Tag: M.W=250-300

More, Swati S.; Vince, Robert published the artcile< A metabolically stable tight-binding transition-state inhibitor of glyoxalase-I>, Quality Control of 77215-54-4, the main research area is glutathione analog urea isostere preparation inhibition glyoxalase I antitumor.

The design, synthesis, and enzyme kinetics evaluation of a transition-state inhibitor of glyoxalase-I is described. The union of the hydroxamic acid zinc-chelator with a urea isostere for the Glu-Cys amide bond led to a glutathione analog which retained inhibitory potency toward glyoxalase-I while possessing resistance toward γ-glutamyltranspeptidase mediated breakdown. This compound is viewed as a potential lead for the development of second-generation glyoxalase-I inhibitors wherein, the problems pertaining to metabolism and selectivity are overcome.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 77215-54-4 belongs to class esters-buliding-blocks, and the molecular formula is C12H24N2O4, Quality Control of 77215-54-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ai, Zhengdong; Ma, Chong; Wan, Ruiming; Yin, Jingyi; Li, Guiming; Li, Yan; Chen, Li published the artcile< Anticancer Activity and Molecular Mechanism of Momordica cochinchinensis Seed Extract in Chronic Myeloid Leukemia Cells>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Momordica chronic myeloid leukemia seed signal transduction anticancer.

Targeting Bcr-Abl is the key to the treatment of chronic myeloid leukemia. Despite great progress in the treatment of patients with chronic CML, advanced CML patients are still unable to obtain effective and safe drugs. Momordica cochinchinensis seed is the dried ripe seed of Momordica cochinchinensis, which is a kind of fruit and consumed for dietary as well as medicinal uses. This study aimed to investigate the anticancer activity of Momordica cochinchinensis seed extract (MCSE) in CML cells. CML cells (KBM5 and KBM5-T315I) were treated with MCSE and analyzed for growth, apoptosis, and signal transduction. Nude mouse xenograft model was used to evaluate the antitumor activity of MCSE In Vivo. MCSE significantly reduced the cell viability of CML cells, triggered G0/G1 phase arrest in KBM5 cells and S phase arrest in KBM5-T315I cells. Concurrently, MCSE caused the activation of caspase-3, -8, -9, PARP and the degradation of Mcl-1, ultimately triggering endogenous and exogenous cell apoptosis. Meanwhile, MCSE downregulated Bcr-Abl levels and its downstream signaling pathways. Addnl., MCSE inhibited the growth of CML cells in nude mouse xenografts. Taken together, this study demonstrated the anticancer mechanism of MCSE, namely blocking Bcr-Abl and downregulating Mcl-1, and finally induced apoptosis of CML cells.

Nutrition and Cancer published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chennaiah, Ande; Vankar, Yashwant D. published the artcile< One-Step TEMPO-Catalyzed and Water-Mediated Stereoselective Conversion of Glycals into 2-Azido-2-deoxysugars with a PIFA-Trimethylsilyl Azide Reagent System>, Synthetic Route of 4098-06-0, the main research area is protecting group disaccharide crystal structure trisaccharide monosaccharide azidolysis antibody; phase transfer catalyst azidodeoxy monosaccharide glycal tempo catalyzed preparation.

An unprecedented water-mediated and TEMPO-catalyzed, one-step, highly regiospecific and stereoselective functionalization of glycals to 2-azido-2-deoxysugars has been developed using a PIFA-Me3SiN3 reagent system in the presence of Bu4NHSO4 as a phase-transfer catalyst. The method is metal-free, proceeds under mild reaction conditions, and tolerates a variety of protecting groups. Using this method, the synthesis of an important trisaccharide unit bound by the monoclonal anti-I Ma antibody has also been demonstrated.

Organic Letters published new progress about Azidation. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Synthetic Route of 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

published the artcile< Dual Temozolomide and ICI Treatment Is Efficacious and Safe in MSS mCRC.>, Related Products of 112-63-0, the main research area is .

Patients with MSS and MGMT-depleted mCRC exhibited clinical benefit post-temozolomide and ICI treatment.

Cancer discovery published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ohkuma, Takeshi; Kurono, Nobuhito; Sakaguchi, Yusuke; Yamauchi, Kohei; Yurino, Taiga published the artcile< Enantioselective Cyanosilylation of Alkynyl Ketones Catalyzed by Combined Systems Consisting of Chiral Ruthenium(II) Complex and Lithium Phenoxide>, SDS of cas: 112-63-0, the main research area is ketone alkynyl cyanotrimethylsilane ruthenium complex lithium cyanosilylation catalyst; alkynyl tertiary cyanohydrin silyl ether stereoselective preparation.

Asym. cyanosilylation of alkynyl ketones with the catalyst systems consisting of amino acid/2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (BINAP)/ruthenium(II) complex and lithium phenoxide (Ru·Li cat.) was studied. The reaction was conducted in tert-Bu Me ether (TBME) at -78 °C with a substrate-to-catalyst molar ratio (S/C) as high as 2000. A series of simple and functionalized ketones was converted into the alkynyl tertiary cyanohydrin derivatives in up to 99% ee. Appropriate selection of an amino-acid ligand of the catalyst according to the substrate structure was crucially important to achieve high enantioselectivity and a wide scope of substrates. Transformation of the chiral cyanohydrin product into a functionalized lactone was also examined

Advanced Synthesis & Catalysis published new progress about Alkoxysilanes Role: SPN (Synthetic Preparation), PREP (Preparation) (alkynyl tertiary cyanohydrin). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Delahaye, Maarten; Tanini, Flaminia; Holloway, Joshua O.; Winne, Johan M.; Du Prez, Filip E. published the artcile< Double neighbouring group participation for ultrafast exchange in phthalate monoester networks>, Electric Literature of 112-63-0, the main research area is phthalate monoester network ultrafast exchange thermal mech rheol property.

Phthalate monoesters (PMEs) were recently introduced as a simple dynamic covalent bond for implementation in covalent adaptable networks (CANs), which undergo rapid transesterifications in the absence of catalysts, due to the neighboring group participation (NGP) of a carboxylic acid moiety. In this work, it is shown that the PME transesterification can be very significantly accelerated by the presence of another neighboring group on the reactive alc. moieties. The kinetic effects are demonstrated using a short model study of PMEs with different substituents at the β-carbon position, showing a remarkable acceleration for alcs. containing tertiary amines on the β-carbon. Following the model study, materials were synthesized by a (partial) replacement of the conventionally used diol with a β-amino-diol, leading to the formation of networks with an increased Tg and Young’s-modulus, which is rationalized as a result of the formation of an ionic network (COO- and NHR3+). Stress relaxation experiments show a decrease in relaxation times by a factor of 500, compared to similar networks derived from non-amine-substituted hydroxyl monomers. This ultrafast relaxation, enabled by a double NGP, resulted in CANs that show potential to be processed through extrusion while maintaining their overall network connectivity.

Polymer Chemistry published new progress about Creep. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gillanders, Ross N.; Glackin, James M. E.; Babic, Zdenka; Mustra, Mario; Simic, Mitar; Kezic, Nikola; Turnbull, Graham A.; Filipi, Janja published the artcile< Biomonitoring for wide area surveying in landmine detection using honeybees and optical sensing>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is amitraz honeybee pheromone REST sampling luminescence quenching environmental modeling; Apis mellifera carnica; Environmental modelling; Honeybee; Luminescence quenching; Nitroaromatic; REST sampling.

Humanitarian demining is a worldwide effort and the range of climates and environments prevent any one detection method being suitable for all sites, so more tools are required for safe and efficient explosives sensing. Landmines emit a chem. flux over time, and honeybees can collect the trace residues of explosives (as particles or as vapor) on their body hairs. This capability was exploited using a passive method allowing the honeybees to freely forage in a mined area, where trace explosives present in the environment stuck to the honeybee body, which were subsequently transferred onto an adsorbent material for anal. by a fluorescent polymer sensor. Potential false pos. sources were investigated, namely common bee pheromones, the anti-varroa pesticide Amitraz, and the environment around a clean apiary, and no significant response was found to any from the sensor. The mined site gave a substantial response in the optical sensor films, with quenching efficiencies of up to 38%. A model was adapted to estimate the mass of explosives returned to the colony, which may be useful for estimating the number of mines in a given area.

Chemosphere published new progress about Apis mellifera carnica. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Bao Qiong; Li, Xin Kang; Lin, Yuan; Li, Ze Ying; Zhang, Xiang-Zhi; Feng, Na; Ma, Ai-Jun; Chen, Chao Yang; Tan, Lin Fan published the artcile< Development and validation of ultra-high performance supercritical fluid chromatography method for quantitative determination of six compounds in Guizhi Fuling capsule and tablet samples>, SDS of cas: 112-63-0, the main research area is Guizhi fuling formula; multiple compounds; ultra-high performance supercritical fluid chromatography.

A fast and simple ultra-high performance supercritical fluid chromatog. method has been developed for the determination of six analytes, namely (paeonol, coumarin, cinnamic alc., cinnamic acid, paeoniflorin, and amygdalin) in Guizhi Fuling capsule and tablet samples. The influence of the key chromatog. parameters for the separation purposes was evaluated. The optimal column was Trefoil CEL1 column. The optimal mobile phase was a gradient mixture of carbon dioxide and methanol at flow rate of 1.0 mL/min. The back pressure of the system was set to 1.38 x 107 Pa and the temperature to 45°C. The six compounds were separated within 11 min by the proposed ultra-high performance supercritical fluid chromatog. method with satisfactory resolution Method validation confirmed that the procedure is accurate with the recovery rates from 87.04 to 104.30%, intraday precision values less than 4.81% and interday precision less than 5.22%, and linear with R2 higher than 0.9967. Therefore, this work provides a simple and novel method for the simultaneous anal. of six compounds in Guizhi Fuling capsule and tablet samples.

Journal of Separation Science published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Beibei; Kong, Tao; Xu, Wenzhi; Su, Ruigong; Gao, Yunhua; Cheng, Guosheng published the artcile< Surface Functionalization of Zinc Oxide by Carboxyalkylphosphonic Acid Self-Assembled Monolayers>, Reference of 112-63-0, the main research area is carboxyalkylphosphonic acid self assembled monolayer zinc oxide antibody biosensor.

Two carboxyalkylphosphonic acids (HOOC(CH2)nP(O)(OH)2, n = 2 for 3-PPA and n = 9 for 10-PDA) were deposited onto 1-dimensional zinc oxide (ZnO) nanowires and bare ZnO wafers to form stable self-assembled monolayers (SAMs). The samples were systematically characterized using wettability, at. force microscopy (AFM), FTIR spectroscopy (FTIR), and XPS. 3-PPA was bound to the ZnO surfaces mainly through the CO2H headgroup, and 10-PDA formed self-assembled monolayers on the nanoscaled ZnO surface through the PO3H2 headgroups. To verify the potential use of the functionalized surfaces in the construction of biosensors or bioelectronics, IgG protein immobilization through SAM bridging was demonstrated. This work expands the application of phosphonic acid-based surface functionalization on sensing and optoelectronic devices.

Langmuir published new progress about Binding energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Beg, Sarwar; Panda, Sagar S.; Singh, Kamalinder K. published the artcile< Chemometrics-assisted development of a validated LC method for simultaneous estimation of temozolomide and γ-linolenic acid: Greenness assessment and application to lipidic nanoparticles>, Reference of 112-63-0, the main research area is Box-Behnken design; Chemometrics; Forced degradation; Green method; Lipid nanoparticles; Liquid chromatography; Simultaneous estimation; Stability indicating; Temozolamide; γ-Linolenic acid.

The described work entails the development of a simple, sensitive, green, and robust high-performance liquid chromatog. (HPLC) method for simultaneous estimation of temozolomide (TMZ) and γ-linolenic acid (GLA). The chemometric factor screening study helped identify the critical method parameters optimized using Box-Behnken design for improved understanding and enhancing the method performance. Chromatog. separation was performed on a Kinetex C18 column (150 x 4.6 mm, 5 μm particle size) using methanol: water (pH adjusted to 3.5 using 0.5% volume/volume O-phosphoric acid) as the mobile phase at 0.5 mL/min flow rate and diode array detection between 210 and 360 nm. The linearity of the method was observed for concentrations of TMZ and GLA ranging between 1 and 100 μg.mL-1 (R2 = 0.999, p < 0.05). Accuracy evaluation showed good percent recovery within 97.9-100%, while intra- and inter-day precision showed RSD values within 0.37%-1.01%. The limit of detection and quantification for TMZ was found to be 0.75 and 1.0 μg.mL-1, resp., while the values 0.55 and 1.0 μg.mL-1, resp., were observed for GLA. System suitability (96.9-102.8%), its limits, and robustness evaluation indicated good percent recovery within, while RSD values were found to be within the acceptable limit of less than 2%. The method was specific for its ability to detect the analytes and their degradation products during forced degradation studies, which also indicated that TMZ was highly prone to alk. conditions while GLA showed mild degradation in all the studied conditions. The estimation of both the analytes from lipid nanoparticles formulation showed good values for total drug content (82.6-85.3%), entrapment efficiency (95.4 to 98.7%), and drug loading (25.2 to 38.4%). Overall, the results indicated that the developed method was reliable for its accuracy, precision, sensitivity, and specificity for simultaneous estimation of the analytes. The method was found to be stability-indicating in nature and suitable for simultaneous estimation of TMZ and GLA from the developed nanoparticles formulation. Further, employing a greenness assessment approach established the method greenness. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics