Tag: M.W=200-300

Related Products of 19063-56-0, The chemical industry reduces the impact on the environment during synthesis 19063-56-0, name is 7-Bromo-2H-chromen-2-one, I believe this compound will play a more active role in future production and life.

General procedure: A 10 mL vial equipped with a small magnetic stirring bar wascharged with the appropriate bromo O-hetarene (1.0 equiv, 100mg), Pd(OAc)2 (5 mol%), and CuI (1.0 equiv). Anhyd DMF (1 mL)and the appropriate 1,3-azole (2.0 equiv) were added, and thevessel was purged with N2 and sealed with a PEEK snap cap. Themixture was stirred for 5 min at r.t. before the vessel was placedin the microwave reactor and the mixture was heated to 140 Cwith stirring for the appropriate time (usually 1 h). The solutionwas then cooled to r.t., diluted with EtOAc (15 mL), washed withsat. aq NH4Cl (2 × 15 mL) and dilute aq Na2S2O3 (10 mL). Theaqueous phases were extracted with EtOAc (2 × 10 mL), and theorganic phases were combined and washed with sat. aq NH4Cl(10 mL) and brine. Some H2O was added if any solids precipitatedduring the extraction. The combined organic phases weredried (MgSO4), filtered, and concentrated. The residue was purifiedby column chromatography (silica gel).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Bromo-2H-chromen-2-one, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Sipos, Zoltan; Konya, Krisztina; Synlett; vol. 29; 18; (2018); p. 2412 – 2416;,
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Reference of 13078-21-2, The chemical industry reduces the impact on the environment during synthesis 13078-21-2, name is Ethyl 2-(2-methoxyphenoxy)acetate, I believe this compound will play a more active role in future production and life.

General procedure: A solution of corresponding substituted ethylaryloxyacetate (3a-f, 25 mmol) in ethanol (100 mL) was treated with 10% aqueous sodium hydroxide (9 mmol). After 4 h at room temperature and evaporation under reduced pressure of ethanol, the aqueous phases were acidified at pH 4 with HCl (2 N). Removal of precipitate by filtration yielded the crude acids, which were recrystallized in ethanol to afford substituted aryloxyacetic acid 4a-f, yield 66-90%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-(2-methoxyphenoxy)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhong, Yan; Xu, Yi; Zhang, Ai-Xia; Li, Xiao-Feng; Xu, Zhao-Ying; Li, Ping; Wu, Bin; Bioorganic and Medicinal Chemistry Letters; vol. 26; 10; (2016); p. 2526 – 2530;,
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Reference of 24393-53-1,Some common heterocyclic compound, 24393-53-1, name is (E)-Ethyl 3-(4-bromophenyl)acrylate, molecular formula is C11H11BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

30 mg (0.02 mmol, 5 mol%) ofpalladiumtetrakis(triphenylphosphine) are added to a solution of 200 mg (0.53 mmol, 1.0 eq.) of methyl[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]octanamide and 204 mg (0.80 mmol, 1.5 eq.) of ethyl 4-bromocinnamate in 3 ml of a mixture of dimethylformamide and of a 2M potassium phosphate solution (6/1). The reaction mixture is stirred at 80C for 2 hours. The reaction is halted by the addition of 5 ml of water and then extraction is carried out with ethyl acetate. The organic phases are combined and dried over sodium sulphate. The solvents are evaporated and then the residue is chromatographed on silica gel (heptane/ethyl acetate 80/20). 145 mg of ethyl 3-(3′-[((methyl)(octanoyl)amino)methyl]biphenyl-4-yl}acrylate are obtained in the form of an oil. Yield = 63%

The synthetic route of 24393-53-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GALDERMA RESEARCH & DEVELOPMENT, S.N.C.; WO2006/18325; (2006); A1;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 20637-08-5 as follows. Application In Synthesis of Methyl 4-(4-methoxyphenyl)butanoate

To a cooled solution of methyl 4- (4-methoxyphenyl) butyrate (3.6 g, 17.3 mmol) in CH2C12 (40 ml) at-78 C under N2 was added dropwise a solution of DIBAL in hexanes (1.0 M, 18.0 ml, 18 mmol). The resulting mixture was stirred at-78 C under N2 for 3 hrs, and then quenched by adding MeOH (-5 ml). The resulting mixture was warmed gradually to room temperature and filtered. The filtrate was concentrated in vacuo to give 4- (4-Methoxy-phenyl)-butyraldehyde as an oil (3.06 g, 100%). lH NMR (CDC13, 300 MHz) 8 1.91 (p, J = 7.5 Hz, 2H), 2.41 (t, J = 7.5 Hz, 2H), 2.58 (t, J = 7.5 Hz, 2H), 3.76 (s, 3H), 6.81 (d, J = 8.4 Hz, 2H), 8.07 (d, J = 8.4 Hz, 2H), 9.73 (s, 1H). The residue was used directly in the next step without any further purification.

According to the analysis of related databases, 20637-08-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LA JOLLA PHARMACEUTICAL COMPANY; WO2005/82343; (2005); A2;,
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Related Products of 238749-50-3,Some common heterocyclic compound, 238749-50-3, name is Ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate, molecular formula is C9H8BrNO2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of NaI (1.8 g, 12.3 mmol) in acetone (100 mL) was added dropwise to a stirred solution of N-cMorosuccinirnide (1.6 g, 12.3 mmol) in acetone (30 mL) protected from light, followed after 15 min by the dropwise addition of 2-bromo- thieno[3,2-delta]pyrrole-5-carboxylic acid ethyl ester (2.8 g, 10.3 mmol; see step (a) above) in acetone (100 mL). After 30 min at rt the mixture was poured into Na2S2O3 (aq, 10%, 140 mL) and extracted with EtOAc. The combined extracts were washed with H2O and brine, dried (Na2SO4), concentrated and purified by chromatography to give the sub-title compound (3.78 g, 92%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate, its application will become more common.

Reference:
Patent; BIOLIPOX AB; WO2006/77412; (2006); A1;,
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Adding a certain compound to certain chemical reactions, such as: 10268-71-0, name is Phenyl 2-methoxybenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10268-71-0, category: esters-buliding-blocks

5,6-dihydro-cyclopenta [b] thiophen-4-one (2.1 g, 15.0 mmol) in 15 mL of THF was treated with NaH (60%, 1.5 g, 36 mmol).To the addition of 2-methoxy-benzeneAcid phenyl ester,The reaction mixture was heated to 100 & lt; 0 & gt; C and maintained for 8 hours. The solution was cooled to room temperature and poured into water. The product mixture was acidified with concentrated hydrochloric acid and ethyl acetate (70 mL) was added. The organic layer was collected, treated with brine, dried over MgSO4 (s) and concentrated under reduced pressure. The resulting precipitate was collected and recrystallized from ethanol to give the corresponding 5- (2-methoxy-benzoyl) -5,6-dihydro-cyclopenta [b] thiophen-4-one (2.53 G, 8.3 mmol) as a yellow solid in 59% yield

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Phenyl 2-methoxybenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DEVELOPMENT CENTER FOR BIOTECHNOLOGY; LIAO, CHU BIN; CHIANG, CHAO CHENG; YANG, HUEI RU; LIAO, YUAN CHUN; CHEN, PAONIEN; (162 pag.)TWI553010; (2016); B;,
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Electric Literature of 113100-86-0, A common heterocyclic compound, 113100-86-0, name is Methyl 4-(3-bromopropyl)benzoate, molecular formula is C11H13BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step D: 4-(3-{2-[3-(tert-Butyl-dimethyl-silanyloxy)-4-(3-phenoxy-phenyl)-butyl]-5-oxo-pyrrolidin-1-yl}-propyl)-benzoic acid methyl ester. Analogous to the procedure described for Example 1A, Step D, 5-[3-(tert-butyl-dimethyl-silanyloxy)-4-(3-phenoxy-phenyl)-butyl]-pyrrolidin-2-one (200 mg, 0.455 mmol) was alkylated with NaHMDS (1M in THF, 0.55 mL, 0.55 mmol) and 4-(3-bromo-propyl)-benzoic acid methyl ester (128 mg, 0.501 mmol) to yield 4-(3-{2-[3-(tert-butyl-dimethyl-silanyloxy)-4-(3-phenoxy-phenyl)-butyl]-5-oxo-pyrrolidin-1-yl}-propyl)-benzoic acid methyl ester (173.1 mg). 1H NMR (CDCl3) delta7.94 (d, 2H), 7.32 (m, 2H), 7.25-7.19 (m, 3H), 7.09 (m, 1H), 6.98 (d, 2H), 6.88-6.81 (m, 3H), 3.88 (s, 3H), 3.84 (m, 1H), 3.64 (m, 1H), 3.50 (m, 1H), 2.95 (m, 1H), 2.76-2.57 (m, 4H), 2.37 (m, 2H), 2.03 (m, 1H), 1.92-1.67 (m, 3H), 1.56 (m, 1H), 1.46-1.25 (m, 3H), 0.84 (s, 9H), -0.04 (d, 3H), -0.15 (d, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Cameron, Kimberly O.; Lefker, Bruce A.; US2002/65308; (2002); A1;,
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Reference of 59227-79-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59227-79-1, name is Ethyl 4-(4-chlorophenoxy)butanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step 1 : To a solution of ethyl-4-(4-chlorophenoxy)butanoate (6.0 g, 24.721 mmol, 1 .0 equiv) in dry tetrahydrofuran (10 mL) was added lithium diisopropylamide solution (2.0 M in THF/heptane/ethylbenzene (18.5 mL, 4.944 mmol, 1 .5 equiv) slowly at -78 C. The reaction mixture was stirred for 2 h at -78 C. A solution of carbon tetrabromide (12.3 g, 37.083 mmol, 1 .5 equiv) in dry tetrahydrofuran (15 mL) was added at -78 C and the reaction was stirred for 10 min and was then allowed to stir at room temperature for 1 h. The mixture was then quenched with a saturated aqueous ammonium chloride solution (100 mL) and extracted with ethyl acetate (3 x 100 mL). The combined organic layer was dried over anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by flash column chromatography using a silica gel column and the product eluted at 2% ethyl acetate in hexane to yield ethyl-2-bromo-4-(4-chlorophenoxy)butanoate (0.6 g crude, 7.59 % yield) as a gum. NMR (400 MHz, CDCI3): delta ppm 1 .30 (t, J = 7.2 Hz, 3 H), 2.34 – 2.43 (m, 1 H), 2.52 – 2.61 (m, 1 H), 4.04 – 4.13 (m, 2 H), 4.22 – 4.28 (m, 2 H), 4.52 – 4.56 (m, 1 H), 6.81 (d, J = 8.8 Hz, 2 H), 7.23 (d, J = 8.8 Hz, 2 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-(4-chlorophenoxy)butanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CHEUNG, Mui; DEMARTINO, Michael P.; KALITA, Biswajit; KRISTAM, Rajendra; (128 pag.)WO2019/8507; (2019); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2672-58-4, name is Trimethyl benzene-1,3,5-tricarboxylate, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 2672-58-4

Synthesis of 1,3,5-Tris(hydroxymethyl)benzene (50)(Y. Yamaqiwa, Y. Koreishi. S. Kivozumi, M. Kobavashi, T. Kamikawa, M. Tsukino, H. Goi M. Yamamaoto, M. Munakata. Bull. Chem. Soc. Jpn. 1996, 69, 3317-3323; J. Houk, G. Whitesides. J. Am. Chem. Soc. 1987, 109, 6825-6836) A solution of 1,3,5-tris(methoxycarbonyl)benzene (10.09 g, 40 mmol) in dry THF (400 ml) was added over a period of 3h to a suspension of LiAlH4 (4.03 g, 0.1 mol) in dry THF (300 ml) under N2. After stirring over night at room temperature, the reaction mixture was cooled to 0 C., hydrolyzed with water (4 ml), 2M NaOH (4 ml) and water (12 ml), filtered, and the filter cake washed thoroughly with THF. The combined filtrates were concentrated and the crude product was recrystallized from hot (not boiling) ethanol to afford 50(5.59 g, 83%) as white needles; mp 76-77 C. (lit. 77-78 C.) 1H NMR (300 MHz, DMSO-d6) delta4.49 (d, 3H, J4.8 Hz, CH2), 5.30 (t, 1H, J5.4 Hz, OH), 7.14 (s, 1H, aromat. H).

According to the analysis of related databases, 2672-58-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Davis, Benjamin G.; Jones, John Bryan; Bott, Richard R.; US2002/19039; (2002); A1;,
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Electric Literature of 1731-79-9,Some common heterocyclic compound, 1731-79-9, name is Dimethyl dodecanedioate, molecular formula is C14H26O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Into a reaction flask dicarboxylic acid dimethyl ester and fatty alcohol or cholesterol were added at the ratio of 1:2, respectively. After addition of the ionic liquid catalyst (2.5 mmol %) the resulting mixture was heated with stirring at 110 C for 16 h. At the end of this, the flask was cooled to room temperature and the resulting solid reaction mixture was crystallized from THF/MeOH to afford pure crystalline product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Dimethyl dodecanedioate, its application will become more common.

Reference:
Article; Yildirim, Ayhan; Kiraylar, Kaan; Turkish Journal of Chemistry; vol. 43; 3; (2019); p. 802 – 808;,
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