Tag: M.W=250-300

Yousaf, Zeshan; Smith, Michael; Potluri, Prasad; Parnell, William published the artcile< Compression properties of polymeric syntactic foam composites under cyclic loading>, Application of C19H34O2, the main research area is polyurethane syntactic foam cyclic compression property.

In the present work, polymer-based syntactic foams were studied under cyclic compression in order to investigate their compressibility, recoverability, energy dissipation and damage tolerance. These syntactic foams were manufactured by adding hollow polymer microspheres of various sizes and wall thicknesses into a polyurethane matrix. The associated loading and unloading curves during cyclic testing were recorded, revealing the viscoelastic nature of the materials. SEM images of the samples were obtained in order to study potential damage mechanisms during compression. It was observed that these syntactic foams exhibit high elastic recovery and energy dissipation over a wide range of compressional strains and the addition of polymer microspheres mitigates the damage under compressional loading.

Composites, Part B: Engineering published new progress about Compressive strength. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lai, Xingrong; Sun, Yanhua; Zhang, Xuedi; Wang, Dan; Wang, Jialing; Wang, Haihua; Zhao, Yao; Liu, Xinling; Xu, Xin; Song, Haoran; Ping, Wenjia; Sun, Yanli; Hu, Zhenbo published the artcile< Honokiol induces ferroptosis by upregulating HMOX1 in acute myeloid leukemia cells>, Reference of 347174-05-4, the main research area is acute myeloid leukemia ferroptosis Honokiol HMOX1; AML; ferroptosis; heme oxygenase (HO)-1; honokiol; lipid peroxidation.

Acute myeloid leukemia (AML) is one of the malignant hematol. cancers with high mortality. Finding a more effective and readily available treatment is of the utmost importance. Here, we aimed to identify the anti-leukemia effect of a natural small mol. compound honokiol on a panel of AML cell lines, including THP-1, U-937, and SKM-1, and explored honokiol′s potential biol. pathways and mechanisms. The results showed that honokiol decreased the viability of the targeted AML cells, induced their cell cycle arrest at G0/G1 phase, and inhibited their colony-formation capacity. Honokiol also triggers a noncanonical ferroptosis pathway in THP-1 and U-937 cells by upregulating the level of intracellular lipid peroxide and HMOX1 significantly. Subsequent studies verified that HMOX1 was a critical target in honokiol-induced ferroptosis. These results reveal that honokiol is an effective anti-leukemia agent in AML cell lines and may be a potential ferroptosis activator in AML.

Frontiers in Pharmacology published new progress about Acute myeloid leukemia. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Reference of 347174-05-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Todo, Tomoki; Ito, Hirotaka; Ino, Yasushi; Ohtsu, Hiroshi; Ota, Yasunori; Shibahara, Junji; Tanaka, Minoru published the artcile< Intratumoral oncolytic herpes virus G47Δ for residual or recurrent glioblastoma: a phase 2 trial>, Application of C19H34O2, the main research area is intratumoral oncolytic herpes virus recurrent glioblastoma.

This investigator-initiated, phase 2, single-arm trial primarily assessed the efficacy of G47Δ, a triple-mutated, third-generation oncolytic herpes simplex virus type 1, in 19 adult patients with residual or recurrent, supratentorial glioblastoma after radiation therapy and temozolomide (UMIN-CTR Clin. Trial Registry UMIN000015995). G47Δ was administered intratumorally and repeatedly for up to six doses. The primary endpoint of 1-yr survival rate after G47Δ initiation was 84.2% (95% confidence interval, 60.4-96.6; 16 of 19). The prespecified endpoint was met and the trial was terminated early. Regarding secondary endpoints, the median overall survival was 20.2 (16.8-23.6) months after G47Δ initiation and 28.8 (20.1-37.5) months from the initial surgery. The most common G47Δ-related adverse event was fever (17 of 19) followed by vomiting, nausea, lymphocytopenia and leukopenia. On magnetic resonance imaging, enlargement of and contrast-enhancement clearing within the target lesion repeatedly occurred after each G47Δ administration, which was characteristic to this therapy. Thus, the best overall response in 2 yr was partial response in one patient and stable disease in 18 patients. Biopsies revealed increasing numbers of tumor-infiltrating CD4+/CD8+ lymphocytes and persistent low numbers of Foxp3+ cells. This study showed a survival benefit and good safety profile, which led to the approval of G47Δ as the first oncolytic virus product in Japan.

Nature Medicine (New York, NY, United States) published new progress about Adult, mammalian. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kovacs, K.; Eros-Takacsy, T.; Ritz, I.; Hegedus-Vajda, J. published the artcile< Determination of the impurity profile of R1/CH-13584 by an online gas chromatography/mass spectrometry method>, Application of C19H34O2, the main research area is antiasthmatic CH 13584 intermediate impurity determination; gas chromatog CH 13584 intermediate impurity; mass spectrometry CH 13584 intermediate impurity.

The impurity profile of the final intermediate in the manufacture of a new, original antiasthmatic drug candidate (CH-13584) was determined by gas chromatog./mass spectrometry. Online GC/MS identification was carried out by using electron-impact ionization. Gas chromatog. separation was performed on a fused-silica column. Identification was based on mass spectral data: fragmentation patterns and elemental composition for the selected ions as well as the NIST library search for the separated impurities. GC retention times were also considered. Reference compounds with the proposed structure were synthesized and confirmed by IR, GC/MS, and NMR data. An identical impurity profile for the certified and the GMP batches proved the reliability of the synthetic process. The possibility of a potential parallel reaction of the impurities in the final reaction step was considered.

Rapid Communications in Mass Spectrometry published new progress about Mass spectra. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jin, Zheng; Zhang, Wenbo; Luo, Yuan; Li, Xiushen; Qing, Lijin; Zuo, Qiang; Fang, Junfeng; Wu, Wei published the artcile< Protective effect of Qingre Huoxue decoction against myocardial infarction via PI3K/Akt autophagy pathway based on UPLC-MS, network pharmacology, and in vivo evidence>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is qingre huoxue decoction autophagy pathway network pharmacol myocardial infarction; Qingre Huoxue decoction; UPLC-MS; network pharmacology; autophagy; myocardial infarction.

ContextQingre Huoxue (QRHX) decoction, a traditional Chinese medicine, has been widely used to prevent and treat myocardial infarction (MI). ObjectiveThis study elucidates the possible mechanisms of QRHX in preventing or treating MI in a rat model. Materials and methodsThe chem. constituents of QRHX were identified by UPLC-MS. Sprague-Dawley rats were randomly divided into the Sham (normal saline), Model (normal saline), QRHX-L, QRHX-M and QRHX-H group (n = 10 per group). QRHX decoction was administered by gavage to the rats for 14 days (5, 10 and 20 g/kg/day). The left anterior descending ligation method was performed to develop MI in Model and QRHX groups, and the same surgical procedures excluding ligation sutures were performed for the sham group. Finally, we evaluated cardiac function, myocardial fibrosis degree, serum inflammatory factors, autophagy levels and verified the signalling pathways in vivo. ResultsA total of 68 active components of QRHX corresponding to 223 active targets were obtained and 2558 MI-related disease targets were collected. After integration, 123 QRHX anti-MI targets were obtained, and 70 signalling pathways, such as PI3K/Akt, were identified by enrichment anal. In vivo experiments suggest that QRHX could reduce the degree of myocardial fibrosis, downregulate serum inflammatory factors, and promote autophagy in MI rats. Discussion and ConclusionsQRHX plays a protective role in the myocardium by mediating PI3K/Akt signalling pathway to activate autophagy and inhibiting inflammatory factor expression. These findings provide a scientific basis for further research and validation of QRHX as a potential therapeutic for MI.

Pharmaceutical Biology (Abingdon, United Kingdom) published new progress about AKT-interacting protein AKTIP Role: BSU (Biological Study, Unclassified), PAC (Pharmacological Activity), THU (Therapeutic Use), BIOL (Biological Study), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Han, Jinshi; Zhou, Yawei; Bai, Guanghang; Wei, Wei; Liu, Xiaoya; Li, Xiaojie published the artcile< Mechanically robust, creep-resistant, intrinsic antibacterial and reprocessable dynamic polyurethane networks based on azine moieties>, Application of C19H34O2, the main research area is polyurethane network azine chain extender creep resistant antibacterial property.

Thermoset polyurethanes have been applied in various fields by virtue of their outstanding properties. However, the thermosets cannot be recycled due to their permanent crosslinking structure, which exerts a detrimental influence on the environment. Recently, the upsurge in the field of covalent adaptable networks (CANs) has attracted tremendous attention. Despite many efforts being dedicated to the design of CANs, the creep resistance of CANs holds much room for further improvement at high temperature Here, we designed a kind of azine chain extender and prepared a series of dynamic polyurethane networks in varying azine proportions. The azine-containing CANs possess high creep temperature of ∼100°C attributed to the stability of the azine moieties. Besides, the azine-containing polyurethanes also exhibit outstanding mech. properties and reprocessability due to the conjugated structure and exchangeability of the azine moieties. The azine-containing polyurethanes also present good antibacterial properties as the azines are a special category of Schiff base. This work demonstrated that azine moieties could enhance the creep resistance, which is a long-term and crucial issue for dynamic covalent polyurethanes and endows the dynamic covalent polyurethane networks with excellent mech. properties and intrinsic antibacterial properties.

Materials Chemistry Frontiers published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reid, Margaret D.; Tirado, Liz; Zhang, Jianwei; Dike, Nwamara; Herndon, James W. published the artcile< Reaction of cyclopropylcarbene-metal complexes with nucleophiles, halogens and HX>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is cyclopropyl chromium carbene complex preparation reaction nucleophile halogen pseudohalogen; chromium cyclopropyl phenylthio carbene complex preparation reaction nucleophile halogen; dihalo thiophenyl butene preparation stereocontrol.

The reaction of halogens, pseudohalogens, and HX with cyclopropyl(phenylthio)carbene-chromium complexes leads to the formation of 1,4-dihalo-1-thiophenyl-1-butene systems with a moderate-high degree of stereocontrol in the formation of the alkene. A mechanism involving electrophilic activation of the carbene complex followed by nucleophilic attack at the cyclopropane carbon has been proposed.

Journal of Organometallic Chemistry published new progress about Alkenes Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Erkang; Whitcomb, Luke A.; Chicco, Adam J.; Wilson, Jesse W. published the artcile< Transient absorption spectroscopy and imaging of redox in muscle mitochondria>, HPLC of Formula: 112-63-0, the main research area is muscle mitochondria imaging transient absorption spectroscopy.

Mitochondrial redox is an important indicator of cell metabolism and health, with implications in cancer, diabetes, aging, neurodegenerative diseases, and mitochondrial disease. The most common method to observe redox of individual cells and mitochondria is through fluorescence of NADH and FAD+, endogenous cofactors serve as electron transport inputs to the mitochondrial respiratory chain. Yet this leaves out redox within the respiratory chain itself. To a degree, the missing information can be filled in by exogenous fluorophores, but at the risk of disturbed mitochondrial permeability and respiration. Here we show that variations in respiratory chain redox can be detected up by visible-wavelength transient absorption microscopy (TAM). In TAM, the selection of pump and probe wavelengths can provide multiphoton imaging contrast between non-fluorescent mols. Here, we applied TAM with a pump at 520nm and probe at 450nm, 490nm, and 620nm to elicit redox contrast from mitochondrial respiratory chain hemeproteins. Experiments were performed with reduced and oxidized preparations of isolated mitochondria and whole muscle fibers, using mitochondrial fuels (malate, pyruvate, and succinate) to set up physiol. relevant oxidation levels. TAM images of muscle fibers were analyzed with multivariate curve resolution (MCR), revealing that the response at 620nm probe provides the best redox contrast and the most consistent response between whole cells and isolated mitochondria.

Biomedical Optics Express published new progress about Flash photolysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Wenchang; Wang, Yaxin; Zhang, Chenggang; Huang, Yongzhou; Yu, Jiaxian; Shi, Liang; Zhang, Peng; Yin, Yuping; Li, Ruidong; Tao, Kaixiong published the artcile< Maresin1 protect against ferroptosis-induced liver injury through ROS inhibition and Nrf2/HO-1/GPX4 activation>, Formula: C15H22N2O2, the main research area is liver injury maresin 1 ROS inhibition Nrf2 HO1 GPX4; Maresin1; Nrf2; ferroptosis; glutathione peroxidase 4; reactive oxygen species.

Drugs, viruses, and chem. poisons stimulating live in a short period of time can cause acute liver injury (ALI). ALI can further develop into serious liver diseases such as cirrhosis and liver cancer. Therefore, how to effectively prevent and treat ALI has become the focus of research. Numerous studies have reported Maresin1 (MaR1) has anti-inflammatory effect and protective functions on organs. In the present study, we used D-galactosamine/lipopolysaccharide (D-GalN/LPS) to establish an ALI model, explored the mechanism of liver cells death caused by D-GalN/LPS, and determined the effect of MaR1 on D-GalN/LPS-induced ALI. In vivo experiments, we found that MaR1 and ferrostatin-1 significantly alleviated D-GalN/LPSinduced ALI, reduced serum alanine transaminase and aspartate transaminase levels, and improved the survival rate of mice. Meanwhile, MaR1 inhibited hepatocyte death, inhibited tissue reactive oxygen species (ROS) expression, reduced malondialdehyde (MDA), reduced glutathione (GSH),GSH/oxidized glutathione (GSSG), and iron content induced byD-GalN/LPS in mice. In addition, MaR1 inhibited ferroptosis-induced liver injury through inhibiting the release of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and IL-6. Subsequently, western blot showed that MaR1 improved the expression of nuclear factor E2-related factor 2(Nrf2)/heme oxygenase-1 (HO-1)/glutathione peroxidase 4 (GPX4). In vitro experiments, we found that MaR1 inhibited LPS-induced and erastin-induced cell viability reduction Meanwhile, we found that MaR1 increased the MDA and GSH levels in cells. Western blot showed that MaR1 increased the expression level of Nrf2/HO-1/GPX4. Next, the Nrf2 was knocked down in HepG2 cells, and the results showed that the protective effect ofMaR1 significantly decreased. Finally, flow cytometry revealed that MaR1 inhibited ROS production and apoptosis. Overall, our study showed MaR1 inhibited ferroptosis-induced liver injury by inhibiting ROS production and Nrf2/HO-1/GPX4 activation.

Frontiers in Pharmacology published new progress about Apoptosis. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Formula: C15H22N2O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yasmeen, Tahira; Arif, Muhammad Saleem; Shahzad, Sher Muhammad; Riaz, Muhammad; Tufail, Muhammad Ammar; Mubarik, Muhammad Salman; Ahmad, Aqeel; Ali, Shafaqat; Albasher, Gadah; Shakoor, Awais published the artcile< Abandoned agriculture soil can be recultivated by promoting biological phosphorus fertility when amended with nano-rock phosphate and suitable bacterial inoculant>, Synthetic Route of 112-63-0, the main research area is Zea nanorock phosphate agriculture soil phosphorus fertility rhizosphere; Maize, Nano-technology; Regenerative agriculture; Rhizosphere; Soil fertility.

In semi-arid regions, post-restoration vegetation recovery on abandoned agricultural lands often fails due to inherently low organic matter content and poor soil fertility conditions, including phosphorus (P). As such, amending these soils with controlled release P fertilizer, especially with suitable P solubilizing bacteria (PSB) may promote plant growth and productivity by stimulating biol. P fertility. To this aim, a pot study was performed to evaluate the agronomic potential of maize and soil biol. P pools, using encapsulated (ENRP) and non-encapsulated (NRP) nano-rock phosphate as the P fertilizer source, on reclaimed agricultural soil in the presence and absence of PSB inoculant. The experiment was setup following a 3 x 2 factorial arrangement with four replicates. Without PSB, NRP treatment showed marginal pos. effects on plant growth, P nutrition and P use efficiency (PUE) compared to control treatment. Although larger gains with NRP treatment were more noticeable under PSB inoculation, ENRP was the most convenient slow-release P fertilizer, increasing plant growth, P nutrition and grain yield compared to all treatments. Importantly, PSB inoculation with ENRP resulted in significantly higher increase in soil CaCl2-P (8.91 mg P kg soil-1), citrate-P (26.98 mg P kg soil-1), enzyme-P (18.98 mg P kg soil-1), resin-P (11.41 mg P kg soil-1), and microbial-P (18.94 mg P kg soil-1), when compared to all treatment combinations. Although a decrease in soil HCl-P content was observed with both types of P fertilizer, significant differences were found only with PSB inoculation. A significant increase in soil biol. P pools could be due to the higher specific area and crystalline structure of nano materials, providing increased number of active sites for PSB activity in the presence of biobased encapsulated shell. Furthermore, the increase in PSB abundance, higher root carboxylate secretions, and decreased rhizosphere pH in response to nano-structured P fertilizer, implies greater extension of rhizosphere promoting greater P mobilization and/or solubilization, particularly under PSB inoculated conditions. We conclude that cropping potential of abandoned agricultural lands can be enhanced by the use of nano-rock phosphate in combination with PSB inoculant, establishing a favorable micro-environment for higher plant growth and biochem. P fertility.

Ecotoxicology and Environmental Safety published new progress about Arable soils (Abandoned). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics