Tag: M.W=250-300

Lacivita, Enza published the artcilePrivileged scaffold-based design to identify a novel drug-like 5-HT₇ receptor-preferring agonist to target Fragile X syndrome, Computed Properties of 115314-17-5, the publication is European Journal of Medicinal Chemistry (2020), 112395, database is CAplus and MEDLINE.

Recent preclin. studies have shown that activation of the serotonin 5-HT₇ receptor has the potential to treat neurodevelopmental disorders such as Fragile X syndrome, a rare disease characterized by autistic features. With the aim to provide the scientific community with diversified drug-like 5-HT₇ receptor-preferring agonists, we designed a set of new long-chain arylpiperazines by exploiting structural fragments present in clin. approved drugs or in preclin. candidates (privileged scaffolds). The new compounds were synthesized, tested for their affinity at 5-HT₇ and 5-HT_1A receptors, and screened for their in vitro stability to microsomal degradation and toxicity. Selected compounds were characterized as 5-HT₇ receptor-preferring ligands, endowed with high metabolic stability and low toxicity. Compound 7g emerged as a drug-like 5-HT₇ receptor-preferring agonist capable to rescue synaptic plasticity and attenuate stereotyped behavior in a mouse model of Fragile X syndrome.

European Journal of Medicinal Chemistry published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Computed Properties of 115314-17-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Mustapha, Siti Noor Hidayah published the artcileSynthesis and characterization of hydrophobic properties of silicon dioxide in palm oil based bio-coating, Name: Trimethylolpropane triacrylate, the publication is Materials Today: Proceedings (2022), 51(Part_2), 1415-1419, database is CAplus.

This research aims to synthesize a biobased polyurethane coating from epoxidized palm oil (EPO) and determine the effect of different silicon dioxide (SiO₂) loadings on the hydrophobicity performance of the coating. In this work, EPO was firstly undergoing an acrylation reaction and followed by the addition of isophorone diisocyanate (IPDI) to form Polyurethane (PU). Improvement was made by adding SiO₂ at different loadings into the palm oil-based PU to provide hydrophobic properties to the coating materials. The sample was characterized using Fourier Transform IR Spectroscopy (FTIR), water sliding angle test, and water absorption test. Based on the FTIR results, PU was successfully synthesized from EPO with SiO₂ addition The results also proved that the addition of SiO₂ successfully improved the hydrophobicity of the coating. The higher the SiO₂ content in palm oil PU, the shorter the time taken for the water to slide down the 25° angle coated glass and lower the water absorption percentage of the coating material. Based on the anal., 3 phr SiO₂ content showed the highest hydrophobicity performance, which could be applied in further research.

Materials Today: Proceedings published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Name: Trimethylolpropane triacrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Okamoto, Akimitsu published the artcileSite-Selective DNA Alkylation of GG Steps by Naphthaldiimide Derivatives Possessing Enantiomeric Epoxide, COA of Formula: C9H9NO6S, the publication is Organic Letters (2000), 2(21), 3249-3251, database is CAplus and MEDLINE.

We have synthesized an enantiomeric pair of novel DNA alkylating agents consisting of a naphthaldiimide intercalator and a chiral epoxy side chain. These naphthaldiimide derivatives have high DNA binding affinity and selectively alkylate 5’G of the GG steps for (S)-epoxide and 3’G for (R)-epoxide.

Organic Letters published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, COA of Formula: C9H9NO6S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Murthy, Satya S. published the artcileA facile stereospecific synthesis of the [²H₆]-isopropyl-labeled metoprolol enantiomers from (2R)- and (2S)-glycidyl 3-nitrobenzenesulfonate, SDS of cas: 115314-17-5, the publication is Journal of Labelled Compounds and Radiopharmaceuticals (1990), 28(12), 1410-16, database is CAplus.

Enantiomers of metoprolol, e.g. I, containing six deuterium atoms in the iso-Pr Me groups were prepared in two steps from the sodium salt of 4-(2-methoxyethyl)phenol and the com. available (2R)- and (2S)-glycidyl 3-nitrobenzenesulfonate. The resulting (2R)- and (2S)-epoxides were opened using [²H₆]-isopropylamine. The enantiomeric excesses were 93 and 95% for the deuterated (2R)- and (2S)-enantiomers of metoprolol as determined by chiral column HPLC.

Journal of Labelled Compounds and Radiopharmaceuticals published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, SDS of cas: 115314-17-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

D. Desai, Prashil published the artcileSynthesis of ultraviolet curable bisphenol-based epoxy acrylates and comparative study on its physico-chemical properties, Product Details of C15H20O6, the publication is Journal of Applied Polymer Science (2022), 139(17), 52022, database is CAplus.

Photocuring resins have emerged as cutting-edge technol. in coatings, adhesives, composites, additive manufacturing, and so forth. In the present work, different bisphenol, namely A, F, and S, were used to synthesize low mol. weight epoxy resin, which was further reacted with acrylic acid monomer to form bisphenol-based epoxy acrylate (BEA). The BEA resins were formulated using reactive diluents, trimethylolpropane triacrylate, and hexanediol diacrylate in the ratio of 0-40 wt% at the increment of 10 wt% alongside a fixed quantity photoinitiator. These resins were then cast into dumbbell-shaped specimens by irradiating them under UV light. The structural elucidation of BEA resins was performed using Fourier transform IR, NMR, and UV-Vis spectroscopy. The formulated resins were also studied for their rheol. properties. Further, the UV cured specimens were evaluated for mech., thermal, contact angle, and extent of curing. These outcomes were utilized for establishing the structure-property relationship based on the functionality, reactivity, and mol. structure of synthesized BEA resins, which controllers the design architecture and crosslinking d. of UV-cured specimens.

Journal of Applied Polymer Science published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Product Details of C15H20O6.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Madhesan, Thirumalai published the artcileProbe anchored porous organic polymer monolithic architectures as optical sensor for ultra-trace analysis of Hg²⁺ in water samples, Computed Properties of 15625-89-5, the publication is Microporous and Mesoporous Materials (2022), 111724, database is CAplus.

In this article, we have demonstrated an effective strategy to detect and remove the toxic Hg²⁺ by an ion-selective optical sensor using chromoionophoric receptor that is homogenously dispersed onto the surface of porous organic polymer (POP) template. Herein, we present a detailed summation of the synthesis of different POPs by employing various kinds of monomers and crosslinkers to discover excellent structural property materials that could cater to the needs of an optical sensor. The resultant POP from the bulk polymerization of N,N-di-Me allylamine (DMA), and trimethylolpropane triacrylate (TMPTA), i.e., poly(DMA-co-TMPTA), manifested a higher surface area with pore size, thus has been utilized as the substrate material for the fabrication of the sensor. Further, the chromoionophoric coordinating ligand, i.e., 7-4(diethylamino)phenyldiazenyl quinolin-8-ol (DPDQ), is immobilized as receptor mols. onto the POP template for ultra-trace detection of Hg²⁺. The surface dispersed receptor forms stable 1:1 charge-transfer complexes [Hg²⁺-DPDQ] with a striking naked-eye color transition from pale orange to bright reddish-brown. The developed optical sensor offers an ultra-fast, selective response for Hg²⁺ with a lower detection limit of 0.1 μg/L (ppb) in the linear range of 0-100 μg/L. The regeneration of the sensor is envisaged with 0.02 M HCl and can be reused for up to six sensing cycles. Actual water samples from different geog. locations of India are tested using the developed sensor, and the method proved effective for real-time monitoring of Hg²⁺.

Microporous and Mesoporous Materials published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Computed Properties of 15625-89-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Dakova, Ivanka published the artcileFe(II) ion-imprinted copolymer gels – smart materials for Fe(II)/Fe(III) speciation in surface waters, Computed Properties of 15625-89-5, the publication is Polymer International (2022), 71(6), 706-714, database is CAplus.

The effect of template species – Fe(II) complexes with 4-(2-pyridylazo)resorcinol or 2,2′-bipyridine as well as the functional monomers: acidic (methacrylic acid) and neutral (hydroxyethyl methacrylate) on the extraction efficiency and applicability of Fe(II) ion-imprinted polymers for iron speciation in surface waters is presented in this study. The polymers were synthesized by precipitation copolymerization of functional monomer, trimethylolpropane trimethacrylate (crosslinking agent) and 2,2′-azo-bis-isobutyronitrile (initiator) in the presence of template and characterized by elemental microanal., SEM and Brunauer-Emmett-Teller analyses. Extraction efficiency was examined by batch solid-phase extraction The equilibrium exptl. data of adsorption processes with different synthesized sorbents were fitted by both Langmuir and Freundlich isotherms and are discussed from the viewpoint of possible bond formation between monomer and template species and the stability of the prepolymerization complex. Pseudo-first-order and pseudo-second-order kinetic models were tested to elucidate the possible controlling mechanism of the sorption process for different sorbents. Under the optimum conditions p^H 7 and equilibrium time of 30 min the highest extraction efficiency and selectivity toward Fe(II) was achieved for Fe(II) ion-imprinted polymer containing methacrylic acid and Fe(II)-4-(2-pyridylazo)resorcinol complex as a template. The anal. procedure for Fe speciation was developed and validated with this sorbent. 2021 Society of Industrial Chem.

Polymer International published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Computed Properties of 15625-89-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

El-Zayat, Mai M. published the artcileEnhancing the physico-mechanical properties of ethylene propylene diene monomer rubber via ?-radiation in the presence of bi-functional and tri-functional monomers, SDS of cas: 15625-89-5, the publication is Radiochimica Acta (2022), 110(2), 145-156, database is CAplus.

This study, uses two polyfunctional monomers (PFMs) namely ethylene glycol dimethacrylate (EGDMA) as a bifunctional monomer and trimethylolpropane triacrylate (TMPTA) as a trifunctional monomer were used as co-agents in irradiation crosslinking of Ethylene Propylene Diene Monomer Rubber (EPDM). The effect of concentration of each PFM and irradiation dose on the crosslinking d., gel content, swelling behavior in motor and brake oils, in addition to the mech. and thermal stability properties of EPDM was investigated in detailed. The results showed a remarkable increase in the gel content, crosslinking d. and mech. properties as the concentration of PFMs increased from 1 to 5 phr (parts per hundred parts of rubber). The various blends of EPDM with the trifunctional monomer express the highest gel content and crosslinking d. than those with the bifunctional monomer. The addition of 5 phr of TMPTA to EPDM causes a dramatic improvement in tensile strength (TS) of the prepared blend reached to 188% compared to neat EPDM at 50 kGy. At the same time, the maximum TS of the blend containing 5 phr of EGDMA achieved only 41% compared to neat EPDM at an irradiation dose of 100 kGy. The swelling of irradiated samples in brake oil revealed a stronger oil resistance than motor oil. For all irradiated samples, the oil uptake decreased with the irradiation dose up to 100 kGy. The EPDM samples containing 5 phr of TMPTA recorded the highest oil resistance at 100 kGy. The results also showed that the addition of PFMs and irradiation treatment of the various prepared blends improved the thermal stability of EPDM. Finally, neat EPDM and the blends containing 1 and 3 phr of EGDMA can be used as radiation dosimeters in the very high dose range (50-200 kGy).

Radiochimica Acta published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, SDS of cas: 15625-89-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Mohd Yunus, Nor Yuziah published the artcileTensile performances of radiation triggered wood-plastic composite and trimethylolpropane triacrylate (TMPTA) as additive at different treatments, Application In Synthesis of 15625-89-5, the publication is Materials Today: Proceedings (2022), 51(Part_2), 1293-1297, database is CAplus.

The blending of wood fibers with polypropylene has been widely reported. The behavior for radiation triggered wood-plastic composite (WPC) may differ for different treatment protocol. This study looks at the effect of combination style of rubberwood fiber, polypropylenes and additive (trimethylolpropane triacrylate, TMPTA) radiation treatment. The effect is measured through the tensile and flexural properties of the resultant WPC. The combination of sep. radiation of fiber, polypropylene combine with TMPTA, showed the best performance for tensile at 48.2 MPa at initial stage and second best reading after 24 mo. Interestingly the combination with only polypropylene irradiated gave lowest initial tensile but developed the highest strength value after 24 mo storage. The dynamic mech. test for the WPC showed the presence of trapped radicals in the completed WPC. The change in strength showed a different ageing effect in radiated sample which need to be studied further prior to usage.

Materials Today: Proceedings published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Application In Synthesis of 15625-89-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Amoozadeh, Pegah published the artcileUV-curable hybrid hydrogels of carbon quantum dots: synthesis, characterizations and investigation of properties and rheological behavior, Related Products of esters-buliding-blocks, the publication is Polymer-Plastics Technology and Materials, database is CAplus.

In this study, we are going to produce UV-curable hydrogel hybrids with carbon quantum dots. For this purpose, after synthesizing CQDs, they were reacted with acrylic acid to establish covalent bonds and create a C = C bond on the surface of CQDs. Then acrylamide hydrogel was synthesized. In the next step, 1, 3 and 5% UV-curable hydrogel hybrids were prepared The exptl. results displayed that increasing the amount of CQDs in the hydrogel increased photoluminescence intensity and water adsorption while boosting the hydrogel′s thermal stability. Besides, increasing the CQDs amount reduces the hydrogel elasticity.

Polymer-Plastics Technology and Materials published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics