Tag: M.W=250-300

Park, Albert K; Waheed, Anem; Forst, Deborah A; Al-Samkari, Hanny published the artcile< Characterization and prognosis of temozolomide-induced aplastic anemia in patients with central nervous system malignancies.>, Electric Literature of 112-63-0, the main research area is CNS malignancy; aplastic anemia; bone marrow failure; pancytopenia; temozolomide.

BACKGROUND: Temozolomide-induced aplastic anemia (TIAA) is a rare but highly challenging complication of temozolomide (TMZ) therapy. Evidence describing prognosis, clinical characteristics, and treatment of this entity is very limited. METHODS: We performed a multicenter, 22-year observational cohort study of patients with central nervous system (CNS) malignancies treated with temozolomide who developed TIAA, retrospectively analyzing prognosis, complications, and recovery. TIAA was defined using adapted evidence-based severe aplastic anemia criteria incorporating profound cytopenias and a minimum duration (4 weeks) without hematologic recovery. RESULTS: Of 3821 patients with CNS malignancies receiving TMZ, 34 patients (0.89%) met criteria for TIAA. Onset was rapid, with 29 patients (85.3%) developing TIAA before completing a second TMZ cycle. 23 patients (67.6%) ultimately achieved a hematologic recovery. Patients without recovery were more likely to develop febrile neutropenia (72.7% vs. 30.4%, P = .03), infectious complications (45.5% vs. 8.7%, P = .02), require hospitalization (81.8% vs. 43.5%, P = .04), and die (100.0% vs. 60.9%, P = .02). Median overall survival from TIAA diagnosis was 752 days in patients achieving a partial hematologic recovery versus 28 days in those who did not (P < .0001). 29 patients (85.3%) received one or more hematopoietic growth factors; hematologic recovery rates were higher in patients receiving thrombopoietin receptor agonists (81.8% vs. 60.9%) but were not higher in patients receiving granulocyte colony-stimulating factors. CONCLUSIONS: TIAA occurs in <1% of patients receiving TMZ for CNS malignancies, but is highly morbid when it occurs and frequently fatal in the one-third of patients not achieving hematologic recovery. Thrombopoietin receptor agonists may improve the likelihood of a hematologic recovery. Neuro-oncology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mziray, Sophia; Maganda, Betty A.; Mwamwitwa, Kissa; Fimbo, Adam M.; Kisenge, Seth; Sambu, Gerald; Mwalwisi, Yonah H.; Bitegeko, Adonis; Alphonce, Emmanuel; Khea, Akida; Shewiyo, Danstan H.; Kaale, Eliangiringa published the artcile< Quality of selected anti-retroviral medicines: Tanzania Mainland market as a case study>, Related Products of 112-63-0, the main research area is anti retroviral medicine quality Tanzania; Antiretroviral medicines; Falsified; Medicines quality; Patient information leaflet; Post market surveillance; Substandard.

Abstract: Background: Antiretroviral drugs (ARVs) have significantly reduced morbidity, mortality and improved the quality of life of people living with HIV infection. Poor quality ARVs may result in harmful consequences such as adverse drug reactions, treatment failure and development of drug resistant strains and sometimes death, which in turn may undermine the healthcare delivery system. To ensure optimal treatment outcomes, medicines quality control must be undertaken regularly. This study was aimed at evaluating the quality of ARVs circulating on the Tanzania Mainland market. Methods: This was a survey study. ARVs samples were collected in 20 regions of Tanzania Mainland, between 2012 and 2018. All sampled ARVs were subjected to screening testing using the Global Pharma Health Fund Mini-Lab kits. Sampled ARV′s that failed screening test or yielded doubtful results and 10 % (10 %) of all that complied with the screening test requirements were selected for full quality control testing. Quality control testing was conducted at the Tanzania Medicines and Medical Devices Authority (TMDA) laboratory a World Health Organization prequalified. Samples collected from the medicine distribution outlets were also, subjected to product information review. Results: A total of 2,630 samples were collected, of which 83.7 % (2200/2630) were from port of entry (POEs). All sampled ARVs were screened and conformed to the specifications, except of the fixed dose combination (FDC) lopinavir/ritonavir 0.27 % (7/2630) and lamivudine/zidovudine/nevirapine 0.27 % (7/2630) that failed the disintegration test. Out of the 100 samples selected for full quality control testing, 3 % of them failed to comply with the specifications, of which FDC stavudine/lamivudine/nevirapine failed disintegration and assay tests 2 % (2/100) and 1 % (1/100), resp. Samples failing the assay test had low content of stavudine (86.6 %) vs. specification limits (90 -110 %). Out of the 430 samples which were subjected to product information review, 25.6 % (110/430) failed to comply with the TMDA packaging and labeling requirements. Conclusions: The quality of majority of ARVs circulating on the Tanzania Mainland market was good, even so, significant deficiencies on labeling and packaging were observed These results call for continuous monitoring of quality of medicines circulating on the Tanzania Mainland market.

BMC Pharmacology and Toxicology published new progress about Fixed-dose combination drug delivery systems. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lesuisse, D.; Albert, E.; Bouchoux, F.; Cerede, E.; Lefrancois, J.-M.; Levif, M.-O.; Tessier, S.; Tric, B.; Teutsch, G. published the artcile< Biphenyls as surrogates of the steroidal backbone. Part 1. Synthesis and estrogen receptor affinity of an original series of polysubstituted biphenyls>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is biphenyl polysubstituted preparation estrogen receptor affinity.

Substituted biphenyls were prepared and evaluated for their binding affinity for the estrogen receptor. Some of them demonstrated binding better than or equivalent to that of estradiol.

Bioorganic & Medicinal Chemistry Letters published new progress about Estrogen receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Marques Mota, Filipe; Kim, Yeonseo; Hong, Haeji; Yu, Subin; Lee, Sangheon; Kim, Dong Ha published the artcile< Revisiting Solvent-Dependent Roles of the Electrolyte Counteranion in Li-O2 Batteries upon CO2 Incorporation>, Application In Synthesis of 112-63-0, the main research area is revisiting solvent dependent roles electrolyte counteranion lithium oxygen battery.

Lithium-oxygen batteries are promising next-generation high-energy storage candidates. Replacing pure O2 with air and uncovering moisture and CO2-contamination effects on the O2 electrochem., however, represent necessary steps toward commercialization. Representatively, a CO2-induced shift toward Li2CO3 formation has been systematically disclosed in a number of electrolyte solvents. Here, we show that in tetraglyme only Li2CO3 is formed without Li2O2. Using explicit theor. calculations, we reveal that discharge is governed by the strong chelation effect induced by oxygen lone electron pairs of the glyme, which emphasizes the importance of assessing direct interat. interactions between Li+ and solvent mols. when determining preferred reaction pathways in these O2/CO2 systems. The choice of the electrolyte counteranion investigated here for the first time, however, has no apparent effect on the O2/CO2 electrochem., leading to Li2CO3. Galvanostatic results and product analysisnonetheless reveal that highly dissociated Li+ counteranions in tetraglyme favorably stabilize soluble peroxocarbonate reaction intermediates during discharge, whereas highly associated salts accelerate Li2CO3 precipitation, dramatically narrowing the cell capacity. Importantly, these observations are also distinct from prior conclusions from rationally designed electrolytes under pure O2 conditions and emphasize the need to revisit established correlations between uncovered counteranion···Li+···solvent interaction degrees and the balance between mechanistic pathways in practical Li-air devices.

ACS Applied Energy Materials published new progress about Battery electrolytes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Wei; Chen, Rong; Cheng, Xinjian; Marin, Luminita published the artcile< Bodipy-based chemosensors for highly sensitive and selective detection of Hg2+ ions>, Formula: C19H34O2, the main research area is bodipy chemosensor sensitive selective detection mercury ion.

Detection of heavy metals with high sensitivity and selectivity is of vital importance. In this study, we report the synthesis of small mol. chemosensors and the fabrication of corresponding macromol. fluorescent chemosensors. Boron dipyrrole methane (BODIPY)-derived chemosensors, BE and BB, were designed and synthesized first. Then, they were incorporated into polymeric derivatives to prepare macromol. fluorescent chemosensors. The small mol. sensors were highly sensitive and selective to Hg2+. Other ions and albumin did not exhibit clear interference to the sensing of Hg2+ ions. Once the macromol. chemosensors were formed, the recognition ability was preserved; moreover, the sensitivity was even enhanced by the “”mol. wire”” mechanism. The min. detection limits of four macromol. chemosensors, PBEP, PBEB, PBBP and PBBB, for Hg2+ reached 2.05 μM, 0.23 μM, 4.23 μM, and 0.15 μM, resp. Under natural light, the addition of Hg2+ led to significant color changes; also, they can be used as Hg2+-sensitive “”naked eye”” indicators in the natural environment.

New Journal of Chemistry published new progress about Sensors. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Garcia-Urricelqui, Ane; de Cozar, Abel; Mielgo, Antonia; Palomo, Claudio published the artcile< Probing α-Amino Aldehydes as Weakly Acidic Pronucleophiles: Direct Access to Quaternary α-Amino Aldehydes by an Enantioselective Michael Addition Catalyzed by Bronsted Bases>, Category: esters-buliding-blocks, the main research area is aminoethanal nitroethene cinchona catalyst enantioselective diastereoselective Michael addition; amino nitrobutanal preparation; Brønsted bases; Michael addition; asymmetric catalysis; hydrogen bonds; quaternary stereocenters.

The chem. of α-amino aldehydes was expanded beyond their limits by documenting the first direct α-alkylation of α-branched α-amino aldehydes with nitroolefins. The reaction produced densely functionalized products bearing up to two, quaternary and tertiary, vicinal stereocenters with high diastereo- and enantioselectivity. DFT modeling lead to the proposal that intramol. hydrogen bonding between the NH group and the carbonyl oxygen atom in the starting α-amino aldehyde was key for reaction stereocontrol.

Chemistry – A European Journal published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Meares, Adam; Yu, Zhanqian; Viswanathan Bhagavathy, Ganga; Satraitis, Andrius; Ptaszek, Marcin published the artcile< Photoisomerization of enediynyl linker leads to slipped cofacial hydroporphyrin dyads with strong through-bond and through-space electronic interactions>, Computed Properties of 112-63-0, the main research area is cis trans photoisomerization porphyrin enediynyl conjugation.

Photoisomerization of 3,4-di(methoxycarbonyl)-enediyne linker in hydroporphyrin (chlorin or bacteriochlorin) dyads leads to thermally stable cis isomers, where macrocycles adopt a slipped cofacial mutual geometry with an edge-to-edge distance of ∼3.6 Å (determined by d. functional theory (DFT) calculations). Absorption spectra exhibit a significant splitting of the long-wavelength Qy band, which indicates a strong electronic coupling with a strength of V = ∼477 cm-1 that increases to 725 cm-1 upon metalation of hydroporphyrins. Each dyad features a broad, structureless emission band, with large Stokes shift, which is indicative of excimer formation. DFT calculations for dyads show both strong through-bond electronic coupling and through-space electronic interactions, due to the overlap of π-orbitals. Overall, geometry, electronic structure, strength of electronic interactions, and optical properties of reported dyads closely resemble those observed for photosynthetic special pairs. Dyads reported here represent a novel type of photoactive arrays with various modes of electronic interactions between chromophores. Combining through-bond and through-space coupling appears to be a viable strategy to engineer novel optical and photochem. properties in organic conjugated materials.

Journal of Organic Chemistry published new progress about Cis-trans photoisomerization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Du, Kun-ze; Cui, Yan; Chen, Shujing; Yang, Rui; Shang, Ye; Wang, Chenhong; Yan, Yiqi; Li, Jin; Chang, Yan-xu published the artcile< An integration strategy combined progressive multivariate statistics with anticoagulant activity evaluation for screening anticoagulant quality markers in Chinese patent medicine>, Synthetic Route of 112-63-0, the main research area is Chinese patent medicine screening anticoagulant quality marker multivariate statistics; FXa inhibitory activity; Multivariate statistical analysis; Naoxintong capsules; Thrombin inhibitory activity.

The cardiovascular and cerebrovascular diseases affect human health globally. Naoxintong capsules (NXTs), a famous Chinese Patent Medicine, has been especially applied to treat cerebral infarction and coronary heart disease in clin. practice. The anticoagulant activity of this prescription plays an important role in this course of treatment. Thrombin and factor Xa (FXa) are two key targets considering the anticoagulant activity. The purpose of this investigation is to screen the quanlity markers as key thrombin and FXa inhibitors for the anticoagulant activity oriented quality control of Chinese patent medicine. Simple multi-polar solvent extraction processes using various proportions of solvents were conducted and their thrombin/FXa inhibitory activities were evaluated in vitro. Bivariate correlation anal. (BCA), gray correlation anal. (GCA), and orthogonal partial least squares discriminate anal. (OPLS-DA) were adopted for screening the potential active markers related to the anticoagulant activity. The chem. structures of these active compounds were identified by UHPLC-Q-TOF-MS/MS and their thrombin/FXa inhibitory activity was determined The mol. docking technol. was applied to explore the interaction between the compounds and targets. The contribution of these anticoagulant active ingredients in NXT was also investigated. Last but not the least, the contents of these markers in NXT were determined by liquid chromatog.-electrospray ionization tandem triple quadrupole mass spectrometry (HPLC-ESI-MS/MS) method. The results showed that the NXT extract exhibited great activity against thrombin and FXa, especially extracted by 75% methanol (volume/volume). Six marker compounds with potential anticoagulant activity were screened out. Therein, four of the active compounds owing thrombin inhibitory activity (paeoniflorin, lithospermic acid, salvianolic acid B, Z-ligustilide) and five of the active compounds owing FXa inhibitory activity (3,5-dicaffeoylquinic acid, rosmarinic acid, lithospermic acid, salvianolic acid B and Z-ligustilide). In addition, these active compounds accounted for a large proportion of thrombin/FXa inhibitory activity of NXTs. The binding energy also showed the strong interaction formed by close connection of the compounds to the residues of targets. The proposed integrated stategy could be an efficient strategy to screen potential thrombin/FXa inhibitors for the bioactivity related quanlity control of Chinese patent medicine.

Journal of Ethnopharmacology published new progress about Anticoagulants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ahmad, Moghis U.; Krishna, U. Murali; Ali, Shoukath M.; Choudhury, Sreeti; Ahmad, Imran published the artcile< Synthesis of 1,3- and 1,2-diphosphatidylglycerol>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is glycerol coupling glyceride phosphite catalyst pyridinium bromide phosphatidylglycerol synthesis; phosphatidylglycerol cardiolipin glycerophospholipid phosphocholine synthesis glycerol protecting group.

A novel phosphonium salt methodol. was utilized for the first time to synthesize 1,3-, and 1,2-diphosphatidylglycerol. Optically active 1,2-di-O-acyl-sn-glyceryl phosphate was coupled with unprotected glycerol in the presence of pyridinium tribromide and triethylamine to yield, after final removal of phosphate protecting group, the title compounds The 1,2-diphosphatidylglycerol (1,2-isomer of cardiolipin) may be a member of a new class of phospholipids for industrial applications similar to other phosphocholines.

Lipids published new progress about Cardiolipins Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kubota, Dai; Ishikawa, Minoru; Ishikawa, Midori; Yahata, Naokazu; Murakami, Shoichi; Fujishima, Kazuyuki; Kitakaze, Masafumi; Ajito, Keiichi published the artcile< Tricyclic pharmacophore-based molecules as novel integrin αvβ3 antagonists. Part IV: Preliminary control of αvβ3 selectivity by meta-oriented substitution>, HPLC of Formula: 77215-54-4, the main research area is piperazine piperidine based integrin antagonist preparation SAR.

To establish the in vivo efficacy of αvβ3/αIIbβ3 dual antagonists possessing a tricyclic pharmacophore, a corresponding αvβ3-selective antagonist was required as a control. We initially took two synthetic approaches to obtain αvβ3-selective antagonists based on the RGD recognition pattern or on modification of the dihedral angle between the central benzene ring and the adjacent heterocycle, but both proved unsuccessful. However, synthesis of novel antagonists with meta-substitution of the central benzene ring generated weak selectivity for αvβ3 over αIIbβ3 for the first time in the family of compounds with the tricyclic pharmacophore. Optimization of meta-oriented antagonists furnished an αvβ3-selective antagonist exhibiting inhibitory activity not only in a receptor-binding assay, but also in a cell adhesion assay.

Bioorganic & Medicinal Chemistry published new progress about Integrin αIIbβ3 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 77215-54-4 belongs to class esters-buliding-blocks, and the molecular formula is C12H24N2O4, HPLC of Formula: 77215-54-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics