Tag: M.W=200-350

Marsaulina, Hutagaol Debora published the artcileApplication of ultraviolet spectrophotometry with dual wavelength method for the simultaneous determination of ecstasy tablet content, Computed Properties of 55981-09-4, the main research area is methylene dioxymetamphetamine methamphetamine aracetamol caffeine ephedrine dual wavelength method.

Ecstasy is a type of narcotic tablet and is very popularly used as a stimulant. The main content is Methylene dioxymetamphetamine (MDMA) and Methamphetamine (MA), but because a large amount of demand is not balanced with sufficient supply, ecstasy tablets are often adulterated with various contents, such as Paracetamol (PCT), Caffeine (KFN) and Ephedrine (EFD). Ecstasy tablets are often combined with other active compounds so that they can cause problems in determining the levels of tablets carried out in the Police Forensic Lab, so a cheaper, effective, and fast method is needed in determining the levels of these tablets. The research was conducted exptl. with the spectrophotometric method, namely the dual-wavelength method, then the validation was tested based on the validation parameters, namely linearity, accuracy, precision, LOD and LOQ. Then, this method was applied to determine levels of MA, EFD, KFN and PCT in tablet preparations The results showed that the application of the dual-wavelength method for the assay was carried out at λ 250.6 nm and 263 nm for KFN, at λ 263 nm and 281.8 nm for MA, at λ 259.4 nm and 255 nm for PCT at λ 255 nm and 236 nm for EFD, resp. with a level result of 40.05; 1.63; 38.11; 20.21 for MA, EFD, KFN and PCT resp., and with good precision and accuracy. The dual-wavelength UV spectrophotometric method was successfully applied to determine the levels of MA, EFD, KFN and PCT mixtures in tablets.

Asian Journal of Pharmaceutical Research and Development published new progress about Absorption. 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, Computed Properties of 55981-09-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Stachulski, Andrew V. published the artcileSynthesis, antiviral activity, preliminary pharmacokinetics and structural parameters of thiazolide amine salts, Name: 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, the main research area is thiazolide amine salt xray crystal structure antiviral activity pharmacokinetics; amine salts; antiviral; pharmacokinetics; thiazolides; x-ray structure.

The thiazolides, typified by nitazoxanide, are an important class of anti-infective agents. A significant problem with nitazoxanide and its active circulating metabolite tizoxanide is their poor solubility We report the preparation and evaluation of a series of amine salts of tizoxanide and the corresponding 5-Cl thiazolide. These salts demonstrated improved aqueous solubility and absorption, as shown by physicochem. and in vivo measurements. They combine antiviral activity against influenza A virus with excellent cell safety indexes. We also report the x-ray crystal structural data of the ethanolamine salt. The ethanol salt of thiazolide retains the activity of the parent together with an improved cell safety index, making it a good candidate for further evaluation.

Future Medicinal Chemistry published new progress about Absorption. 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, Name: 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Siddalinga Swamy, M. S. published the artcileRP-HPLC method for simultaneous estimation of nitazoxanide and ofloxacin in bulk drug and in pharmaceutical formulation, Recommanded Product: 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, the main research area is nitazoxanide ofloxacin pharmaceutical formulation reverse phase high; performance liquid chromatog.

A simple, precise, accurate, rapid and reproducible reverse phase high performance liquid chromatog. procedure was developed for simultaneous determination of nitazoxanide and ofloxacin in tablet dosage form was carried on an Inert ODS-3V (250X4.6 nm, 5micro) column using a mobile phase consisting of methanol and buffer (20:80 volume/volume) with a pH3.3 ± at a rate of 1.5 mL/min and the detection was carried out at 230 nm. The linearity was found to be in the range of 5-60μg/mL and 2-24μg/mL Nitazoxanide and Ofloxacin resp. with (r2=0.9990, and r2=0.9994). The peaks obtained were sharp having clear baseline separation with a retention time of 9.093μ 0.03 and 5.946μ 0.03 min for Nitazoxanide and Ofloxacin resp. The results of the anal. were validated statistically and recovery studies confirmed the accuracy of the proposed method.

International Journal of PharmTech Research published new progress about Flow. 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, Recommanded Product: 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Laghari, Saif-ul-Rehman published the artcileAssessment of drug utilization of antimicrobials in different infectious diseases at various clinics of Sanghar, Pakistan, Category: esters-buliding-blocks, the main research area is antimicrobials infectious diseases metronidazole.

The aim was to assess the frequency of antimicrobial medications in various diseases at clin. setups. This study was conducted for a period of six months from Apr. 2019 to Sept. 2019. A total of 10 Clin. setups were part of this study including the OPDs of general practitioners. A total of 1000 prescription were collected by purposive sampling. A specially designed data form was used for collecting the data The data were analyzed and compared with WHO guidelines. A drug utilization study of antimicrobial agents was carried out from 1000 prescriptions. A total of 1060 antimicrobial medications were prescribed. Mostly observed patients with microbial infection came from 51-60 years of age group. Most common observed microbial diseases are upper respiratory tract infections (22.4%), acute gastroenteritis (20.2%) and urinary tract infections (16.4%). The percentage of drugs prescribed with the generic name was only 10%. This study showed that only 31.5% patients tested from laboratory for disease diagnosis. Among the wide range of antimicrobials, antibiotics were the most common prescribed drug i.e. 68% of total antimicrobial drugs. Most commonly prescribed antibiotic drugs were Co-amoxiclave (26.8%) followed by levofloxacin (18.5%), and ciprofloxacin (17.6%). Most commonly used antiprotozoal drug was metronidazole i.e. 60% of total prescribed antiprotozoal drugs, while commonly prescribed anti-fungal drug was fluconazole i.e. 44.2% of total prescribed antifungal drugs and most commonly antiviral drug was Acyclovir i.e. 46%. As compared with WHO guidelines, the utilization of Injectable was on higher side i.e. 28%. The conclusion revealed that drug utilization practice was not appropriate in accordance to WHO prescribing indicators. Polypharmacy and over prescriptions of antimicrobials was too high which leads to poor treatment outcomes and high economic burden on patients. Irrational drugs therapy is one of the top leading causes of death in developing countries including Pakistan and the results of our study also agree with the above fact.

Latin American Journal of Pharmacy published new progress about Acne. 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hanafy, Amr Shaaban published the artcileChallenges in covid-19 drug treatment in patients with advanced liver diseases: a hepatology perspective, Synthetic Route of 55981-09-4, the main research area is review human COVID drug treatment advanced liver disease hepatol; Advanced liver disease; Anticoagulation; COVID-19; Cirrhosis; Coagulopathy; Drugs.

The global incidence of coronavirus disease 2019 (COVID-19) continues to increase despite health care efforts. The disease is caused by coronavirus 2 with high transmission and mortality rates. Little is known about the management of COVID-19 in advanced liver disease. The aim of work was to propose a plan for management of this drastic disease in case of this specific population with review of medications that could be suitable for advanced liver disease. All the guidelines and medications available for treatment of COVID-19 were reviewed with selection of the less toxic medications that could be used in advanced liver disease. Drugs suitable to manage COVID-19 in patients with liver disease might include remdesivir i.v., nitazoxanide + sofosbuvir, ivermectin, tocilizumab, convalescent plasma, and low mol. weight heparin in certain situations. Advanced liver disease is associated with portal hypertension and splenomegaly with reduction of blood elements and immune dysfunction and impaired T cell function. Thus, when confronted by cytokine storm as an immune response to COVID-19, there may be an increase in the mortality rate of these patients. Through this review, a plan to treat COVID-19 in this special group of patients with advanced cirrhosis is proposed.

World Journal of Gastroenterology published new progress about Blood. 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, Synthetic Route of 55981-09-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vinaud, Marina Claire published the artcileNanodelivery of nitazoxanide: impact on the metabolism of Taenia crassiceps cysticerci intracranially inoculated in mice, SDS of cas: 55981-09-4, the main research area is nitazoxanide metabolism Taenia crassiceps cysticerci intracranially inoculated; energetic metabolism; experimental neurocysticercosis; nanosystems; nitazoxanide.

Aim: To formulate nanocapsules and nanoemulsions of nitazoxanide (NTZ) and evaluate the metabolic effect on Taenia crassiceps cysticerci inoculated intracranially into mice. Materials & methods: NTZ nanosystems were formulated through solvent diffusion methodol. These nanoformulations were administered perorally and their impact on glycolysis, the tricarboxylic acid cycle and fatty acid metabolism in T. crassiceps cysticerci was investigated. Results: Gluconeogenesis and protein catabolism were significantly increased by the nanoformulations when compared with the control group and the NTZ-treated group. All the other metabolic pathways were inhibited by the nanoformulation treatments. Conclusion: The remarkable metabolic modifications that occur in this in vivo model through the application of these developed nanosystems confirm their capability to deliver NTZ into targeted tissues.

Therapeutic Delivery published new progress about Brain. 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, SDS of cas: 55981-09-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

El-Kowrany, Samy Ibrahim published the artcileEvaluation of nitazoxanide as a novel drug for the treatment of acute and chronic toxoplasmosis, Product Details of C12H9N3O5S, the main research area is Toxoplasma nitazoxanid antiparasitic agent toxoplasmosis; IFN-γ; Immunohistochemistry; Immunomodulatory; T. gondii; iNOS.

For this purpose, mice were infected with 20 cysts (acute infection model) or 10 cysts (chronic infection model) of Toxoplasma gondii (ME 49 strain). Treated mice received NTZ (at doses of 100 and 150 mg/kg), starting from third day (acute model) or fifth week (chronic model) post-infection, which continued for 14 consecutive days. Effects of NTZ were evaluated in comparison to the pyrimethamine/sulfadiazine combination. Evaluation included mortality rates, brain cyst count, inflammatory scoring and immunol. studies. The latter included estimation of interferon-gamma (IFN-γ) and induced nitric oxide synthase (iNOS). In the acute infection model, NTZ at 100 and 150 mg/kg significantly reduced the number of brain cysts by 78 and 87% compared to the infected untreated controls and reduced the mortality rate to 24 and 20%, resp., compared with 44% in the infected untreated control. In the chronic infection model, cyst reduction reached 32 and 38% for 100 and 150 mg/kg NTZ treatments, resp. NTZ was significantly able to reduce inflammation caused by acute and chronic T. gondii infection with slight necrosis and few infiltrating mononuclear cells. Addnl., the immunol. anal. revealed that NTZ significantly increased the production of serum IFN-γ and enhanced iNOS production in brain tissue, suggesting an immunomodulatory role for the drug. Based on the findings of the present study, it can be concluded that NTZ is a potential drug for the treatment of acute and chronic toxoplasmosis.

Acta Tropica published new progress about Brain. 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, Product Details of C12H9N3O5S.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guo, Sixun published the artcileAnalysis of tizoxanide, active metabolite of nitazoxanide, in rat brain tissue and plasma by UHPLC-MS/MS, Computed Properties of 55981-09-4, the main research area is brain plasma tizoxanide nitazoxanide UHPLC MS; UHPLC-MS/MS; brain tissue; nitazoxanide; tizoxanide.

Tizoxanide, the active metabolite of nitazoxanide, has recently been reported as an effective agent for the treatment of glioma. As there had been no report about the anal. of tizoxanide in brain tissue, we established extraction and UHPLC-MS/MS methods to quantify tizoxanide in rat brain and plasma to evaluate the brain-to-plasma ratio of tizoxanide. The biol. samples were mainly prepared by acetonitrile and the separation was performed on a Waters XBridge BEH C18 column. The mobile phase was composed of water mixed with 10 mM ammonium formate (pH 3.0) and acetonitrile according a gradient volume Tizoxanide and topiramate (internal standard) were monitored utilizing neg. electron spray ionization in multiple reaction monitoring mode. The methods were validated to be precise and accurate within the dynamic range of 5-1000 ng/mL and 0.2-50 ng/g for plasma and brain tissue samples, resp. The lower limit of quantitation of the method was 0.2 ng/g, which was far more sensitive than all existing methods to quantify tizoxanide in biol. samples. Application performed on rats exhibited that the brain-to-plasma ratio of tizoxanide ranged from 3.16 to 26.86% in 1 h after administration of 10 mg/kg nitazoxanide.

Biomedical Chromatography published new progress about Brain. 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, Computed Properties of 55981-09-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yaqoob, Urwa published the artcileEfficacy of first dose of nitazoxanide in management of rotavirus diarrhea in children, Application of 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, the main research area is nitazoxanide child rotavirus diarrhea.

Rotavirus is a leading cause of morbidity and mortality in children younger than 5 years. This study was planned to record mean duration of rotavirus diarrhea in children after administration of first dose of nitazoxanide as this drug is cost effective but no local data is available evaluating mean duration of diarrhea after first dose of Nitazoxanide in children with rota virus, while the previous studies were conducted on smaller sample size. To determine the mean duration of rotavirus diarrhea in children after administration of first dose of Nitazoxanide. Descriptive Case study. The calculated sample size is 175, with d = 1, 95% confidence level taking expected mean duration of diarrhea after first dose of administration of Nitazoxanide i.e. 31.0+6.87 h. The study was conducted in Department of Pediatric Medicine, Children Hospital, Faisalabad. Duration of study: Six month from the date of approval of synopsis from board of study (July 2019 to Dec 2019). All 175 patients fulfilling the inclusion/exclusion criteria were enrolled in the study. An informed consent to include their data with the assurance of confidentiality was obtained from their parents. All study cases were administered by the nursing staff as (200 mg nitazoxanide) twice a day for 3 days in patients 4-5 years of age, (100 mg nitazoxanide) twice a day in patients 12-47 mo of age, and (7.5 mg/kg nitazoxanide) twice a day in patients younger than 12 mo. In addition to the study education, all patients were receiving routine care including fluid replacement therapy and nutritional and metabolic management of diarrhoea. The nursing staff followed the children for every 12 h till the normal formed stools. All this information was recorded on a pre-designed proforma. Duration of diarrhea was recorded as per operational definitions. In our study, out of 175 cases, 58.86%(n = 103) were between 2-36 mo of age while 41.14%(n = 72) were between 37-60 mo of age, mean+sd was calculated as 35.06+13.34 mo, 44%(n = 77) were male and 56%(n = 98) were females, mean duration of rotavirus diarrhea in children after administration of first dose of Nitazoxanide was recorded as 32.85+2.32 h. We concluded that the mean duration of rotavirus diarrhea in children after administration of first dose of Nitazoxanide is not more than 1.5 days and it is suitable in our population for the management of rotavirus diarrhea.

Indo American Journal of Pharmaceutical Sciences published new progress about Child. 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, Application of 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Biendl, Stefan published the artcileDiscovery of novel antischistosomal scaffolds from the open access Pandemic Response Box, Product Details of C12H9N3O5S, the main research area is antischistosomal scaffold pandemic response box schistosomiasis praziquantel; Anthelminthics; Pandemic Response Box; Schistosoma mansoni; drug discovery; drug repurposing; schistosomiasis.

BackgroundTreatment and control of schistosomiasis rely on a single drug, praziquantel. New orally active antischistosomals featuring novel mol. scaffolds are urgently needed to prevent the emergence of resistance. MethodsWe screened 400 drug-like compounds contained in the open-access Pandemic Response Box (PRB) against newly transformed schistosomula (NTS) at a concentration of 10 μM scoring death, changes in motility, and morphol. alterations. Compounds displaying an activity ≥66% at 72 h underwent testing against adult Schistosoma mansoni in vitro. Fast-acting (≥66% at 24 h), nontoxic drugs focusing on late-stage and approved drugs were investigated in the patent S. mansoni mouse model. ResultsWe identified 26 hits active against NTS, of which 17 elicited ≥66% activity against adult S. mansoni following 24 h of drug exposure. The highest activity against adult S. mansoni was observed with MMV1581558 (EC50 value of 0.18 ± 0.01 μM) and nitazoxanide (0.47 ± 0.07 μM). Of the five compounds tested in vivo, MMV1581558 and the approved drug ozanimod reduced average worm burden vs. controls by 42 % and 36 %, resp., after a single oral dose of 200 mg/kg bodyweight in mice harboring a chronic S. mansoni infection. ConclusionMMV1581558 discovered from screening the PRB represents a novel antischistosomal scaffold with high in vitro antischistosomal activity amenable to chem. modification for drug development.

Expert Review of Anti-Infective Therapy published new progress about Death. 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, Product Details of C12H9N3O5S.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics