Tag: M.W=250-300

Mo, F.; Meletti, S.; Belcastro, V.; Quadri, S.; Napolitano, M.; Bello, L.; Dainese, F.; Scarpelli, M.; Florindo, I.; Mascia, A.; Pauletto, G.; Bruno, F.; Pellerino, A.; Giovannini, G.; Polosa, M.; Sessa, M.; Conti Nibali, M.; Di Gennaro, G.; Gigli, G. L.; Pisanello, A.; Cavallieri, F.; Ruda, R. published the artcile< Lacosamide in monotherapy in BTRE (brain tumor-related epilepsy): results from an Italian multicenter retrospective study>, Formula: C19H34O2, the main research area is lacosamide brain tumor epilepsy monotherapy population; Epilepsy; Lacosamide; Primary brain tumor; Seizure freedom; Side effects.

Lacosamide (LCM) is a third-generation anti-seizure medication (ASM) approved for focal onset epilepsy in patients aged ≥ 4.378 Previous studies have reported an efficacy of LCM as add-on treatment in brain tumor-related epilepsy (BTRE). To date, there are no studies in the literature focusing on lacosamide used in monotherapy to treat BTRE. In our retrospective study we investigated efficacy and tolerability of LCM in monotherapy in a multicenter national cohort of primary brain tumor patients. We collected from 12 Italian Centers 132 patients with primary brain tumors who were treated with LCM in monotherapy. For each patient we evaluated seizure freedom at 3 and 6 mo (primary endpoints), side effects and drop-out rate (secondary endpoints). Overall, LCM led to seizure freedom in 64.4% of patients at 3 mo and 55% at 6 mo. Patients who used two or more ASMs before LCM had a worse seizure control than patients in monotherapy with LCM as first choice. In 14 patients, we observed seizure control despite tumor progression on magnetic resonance (MRI). Multivariate anal. showed that gross-total resection at diagnosis was significantly associated with higher seizure freedom rate at 6 mo. Side effects were mainly mild (grade 1-2 according to CTCAE classification) and drop-out rate was low (1.5%). Main side effects were dizziness and somnolence. This is the first study showing a good efficacy and tolerability of LCM when used in monotherapy in BTRE. Further prospective studies are needed to confirm these preliminary data, investigating also quality of life and neurocognitive functions.

Journal of Neuro-Oncology published new progress about Anticonvulsants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peddagopu, Nishant; Sanzaro, Salvatore; Rossi, Patrizia; Paoli, Paola; Malandrino, Graziella published the artcile< A One-Pot Synthesis of ""K(hfa) glyme"" Adducts: Effect of the Polyether Length on the Ion Coordination Sphere>, Synthetic Route of 112-63-0, the main research area is potassium diketonate polyether polymeric complex preparation crystal structure; thermal stability potassium diketonate polyether polymeric complex.

Potassium complexes are starting to gather more and more interest from academia and industry because of their intriguing application possibilities. Novel adducts of potassium hexafluoroacetylacetonato [K(hfa)] with polyethers (monoglyme, diglyme, triglyme, and tetraglyme) were synthesized through a single step reaction and characterized through FTIR spectroscopy as well as 1H and 13C NMR spectroscopy. Single crystal x-ray diffraction studies enabled the identification of fascinating K coordination polymeric networks.

European Journal of Inorganic Chemistry published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glinsky-Olivier, Nicolas; Yang, Shengwen; Retailleau, Pascal; Gandon, Vincent; Guinchard, Xavier published the artcile< Enantioselective Gold-Catalyzed Pictet-Spengler Reaction>, SDS of cas: 112-63-0, the main research area is tetrahydro carboline enantioselective preparation gold catalyst; tryptamine arylaldehyde Pictet Spengler reaction.

Cationic chiral Au(I) complexes catalyze asym. Pictet-Spengler reactions between tryptamines and arylaldehydes. The resulting tetrahydro-β-carbolines I (R1 = H, 5-Me, 5-OMe; R2 = Allyl, Bn, CH2Mes, etc.; R3 = Ph, 4-Et-C6H4, 2-CN-C6H4, 3ClC6H4, etc.)are obtained with wide functional group tolerance in high yield and with high enantioselectivities (up to 95%). Aldehydes bearing polar or protic functions are well tolerated. The reaction features a hitherto unknown C2-auration of the indole as the key step, supported by d. functional theory calculations

Organic Letters published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mori, Yoshihiro; Shinoda, Hiroyuki; Nakano, Taku; Kitagawa, Taiji published the artcile< Formation and Decay Behaviors of Laser-Induced Transient Species from Pyrene Derivatives 1. Spectral Discrimination and Decay Mechanisms in Aqueous Solution>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is decay mechanism transient species pyrene derivative spectra.

The UV and visible absorption spectra of laser-induced transient species from the following pyrene derivatives were measured in aqueous or aqueous ethanol solution: Na pyrenesulfonate (NaPS), tetrasodium pyrenetetrasulfonate (Na4PS4), pyrenecarboxylic acid (HPC), and pyrenebutyric acid (HPB). The major transient species contributing to the intense absorption peaks were revealed from the quenching experiments The absorption spectra of triplets, as well as cation radicals, were separable from the other transients by selecting the exptl. conditions (atm., coexisting quencher, and delay time). The cation radicals produced from PS-, PB- and PC- anions showed an absorption maximum at ∼460 nm, close to that of pyrene cation radical. Their decay behaviors in the absence of any addnl. quenchers were dominated by bimol. reaction kinetics with each parent mol., of which the rate constants were very similar. This result is consistent with the previous proposal that these cation radicals exist as zwitterions such as P•+S-. The cation radical from Na4PS4 showed a strong absorption peak at 505 nm and exhibited different decay behaviors, suggesting that this cation radical appears not to be a simple zwitterion. Three specific quenchers, I-, OH-, and SO32-, strongly accelerate the decay rates of these cation radicals. MeSO3- anion, mimicking the headgroup of tentative anionic surfactants, and several inorganic anions such as ClO4- were poor quenchers for the cation radicals even at the highest concentration The authors also discussed the origin of two addnl. peaks at 375 and 395 nm observed in the transient absorption spectra of NaPS and HPB. On the triplet-triplet absorption, the molar absorptivities of Na4PS4 and NaPS could be determined using the ground-state depletion method. These results are discussed in terms of applications to probe the micellar microenvironment.

Journal of Physical Chemistry A published new progress about Anionic surfactants (effect on decay of zwitterion of radical cation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sugai, Tomoya; Okuyama, Yuya; Shin, Jaehyun; Usui, Shunme; Hisada, Shoko; Osanai, Ryosuke; Oishi, Takeshi; Sato, Takaaki; Chida, Noritaka published the artcile< Synthesis of kaitocephalin facilitated by three stereoselective allylic transposition reactions>, COA of Formula: C19H34O2, the main research area is kaitocephalin preparation stereoselective Overman Ichikawa rearrangement.

A stereoselective synthesis of kaitocephalin is described. The central strategy is based on chirality transfer reactions of three secondary alcs. derived from L-arabinose. The Overman rearrangement of an α,β-unsaturated ester and intramol. anti-type SN2′ reaction constructed a β-hydroxy-α,α- disubstituted amino acid moiety. The third chirality transfer reaction is the Ichikawa rearrangement. These stereoselective reactions successfully established the three contiguous stereocenters embedded in kaitocephalin.

Chemistry Letters published new progress about Diastereoselective synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jansze, Suzanne M.; Ortiz, Daniel; Fadaei Tirani, Farzaneh; Scopelliti, Rosario; Menin, Laure; Severin, Kay published the artcile< Inflating face-capped Pd6L8 coordination cages>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is preparation inflating face capped palladium iron coordination cage complex; crystal structure face capped palladium iron coordination cage complex.

Tritopic metalloligands were used to form two Pd6L8-type coordination cages. With mol. weights of >15 kDa and Pd···Pd distances of up to 4.2 nm, these complexes are among the largest palladium cages described to date. The metalloligands (L1 and L2) were synthesized and characterized by single crystal structure determination One of the two cage complexed were characterized by single crystal structure determination

Chemical Communications (Cambridge, United Kingdom) published new progress about Cage compounds Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation) (Crystal structure). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ma, Zhiwei; Liu, Zhijing; Wang, Chuanchuan; Chen, Xiaopei; Tao, Jingchao; Lv, Quanjian published the artcile< A novel isosteviol-based bifunctional squaramide organocatalyst for enantioselective Michael addition of acetylacetone to nitroolefins>, Category: esters-buliding-blocks, the main research area is nitroalkane preparation enantioselective; diketone nitroolefin Michael addition bifunctional squaramide catalyst; Michael addition; acetylacetone; nitroolefin; organocatalysis; tertiary amine-squaramide.

In this study, novel chiral tertiary amine-squaramide I derived from the natural product of the stevioside was developed and applied into the asym. Michael addition of acetylacetones RC(O)CH2C(O)R1 (R = R1 = Me, Ph) to nitroolefins (E)-R2CH=CHNO2 (R2 = naphthalen-1-yl, 4-chlorophenyl, 2-furanyl, etc.). This asym. reaction performed well, and a series of enantiomerically enriched compounds (S/R)-RC(O)CH(CH(R2)CH2NO2)C(O)R1 were obtained in high yields (up to 96%) with excellent enantioselectivities (up to 99% ee).

Chirality published new progress about Alkanes, nitro Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhdanov, A. K. published the artcile< The heat capacities of some pure liquids and azeotropic mixtures>, Application of C19H34O2, the main research area is .

Measurements of the heat capacities (Cp) were made for CCl4, PrOH, benzene, iso-BuOH, PhMe and the azeotropic mixtures: benzene-MeCOEt, PhMe-iso-AmOH, benzene-PrOH, CCl4-PrOH, CCl4-iso-BuOH, PhMe-PrOH, CCl4-iso-BuOH and PhMe-iso-BuOH at 4.5-6°, 24-5° and 44.5-47.2°. The deviations of results were ± 0.001 and the exptl. errors of the Cp values did not exceed 0.5%. Interpolation equations of the type Cp = A + BT + CT2 were also obtained. The following values were obtained for CCl4 at 278.68, 298.01 and 319.28°, resp.: Cp 0.2013, 0.2053 and 0.2095. For PrOH the corresponding values at 279.66, 290.76, 297.57, 304.06 and 318.83° were Cp 0.5431, 0.5623, 0.5781, 0.5951 and 0.6480. For iso-BuOH at 278.34, 296.35 and 319.01° the values were Cp 0.5322, 0.5916 and 0.6600. For benzene at 281.38, 295.61 and 318.81° the values were Cp 0.4044, 0.4141 and 0.4316. For PhMe at 278.51, 296.80 and 320.42° the values were Cp 0.3871, 0.4077 and 0.4312. For the azeotropic mixture benzene (62.5%)-MeCOEt (37.5%) at 278.33, 298.27 and 318.8° the values were Cp 0.4390, 0.4587 and 0.4787. For PhMe (86%)-iso-AmOH (14%) at 278.25, 289.56, 305.36 and 319.77° the values were, resp., Cp 0.4328, 0.4147, 0.4647 and 0.4777. For benzene (83.1%)-PrOH (16.9%) at 278.43, 297.59 and 318.88° the values were, resp., Cp 0.4623, 0.4908 and 0.5115. For CCl4 (88.5%)-PrOH (1.5%) at 278.86, 297.04 and 319.65° the values were Cp 0.2523, 0.2681 and 0.2781. For CCl4 (82%)-iso-PrOH (18%) at 278.26, 296.65 and 320.12° the values were Cp 0.2814, 0.3003 and 0.3316. For PhMe (47.5%)-PrOH (52.5%) at 278.44, 296.09 and 318.41° the values were Cp 0.5041, 0.5365 and 0.5787. For PhMe (55.5%)-iso-BuOH (45.5%) at 278.62, 295.34 and 317.75° the values were Cp 0.4987, 0.5223 and 0.5667. For CCl4 (94.5%)-iso-BuOH (5.5%) at 278.56, 298.77 and 319.60° the values were Cp 0.2320, 0.2462 and 0.2540. The values of A, B × 102 and C × 104 in the interpolation equation and the value k1 × 106 for the equation MCpe = k1Te3 are, resp., CCl4, 22.32, 3.103, – and 0.78; PrOH 176.34, -110.5483, 21.1542 and 1.12; iso-BuOH -25.31, 23.26, – and 1.14; benzene 18.45, 3.5627, 0.3813 and 0.81; PhMe 8.42, 9.76, – and 0.82; benzene-PrOH -75.06, 65.699, -9.4844 and 0.94; benzene-MeCOEt 12.56, 7.428, – and 0.89; PhMe-iso-AmOH 12.12, 9.875, – and 0.89; CCl4-PrOH -111.20, 89.5549, 13.5827 and 0.93; CCl4-iso-PrOH 71.85, -38.0897, 8.7729 and 1.07; CCl4-iso-BuOH -90.26, 76.4934, -11.4848 and 0.93; PhMe-PrOH 7.65, 7.5249, 0.9889 and 1.00; PhMe-iso-BuOH 108.42, -57.7821, 12.1092 and 1.15. Four references.

Zhurnal Obshchei Khimii published new progress about Azeotropes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Singh, Yashvir; Sharma, Abhishek; Singh, Nishant Kumar; Chen, Wei-Hsin published the artcile< Development of bio-based lubricant from modified desert date oil (balanites aegyptiaca) with copper nanoparticles addition and their tribological analysis>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is lubricant modified desert date oil copper nanoparticles.

Based on the environmental concerns related to the pollution caused by the vehicles and the demand for an alternative to the conventional lubricant resulted in the studies to be conducted that are environmental-friendly. In this study, friction and wear behavior of the surfaces in contact was conducted to observe their tendency during the application of an alternative lubricant to the mineral oil. Desert date oil was having the potential of an alternative to the mineral oil and they were available in abundant amount During the initial stage, desert date oil was transesterified using the two-step transesterification process and further it was added to the trimethylolpropane. After this process, nanoparticles were added in different amounts to the modified desert date oil. The friction and wear behavior of the modified desert date oil was tested using four-ball tester under different conditions. For the surface topog. anal., SEM and EDS anal. were conducted. The concentration of the nanoparticles added to the biolubricant was considered based on the previous work conducted. The input parameters which were considered during the test consists of normal load, sliding speed, variation in the addition of the nanoparticles to the biolubricant (0.3-1.6% with a gap of 0.3%). Based on the study conducted, 0.9% concentration of the copper nanoparticles showed a significant improvement in term of reducing COF, wear rate, mean wear scar diameter and improved worn surface morphol. was obtained with comparison to the mineral oil. The maximum increment in the properties relative to the tribol. anal. was shown when the concentration of the copper nanoparticles to the modified desert date oil increases beyond 0.9% copper nanoparticles during the addition in the amount of 1.3% and 1.6%. Conclusively, the performance of the modified desert date oil with 0.9% copper nanoparticles addition has the potential impact as a lubricant with comparison to the mineral oil and other samples. The modified desert date oil with an application of 0.9% copper nanoparticles could be considered as a suitable alternative to the mineral oil while considering environmental concern and energy saving.

Fuel published new progress about Balanites aegyptiaca. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tang, Feiyu; Shao, Deyi; Chen, Gong; Luo, Haihua published the artcile< Osmotic components in cotton (Gossypium Hirsutum L.) fibers in response to soil moisture deficit during fiber expansion>, Synthetic Route of 112-63-0, the main research area is Gossypium Hirsutum fiber expansion soil moisture deficit.

The present study aimed to determine how main osmotic active substances (malate, potassium and soluble sugars) in cotton fibers respond to soil drought. A pot study with two water regimes was performed in 2015 and 2016 using two cotton lines A001 and A705. The irrigated plants (control) were watered at 1-d interval with the optimum quantity of underground water determined on the basis of a gravimetric method. Drought treatment was defined as withdrawing water from pots until the leaf wilting symptom was visible, and water stressed plants were exposed to limited water supply for 25 days receiving 50% of the control irrigation at 2-d interval. Following 25 days of water deficit treatment, those plants were re-watered with the same quantity as the control. Drought induction caused a significant reduction in fiber length and strength in A001. Net photosynthetic rate (Pn), stomatal conductance (gs), and transpiration rate (E) in A001 and A705 were reduced significantly by soil drought indicating the present water deficit design did generate a photosynthetically physiol. difference. The depressed leaf photosynthesis led to the deficient accumulation of soluble sugars, malate and potassium in water stressed fibers, and in turn to the reduced fiber length.

Pakistan Journal of Botany published new progress about Bioaccumulation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics