Tag: M.W=250-300

Takino, Toshikazu; Yasui, Hiroyuki; Yoshitake, Akira; Hamajima, Yoshio; Matsushita, Rokuji; Takada, Jitsuya; Sakurai, Hiromu published the artcile< A new halogenated antidiabetic vanadyl complex, bis(5-iodopicolinato)oxovanadium(IV): in vitro and in vivo insulinomimetic evaluations and metallokinetic analysis>, Application In Synthesis of 112-63-0, the main research area is vanadyl iodopicolinate diabetes treatment.

A new vanadyl complex, bis(5-iodopicolinato)oxovanadium(IV), VO(IPA)2, with a VO(N2O2) coordination mode, was prepared by mixing 5-iodopicolinic acid and VOSO4 at pH 5, with the structure characterized by electronic absorption, IR, and EPR spectra. Introduction of the halogen atom on to the ligand enhanced the in vitro insulinomimetic activity (IC50=0.45 mM) compared with that of bis(picolinato)oxovanadium(IV) (IC50=0.59 mM). The hyperglycemia of streptozotocin-induced insulin-dependent diabetic rats was normalized when VO(IPA)2 was given by daily i.p. injection. The normoglycemic effect continued for more than 14 days after the end of treatment. To understand the insulinomimetic action of VO(IPA)2, the organ distribution of vanadium and the blood disposition of vanadyl species were investigated. In diabetic rats treated with VO(IPA)2, vanadium was distributed in almost all tissues examined, especially in bone, indicating that the action of vanadium is not peripheral. Vanadyl concentrations in the blood of normal rats given VO(IPA)2 remain significantly higher and longer than those given other complexes because of its slower clearance rate. VO(IPA)2 binds with the membrane of erythrocytes, probably owing to its high hydrophobicity in addition to its binding with serum albumin. The longer residence of vanadyl species shows the higher normoglyceric effects of VO(IPA)2 among three complexes with the VO(N2O2) coordination mode. On the basis of these results, VO(IPA)2 is indicated to be a preferred agent to treat insulin-dependent diabetes mellitus in exptl. animals.

JBIC, Journal of Biological Inorganic Chemistry published new progress about Antidiabetic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guo, Aishun; Fang, Guixia; Lin, Zhenrong; Zheng, Shuishun; Zhuang, Zhijun; Lin, Ruisheng; Lin, Yanling published the artcile< Overexpression of lncRNA IRAIN restrains the progression and Temozolomide resistance of glioma via repressing IGF-1R-PI3K-NF-κB signaling pathway>, Reference of 112-63-0, the main research area is .

Background. Increasing studies have found that long noncoding RNAs (lncRNAs) contribute to regulating tumor progression. This study explores the expression characteristics, effects, and related mechanisms of lncRNA IGF1R antisense imprinted non-protein coding RNA (IRAIN) in glioma. Methods. Quant. real-time PCR (qRT-PCR) was implemented to testify the IRAIN profile in glioma tissues and paracancerous tissues, and the link between the IRAIN level and the clinicopathol. indicators of glioma was analyzed. IRAIN overexpression and knockdown cell models were constructed in glioma cells. Cell proliferation was verified by the colony formation experiment, while flow cytometry was implemented to monitor apoptosis. Transwell assay was performed to examine cell invasion and migration. Western blot (WB) was adopted to compare the profiles of the apoptosis-related proteins (Bax, Bcl2, and Caspase3) and IGF-1R-PI3K-NF-κB pathway. Results. IRAIN was down-regulated in glioma tissues (compared with adjacent normal tissues), and the low IRAIN expression was significantly linked with the larger tumor volume and higher pathol. stages. Functionally, overexpressing IRAIN abated glioma cell proliferation, invasion, and migration, promoted apoptosis, and attenuated IGF-1R-PI3K-NF-κB expression and temozolomide (TMZ) resistance, which was also confirmed in the xenograft tumor experiment The WB result showed that overexpressing IRAIN inactivated the IGF-1R-PI3K-NF-κB pathway. Addnl., the IGF-1R knockdown model was established in U251 cells. Si-IGF-1R induced cell proliferation inhibition, promoted cell death, and reduced cell migration and TMZ resistance, whereas Si-IGF-1R + IRAIN group showed no addnl. effects on glioma cells compared with the Si-IGF-1R group. Conclusion. IRAIN repressed glioma development and TMZ resistance by inactivating the IGF-1R-PI3K-NF-κB axis.

Histology and Histopathology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Altinoz, Meric A.; Ozpinar, Aysel published the artcile< Oxamate targeting aggressive cancers with special emphasis to brain tumors>, Electric Literature of 112-63-0, the main research area is oxamate brain tumor progression; Glioblastoma; Invasive pituitary adenoma; Medulloblastoma; Oxamate; Phenformin; Warburg effect.

Cancer is one of the main causes of human mortality and brain tumors, including invasive pituitary adenomas, medulloblastomas and glioblastomas are common brain malignancies with poor prognosis. Therefore, the development of innovative management strategies for refractory cancers and brain tumors is important. In states of mitochondrial dysfunction – commonly encountered in malignant cells – cells mostly shift to anaerobic glycolysis by increasing the expression of LDHA (Lactate Dehydrogenase-A) gene. Oxamate, an isosteric form of pyruvate, blocks LDHA activity by competing with pyruvate. By blocking LDHA, it inhibits protumorigenic cascades and also induces ROS (reactive oxygen species)-induced mitochondrial apoptosis of cancer cells. In preclin. studies, oxamate blocked the growth of invasive pituitary adenomas, medulloblastomas and glioblastomas. Oxamate also increases temozolomide and radiotherapy sensitivity of glioblastomas. Oxamate is highly polar, which may preclude its clin. utilization due to low penetrance through cell membranes. However, this obstacle could be overcome with nanoliposomes. Moreover, different oxamate analogs were developed which inhibit LDHC4, an enzyme also involved in cancer progression and germ cell physiol. Lastly, phenformin, an antidiabetic agent, exerts anticancer effects via complex I inhibition in the mitochondria and leading the overproduction of ROS. Oxamate combination with phenformin reduces the lactic acidosis-causing side effect of phenformin while inducing synergistic anticancer efficacy. In sum, oxamate as a single agent and more efficiently with phenformin has high potential to slow the progression of aggressive cancers with special emphasis to brain tumors.

Biomedicine & Pharmacotherapy published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Al-Ansari, Sali; Jalali, Rozita; Bronckers, Antonius L. J. J.; van Tellingen, Olaf; Raber-Durlacher, Judith; Nadjmi, Nasser; Brook, Alan Henry; de Lange, Jan; Rozema, Frederik R. published the artcile< Tooth Formation as Experimental Model to Study Chemotherapy on Tissue Development: Effect of a Specific Dose of Temozolomide/Veliparib>, Reference of 112-63-0, the main research area is ameloblast; antineoplastic agents; dental epithelium; gap junction; ion and fluid transport; tooth formation.

Background: Chemotherapy treatment of cancer in children can influence formation of normal tissues, leading to irreversible changes in their structure and function. Tooth formation is susceptible to several types of chemotherapy that induce irreversible changes in the structure of enamel, dentin and dental root morphol. These changes can make the teeth more prone to fracture or to caries when they have erupted. Recent studies report successful treatment of brain tumors with the alkylating drug temozolomide (TMZ) in combination with veliparib (VLP) in a glioblastoma in vivo mouse model. Whether these drugs also affect tooth formation is unknown. Aim: In this study the effect of TMZ/VLP on incisor formation was investigated in tissue sections of jaws from mice and compared with mice not treated with these drugs. Materials and method: The following aspects were studied using immunohistochem. of specific protein markers including: (1) proliferation (by protein expression of proliferation marker Ki67) (2) a protein involved in paracellular ion transport (expression of tight junction (TJ) protein claudin-1) and (3) in transcellular passage of ions across the dental epithelium (expression of Na+, K+ 2Cl- cotransporter/NKCC1). Results: Chemotherapy with TMZ/VLP strongly reduced immunostaining for claudin-1 in distal parts of maturation ameloblasts. No gross changes were found in the treated mice, either in cell proliferation in the dental epithelium at the cervical loop or in the immunostaining pattern for NKCC1 in (non-ameloblastic) dental epithelium. The salivary glands in the treated mice contained strongly reduced immunostaining for NKCC1 in the basolateral membranes of acinar cells. Discussion/Conclusions: Based on the reduction of claudin-1 immunostaining in ameloblasts, TMZ/VLP may potentially influence forming enamel by changes in the structure of TJs structures in maturation ameloblasts, structures that are crucial for the selective passage of ions through the intercellular space between neighboring ameloblasts. The strongly reduced basolateral NKCC1 staining seen in fully-grown salivary glands of TMZ/VLP-treated mice suggests that TMZ/VLF could also influence ion transport in adult saliva by the salivary gland epithelium. This may cause treated children to be more susceptible to caries.

Genes published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ahmed, Ghadia; Awan, Zahoor ul Hussain; Butt, Faaz Ahmed; Raza, Faizan; Hashmi, Saud; Gnana Kumar, G.; Christy, Maria published the artcile< The study of different redox mediators for competent Li-air batteries>, Product Details of C19H34O2, the main research area is review lithium air battery energy storage stability.

A review. Li-air batteries attract abundant attention in recent years with superior performance, and have largely replaced traditional methods of energy storage. The main objective of Li-air battery is to provide long-range elec.-vehicles, while functioning as an environmentally friendly and compact energy storage solution They offer the highest theor. energy d. (3500 Wh/kg), almost 20% higher than the ordinary Li-ion batteries. Nonetheless, Li-air batteries still face numerous issues, the most serious of which are high overpotential and parasitic reactions. Several redox mediators (RM) have been studied in order to reduce the high overpotential and the influence of side reactions. RM function in the electrolyte as soluble catalysts, limiting the formation of singlet oxygen while promoting the formation of discharge product Li2O2. This research primarily focuses on the optimization of Li-air cells with different redox mediators in conjunction with appropriate electrolyte, as a result reducing overpotential, parasitic byproducts and increasing efficiency. Under standard electrolytic conditions, ruthenocene exhibits high stability by completing 83 cycles, thus outperforming the other mediators being investigated. Further, di-tert-butyl-1,4-benzoquinone is more commonly used for discharge reaction and has been shown to increase the capacity of Li-O2 batteries by 80 times. This study reconfirms lithium bis(trifluoromethylsulfonyl) imide in tetraethyleneglycol dimethylether as the most stable electrolyte.

Journal of Power Sources published new progress about Batteries (lithium air). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dai, Peng-Fei; Ning, Xiao-Shan; Wang, Hua; Cui, Xian-Chao; Liu, Jie; Qu, Jian-Ping; Kang, Yan-Biao published the artcile< Cleavage of C(aryl)-CH3 Bonds in the Absence of Directing Groups under Transition Metal Free Conditions>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is carbon carbon bond cleavage borylation metal free condition diboron; tolyl bond cleavage borylation metal free condition; boranes aryl preparation reactivity; borylation; cross-coupling; oxidation; radicals; reaction mechanisms.

Organic chemists now can construct C-C σ-bonds selectively and sequentially, whereas methods for the selective cleavage of C-C σ-bonds, especially for unreactive hydrocarbons, remain limited. Activation by ring strain, directing groups, or in the presence of a carbonyl or a cyano group is usually required. By using a sequential strategy site-selective cleavage and borylation of C(aryl)-CH3 bonds was developed under directing group free and transition metal free conditions. Me groups of various arenes are selectively cleaved and replaced by boryl groups. Mechanistic anal. suggests that it proceeds by a sequential intermol. oxidation and coupling of a transient aryl radical, generated by radical decarboxylation, involving a pyridine-stabilized persistent boryl radical.

Angewandte Chemie, International Edition published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Choochottiros, Chantiga published the artcile< Thermal crosslinking of polylactide/star-shaped polycaprolactone for toughening and resistance to thermal deformation>, HPLC of Formula: 112-63-0, the main research area is polylactide star polycaprolactone blend thermal crosslinking deformation toughening.

The applications of polylactic acid (PLA) are limited by its brittleness and poor thermal resistance. Here, the toughness of PLA and its resistance to thermal deformation were enhanced by crosslinking it with star-shaped polycaprolactone using dicumyl peroxide as a thermal initiator. The mech. properties of the blended and crosslinked films were investigated via tensile testing. The crosslinked films of PLA/st4PCL-G exhibited toughness 1.2 times greater than that of neat PLA. The resistance to thermal deformation was investigated in a hot oven and in hot water. Although the glass-transition temperature (Tg) of the crosslinked films was lower than that of neat PLA, the crosslinked films exhibited resistance to thermal deformation and maintained shape stability without any shrinkage or distortion at temperatures greater than Tg.

Polymer Journal (Tokyo, Japan) published new progress about Crystallinity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mailliet, Patrick; Segal-Bendirdjian, Evelyne; Kozelka, Jiri; Barreau, Michel; Baudoin, Bernard; Bissery, Marie-Christine; Gontier, Sylvie; Laoui, Abdelazize; Lavelle, Francois published the artcile< Asymmetrically substituted ethylenediamine platinum(II) complexes as antitumor agents: synthesis and structure-activity relationships>, Category: esters-buliding-blocks, the main research area is antitumor ethylenediamine platinum complex preparation.

A series of platinum dichloroethylenediamine complexes [PtCl2(R-en)] bearing a side chain on one carbon atom of the ethylenediamine ligand, with or without a functional group on the side chain, have been prepared and investigated for antitumor activity against L1210 leukemia. They were tested both in vitro, with cisplatin-sensitive and resistant cell lines, and in vivo, with cisplatin-sensitive and resistant tumors grafted i.p. in B6D2F1 mice. The rationale for this study was to test how charge, polarity and shape fo the R side chain influence antitumor activity. Complexes carrying one or more ammonium groups on the side chain were all inactive. Derivatives with a carbamate function attached by the nitrogen atom, via a methylene group, to the ethylenediamine moiety (‘N-bound’ carbamate) were highly active in vitro and in vivo. The best results were obtained with those carbamates bearing hydrophobic substituents of intermediate size. Replacement of N-bound by O-bound carbamate or by urea groups led to decreased in vivo activity. Sulfonamide derivatives were all inactive. Good to excellent activities were also recorded for complexes bearing bulky bicycloalkyl substituents, without any functional group, attached to one ethylenediamine carbon atom. Thus, it is the steric features of the side chain rather than its polarity that appear to favor the antitumor activity of the complex. Compared to cisplatin and oxaliplatin, the present complexes do not exhibit advantages in terms of exptl. antitumor activities in solid tumor models.

Anti-Cancer Drug Design published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Marso, Tuan Mohommed Mudassar; Kalpage, Chandrakantha Senajith; Udugala-Ganehenege, Manawadevi Yasatissa published the artcile< ZnO/CuO composite catalyst to pre-esterify waste coconut oil for producing biodiesel in high yield>, COA of Formula: C19H34O2, the main research area is zinc copper oxide composite catalyst waste coconut oil biodiesel.

The study reported herein describes a two-stepped catalytic approach to produce biodiesel from waste-coconut oil in high (> 90%) yield. In this regard, pre-esterification of the Free Fatty Acid (FFA) content (9.58 mg KOH g-1) of waste coconut oil in the presence of a simple ZnO/CuO composite, as a heterogeneous acid-catalyst to prevent competitive saponification and hydrolysis side reactions caused by FFA, followed by the base-catalyzed transesterification of the triglyceride of oil was performed. The ZnO/CuO catalyst was synthesized using a simultaneous precipitation method, and characterized by spectroscopic (FTIR, UV-Vis), SEM, XRD and XRF techniques. The surface acidity of the catalyst and the FFA value (AV) of the oil before and after the pre-esterification was determined using the Hammett indicator method. The pre-esterification was performed at different temperatures (5-125°C), time intervals (15-235 min), and using different weight percentages (wt%) of catalyst loading (0.005-2.665) and methanol-to-oil ratios. The optimum reaction conditions were identified using a central composite rotatable design (CCRD). The results of the study revealed that a small amount of the catalyst (1.66 wt%) is enough, and the catalyst could be easily recovered and reused 3-4 catalytic runs for reducing the AV of waste coconut oil by 94.53% under milder conditions (within 113 min, at 55°C in the presence of 10.5:1 methanol-to-oil ratio) than those conditions reported so far. The biodiesel obtained this way was free from soap, and consistent with ASTM-D6751 and EN-14214 standards

Reaction Kinetics, Mechanisms and Catalysis published new progress about Acid number. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fang, Junwei; Wang, Liping; Wang, Yang; Qiu, Mingfeng; Zhang, Yongyu published the artcile< Metabolomics combined with pattern recognition and bioinformatics analysis methods for the development of pharmacodynamic biomarkers on liver fibrosis>, Related Products of 112-63-0, the main research area is liver fibrosis pharmacodynamic biomarker metabolomics bioinformatics analysis method.

The major obstacle for the development of targeted therapies is the lack of pharmacodynamic (PD) biomarkers to provide an early readout of biol. activities. As the modulation of metabolites may reflect the biol. changes occurring in the targets, metabolomics is promising to be an efficient way to explore PD biomarkers. In the present study, a liver fibrosis rat model was established by i.p. injection of CCl4 twice weekly for 6 wk, the treatment of total aglycon extracts of Scutellaria baicalensis (TAES) was begun 4 wk after the modeling, and gas chromatog.-mass spectrometry (GC-MS) based metabolomics combined with pattern recognition and network anal. were carried out for the research on PD biomarkers of TAES on liver fibrosis. After 2 wk of treatment, TAES shows pos. effects on CCl4-induced liver fibrosis. In the metabolomics study, 63 urinary metabolites contributing to liver fibrosis were identified. Six metabolic pathways significantly enriched in metabolomics data were mapped onto a network to determine global patterns of metabolic alterations in liver fibrosis. By topol. anal., 6 metabolites with high centrality in the metabolic sub-network were selected as potential PD biomarkers. Within 24 h of the final administration, the 6 identified urine metabolic biomarkers with response to time variation of TAES were validated as PD biomarkers. This integrative study presents an attractive strategy to explore PD biomarkers, which may give insight into the actual pharmacol. effect of target drugs, and the information from PD biomarkers can be combined with pharmacokinetics to select the optimal dose and a schedule of administration for the drugs.

Molecular BioSystems published new progress about Aglycons Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics