Tag: M.W=250-300

Agai, Bela; Proszenyak, Agnes; Tarkanyi, Gabor; Vida, Laszlo; Faigl, Ferenc published the artcile< Convenient, benign and scalable synthesis of 2- and 4-substituted benzylpiperidines>, Quality Control of 112-63-0, the main research area is benzylpiperidine preparation carbinol ketone deoxygenation pyridine hydrogenation temperature acidity.

A short, scalable and environmentally benign synthesis of 2- and 4-substituted benzylpiperidines, e.g. I, has been developed. The method is based on the temperature-programmed consecutive deoxygenation and heteroaromatic ring saturation of aryl(pyridin-2-yl)- and aryl(pyridin-4-yl)methanols and aryl(pyridin-4-yl)methanones in the presence of Pd/C catalyst. The crucial roles of the temperature, the acidity and the substrate structure in the change of selectivity have been demonstrated by isolation of several substituted aryl(piperidine)methanols. The carbinols and ketones were prepared from com. available pyridinecarbaldehydes or 4-cyanopyridine and substituted bromobenzenes via organometallic intermediates.

European Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Deussen, Heinz-Josef; Boutton, Carlo; Thorup, Niels; Geisler, Tommy; Hendrickx, Eric; Bechgaard, Klaus; Persoons, Andre; Bjornholm, Thomas published the artcile< New chiral bis(dipolar) 6,6'-disubstituted binaphthol derivatives for second-order nonlinear optics>, Electric Literature of 112-63-0, the main research area is chiral binaphthol naphthodioxepin derivative nonlinear optic; dioxepin dinaphtho chiral derivative nonlinear optic; crystal structure chiral binaphthol derivative; mol structure chiral binaphthol derivative; dipole moment chiral binaphthol derivative; second harmonic generation chiral binaphthol derivative; hyperpolarizability chiral binaphthol derivative; SHG chiral binaphthol derivative; NLO chiral binaphthol derivative; atropisomer chiral binaphthol derivative NLO.

Several chiral mols. with C2 symmetry derived from two geometries of the binaphthol (BN) system substituted with different acceptors have been synthesized in order to study the possibility of producing noncentrosym. crystals formed from these chiral structures. All the mols. possess two equal donor-acceptor (D – A) systems linked together to give a bis(dipolar) V-shaped system. The dihedral angle θ between the two connected D – A systems has been controlled by chem. methods; this leads to distinct changes in the optical spectra of the connected D – A chromophores, primarily changes caused by effective conjugation of the D – A system imposed by conformation constraints. The crystal structure of chiral (S)-2,2′-diethoxy-1,1′-binaphthyl-6,6′-dicarbaldehyde has been elucidated and indicates that the dipoles in the naphthyl moiety within the overall noncentrosym. crystal can cancel out exactly despite the noncentrosymmetry. The crystal structure of racemic 9,14-dicyanodinaphtho[2,1-d:1′,2′-f][1,3]-dioxepin [(±)-I, A = CN] was found to be centrosym. The new compounds were investigated for second-harmonic generation (including BN derivatives reported earlier) by the Kurtz – Perry powder test to evaluate the second-order nonlinear optical (NLO) properties of polycrystalline samples. Although chirality ensures noncentrosym. crystals, only modest (≈ 2-methyl-4-nitroaniline) or no nonlinearities were observed in the powder test. For a representative selection of the mols., the first mol. hyperpolarizabilities βz were shown to be very high [up to 888 × 10-30 esu for II with A = (E)-CH:CH(p-PhCHC(CN)2)] by elec. field induced second harmonic generation (EFISHG) measurements. Synthetic routes are reported for optically pure 6,6′-disubstituted-2,2′-diethoxy-1,1′-binaphthyls [II; A = CN, SO2CH3, (E)-CH:CHSO2CH3, (E)-CH:CH(p-PhCN), (E)-CH:CH(p-PhSO2CH3), (E)-CH:CH(p-PhCH:C(CN)2), (E)-CH:CHCH:C(CN)2] and optically pure 9,14-disubstituted-dinaphtho[2,1-d:1′,2′-f][1,3]dioxepins [I; A = CN (only racemic), SO2CH3, (E)-CH:CH(p-PhCN), (E)-CH:CH(p-PhSO2CH3), (E)-CH:CH(p-PhNO2), (E)-CH:CH(p-PhCH:C(CN)2), (E)-CH:CHCH:C(CN)2].

Chemistry – A European Journal published new progress about Acetals, cyclic Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Crittall, Matthew R.; Fairhurst, Nathan W. G.; Carbery, David R. published the artcile< Point-to-helical chirality transfer for a scalable and resolution-free synthesis of a helicenoidal DMAP organocatalyst>, Quality Control of 112-63-0, the main research area is helicenoidal DMAP organocatalyst stereoselective preparation rhodium catalyzed triyne cycloisomerization; point helical chirality transfer cycloisomerization resolution free.

The synthesis of a second-generation [6]-helicenoidal DMAP organocatalyst I is reported. The synthesis is reliant upon a highly diastereoselective Rh-catalyzed [2+2+2] triyne cycloisomerization, using an existing stereocenter to control the sense of forming helicity. Taken together, a scalable (>1 g), resolution-free entry to a helical DMAP with the capacity for subsequent functionalization, has been achieved.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cycloisomerization (stereoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Jianfeng; Jin, Zhichao; Chi, Yonggui Robin published the artcile< Organocatalytic Enantioselective γ-Aminoalkylation of Unsaturated Ester: Access to Pipecolic Acid Derivatives>, Product Details of C19H34O2, the main research area is pipecolic acid substituted preparation; unsaturated ester enantioselective aminoalkylation hydrazone heterocyclic carbene organocatalyst.

The direct γ-carbon functionalization of α,β-unsaturated esters via N-heterocyclic carbene (NHC) catalysis is disclosed. This catalytically generated nucleophilic γ-carbon undergoes highly enantioselective additions to hydrazones. The resulting δ-lactam products can be readily transformed to optically enriched pipecolic acid derivatives

Organic Letters published new progress about Aminoalkylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Qian; Feng, Li-Ying; Huang, Wei; He, Xiang-Hong; Peng, Cheng; Han, Bo published the artcile< An NHC-Catalyzed Cross-Benzoin-Esterification Sequential Reaction for the Synthesis of Trifluoromethyl-Substituted α,β-Unsaturated Esters>, SDS of cas: 112-63-0, the main research area is ester unsaturated trifluoromethylated preparation NHC organocatalytic multicomponent reaction; benzaldehyde ethoxytrifluoroethanol bromocinnamaldehyde cross benzoin esterification sequential reaction.

Efficient preparation of synthetically important CF3-containing α,β-unsaturated esters is described using an NHC-catalyzed multicomponent reaction. This approach combines sequential NHC-mediated HOMO and LUMO activation to produce a C-C bond and C-O bond in a one-pot operation.

Synlett published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lo, Kong Mun; Ng, Seik Weng published the artcile< Dipyridinium tribromidochloridobis(4-chlorophenyl)stannate(IV)>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is crystal structure stannate chlorophenyl bromo chloro complex dipyridinium salt; mol structure stannate chlorophenyl bromo chloro complex dipyridinium salt; hydrogen bond stannate chlorophenyl bromo chloro complex dipyridinium salt.

The tin atom in the substituted ammonium stannate(IV), (C5H6N)2[SnBr3(C6H4Cl)2Cl], lies on a center of symmetry in a distorted octahedral coordination geometry. Each independent halogen site is occupied by bromine and chlorine anions in an approx. 3:1 ratio. The pyridinium cation forms a hydrogen bond to only one of the halogen atoms. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

I-Ju Leu, Julia; Murphy, Maureen E.; George, Donna L. published the artcile< Targeting ErbB3 and cellular NADPH/NADP+ abundance sensitizes cutaneous melanomas to ferroptosis inducers>, Computed Properties of 347174-05-4, the main research area is drug targeting ErbB3 NADPH NADP tachyphylaxis melanoma ferroptosis.

Melanoma is a serious health challenge. Ferroptosis is a regulated form of oxidative cell death that shows varied efficacy in melanoma. We aimed to better understand the mol. basis for this differential ferroptosis sensitivity. We find that elevated expression of ErbB3 (V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3) associates with ferroptosis resistance and that ErbB3 knockdown sensitizes to ferroptosis inducers. ErbB3 depletion also promotes a marked reduction in the cellular ratio of GSH/GSSG (reduced/oxidized glutathione) and that of NADPH/NADP+ (reduced/oxidized NADP), together with an increase in the abundance of the lipid peroxidation product malondialdehyde (MDA). We identify several small mol. inhibitors targeting ErbB3 signaling pathways that also reduce the NADPH/NADP+ and GSH/GSSG ratios, concomitantly sensitizing the melanomas to ferroptosis activators. These findings point to a previously unrecognized role of ErbB3 in ferroptosis sensitivity and provide new insight into pathways that regulate this cell death process.

ACS Chemical Biology published new progress about Antioxidants. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Computed Properties of 347174-05-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Amin, Iyman; Prashant Saxena published the artcile< Glioblastoma a Malignant Form of Tumor: a Review on Its Cellular Target, Route, and Its Treatment>, Computed Properties of 112-63-0, the main research area is review bevacizumab temozolomide anticancer agent glioblastoma.

A review. The pathophysiol. of glioblastoma is so complex; it affects a number of different cellular processes. The FDA has approved a number of treatments, including temozolomide and bevacizumab, yet the survival rate remains the same at 1 yr or less. As a result of the failure of different chemotherapies and target pharmacol. therapies, we must concentrate on the use of less toxic agents, such as natural compounds, which may have a greater prognostic value. This quick overview covers the following topics: Glioblastoma has a variety of various routes associated with it, including mol. and patrimonial indications. Treatments for glioblastoma are available. Certain natural compounds may have the ability to minimize toxicity while also improving prognostic value. Glioblastoma multiforme is a grade 4 glioma brain tumor that develops from glial cells in the brain. The grade of a brain tumor indicates how probable it is to grow and spread. Grade 4 tumors are the most dangerous and aggressive. Despite the FDAs approval of temozolomide with bevacizumab and several other drugs, the 1-yr survival rate remains constant We must focus on the use of less toxic agents, such as natural compounds, that may have a greater prognostic value and less toxicity, due to the failure of various chemotherapies, surgeries, radiation, and target pharmaceutical therapies.

Current Tissue Microenvironment Reports published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Tianzeng; Chen, Tieqiao; Han, Li-Biao published the artcile< Oxidative Dephosphorylation of Benzylic Phosphonates with Dioxygen Generating Symmetrical trans-Stilbenes>, Application In Synthesis of 112-63-0, the main research area is benzylic phosphonate oxidative dephosphorylation; stilbene stereoselective preparation.

Under a dioxygen atm., benzylphosphonates and related phosphoryl compounds can readily produce the corresponding trans-stilbenes in high yields with high selectivity upon treatment with bases. Various functional groups were tolerable under the reaction conditions.

Journal of Organic Chemistry published new progress about Dephosphorylation (oxidative). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Stefancich, Giorgio; Artico, Marino; Massa, Silvio; Vomero, Salvatore published the artcile< Research on nitrogen heterocyclic compounds. XII. Synthesis of 5H-pyrrolo[1,2-b][2]benzazepine derivatives>, Electric Literature of 112-63-0, the main research area is pyrrolobenzazepine; carboxymethylbenzylpyrrole preparation cyclization; chloromethylbenzylpyrrolecarboxaldehyde cyclization.

Several routes to the unknown 5H-pyrrolo[1,2-b][2]benzazepine ring system have been explored. 1-(2-Cyanobenzyl)pyrrole was useful as starting material for 1-(2-carboxymethylbenzyl)pyrrole and 1-(2-chloromethylbenzyl)-2-pyrrolecarboxaldehyde. Polyphosphoric acid-catalyzed intramol. cyclization of the former substance and treatment of the latter compound with KCN led to 11-oxo-10,11-dihydo-5H-pyrrolo[1,2-b][2]benzazepine and to 10-cyano-5H-pyrrolo[1,2-b][2]benzazepine, resp., which were converted to the parent nucleus 5H-pyrrolo[1,2-b][2]benzazepine and its 10,11-dihydro- and 1,2,3,10,11,11a-hexahydro derivatives

Journal of Heterocyclic Chemistry published new progress about Cyclization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics