Tag: M.W=250-300

Kumar, Manoj; Reddy, Thurpu Raghavender; Gurawa, Aakanksha; Kashyap, Sudhir published the artcile< Copper(II)-catalyzed stereoselective 1,2-addition vs. Ferrier glycosylation of ""armed"" and ""disarmed"" glycal donors>, Category: esters-buliding-blocks, the main research area is trisaccharide stereoselective addition copper catalyzed glycoconjugate glycal nucleoside; amino acid glycoside preparation stereoselective glycosylation Ferrier glycal alc.

Selective activation of “”armed’ and ”disarmed”” glycal donors enabling the stereo-controlled glycosylations by employing Cu(II)-catalyst as the promoter has been realized. The distinctive stereochem. outcome in the process is mainly influenced by the presence of diverse protecting groups on the donor and the solvent system employed. The protocol is compatible with a variety of aglycons including carbohydrates, amino acids, and natural products to access deoxy-glycosides and glycoconjugates with high α-anomeric selectivity. Notably, the synthetic practicality of the method is amply verified for the stereoselective assembling of trisaccharides comprising 2-deoxy components. Mechanistic studies involving deuterated experiments validate the syn-diastereoselective 1,2-addition of acceptors on the double bond of armed donors.

Organic & Biomolecular Chemistry published new progress about Addition reaction catalysts, stereoselective. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ono, Masahiro; Haratake, Mamoru; Nakayama, Morio; Kaneko, Yoshikazu; Kawabata, Koichi; Mori, Hiroshi; Kung, Mei-Ping; Kung, Hank F. published the artcile< Synthesis and biological evaluation of (E)-3-styrylpyridine derivatives as amyloid imaging agents for Alzheimer's disease>, Computed Properties of 112-63-0, the main research area is iodine 125 dimethylaminostyrylpyridine preparation amyloid imaging agent Alzheimer.

A new series of (E)-3-styrylpyridine derivatives as potential diagnostic imaging agents targeting amyloid plaques in Alzheimer’s disease (AD) were synthesized and examined When in vitro binding studies using AD brain homogenates were carried out with a series of styrylpyridine derivatives, (E)-2-Bromo-5-(4-dimethylaminostyryl)pyridine (7) with a dimethylamino group showed the highest binding affinity. Compound 7 intensely stained neuritic and diffused plaques and cerebrovascular amyloids on postmortem AD brain sections. (E)-2-Iodo-5-(4-dimethylaminostyryl)pyridine (9), the iodo derivative of compound 7, also stained senile plaques in human AD sections. The radioiodinated ligand [125I]9 was successfully prepared through an iododestannylation reaction from the corresponding tributyltin derivatives using hydrogen peroxide as the oxidant in high yields and with high radiochem. purity. A biodistribution study in normal mice after an i.v. injection of [125I]9 displayed high brain uptake and fast washout. Taken together, the data suggest that the new radio tracer, [125I]9, may be useful as a radioiodinated imaging agent for mapping Aβ plaques in the brains of patients with AD.

Nuclear Medicine and Biology published new progress about Alzheimer disease. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Yu-Qi; Luo, Min; Shi, Yu; Guo, Ying; Zhang, Hua; Yang, Kai-Di; Li, Tian-Ran; Yang, Liu-Qing; Liu, Ting-Ting; Huang, Bo; Liu, Qing; He, Zhi-Cheng; Zhang, Xiao-Ning; Wang, Wen-Ying; Wang, Shuai; Zeng, Hui; Niu, Qin; Zhang, Xia; Cui, You-Hong; Zhang, Zhi-Ren; Bian, Xiu-Wu; Ping, Yi-Fang published the artcile< Dicer deficiency impairs proliferation but potentiates anti-tumoral effect of macrophages in glioblastoma>, Formula: C19H34O2, the main research area is glioblastoma cell proliferation macrophage phagocytosis dicer anti tumor immunotherapy.

Glioblastoma is a lethal primary brain tumor with abundant immune-suppressive glioblastoma-associated macrophage (GAM) infiltration. Skewing immune suppressive GAMs towards an immune-activating phenotype represents a promising immunotherapeutic strategy against glioblastoma. Herein, we reported that genetic deletion of miRNA-processing enzyme Dicer in macrophages inhibited the growth of GL261 murine glioblastoma xenografts and prolonged survival of tumor-bearing mice. Single cell RNA sequencing (scRNA-seq) of the tumor-infiltrating immune cells revealed that Dicer deletion in macrophages reduced the proportion of cell-cycling GAM cluster and reprogramed the remaining GAMs towards a proinflammatory activation state (enhanced phagocytotic and IFN-producing signature). Dicer-deficient GAMs showed reduced level of cyclin-dependent kinases (CDK1 and CDK2) and increased expression of CDK inhibitor p27 Kip1, thus manifesting impaired proliferation. Dicer knockout enhanced phagocytotic activity of GAMs to eliminate GL261 tumor cells. Increased proinflammatory GAM clusters in macrophage Dicer-deficient mice actively interacted with tumor-infiltrating T cells and NK cells through TNF paracrine signaling to create a pro-inflammatory immune microenvironment for tumor cell elimination. Our work identifies the role of Dicer deletion in macrophages in generating an immune-activating microenvironment, which could be further developed as a potential immunotherapeutic strategy against glioblastoma.

Oncogene published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (Ereg). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wan, Feifei; Yang, Bo; Zhu, Jiekun; Jiang, Dabo; Zhang, Huanhuan; Zhang, Qiao; Chen, Shuainan; Zhang, Chao; Liu, Yachun; Fu, Zaihui published the artcile< The transfer hydrogenation of high concentration levulinic acid to γ-valerolactone catalyzed by glucose phosphate carbamide zirconium>, Product Details of C19H34O2, the main research area is glucose phosphate carbamide zirconium levulinic acid transfer hydrogenation catalyst; gamma valerolactone turnover frequency.

Zr-Based catalysts have been extensively applied in Meerwein-Ponndorf-Verley type catalytic transfer hydrogenation (CTH) reactions, but they are easily deactivated in the CTH conversion of high concentrations of levulinic acid (LA) to γ-valerolactone (γ-GVL). This work discloses that by using cheap glucose and ZrCl4 as two main raw materials, glucose phosphate carbamide zirconium (GluPC-Zr) is easily synthesized at large scale and low cost via a simple two-step conversion. The constructed GluPC-Zr has enhanced Lewis acid-base properties and good porosity, thus exhibiting outstanding activity for the CTH reactions of LA or its esters with isopropanol (IPA), providing 95-98% γ-GVL yields. Because of the excellent esterification performance of the introduced acidic phosphate groups, GluPC-Zr also works well at high LA concentrations, achieving a much higher turnover frequency (TOF, 8.2 mmol γ-GVL per g catalyst per h) than previously reported Zr-based catalysts (TOF, 0.2-2.4). And it shows excellent reusability in the reaction of LA with IPA, still providing ca. 95% γ-GVL yield after the seventh cycle run. This work provides a preferential esterification strategy for LA to hamper catalyst deactivation, which is of special significance for the large-scale production of γ-GVL from biomass-derived LA and a low-cost GluPC-Zr catalyst.

Green Chemistry published new progress about Bronsted acidity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rauen, H. M.; Nonhof, R. published the artcile< Pattern of anticytogenic activity of pyrimidine derivatives on Neurospora crassa>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .

The anticytogenic activity of 71 pyrimidine derivatives on N. crassa was determined in the horizontal proliferation test. Of these, the following 12 were found to meet the criteria of the Cancer Chemotherapy National Service Center; i.e., their inhibitory doses (H.D.50) were under the limit of 10 mg./ml. of culture medium: 2-ethylmercapto-4-chloro-5-carbethoxypyrimidine, 0.025; bis(4-methylpyrimidyl-2-disulfide, 0.044; 4,6-dichloropyrimidine, 0.060; 4-methylpyrimidyl-2-sulfenmorpholide, 0.086; 2-ethylmercapto-4-amino-4-carbethoxypyrimidine, 0.130; 2-ethylmercapto-4-hydroxycarbethoxypyrimidine, 0.85; 4-phenylpyrimidine ,0.200; 2,4,5,6-tetraaminopyrimidine sulfate, 0.350; 2-amino-4-chloro-6-methylpyrimidine, 0.370; 2,4-dimercaptopyrimidine, 0.400; 2-mercapto-4-methylpyrimidine-HCl, 0.500; 2-mercapto-4,6-dimethylpyrimidine, 0.550 mg. Combinations of 2 or more inhibitory materials showed additive, synergistic, or diminished effects. The possible inhibitory mechanism is discussed. Relations are shown between the structures of the compounds and their cytotoxic action.

Arzneimittel-Forschung published new progress about Neurospora crassa. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kostenko, Alexey A.; Kucherenko, Alexander S.; Zlotin, Sergei G. published the artcile< Recyclable C2-symmetric tertiary amine-squaramide organocatalysts: Design and application to asymmetric synthesis of γ-nitrocarbonyl compounds>, Product Details of C19H34O2, the main research area is sym tertiary amine squaramide organocatalyst preparation; gamma nitrocarbonyl compound enantioselective preparation; beta dicarbonyl compound nitroolefin Michael addition sym squaramide organocatalyst.

Simple C2-sym. chiral tertiary amines I [R = Ph, 2-pyridyl, (CH2)4; stereo = R,R or S,S] bearing squaramide fragments along with the 1,2-di-(pyridin-2-yl)ethane spacer group were synthesized. Among them, amine I [R = 2-pyridyl, stereo = S,S] efficiently catalyzed asym. additions of β-dicarbonyl compounds to nitroolefins in H2O/DCM, affording corresponding adducts II [R1 = Me, MeO, O(CH2)2O; R2 = C6H5, 2-BrC6H4, 2-furyl, etc.] in up to 99% yield and 94% ee. The developed procedure was scalable. Due to poor solubility in organic solvents and water, catalyst could be readily separated from the reaction mixture and reused without compromising enantiomeric enrichment and yield of product.

Tetrahedron published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dias, L. G.; Hacke, A.; Bergara, S. F.; Villela, O. V.; Mariutti, L. R. B.; Bragagnolo, N. published the artcile< Identification of volatiles and odor-active compounds of aromatic rice by OSME analysis and SPME/GC-MS>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is aromatic rice volatile odor compound OSME analysis SPME GCMS; 2-acetyl-1-pyrroline; Aroma; Flavor; Olfactometry; Oryza sativa; Volatile profile.

During cooking, aromatic rice has a pleasant and characteristic aroma, a relevant factor to add sale value and attract consumer interest. This work studied the volatile compounds of aromatic rice (IAC 500) aiming at identifying those responsible for the aroma and flavor of the cooked rice. The description of the aromatic notes of the IAC 500 rice was carried out by a trained and selected sensory panel, followed by olfactometry (OSME) and identification by GC-MS of the rice volatile compounds extracted by SPME. A total of 80 volatiles was sensorially perceived and/or detected in the chromatog. effluent, of which 65 were identified, 44 presented some odor, and 36 were odorless. Among the odorous compounds, 15 were not detected by GC-FID or GC-MS. This study confirmed the compound 2-acetyl-1-pyrroline as the impacting volatile compound to the aroma of aromatic rice since it presented a very low percentage of area in the chromatogram and a high odor intensity. Other 43 compounds presented odor in lower intensities, but also contributed to the overall aroma of IAC 500 rice. From the 11 aromatic notes mentioned by the trained panel (cooked vegetable/seed, corn, hominy, green, porridge, popcorn, fresh baked cake/bread, milk, caramel, tapioca flour and flower), eight were related to the volatile compounds responsible for their aroma.

Food Research International published new progress about Analysis (olfactometry). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dunn, Robert O. published the artcile< Fuel properties of low-erucic acid pennycress (LEAP) oil biodiesel>, Reference of 112-63-0, the main research area is low erucic acid pennycress oil biodiesel fuel property.

Biodiesel is a renewable biobased fuel obtained from transesterification of plant seed oil with methanol. This fuel has phys. properties that make it attractive as an alternative fuel for compression-ignition (diesel) engines. In the United States (US), there is a need to increase the production of sustainable and environmentally friendly biofuels, including biodiesel, to supplement fossil fuels. To meet these challenges, emphasis is being placed on expanding the use of low-cost non-food oils as feedstocks for biodiesel. Low-erucic acid pennycress (LEAP) was developed from field pennycress as a cover crop for use in the Upper Midwestern US. The objective of the present study was to convert LEAP oil to biodiesel (fatty acid Me esters [FAME]) and evaluate its fuel properties. The same process was applied to FAME made from natural field pennycress (FPC) oil as a baseline for comparison of results. The LEAP oil-FAME (LEAP-ME) had a kinematic viscosity at 40°C (KV40) that was lower than that of FPC oil-FAME (FPC-ME), and nearly equivalent to the KV40 of soybean oil-FAME (SME). The total saturated-FAME (SFAME) concentration of LEAP-ME (5.40 mass%) was greater than that of FPC-ME. Since SFAME have high m.ps., this caused LEAP-ME to have a higher cloud point (CP) than FPC-ME. However, the CP of LEAP-ME (-6.8°C) was lower than those of canola oil-FAME (CaME; -2.5°C) and SME (-2.8°C). The oxidative induction period at 110°C (IP110) of LEAP-ME was poor (0.83 h), indicating that it would need to be treated with antioxidants before distribution as an alternative diesel fuel.

Industrial Crops and Products published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Urbanczyk, Sophia; Baris, Olivier R.; Hofmann, Joerg; Taudte, R. Verena; Guegen, Naig; Golombek, Florian; Castiglione, Kathrin; Meng, Xianyi; Bozec, Aline; Thomas, Jana; Weckwerth, Leonie; Mougiakakos, Dimitrios; Schulz, Sebastian R.; Schuh, Wolfgang; Schloetzer-Schrehardt, Ursula; Steinmetz, Tobit D.; Brodesser, Susanne; Wiesner, Rudolf J.; Mielenz, Dirk published the artcile< Mitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling the flux of the TCA cycle>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is mitochondrial respiration B lymphocyte humoral immunity TCA cycle DNT; B lymphocyte; CP: Immunology; HIF1; TCA cycle; class switch recombination; germinal center; hypoxia inducible factor 1; mTOR; mammalian target of Rapamycin; mitochondrial DNA; mitochondrial respiration; oxidative phosphorylation; phosphatidic acid; plasma cell.

To elucidate the function of oxidative phosphorylation (OxPhos) during B cell differentiation, we employ CD23Cre-driven expression of the dominant-neg. K320E mutant of the mitochondrial helicase Twinkle (DNT). DNT-expression depletes mitochondrial DNA during B cell maturation, reduces the abundance of respiratory chain protein subunits encoded by mitochondrial DNA, and, consequently, respiratory chain super-complexes in activated B cells. Whereas B cell development in DNT mice is normal, B cell proliferation, germinal centers, class switch to IgG, plasma cell maturation, and T cell-dependent as well as T cell-independent humoral immunity are diminished. DNT expression dampens OxPhos but increases glycolysis in lipopolysaccharide and B cell receptor-activated cells. Lipopolysaccharide-activated DNT-B cells exhibit altered metabolites of glycolysis, the pentose phosphate pathway, and the tricarboxylic acid cycle and a lower amount of phosphatidic acid. Consequently, mTORC1 activity and BLIMP1 induction are curtailed, whereas HIF1α is stabilized. Hence, mitochondrial DNA controls the metabolism of activated B cells via OxPhos to foster humoral immunity.

Cell Reports published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Selman, Mohammed; Ou, Paula; Rousso, Christopher; Bergeron, Anabel; Krishnan, Ramya; Pikor, Larissa; Chen, Andrew; Keller, Brian A.; Ilkow, Carolina; Bell, John C.; Diallo, Jean-Simon published the artcile< Dimethyl fumarate potentiates oncolytic virotherapy through NF-κB inhibition>, HPLC of Formula: 112-63-0, the main research area is dimethyl fumarate anticancer antiviral agent NFkappaB breast colon cancer.

Resistance to oncolytic virotherapy is frequently associated with failure of tumor cells to get infected by the virus. Di-Me fumarate (DMF), a common treatment for psoriasis and multiple sclerosis, also has anticancer properties. We show that DMF and various fumaric and maleic acid esters (FMAEs) enhance viral infection of cancer cell lines as well as human tumor biopsies with several oncolytic viruses (OVs), improving therapeutic outcomes in resistant syngeneic and xenograft tumor models. This results in durable responses, even in models otherwise refractory to OV and drug monotherapies. The ability of DMF to enhance viral spread results from its ability to inhibit type I interferon (IFN) production and response, which is associated with its blockade of nuclear translocation of the transcription factor nuclear factor κB (NF-κB). This study demonstrates that unconventional application of U.S. Food and Drug Administration-approved drugs and biol. agents can result in improved anticancer therapeutic outcomes.

Science Translational Medicine published new progress about Adenoviridae. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics