Tag: M.W=250-300

Albini, Angelo; Fasani, Elisa; Dacrema, Lucia Maggi published the artcile< Photochemistry of methoxy-substituted quinoline and isoquinoline N-oxides>, SDS of cas: 112-63-0, the main research area is quinoline oxide methoxy photochem; rearrangement photochem methoxyquinoline methoxyisoquinoline oxide; isoquinoline oxide methoxy photochem; substituent effect methoxyquinoline oxide photorearrangement; solvent effect methoxyquinoline oxide photorearrangement; isomerization photochem methoxyisoquinoline oxide; deoxygenation photochem methoxyquinoline methoxyisoquinoline oxide.

Irradiation of methoxyquinoline and -isoquinoline N-oxides gave a variety of photoisomers as well as deoxygenation and secondary reaction products, the nature of the products being dependent on the solvent and the position of the -OMe group. E.g., the irradiation of I (R = H, R1 = OMe) (medium-pressure Hg vapor lamp, 15°) gave 83% II in H2O whereas in C6H6 50% III (R = H, R1 = OMe) was obtained; however I (R = OMe, R1 = H) gave, under the same conditions, o-HOC6H4CH:CHNHCO2Me and IV (22 and 22%, resp.) in water, and III (R = OMe, R1 = H) (40%) in C6H12.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Photolysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hippmann, Anna A.; Schuback, Nina; Moon, Kyung-Mee; McCrow, John P.; Allen, Andrew E.; Foster, Leonard F.; Green, Beverley R.; Maldonado, Maria T. published the artcile< Proteomic analysis of metabolic pathways supports chloroplast-mitochondria cross-talk in a Cu-limited diatom>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is proteome copper metabolism signaling mitochondria chloroplast oxidative stress Thalassiosira; Cu limitation; copper; cross‐talk; diatom; proteomics.

Diatoms are one of the most successful phytoplankton groups in our oceans, being responsible for over 20% of the Earth’s photosynthetic productivity. Their chimeric genomes have genes derived from red algae, green algae, bacteria, and heterotrophs, resulting in multiple isoenzymes targeted to different cellular compartments with the potential for differential regulation under nutrient limitation. The resulting interactions between metabolic pathways are not yet fully understood. We previously showed how acclimation to Cu limitation enhanced susceptibility to overredn. of the photosynthetic electron transport chain and its reorganization to favor photoprotection over light harvesting in the oceanic diatom Thalassiosira oceanica (Hippmann et al., 2017, 10.1371/journal.pone.0181753). In order to gain a better understanding of the overall metabolic changes that help alleviate the stress of Cu limitation, we have further analyzed the comprehensive proteomic datasets generated in that study to identify differentially expressed proteins involved in carbon, nitrogen, and oxidative stress-related metabolic pathways. Metabolic pathway anal. showed integrated responses to Cu limitation. The upregulation of ferredoxin (Fdx) was correlated with upregulation of plastidial Fdx-dependent isoenzymes involved in nitrogen assimilation as well as enzymes involved in glutathione synthesis, thus suggesting an integration of nitrogen uptake and metabolism with photosynthesis and oxidative stress resistance. The differential expression of glycolytic isoenzymes located in the chloroplast and mitochondria may enable them to channel both excess electrons and/or ATP between these compartments. An addnl. support for chloroplast-mitochondrial cross-talk is the increased expression of chloroplast and mitochondrial proteins involved in the proposed malate shunt under Cu limitation.

Plant Direct published new progress about Chloroplast. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Yuanhui; Hao, Liang; Bai, Minli published the artcile< Modeling the multi-step discharge and charge reaction mechanisms of non-aqueous Li-O2 batteries>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is charge discharge reaction lithium oxygen battery.

The modeling study plays a critical role in understanding the reaction mechanisms and predicting the performance of lithium-oxygen (Li-O2) batteries. Although several models have successfully captured the discharge behaviors of the Li-O2 batteries, modeling the charge behaviors of the Li-O2 batteries is a challenge due to lacking a thorough understanding of the related reaction processes. This work proposes a multi-step reversible discharge/charge model for the non-aqueous Li-O2 batteries. Both the surface and solution reaction pathways of lithium peroxide (Li2O2) are taken into account. The proposed model can predict the discharge behaviors well, and more importantly, can accurately capture the charge behaviors of the Li-O2 batteries by considering the following three aspects: the effect of Li2O2 morphol. on its decomposition potential, the evolution of interfacial resistance by Li2O2 film collapse, and the different desorption rates of absorbed lithium superoxide (LiO*2) in different electrolytes. Based on this model, the discharge/charge processes of the Li-O2 batteries using dimethoxyethane(DME), tetraethylene glycol di-Me ether (TEGDME) and DMSO (DMSO) electrolytes, as well as a redox mediator TEMPO, are simulated and verified. The Li2O2 formation/decomposition through the surface and solution pathways are dominated by the sp. surface area of the electrode and the potential, resp. The Li2O2 generated by the solution pathway is more difficult to be decomposed during charge. The use of redox mediator TEMPO lowers the discharge capacity of the Li-O2 batteries due to the weakened solution reaction, while remarkably reduces the reversible capacity loss. The desorption time constant of LiO*2 in electrolyte is a critical parameter that determines the degree of the reaction through the solution pathway, thus determining the discharge/charge cycling performance of the Li-O2 batteries with various electrolytes.

Applied Energy published new progress about Battery electrodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liang, Jia-Quan; Chen, Xi; Cheng, Yong published the artcile< Paeoniflorin rescued MK-801-induced schizophrenia-like behaviors in mice via oxidative stress pathway>, HPLC of Formula: 112-63-0, the main research area is peoniflorin neuroprotectant oxidative stress schizophrenia; MK-801; olanzapine; oxidative stress; paeoniflorin; schizophrenia.

Schizophrenia (SCZ) affects approx. 1% population worldwide, and the first-line antipsychotics have partial reactivity or non-reactivity with side effects. Therefore, there is an urgent need to find more effective drugs. Paeoniflorin (PF) is the main effective component of traditional Chinese medicine from white peony, red peony and peony bark, which acts as a neuroprotective agent. The purpose of this study was to investigate whether PF can rescue MK-801 induced schizophrenia-like behavior in mice. Our results demonstrated that intragastric administration of PF ameliorated MK-801 induced schizophrenia-like behaviors in mice as demonstrated by prepulse inhibition of acoustic startle response, fear conditioning test for memory and open field test for activity. In contrast, the first-line antipsychotics-olanzapine reversed the prepulse inhibition deficits and hyperactivities, but not memory deficits, in the model mice. Further anal. showed that PF reduced oxidative stress in the MK-801-treated mice, as evidenced by the increased superoxide dismutase levels and decreased malondialdehyde levels in the blood of the model mice. In addition, PF treatment inhibited the expression of the apoptotic protein Bax and restored the expression of tyrosine hydroxylase in the brains of the model mice. in vitro data indicated that PF protected against oxidative stress induced neurotoxicity in the primary cultured hippocampal neurons. In conclusion, our results were the first to provide evidence that PF rescued schizophrenia-like behaviors (both pos. symptoms and cognitive impairments) in rodents through oxidative stress pathway, and therefore provide a novel strategy for treatment of SCZ. However, more pre-clin. and clin. research are needed to translate the present findings into clinics for a treatment of schizophrenia.

Frontiers in Nutrition published new progress about Antiapoptotic proteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (bax). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chapman, Lauren M.; Beck, Jordan C.; Lacker, Caitlin R.; Wu, Linglin; Reisman, Sarah E. published the artcile< Evolution of a Strategy for the Enantioselective Total Synthesis of (+)-Psiguadial B>, Formula: C19H34O2, the main research area is enantioselective synthesis psiguadial B Wolff rearrangement asym ketene trapping; aminoquinolinamide enantioenriched synthesis; ortho quinone methide hetero Diels Alder psiguadial B synthesis; Prins cyclization psiguadial B synthesis; Norrish Yang cyclization psiguadial B synthesis; ring closing metathesis psiguadial B synthesis; intramol arylation psiguadial B synthesis.

(+)-Psiguadial B is a diformyl phloroglucinol meroterpenoid that exhibits antiproliferative activity against the HepG2 human hepatoma cancer cell line. This full account details the evolution of a strategy that culminated in the first enantioselective total synthesis of (+)-psiguadial B. A key feature of the synthesis is the construction of the trans-cyclobutane motif by a Wolff rearrangement with in situ catalytic, asym. trapping of the ketene. An investigation of the substrate scope of this method to prepare enantioenriched 8-aminoquinolinamides is disclosed. Three routes toward (+)-psiguadial B were evaluated that featured the following key steps: (1) an ortho-quinone methide hetero-Diels-Alder cycloaddition to prepare the chroman framework, (2) a Prins cyclization to form the bridging bicyclo[4.3.1]decane system, and (3) a modified Norrish-Yang cyclization to generate the chroman. Ultimately, the successful strategy employed a ring-closing metathesis to form the seven-membered ring and an intramol. O-arylation reaction to complete the polycyclic framework of the natural product.

Journal of Organic Chemistry published new progress about Addition reaction, stereoselective (tandem photochem. Wolff rearrangement/enantioselective ketene addition). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lin, Aijun; Wang, Junying; Mao, Haibin; Shi, Yan; Mao, Zhijie; Zhu, Chengjian published the artcile< Organocatalytic Asymmetric Allylic Alkylation of Morita-Baylis-Hillman Carbonates with Phosphorus Ylides: Synthesis of Chiral 3-Substituted 2,4-Functionalized 1,4-Pentadienes>, Synthetic Route of 112-63-0, the main research area is chiral pentadiene preparation asym allylic alkylation cinchona alkaloid organocatalyst; enantioselective allylic substitution Morita Baylis Hillman carbonate phosphorus ylide.

A highly efficient asym. allylic substitution of Morita-Baylis-Hillman (MBH) carbonates with phosphorus ylides under the catalysis of modified cinchona alkaloids was developed. The reaction delivered products in moderate to good yields with excellent enantioselectivities (up to 98 % ee) for a wide range of MBH carbonates. The scope of the reaction was demonstrated by the synthesis of chiral 3-substituted 2,4-functionalized 1,4-pentadienes.

European Journal of Organic Chemistry published new progress about Alkadienes Role: SPN (Synthetic Preparation), PREP (Preparation) (pentadienes). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Garcia, Nuria; Garcia-Garcia, Patricia; Fernandez-Rodriguez, Manuel A.; Rubio, Ruben; Pedrosa, Maria R.; Arnaiz, Francisco J.; Sanz, Roberto published the artcile< Pinacol as a New Green Reducing Agent: Molybdenum-Catalyzed Chemoselective Reduction of Sulfoxides and Nitroaromatics>, Application of C19H34O2, the main research area is pinacol green reducing agent chemoselective reduction sulfoxide nitroarom; molybdenum catalyzed chemoselective reduction sulfoxide nitroarom pinacol reducing agent.

Pinacol is disclosed as a new chemoselective and environmentally benign reducing agent for sulfoxides and nitroaroms. assisted by readily available dichlorodioxomolybdenum(VI) complexes as catalysts. A wide range of substrates including those bearing challenging functional groups has been efficiently and selectively reduced with acetone and water being the only byproducts of these reactions.

Advanced Synthesis & Catalysis published new progress about Alkyl sulfoxides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hussain, Mudassar; Liaqat, Iram; Hanif, Uzma; Sultan, Aisha; Ara, Chaman; Aftab, Nauman; Urooj; Butt, Abida published the artcile< Medicinal perspective of antibacterial bioactive agents in earthworms (Clitellata, Annelida): a comprehensive review>, SDS of cas: 112-63-0, the main research area is review Clitellata Annelida peptide protein antibacterial bioactive agent; annelida; bioactive agents; earthworm; medicinal; peptides; proteins.

A review. Humoral practice is a fundamental natural biol. phenomenon in earthworm defensive system which protects them from infectious bacteria and irritating agents by different mechanisms. The defensive system of earthworms is highly complicated because they lack antibodies in their blood circulatory system but their body extracts and coelomic fluid comprise of different bioactive agents (i.e. peptides and proteins) that defend these worms. There are various groups of bioactive agents such as proteases (name depends on proteins/peptide function or formal earthworm species name), metabolites (total 59 metabolites found in Eisenia fetida), metal binding proteins (2 proteins such as Ca2+ binding calmodulin and metallothionein), active proteins (include lysozyme, lysenin and eiseniapore etc.), antimicrobial peptides (antibacterial vermi-peptides family (AVPF), antimicrobial peptide I (PP-I), coelomic cytolytic factor (CCF, CCF-I and CCF like protein)), fetidin, lysenin, lumbricin (lumbricin I, lumbricin PG, and lumbricusin), organic acids (fatty acids, succinic acids, and lauric acid) and other organic compounds (such as purine and vitamin D). The presence of above mentioned mols. confer therapeutic potential that affect energy intake and involve in decreasing oxidative stress, metabolic disturbances and pro-inflammatory conditions. The future perspectives of earthworm bioactive compounds are concerned with the development of provisional standards, purification and classification for utilizations in pharma industry.

Journal of Oleo Science published new progress about Annelida. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lv, Daqi; Sun, Qiao; Zhou, Huan; Ge, Liang; Qu, Yanjie; Li, Taian; Ma, Xiaoxu; Li, Yajun; Bao, Hongli published the artcile< Iron-Catalyzed Radical Asymmetric Aminoazidation and Diazidation of Styrenes>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is azidoarylethyl benzenesulfonimide diazidoarylalkane enantioselective preparation; iron dioxazolinyldibenzofuran catalyst enantioselective aminoazidation diazidation aryl alkene; radical reaction mechanism iron catalyzed aminoazidation diazidation aryl alkene; aminoazidation; asymmetric catalysis; iron catalysis; radical group transfer.

Asym. aminoazidation and diazidation of alkenes are straightforward strategies to build value-added chiral nitrogen-containing compounds from feedstock chems. They provide direct access to chiral organoazides and complement enantioselective diamination. Despite the advances in non-asym. reactions, asym. aminoazidation or diazidation based on acyclic systems has not been previously reported. Here we describe the iron-catalyzed intermol. asym. aminoazidation and diazidation of styrenes. The method is practically useful and requires relatively low loading of catalyst and chiral ligand. With mild reaction conditions, the reaction can be completed on a 20 mmol scale. Studies of the mechanism suggest that the reaction proceeds via a radical pathway and involves stereocontrol of an acyclic free radical which probably takes place through a group transfer mechanism.

Angewandte Chemie, International Edition published new progress about Alkyl azides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (benzylic). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Clugston, D. M.; MacLean, D. B. published the artcile< Mass spectra of oxygenated quinolines>, SDS of cas: 112-63-0, the main research area is .

The mass spectra of the monohydroxyquinolines, the monomethoxyquinolines, N-methyl-2-quinolone, and N-methyl-4-quinolone have been recorded. The isomeric hydroxy compounds vary somewhat in the stability of the mol. ion, but all show the same fragmentation mechanism. Two general fragmentation patterns are discernible in the spectrum of each of the monomethoxyquinolines, but there is considerable variation among the isomers in the extent to which the two patterns occur. In addition, 8-methoxyquinoline undergoes a peculiar fragmentation wherein all three Me hydrogens are lost. The 3-methoxy compound is unusual in that loss of 43 mass units from the mol. ion occurs in one step. Deuterium- and 13C-labeling experiments have proved to be useful in interpreting the fragmentation pathways. The spectra of the two N-methylquinolones prove that O to N Me rearrangement does not occur to any significant extent upon electron impact.

Canadian Journal of Chemistry published new progress about Mass spectra. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics