxylation deoxyiminogalactitol; 1,4-Dideoxy-1,4-imino-D-galactitol; 1,4-Dideoxy-1,4-imino-D-iditol; Asymmetric dihydroxylation; Iminosugars.

The first stereocontrolled total synthesis of iminosugar 1,4-dideoxy-1,4-imino-D-iditol is described. The key step in our approach was the double diastereo-selection in the asym. dihydroxylation (AD) of suitable optically active olefin, the chiral vinyl azido alc. Performing the AD using the most common Cinchona alkaloids as ligands enabled us to identify the ligand of choice for the stereodivergent synthesis of 1,4-dideoxy-1,4-imino-D-iditol and 1,4-dideoxy-1,4-imino-D-galactitol. These type of iminosugars, both natural and unnatural, are intensively studied for their promising chemotherapeutic properties against viral infections, diabetes, cancer, and tuberculosis.

Carbohydrate Research published new progress about Alditols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guo, Xiangyang; Ho, Chi-Tang; Wan, Xiaochun; Zhu, Hui; Liu, Qiong; Wen, Zhen published the artcile< Changes of volatile compounds and odor profiles in Wuyi rock tea during processing>, Category: esters-buliding-blocks, the main research area is Wuyi rock tea Odor profile favor Odor activity value; Sensory evaluation Tea processing; Odor activity value (OAV); Odor profile; Rock flavor; Sensory evaluation; Tea processing; Wuyi rock tea.

Wuyi rock tea (WRT), is one kind of oolong tea and widely appreciated for its typical ′rock flavor′. The odor characteristics of WRT during processing were comprehensive investigated by gas chromatog.-mass spectrometry, sensory evaluation and odor activity value (OAV). Alcs., alkenes and esters were the main volatiles formed during tea processes, but the WRT contained more heterocyclic compounds, among which 15 N-containing volatiles were newly identified in this study, accounting for 60.52% of total amounts of volatiles in WRT. In response, the original green and chem. odors converted to roasted and woody odors, and full fire processing was effective to enhance roasted, floral and woody odors, weaken chem. odor. 2-Ethyl-3,5-dimethylpyrazine (OAV 4.71) was confirmed as the aroma-active compound of WRT with roasted odor by aroma recombination experiment In addition, strong roasted, floral and moderate woody odors were perceived as the outline of ′rock flavor′ in WRT aroma. These results provide theor. basis for processing and quality control of WRT.

Food Chemistry published new progress about Lactones Role: ANT (Analyte), PRP (Properties), ANST (Analytical Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sheng, Changting; Guo, Yang; Ma, Jing; Hong, Eun-Kyung; Zhang, Benyin; Yang, Yongjing; Zhang, Xiaofeng; Zhang, Dejun published the artcile< Metabolomic Profiling Reveals Protective Effects and Mechanisms of Sea Buckthorn Sterol against Carbon Tetrachloride-Induced Acute Liver Injury in Rats>, Formula: C19H34O2, the main research area is metabolomics sea buckthorn sterol hepatoprotective agent acute liver injury; acute liver injury; carbon tetrachloride; metabolomics; sea buckthorn sterol.

The present study was designed to examine the efficacy and protection mechanisms of sea buckthorn sterol (SBS) against acute liver injury induced by carbon tetrachloride (CCl4) in rats. Five-week-old male Sprague-Dawley (SD) rats were divided into six groups and fed with saline (Group BG), 50% CCl4 (Group MG), or bifendate 200 mg/kg (Group DDB), or treated with low-dose (Group LD), medium-dose (Group MD), or high-dose (Group HD) SBS. This study, for the first time, observed the protection of SBS against CCl4-induced liver injury in rats and its underlying mechanisms. Investigation of enzyme activities showed that SBS-fed rats exhibited a significant alleviation of inflammatory lesions, as evidenced by the decrease in cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), and gamma-glutamyl transpeptidase (γ-GT). In addition, compared to the MG group, the increased indexes (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), total antioxidant capacity (T-AOC), and total protein (TP)) of lipid peroxidation and decreased malondialdehyde (MDA) in liver tissues of SBS-treated groups showed the anti-lipid peroxidation effects of SBS. Using the wide range of targeted technologies and a combination of means (UPLC-MS/MS detection platform, self-built database, and multivariate statistical anal.), the addition of SBS was found to restore the expression of metabolic pathways (e.g., L-malic acid, N-acetyl-aspartic acid, N-acetyl-l-alanine, etc.) in rats, which means that the metabolic damage induced by CCl4 was alleviated. Furthermore, transcriptomics was employed to analyze and compare gene expression levels of different groups. It showed that the expressions of genes (Cyp1a1, Noct, and TUBB6) related to liver injury were regulated by SBS. In conclusion, SBS exhibited protective effects against CCl4-induced liver injury in rats. The liver protection mechanism of SBS is probably related to the regulation of metabolic disorders, anti-lipid peroxidation, and inhibition of the inflammatory response.

Molecules published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (Noct). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Barbato, Cinzia; Baldino, Salvatore; Ballico, Maurizio; Figliolia, Rosario; Magnolia, Santo; Siega, Katia; Herdtweck, Eberhardt; Strazzolini, Paolo; Chelucci, Giorgio; Baratta, Walter published the artcile< OsXCl(phosphine)2(diamine) and OsXCl(diphosphine)(diamine) (X = Cl, H) Complexes for Ketone Hydrogenation>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is diphoshine derivative coordinative substitution osmium chloride complex; crystal structure ferrocenediphosphino osmium diamine chloride complex; mol structure ferrocenediphosphino osmium diamine chloride complex; ferrocenediphosphino osmium diamine chloride complex preparation catalyst hydrogenation.

The Os complex trans-[OsCl2(PPh3)2(en)] (2) was prepared by reaction of [OsCl2(PPh3)3] (1a) with ethylenediamine (en), whereas the diphosphine derivatives trans-[OsCl2(dppf)(NN)] (NN = en, 3; bn = 1,4-butanediamine, 4) and trans-[OsCl2(dpbp)(en)] (5) were obtained from 1a, dppf or dpbp and the corresponding NN ligand in CH2Cl2 or toluene. An x-ray diffraction study was provided for 3. The isolation of the chiral derivatives trans-[OsCl2(diphosphine)((R,R)-dpen)] (diphosphine = dppf, 6; dpbp, 7; (R,R)-skewphos, 8) was achieved by reacting 1a with the diphosphine and (R,R)-dpen in toluene. Treatment of the precursor [Os2Cl4(P(m-tolyl)3)5] (1b) with en afforded [OsCl2(P(m-tolyl)3)2(en)] (9), while reaction of 1b with dppb and N,N-dmen gave [OsCl2(dppb)(N,N-dmen)] (10). The chiral derivatives [OsCl2(diphosphine)(NN)] (11-21) (diphosphine = (S)-MeObiphep, (R)-MeObiphep, (R)-xylMeObiphep, (R)-binap, (S)-xylbinap, (R)-xylbinap, (R,S)-Josiphos*; NN = en, (R,R)-dpen, (R)-daipen, (R,R)-dppn) were prepared from 1b and the corresponding diphosphine and NN ligands in toluene. The monohydride trans-[OsHCl(P(m-tolyl)3)2(en)] (22) was synthesized by reaction of 1b with H2 (1 atm) in the presence of NEt3, followed by addition of en in toluene. Similarly, trans-[OsHCl(dppf)(en)] (23) was synthesized from 1a, H2 and NEt3, followed by treatment with dppf and en. Complexes 2-5, 9, 10, 22 and 23 efficiently catalyzed the hydrogenation of acetophenone with H2 under low pressure (5 atm) at 60-70° in EtOH (1-2 mol% of NaOEt). The chiral derivatives 6-8 and 11-21 afforded the asym. hydrogenation of acetophenone with up to 90% ee (S/C = 10000) by combining bulky xylyl substituted MeObiphep or binap-type ligands with (R)-daipen or (R,R)-dpen ligands. Catalytic transfer hydrogenation of acetophenone was observed with 3, 6 and 7 (S/C = 2000) in iso-PrOH and in the presence of NaOiPr (2 mol%) at 60-82°.

Organometallics published new progress about Bidentate ligands Role: RCT (Reactant), RACT (Reactant or Reagent) (diamine and diphoshine derivatives). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fan, Yi Chiao; Kwon, Ohyun published the artcile< Phosphine/Palladium-Catalyzed Syntheses of Alkylidene Phthalans, 3-Deoxyisoochracinic Acid, Isoochracinic Acid, and Isoochracinol>, Electric Literature of 112-63-0, the main research area is alkylidene phthalan preparation phosphine catalyst Michael palladium catalyst Heck; stereoselective synthesis alkylidene phthalan Michael Heck catalytic.

In this study, we used sequential catalysis-PPh3-catalyzed nucleophilic addition followed by Pd(0)-catalyzed Heck cyclization-to construct complex functionalized alkylidene phthalans, e.g., I (R1 = H, R, R2 = H, OCH2Ph, OMe, CF3, etc., R3 = H, OCH2Ph, OMe, Me, R4 = H, Me, MeO), rapidly, in high yields, and with good stereoselectivities (E/Z ratios of up to 1:22). The scope of this Michael-Heck reaction includes substrates bearing various substituents around the alkylidene phthalan backbone. Applying this efficient sequential catalysis, we accomplished concise total syntheses of 3-deoxyisoochacinic acid II (X = none, Y = CO2H) isoochracinic acid II (X = O, Y = CO2H), and isoochracinol II (X = O, Y = CH2OH).

Organic Letters published new progress about Diastereoselective synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Majchrzak-Celinska, Aleksandra; Kleszcz, Robert; Studzinska-Sroka, Elzbieta; Lukaszyk, Agnieszka; Szoszkiewicz, Anna; Stelcer, Ewelina; Jopek, Karol; Rucinski, Marcin; Cielecka-Piontek, Judyta; Krajka-Kuzniak, Violetta published the artcile< Lichen Secondary Metabolites Inhibit the Wnt/β-Catenin Pathway in Glioblastoma Cells and Improve the Anticancer Effects of Temozolomide>, Application of C19H34O2, the main research area is Wnt/β-catenin pathway; blood-brain barrier permeability; caperatic acid; glioblastoma; lichen secondary metabolites; microarrays; physodic acid; temozolomide.

Lichens are a source of secondary metabolites with significant pharmacol. potential. Data regarding their possible application in glioblastoma (GBM) treatment are, however, scarce. The study aimed at analyzing the mechanism of action of six lichen secondary metabolites: atranorin, caperatic acid, physodic acid, squamatic acid, salazinic acid, and lecanoric acid using two- and three-dimensional GBM cell line models. The parallel artificial membrane permeation assay was used to predict the blood-brain barrier penetration ability of the tested compounds Their cytotoxicity was analyzed using the MTT test on A-172, T98G, and U-138 MG cells. Flow cytometry was applied to the anal. of oxidative stress, cell cycle distribution, and apoptosis, whereas qPCR and microarrays detected the induced transcriptomic changes. Our data confirm the ability of lichen secondary metabolites to cross the blood-brain barrier and exert cytotoxicity against GBM cells. Moreover, the compounds generated oxidative stress, interfered with the cell cycle, and induced apoptosis in T98G cells. They also inhibited the Wnt/β-catenin pathway, and this effect was even stronger in case of a co-treatment with temozolomide. Transcriptomic changes in cancer related genes induced by caperatic acid and temozolomide were the most pronounced. Lichen secondary metabolites, caperatic acid in particular, should be further analyzed as potential anti-GBM agents.

Cells published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics