Tag: M.W=250-300

Wannick, Melanie; Assmann, Julian C.; Vielhauer, Jakob F.; Offermanns, Stefan; Zillikens, Detlef; Sadik, Christian D.; Schwaninger, Markus published the artcile< The immunometabolomic interface receptor hydroxycarboxylic acid receptor 2 mediates the therapeutic effects of dimethyl fumarate in autoantibody-induced skin inflammation>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is dimethyl fumarate antiinflammatory agent HCA2 inflammation; G protein-coupled receptor; autoimmune blistering skin disease; immunomodulatory therapy; neutrophils; pemphigoid disease.

The drug di-Me fumarate (DMF) is in clin. use for the treatment of psoriasis and multiple sclerosis. In addition, it has recently been demonstrated to ameliorate skin pathol. in mouse models of pemphigoid diseases, a group of autoimmune blistering diseases of the skin and mucous membranes. However, the mode of action of DMF in inflammatory skin diseases has remained elusive. Therefore, we have investigated here the mechanisms by which DMF improves skin pathol., using the antibody transfer model of bullous pemphigoid-like epidermolysis bullosa acquisita (EBA). Exptl. EBA was induced by transfer of antibodies against collagen VII that triggered the infiltration of immune cells into the skin and led to inflammatory skin lesions. DMF treatment reduced the infiltration of neutrophils and monocytes into the skin explaining the improved disease outcome in DMF-treated animals. Upon ingestion, DMF is converted to monomethyl fumarate that activates the hydroxycarboxylic acid receptor 2 (HCA2). Interestingly, neutrophils and monocytes expressed Hca2. To investigate whether the therapeutic effect of DMF in EBA is mediated by HCA2, we administered oral DMF to Hca2-deficient mice (Hca2-/-) and wild-type littermates (Hca2+/+) and induced EBA. DMF treatment ameliorated skin lesions in Hca2+/+ but not in Hca2-/- animals. These findings demonstrate that HCA2 is a mol. target of DMF treatment in EBA and suggest that HCA2 activation limits skin pathol. by inhibiting the infiltration of neutrophils and monocytes into the skin.

Frontiers in Immunology published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Du, Kang; Rudola, Ashish; Balaya, Palani published the artcile< Investigations of Thermal Stability and Solid Electrolyte Interphase on Na2Ti3O7/C as a Non-carbonaceous Anode Material for Sodium Storage Using Non-flammable Ether-based Electrolyte>, Product Details of C19H34O2, the main research area is sodium ion battery titanium oxide carbon anode electrolyte; anode; carbonate-based electrolyte; non-flammable electrolyte; sodium-ion battery; solid electrolyte interphase; tetraglyme.

In order to become com. viable, sodium-ion batteries need to deliver long cycle life with good capacity and energy d. while still ensuring safety. Electrolyte plays a key role forming solid electrolyte interphase (SEI) layers at low potential, which affects the thermal stability and cycle life of the anode materials under consideration. In this study, an ether-based non-flammable electrolyte, 1 M NaBF4 in tetraglyme, is tested for sodium storage using a non-carbonaceous anode material Na2Ti3O7/C, and the results are compared with those obtained with the popularly used carbonate-based electrolyte, 1 M NaClO4 in ethylene carbonate (EC) and propylene carbonate (PC) (volume/volume = 1:1). The Na2Ti3O7/C vs. Na cells using 1 M NaBF4 in tetraglyme show a much higher first cycle Coulombic efficiency (73%) than those using 1 M NaClO4 in EC/PC (33%). Thermal stability studies using differential scanning calorimetry (DSC) conclusively show that Na2Ti3O7/C electrodes cycled with 1 M NaBF4 in tetraglyme are more thermally stable than the one cycled with 1 M NaClO4 in EC/PC. Further investigations on the formation of SEI layers were performed using attenuated total reflection-Fourier transform IR spectroscopy, field-emission SEM, transmission electron microscopy, energy-dispersive X-ray spectroscopy, electrochem. impedance spectroscopy, and DSC studies. These studies unambiguously demonstrate that the SEI formed on Na2Ti3O7/C using 1 M NaBF4 in tetraglyme is not only less resistive but also more stable than the SEI formed using 1 M NaClO4 in EC/PC.

ACS Applied Materials & Interfaces published new progress about Battery anodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jiang, Minbao; Yuan, Yong; Wang, Tao; Xiong, Yunkui; Li, Jun; Guo, Huijiao; Lei, Aiwen published the artcile< Exogenous-oxidant- and catalyst-free electrochemical deoxygenative C2 sulfonylation of quinoline N-oxides>, Electric Literature of 112-63-0, the main research area is sulfonylated quinoline regioselective green preparation; quinoline oxide sodium sulfinate electrochem deoxygenative sulfonylation.

An exogenous-oxidant- and catalyst-free electrochem. deoxygenative C2 sulfonylation reaction was achieved. By employing quinoline N-oxides with sodium sulfinates as the starting materials, the electrochem. C-H sulfonylation of electron-deficient quinolines was indirectly achieved at room temperature and a variety of sulfonylated quinoline derivatives I [R = Et, Ph, 4-ClC6H4, etc.; R1 = H, 3-Me, 6-Br, etc.] were synthesized in modest to high yield with excellent regioselectivity. Notably, this protocol was the first example for synthesizing sulfonylated electron-deficient heteroarenes/arenes through electrochem.

Chemical Communications (Cambridge, United Kingdom) published new progress about Amine oxides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yoshida, Shigeru; Unoki, Makoto published the artcile< Compounds allied to vitamin B1. I. Synthesis of 3-(2-methyl-4-amino-5-pyrimidylmethyl)-4-methyl-5-(2-hydroxyethylthio)-2-thiazolone>, Application of C19H34O2, the main research area is .

RCH2NH2.HCl (I, R = C(NH2):N.CMe:N.CH:C-) (2.1 g.) and 0.8 g. NaOH (II) in 10 ml. MeOH heated a while, filtered (to remove NaCl), mixed with 0.5 g. CS2, filtered, and washed with MeOH give 1.4 g. RCH2NHCS2NH3CH2R (III), needles, m. 235° (from hot water), less soluble in cold water, soluble in dilute acid, alkali hydroxide, and carbonate. AcCHCl(CH2)2OH (IV) prepared by boiling 0.7 g. α-aceto-α-chlorobutyrolactone (V) with 2.5 ml. 5% HCl for 1 hr., and neutralized with NaHCO3, added into 1.4 g. III in 6 ml. MeOH, heated 2-5 hrs. at 100°, filtered, washed with water, the filtrate treated with 0.21 g. Na2CO3 and 0.2 g. CS2 gives 1.2 g. VI, and the filtrate treated with IV prepared from 0.35 g. V gives 0.6 g. RCH2NHCS2-CHAc(CH2)2OH (VI), m. 255°; or treating 1.4 g. III and 0.42 g. Na2CO3 in 6 ml. water with aqueous IV (from 1.4 g. V) in 6 ml. MeOH and 0.4 g. CS2 on a water bath for several min., filtering, and washing with water give 2.4 g. VI, decompose 255°. III and AcCHCl(CH2)2OAc (VII) heated in the same way as in the preparation of VI give RCH2NHCS2-CHAc(CH2)2OAc (VIII), decompose 250°. VIII (1 g.) and 0.6 g. NaHSO4 or 0.2 g. AlCl3 heated on an oil bath 1 hr. at 140°, taken up with 5 ml. hot water, NaOH added in excess, and the product filtered and washed with water give 0.92 g. S.CS.N(CH2R).CMe:C(CH2)2OAc (IX), m. 169-70° (from dilute alc.), also prepared by refluxing the above mixture with 10 volumes dioxane. VI (1 g.) and 0.6 g. NaHSO4 or 0.2 g. AlCl3 fused on an oil bath or refluxed in dioxane give 0.8 g. S.CS.N(CH2R).CMe:C(CH2)2OH (X), m. 237-8° (from dilute alc.); hydrolysis of 1 g. IX with 0.2 g. NaOH in 13 ml. 60% alc. 10 min. on a water bath give X.

Yakugaku Zasshi published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Veerabhadraswamy, B. N.; Bhat, Sachin A.; Hiremath, Uma S.; Yelamaggad, Channabasaveshwar V. published the artcile< Light-emitting chiral nematic dimers with anomalous odd-even effect>, Category: esters-buliding-blocks, the main research area is liquid crystal chiral oligomers microphase dimer Schiff base; chiral nematic phase; dimers; liquid crystals; odd-even effect; photoluminescence.

In this report, based on the results derived from the extensive study into the thermal and photophys. properties, an anomalous mesomorphic behavior of photoluminescent, chiral nematic (N*) liquid crystalline dimers, belonging to two different series has been revealed. They comprise cholesterol and fluorescent three-ring Schiff base or salicylaldimine core interlinked via an ω-oxyalkanoyloxy spacer of varying length and parity. The effect of mol. structure on the liquid crystal (LC) behavior and photophys. properties of both the series has been probed by varying the length of the terminal n-alkoxy tails for a fixed (odd or even) parity of the spacer. The detailed investigations using complementary techniques not only evidenced the existence of the N* phase in all the dimers synthesized but also the occurrence of an intriguing odd-even effect; blue phases (BPs) exist in all the dimers comprising even-membered spacer, which surprisingly remains totally absent in their odd-membered counterparts. While the results reported hitherto are exactly opposite to the aforesaid findings, this atypical behavior has been interpreted in terms of the over-all shape of the dimers rendered by the orientation of terminal tails. Photophys. studies carried out clearly revealed the intrinsic light emitting feature of the dimers not only in their dilute solutions but also in their three condensed states viz., solid, N* phase, and isotropic liquid state; the emission intensities of the N* phase varies with the change in temperature, as expected. CD spectra of the N* phase recorded as a function of temperature show bisignate CD band characteristically, signifying large chiral correlations in the mol. self-assembly, while the origin of bands from pos. to neg. region suggests a right-handed twist of the N* helix.

ChemPhysChem published new progress about Cholesteric liquid crystals. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Wenjuan; Li, Jing; Jin, Qianwen; Liu, Yanyu; Zhang, Yongguang; Zhao, Yan; Wang, Xin; Nurpeissova, Arailym; Bakenov, Zhumabay published the artcile< Rational Construction of Sulfur-Deficient NiCo2S4-x Hollow Microspheres as an Effective Polysulfide Immobilizer toward High-Performance Lithium/Sulfur Batteries>, SDS of cas: 112-63-0, the main research area is hollow microsphere nickel cobalt sulfide polysulfide immobilizer; lithium sulfur battery.

The synergistic strategy combining architectural design with defect engineering in transition-metal sulfides offers a promising opportunity to realize high-efficiency polysulfide adsorption/conversion surface catalysis in lithium/sulfur (Li/S) batteries. Here, defect-rich yolk-shell hollow spheres composed of ultrafine NiCo2S4-x nanoparticles as sulfur hosts prepared by an anion-exchange method are reported. The elaborate design of sulfur defects endows the NiCo2S4-x hollow spheres with significantly enhanced electronic conductivity and superior affinity for polysulfides as well as expedited sulfur conversion. Meanwhile, the unique yolk-shell NiCo2S4-x hollow sphere structure provides large cavities that not only increase sulfur storage but also relieve the electrode volume expansion during cycling. Combining these favorable features, the NiCo2S4-x-hosted sulfur cathode revealed enhanced cycling stability, corresponding to a negligible capacity fading rate of 0.0754% per cycle after 500 cycles at 1 C, and achieved an outstanding rate capability (628.9 mA-h g-1 up to 5 C).

ACS Applied Energy Materials published new progress about Carbon black Role: TEM (Technical or Engineered Material Use), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hua, Wuxing; Li, Huan; Pei, Chun; Xia, Jingyi; Sun, Yafei; Zhang, Chen; Lv, Wei; Tao, Ying; Jiao, Yan; Zhang, Bingsen; Qiao, Shi-Zhang; Wan, Ying; Yang, Quan-Hong published the artcile< Selective Catalysis Remedies Polysulfide Shuttling in Lithium-Sulfur Batteries>, Reference of 112-63-0, the main research area is indium catalyst polysulfide electrolyte selective catalysis lithium sulfur battery; lithium polysulfides; lithium-sulfur batteries; selective catalysis; shuttle effect.

The shuttling of soluble lithium polysulfides between the electrodes leads to serious capacity fading and excess use of electrolyte, which severely bottlenecks practical use of Li-S batteries. Here, selective catalysis is proposed as a fundamental remedy for the consecutive solid-liquid-solid sulfur redox reactions. The proof-of-concept Indium (In)-based catalyst targetedly decelerates the solid-liquid conversion, dissolution of elemental sulfur to polysulfides, while accelerates the liquid-solid conversion, deposition of polysulfides into insoluble Li2S, which basically reduces accumulation of polysulfides in electrolyte, finally inhibiting the shuttle effect. The selective catalysis is revealed, exptl. and theor., by changes of activation energies and kinetic currents, modified reaction pathway together with the probed dynamically changing catalyst (LiInS2 catalyst), and gradual deactivation of the In-based catalyst. The In-based battery works steadily over 1000 cycles at 4.0 C and yields an initial areal capacity up to 9.4 mAh cm-2 with a sulfur loading of ∼9.0 mg cm-2.

Advanced Materials (Weinheim, Germany) published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wiernicki, Bartosz; Maschalidi, Sophia; Pinney, Jonathan; Adjemian, Sandy; Vanden Berghe, Tom; Ravichandran, Kodi S.; Vandenabeele, Peter published the artcile< Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity>, Product Details of C15H22N2O2, the main research area is cancer ferroptosis impede dendritic cell antitumor immunity.

Immunogenic cell death significantly contributes to the success of anti-cancer therapies, but immunogenicity of different cell death modalities widely varies. Ferroptosis, a form of cell death that is characterized by iron accumulation and lipid peroxidation, has not yet been fully evaluated from this perspective. Here we present an inducible model of ferroptosis, distinguishing three phases in the process-‘initial’ associated with lipid peroxidation, ‘intermediate’ correlated with ATP release and ‘terminal’ recognized by HMGB1 release and loss of plasma membrane integrity-that serves as tool to study immune cell responses to ferroptotic cancer cells. Co-culturing ferroptotic cancer cells with dendritic cells (DC), reveals that ‘initial’ ferroptotic cells decrease maturation of DC, are poorly engulfed, and dampen antigen cross-presentation. DC loaded with ferroptotic, in contrast to necroptotic, cancer cells fail to protect against tumor growth. Adding ferroptotic cancer cells to immunogenic apoptotic cells dramatically reduces their prophylactic vaccination potential. Our study thus shows that ferroptosis neg. impacts antigen presenting cells and hence the adaptive immune response, which might hinder therapeutic applications of ferroptosis induction.

Nature Communications published new progress about Adaptive immunity. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Product Details of C15H22N2O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mu, Anthony U.; Kim, Yeon-Ju; Miranda, Octavio; Vazquez, Mariela; Strzalka, Joseph; Xu, Jie; Fang, Lei published the artcile< Hydrogen-Bond-Promoted Planar Conformation, Crystallinity, and Charge Transport in Semiconducting Diazaisoindigo Derivatives>, Application of C19H34O2, the main research area is semiconducting diazaisoindigo derivative field effect transistor hydrogen bond conjugation.

Conformational control of π-conjugated mols. using intramol. noncovalent bonds represents a promising strategy to tailor the solid-state mol. packing and electronic properties of these materials. Here, we report the design and synthesis of two model compounds featuring intramol. hydrogen bonds formed between a center diazaisoindigo unit (the acceptor) and flanking indole units (the donor). Computational and exptl. investigations show that these hydrogen bonds enthalpically stabilize the coplanar mol. conformation by >10 kcal/mol. The formation of these hydrogen bonds is also slightly favorable in terms of entropy, ensuring the high-temperature stability of the planar conformation. Thermal annealing of thin films of these compounds imparts high crystallinity and orientation in the solid state, while the non-hydrogen bond control only gave an amorphous solid. Field-effect transistor devices fabricated from these thin films exhibit hole mobilities up to 0.270 cm2 V-1 s-1, in contrast to the lack of measurable charge carrier mobility for the non-hydrogen bond control. This work demonstrates an efficient synthetic strategy to incorporate robust intramol. hydrogen bonds into conjugated π-systems and elucidates the mechanism on how such hydrogen bonds promote the desired mol. conformation, solid-state packing, and electronic performances of conjugated organic materials.

ACS Materials Letters published new progress about Annealing. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tanabe, Tadashi; Okuda, Kazuo; Izumi, Yoshiharu published the artcile< Asymmetric hydrogenation of carbon-oxygen double bond with modified Raney nickel catalyst. XXV. Contributions of pH-adjusting reagents in asymmetric hydrogenation>, SDS of cas: 112-63-0, the main research area is asymmetric hydrogenation nickel; Raney asymmetric hydrogenation; pH Raney asymmetric hydrogenation.

In the asymmetric hydrogenation of Me acetoacetate with modified Raney Ni catalysts, the effect of pH-adjusting reagents were studied using DS-tartaric acid, Ls-2-hydroxyiosovaleric acid, L-glutamic acid, and L-aspartic acid as the modifying reagents. The effects of metal ions and ammonium ion were examined at pH 5.0. The asymmetric activity of the catalyst modified with the 2-hydroxy monocarboxylic acid or 2-amino dicarboxylic acid was not affected by the pH-adjusting reagents. However, 2-hydroxy dicarboxylic acid was markedly influenced by the reagents. The univalent metal ion was more effective than divalent or ammonium ions. Sodium hydroxide was the best pH-adjusting reagent. The adsorption state of the modifying reagent was discussed on the basis of the effects of the pH-adjusting reagent.

Bulletin of the Chemical Society of Japan published new progress about Hydrogenation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics